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However, recent studies demonstrate a significant contribution of Ca<jats:sup>2+<\/jats:sup> influx to spontaneous and evoked Ca<jats:sup>2+<\/jats:sup> signaling in astrocytes, suggesting that Ca<jats:sup>2+<\/jats:sup> influx might account for astrocytic Ca<jats:sup>2+<\/jats:sup> signaling to a greater extent than previously thought. Here, we investigated AMPA-evoked Ca<jats:sup>2+<\/jats:sup> influx into olfactory bulb astrocytes in mouse brain slices using Fluo-4 and GCaMP6s, respectively. Bath application of AMPA evoked Ca<jats:sup>2+<\/jats:sup> transients in periglomerular astrocytes that persisted after neuronal transmitter release was inhibited by tetrodotoxin and bafilomycin A1. Withdrawal of external Ca<jats:sup>2+<\/jats:sup> suppressed AMPA-evoked Ca<jats:sup>2+<\/jats:sup> transients, whereas depletion of Ca<jats:sup>2+<\/jats:sup> stores had no effect. Both Ca<jats:sup>2+<\/jats:sup> transients and inward currents induced by AMPA receptor activation were partly reduced by Naspm, a blocker of Ca<jats:sup>2+<\/jats:sup>-permeable AMPA receptors lacking the GluA2 subunit. Antibody staining revealed a strong expression of GluA1 and GluA4 and a weak expression of GluA2 in periglomerular astrocytes. Our results indicate that Naspm-sensitive, Ca<jats:sup>2+<\/jats:sup>-permeable AMPA receptors contribute to Ca<jats:sup>2+<\/jats:sup> signaling in periglomerular astrocytes in the olfactory bulb.<\/jats:p>","DOI":"10.1038\/srep44817","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T16:19:35Z","timestamp":1490113175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes"],"prefix":"10.1038","volume":"7","author":[{"given":"Damian","family":"Droste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Seddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"J\u00e4dtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steinh\u00e4user","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"BFsrep44817_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1471-4159.2012.07664.x","volume":"121","author":"V Parpura","year":"2012","unstructured":"Parpura, V. et al. 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