{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:18:49Z","timestamp":1771863529971,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various stem cells have been explored for the purpose of cardiac repair. However, any individual stem cell population has not been considered as the ideal source. Recently, trophoblast stem cells (TSCs), a newly described stem cell type, have demonstrated extensive plasticity. The present study evaluated the therapeutic effect of TSCs transplantation for heart regeneration in a mouse model of myocardial infarction (MI) and made a direct comparison with the most commonly used mesenchymal stem cells (MSCs). Transplantation of TSCs and MSCs led to a remarkably improved cardiac function in contrast with the PBS control, but only the TSCs exhibited the potential of differentiation into cardiomyocytes <jats:italic>in vivo<\/jats:italic>. In addition, a significantly high proliferation level of both transplanted stem cells and resident cardiomyocytes was observed in the TSCs group. These findings primary revealed the therapeutic potential of TSCs in transplantation therapy for MI.<\/jats:p>","DOI":"10.1038\/srep44376","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T14:48:06Z","timestamp":1489589286000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardiac repair in a mouse model of acute myocardial infarction with trophoblast stem cells"],"prefix":"10.1038","volume":"7","author":[{"given":"Guannan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"BFsrep44376_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/01.CIR.97.3.282","volume":"97","author":"M Gheorghiade","year":"1998","unstructured":"Gheorghiade, M. & Bonow, R. O. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation 97, 282\u2013289 (1998).","journal-title":"Circulation"},{"key":"BFsrep44376_CR2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/s0140-6736(14)60921-1","volume":"385","author":"J Li","year":"2015","unstructured":"Li, J. et al. ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data. Lancet (London, England) 385, 441\u2013451, doi: 10.1016\/s0140-6736(14)60921-1 (2015).","journal-title":"Lancet (London, England)"},{"key":"BFsrep44376_CR3","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","volume":"101","author":"MG Sutton","year":"2000","unstructured":"Sutton, M. G. & Sharpe, N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101, 2981\u20132988 (2000).","journal-title":"Circulation"},{"key":"BFsrep44376_CR4","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1161\/circulationaha.108.784215","volume":"118","author":"RS Velagaleti","year":"2008","unstructured":"Velagaleti, R. S. et al. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 118, 2057\u20132062, doi: 10.1161\/circulationaha.108.784215 (2008).","journal-title":"Circulation"},{"key":"BFsrep44376_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann, O. et al. Evidence for Cardiomyocyte Renewal in Humans. Science 324, 98\u2013102, doi: DOI 10.1126\/science.1164680 (2009).","journal-title":"Science"},{"key":"BFsrep44376_CR6","doi-asserted-by":"publisher","first-page":"8850","DOI":"10.1073\/pnas.1408233111","volume":"111","author":"SR Ali","year":"2014","unstructured":"Ali, S. R. et al. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. P Natl Acad Sci USA 111, 8850\u20138855, doi: 10.1073\/pnas.1408233111 (2014).","journal-title":"P Natl Acad Sci USA"},{"key":"BFsrep44376_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.stem.2014.03.009","volume":"14","author":"PK Nguyen","year":"2014","unstructured":"Nguyen, P. K., Riegler, J. & Wu, J. C. Stem cell imaging: from bench to bedside. Cell Stem Cell 14, 431\u2013444, doi: 10.1016\/j.stem.2014.03.009 (2014).","journal-title":"Cell Stem Cell"},{"key":"BFsrep44376_CR8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature10147","volume":"473","author":"MA Laflamme","year":"2011","unstructured":"Laflamme, M. A. & Murry, C. E. Heart regeneration. Nature 473, 326\u2013335, doi: 10.1038\/nature10147 (2011).","journal-title":"Nature"},{"key":"BFsrep44376_CR9","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/nature06800","volume":"451","author":"VF Segers","year":"2008","unstructured":"Segers, V. F. & Lee, R. T. Stem-cell therapy for cardiac disease. Nature 451, 937\u2013942, doi: 10.1038\/nature06800 (2008).","journal-title":"Nature"},{"key":"BFsrep44376_CR10","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.stem.2013.05.008","volume":"12","author":"JC Garbern","year":"2013","unstructured":"Garbern, J. C. & Lee, R. T. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell 12, 689\u2013698, doi: 10.1016\/j.stem.2013.05.008 (2013).","journal-title":"Cell Stem Cell"},{"key":"BFsrep44376_CR11","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1161\/CIRCRESAHA.111.243071","volume":"109","author":"S Mohsin","year":"2011","unstructured":"Mohsin, S., Siddiqi, S., Collins, B. & Sussman, M. A. Empowering adult stem cells for myocardial regeneration. Circulation research 109, 1415\u20131428, doi: 10.1161\/CIRCRESAHA.111.243071 (2011).","journal-title":"Circulation research"},{"key":"BFsrep44376_CR12","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1095\/biolreprod.110.088724","volume":"84","author":"RM Roberts","year":"2011","unstructured":"Roberts, R. M. & Fisher, S. J. Trophoblast stem cells. Biology of reproduction 84, 412\u2013421, doi: 10.1095\/biolreprod.110.088724 (2011).","journal-title":"Biology of reproduction"},{"key":"BFsrep44376_CR13","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00018-015-2086-9","volume":"73","author":"J Prudhomme","year":"2016","unstructured":"Prudhomme, J. & Morey, C. Epigenesis and plasticity of mouse trophoblast stem cells. Cellular and molecular life sciences: CMLS 73, 757\u2013774, doi: 10.1007\/s00018-015-2086-9 (2016).","journal-title":"Cellular and molecular life sciences: CMLS"},{"key":"BFsrep44376_CR14","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/stem.617","volume":"29","author":"T Wu","year":"2011","unstructured":"Wu, T. et al. Reprogramming of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4. Stem Cells 29, 755\u2013763, doi: 10.1002\/stem.617 (2011).","journal-title":"Stem Cells"},{"key":"BFsrep44376_CR15","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.stemcr.2013.12.013","volume":"2","author":"C Kubaczka","year":"2014","unstructured":"Kubaczka, C. et al. Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem cell reports 2, 232\u2013242, doi: 10.1016\/j.stemcr.2013.12.013 (2014).","journal-title":"Stem cell reports"},{"key":"BFsrep44376_CR16","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1172\/JCI22991","volume":"114","author":"K Red-Horse","year":"2004","unstructured":"Red-Horse, K. et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. The Journal of clinical investigation 114, 744\u2013754, doi: 10.1172\/JCI22991 (2004).","journal-title":"The Journal of clinical investigation"},{"key":"BFsrep44376_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1161\/CIRCRESAHA.111.249037","volume":"110","author":"RJ Kara","year":"2012","unstructured":"Kara, R. J. et al. Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation. Circulation research 110, 82\u201393, doi: 10.1161\/CIRCRESAHA.111.249037 (2012).","journal-title":"Circulation research"},{"key":"BFsrep44376_CR18","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1242\/Dev.01801","volume":"132","author":"D Strumpf","year":"2005","unstructured":"Strumpf, D. et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132, 2093\u20132102, doi: Doi 10.1242\/Dev.01801 (2005).","journal-title":"Development"},{"key":"BFsrep44376_CR19","doi-asserted-by":"publisher","first-page":"19155","DOI":"10.1038\/srep19155","volume":"6","author":"D Mu","year":"2016","unstructured":"Mu, D. et al. Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction. Scientific reports 6, 19155, doi: 10.1038\/srep19155 (2016).","journal-title":"Scientific reports"},{"key":"BFsrep44376_CR20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.stem.2011.02.002","volume":"8","author":"FS Loffredo","year":"2011","unstructured":"Loffredo, F. S., Steinhauser, M. L., Gannon, J. & Lee, R. T. Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair. Cell Stem Cell 8, 389\u2013398, doi: DOI 10.1016\/j.stem.2011.02.002 (2011).","journal-title":"Cell Stem Cell"},{"key":"BFsrep44376_CR21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-3-319-22380-3_7","volume":"887","author":"M Gnecchi","year":"2015","unstructured":"Gnecchi, M., Pisano, F. & Bariani, R. microRNA and Cardiac Regeneration. Advances in experimental medicine and biology 887, 119\u2013141, doi: 10.1007\/978-3-319-22380-3_7 (2015).","journal-title":"Advances in experimental medicine and biology"},{"key":"BFsrep44376_CR22","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3892\/or.2013.2897","volume":"31","author":"J Yu","year":"2014","unstructured":"Yu, J. et al. miR-200b suppresses cell proliferation, migration and enhances chemosensitivity in prostate cancer by regulating Bmi-1. Oncology reports 31, 910\u2013918, doi: 10.3892\/or.2013.2897 (2014).","journal-title":"Oncology reports"},{"key":"BFsrep44376_CR23","doi-asserted-by":"publisher","first-page":"36502","DOI":"10.1074\/jbc.M113.502047","volume":"288","author":"Y Kim","year":"2013","unstructured":"Kim, Y. et al. miR-200b and cancer\/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs. The Journal of biological chemistry 288, 36502\u201336518, doi: 10.1074\/jbc.M113.502047 (2013).","journal-title":"The Journal of biological chemistry"},{"key":"BFsrep44376_CR24","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/1346-8138.12600","volume":"41","author":"P Li","year":"2014","unstructured":"Li, P., He, Q. Y. & Luo, C. Q. Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro . The Journal of dermatology 41, 903\u2013911, doi: 10.1111\/1346-8138.12600 (2014).","journal-title":"The Journal of dermatology"},{"key":"BFsrep44376_CR25","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.3892\/mmr.2016.4995","volume":"13","author":"XY Li","year":"2016","unstructured":"Li, X. Y. et al. MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a. Molecular medicine reports 13, 3929\u20133935, doi: 10.3892\/mmr.2016.4995 (2016).","journal-title":"Molecular medicine reports"},{"key":"BFsrep44376_CR26","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1161\/CIRCRESAHA.111.249052","volume":"109","author":"VF Segers","year":"2011","unstructured":"Segers, V. F. & Lee, R. T. Biomaterials to enhance stem cell function in the heart. Circulation research 109, 910\u2013922, doi: 10.1161\/CIRCRESAHA.111.249052 (2011).","journal-title":"Circulation research"},{"key":"BFsrep44376_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bbrc.2014.03.131","volume":"447","author":"XQ Chen","year":"2014","unstructured":"Chen, X. Q. et al. Stem cells with FGF4-bFGF fused gene enhances the expression of bFGF and improves myocardial repair in rats. Biochemical and biophysical research communications 447, 145\u2013151, doi: 10.1016\/j.bbrc.2014.03.131 (2014).","journal-title":"Biochemical and biophysical research communications"},{"key":"BFsrep44376_CR28","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1161\/CIRCRESAHA.113.300215","volume":"113","author":"SM Jay","year":"2013","unstructured":"Jay, S. M. & Lee, R. T. Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair. Circulation research 113, 933\u2013943, doi: 10.1161\/CIRCRESAHA.113.300215 (2013).","journal-title":"Circulation research"},{"key":"BFsrep44376_CR29","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1161\/atvbaha.109.189662","volume":"29","author":"YJ Yang","year":"2009","unstructured":"Yang, Y. J. et al. Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts. Arteriosclerosis, thrombosis, and vascular biology 29, 2076\u20132082, doi: 10.1161\/atvbaha.109.189662 (2009).","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"BFsrep44376_CR30","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1161\/ATVBAHA.113.300138","volume":"33","author":"FH Seeger","year":"2013","unstructured":"Seeger, F. H., Zeiher, A. M. & Dimmeler, S. MicroRNAs in stem cell function and regenerative therapy of the heart. Arteriosclerosis, thrombosis, and vascular biology 33, 1739\u20131746, doi: 10.1161\/ATVBAHA.113.300138 (2013).","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"BFsrep44376_CR31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.4161\/rna.24370","volume":"10","author":"CX Yao","year":"2013","unstructured":"Yao, C. X. et al. miR-200b targets GATA-4 during cell growth and differentiation. RNA biology 10, 465\u2013480, doi: 10.4161\/rna.24370 (2013).","journal-title":"RNA biology"},{"key":"BFsrep44376_CR32","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1096\/fj.06-6769com","volume":"21","author":"J Nussbaum","year":"2007","unstructured":"Nussbaum, J. et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 21, 1345\u20131357, doi: 10.1096\/fj.06-6769com (2007).","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"BFsrep44376_CR33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.2217\/rme.15.41","volume":"10","author":"KA Campbell","year":"2015","unstructured":"Campbell, K. A., Terzic, A. & Nelson, T. J. Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery. Regenerative medicine 10, 773\u2013783, doi: 10.2217\/rme.15.41 (2015).","journal-title":"Regenerative medicine"},{"key":"BFsrep44376_CR34","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/jcmm.12242","volume":"18","author":"Q Li","year":"2014","unstructured":"Li, Q. et al. Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction. Journal of cellular and molecular medicine 18, 919\u2013928, doi: 10.1111\/jcmm.12242 (2014).","journal-title":"Journal of cellular and molecular medicine"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep44376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep44376","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep44376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:30:41Z","timestamp":1671841841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep44376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,6,1]]}},"alternative-id":["BFsrep44376"],"URL":"https:\/\/doi.org\/10.1038\/srep44376","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]},"assertion":[{"value":"26 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44376"}}