{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:12:43Z","timestamp":1784754763021,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to compare the therapeutic efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy. A double-blinded, randomized, controlled trial was conducted. One hundred pregnant women at less than 36 weeks gestation with heartburn at least twice per week were randomized to either alginate-based reflux suppressant or to magnesium-aluminium antacid gel. Details of heartburn were recorded before beginning the treatment and the second week of study. Primary outcome measure was the improvement of heartburn frequency after treatment and secondary outcome were the improvement of heartburn intensity, quality of life, maternal satisfaction, maternal side effects, pregnancy and neonatal outcomes. There was no difference between treatment and control groups in improvement of heartburn frequency (80% vs 88%, p\u2009=\u20090.275), 50% reduction of frequency of heartburn (56% vs 52%, p\u2009=\u20090.688), improvement of heartburn intensity (92% vs 92%, p\u2009=\u20091.000) and 50% reduction of heartburn intensity (68% vs 80% cases, p\u2009=\u20090.075). There were also no significant differences in quality of life, maternal satisfaction, maternal side effects, pregnancy and neonatal outcomes. Alginate-based reflux suppressant was not different from magnesium-aluminium antacid gel in the treatment of heartburn in pregnancy.<\/jats:p>","DOI":"10.1038\/srep44830","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T10:31:33Z","timestamp":1490005893000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy: a randomized double-blind controlled trial"],"prefix":"10.1038","volume":"7","author":[{"given":"Pontip","family":"Meteerattanapipat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vorapong","family":"Phupong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"BFsrep44830_CR1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/j.1365-2036.2005.02654.x","volume":"22","author":"JE Richter","year":"2005","unstructured":"Richter, J. E. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 22, 749\u2013757 (2005).","journal-title":"Aliment Pharmacol Ther."},{"key":"BFsrep44830_CR2","doi-asserted-by":"crossref","unstructured":"Phupong, V. & Hanprasertpong, T. Interventions for heartburn in pregnancy. Cochrane Database Syst Rev. CD011379 (2015).","DOI":"10.1002\/14651858.CD011379.pub2"},{"key":"BFsrep44830_CR3","doi-asserted-by":"crossref","unstructured":"Dowswell, T. & Neilson, J. P. Interventions for heartburn in pregnancy. Cochrane Database Syst Rev. CD007065 (2008).","DOI":"10.1002\/14651858.CD007065"},{"key":"BFsrep44830_CR4","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/j.1471-0528.1992.tb13873.x","volume":"99","author":"JM Marrero","year":"1992","unstructured":"Marrero, J. M., Goggin, P. M., de Caestecker, J. S., Pearce, J. M. & Maxwell, J. D. Determinants of pregnancy heartburn. Br J Obstet Gynaecol. 99, 731\u2013734 (1992).","journal-title":"Br J Obstet Gynaecol."},{"key":"BFsrep44830_CR5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0016-5085(77)80151-0","volume":"72","author":"DH Van Thiel","year":"1977","unstructured":"Van Thiel, D. H., Gavaler, J. S., Joshi, S. N., Sara, R. K. & Stremple, J. Heartburn of pregnancy. Gastroenterology. 72, 666\u2013668 (1977).","journal-title":"Gastroenterology."},{"key":"BFsrep44830_CR6","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/0002-9378(81)90037-5","volume":"140","author":"DH Van Thiel","year":"1981","unstructured":"Van Thiel, D. H. & Wald, A. Evidence refuting a role for increased abdominal pressure in the pathogenesis of the heartburn associated with pregnancy. Am J Obstet Gynecol. 140, 420\u2013422 (1981).","journal-title":"Am J Obstet Gynecol."},{"key":"BFsrep44830_CR7","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1053\/j.gastro.2006.04.049","volume":"131","author":"U Mahadevan","year":"2006","unstructured":"Mahadevan, U. & Kane, S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 131, 283\u2013311 (2006).","journal-title":"Gastroenterology."},{"key":"BFsrep44830_CR8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2165\/00003495-199447020-00006","volume":"47","author":"CK Ching","year":"1994","unstructured":"Ching, C. K. & Lam, S. K. Antacids. Indications and limitations. Drugs. 47, 305\u2013317 (1994).","journal-title":"Drugs."},{"key":"BFsrep44830_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijpharm.2005.01.036","volume":"294","author":"FC Hampson","year":"2005","unstructured":"Hampson, F. C. et al. Alginate rafts and their characterisation. Int J Pharm. 294, 137\u2013147 (2005).","journal-title":"Int J Pharm."},{"key":"BFsrep44830_CR10","first-page":"541","volume":"65","author":"G Quartarone","year":"2013","unstructured":"Quartarone, G. Gastroesophageal reflux in pregnancy: a systematic review on the benefit of raft forming agents. Minerva Ginecol. 65, 541\u2013549 (2013).","journal-title":"Minerva Ginecol."},{"key":"BFsrep44830_CR11","doi-asserted-by":"crossref","first-page":"481870","DOI":"10.5402\/2012\/481870","volume":"2012","author":"V Strugala","year":"2012","unstructured":"Strugala, V. et al. Assessment of the Safety and Efficacy of a Raft-Forming Alginate Reflux Suppressant (Liquid Gaviscon) for the Treatment of Heartburn during Pregnancy. ISRN Obstet Gynecol. 2012, 481870 (2012).","journal-title":"ISRN Obstet Gynecol."},{"key":"BFsrep44830_CR12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1742-1241.2003.tb10458.x","volume":"57","author":"SW Lindow","year":"2003","unstructured":"Lindow, S. W., Regnell, P., Sykes, J. & Little, S. An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy. Int J Clin Pract. 57, 175\u2013179 (2003).","journal-title":"Int J Clin Pract."},{"key":"BFsrep44830_CR13","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1046\/j.1365-2036.2000.00759.x","volume":"14","author":"KG Mandel","year":"2000","unstructured":"Mandel, K. G., Daggy, B. P., Brodie, D. A. & Jacoby, H. I. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther. 14, 669\u2013690 (2000).","journal-title":"Aliment Pharmacol Ther."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep44830.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep44830","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep44830.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:35:17Z","timestamp":1692729317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep44830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,3]]}},"alternative-id":["BFsrep44830"],"URL":"https:\/\/doi.org\/10.1038\/srep44830","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,20]]},"assertion":[{"value":"7 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44830"}}