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In cultured human umbilical vein endothelial cells (HUVECs), the expression of miR-455-3p, eNOS protein and the NO production was detected after administration with 50\u2009\u03bcM NaHS. The results indicated that H\n                    <jats:sub>2<\/jats:sub>\n                    S could augment the expression of miR-455-3p and eNOS protein, leading to the increase of NO level. We also found that overexpression of miR-455-3p in HUVECs increased the protein levels of eNOS whereas inhibition of miR-455-3p decreased it. Moreover, H\n                    <jats:sub>2<\/jats:sub>\n                    S and miR-455-3p could no longer increase the protein level of eNOS in the presence of proteasome inhibitor, MG-132.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , miR-455-3p and eNOS expression were considerably increased in C57BL\/6 mouse aorta, muscle and heart after administration with 50\u2009\u03bcmol\/kg\/day NaHS for 7 days. We also identified that H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and miR-455-3p expression increased in human atherosclerosis plaque while H\n                    <jats:sub>2<\/jats:sub>\n                    S levels decreased in plasma of atherosclerosis patients. Our data suggest that the stability of eNOS protein and the NO production could be regulated by H\n                    <jats:sub>2<\/jats:sub>\n                    S through miR-455-3p.\n                  <\/jats:p>","DOI":"10.1038\/srep44807","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T12:16:31Z","timestamp":1490098591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression"],"prefix":"10.1038","volume":"7","author":[{"given":"Xing-Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Long","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Bei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"BFsrep44807_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","volume":"237","author":"R Hosoki","year":"1997","unstructured":"Hosoki, R., Matsuki, N. & Kimura, H. 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