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In mouse models, they cause progressive dilated cardiomyopathy (DCM) whose characterization with echocardiography requires prolonged protocols with numerous animals, complicating the evaluation of new treatments. Here, we report on the characterization of \u03b21-aabs-induced DCM in mice using 11.7T MRI. C57BL\/6J mice (n\u2009=\u200910 per group) were immunized against the \u03b21-AR and left ventricular (LV) systolic function was assessed at 10, 18 and 27 weeks. Increase in LV mass\/tibial length ratio was detected as the first modification at 10 weeks together with dilation of cavities, thereby outperforming echocardiography. Significant impairment in diastolic index was also observed in immunized animals before the onset of systolic dysfunction. Morphometric and histological measurements confirmed these observations. The same protocol performed on \u03b23-AR-overexpressing mice and wild-type littermates (n\u2009=\u20098\u201312 per group) showed that transgenic animals were protected with reduced LV\/TL ratio compared to wild-type animals and maintenance of the diastolic index. This study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by \u03b21-aabs and that \u03b23-AR stimulation blunts the development of \u03b21-aabs-induced DCM, thereby paving the way for the use of \u03b23AR-stimulating drugs to treat this autoimmune cardiomyopathy.<\/jats:p>","DOI":"10.1038\/srep43951","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T10:48:40Z","timestamp":1489056520000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MRI Assessment of Cardiomyopathy Induced by \u03b21-Adrenoreceptor Autoantibodies and Protection Through \u03b23-Adrenoreceptor Overexpression"],"prefix":"10.1038","volume":"7","author":[{"given":"Laetitia","family":"Vanhoutte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Guilbaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Martherus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bouzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Gallez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Dessy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Balligand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Moniotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Feron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"BFsrep43951_CR1","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0002-8703(92)90704-Y","volume":"123","author":"CJ Limas","year":"1992","unstructured":"Limas, C. 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