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On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1\u03b2 and pro-IL-18 into their biologically active forms. \u201cICE<jats:sup>\u2212\/\u2212<\/jats:sup>\u201d or \u201c<jats:italic>Casp1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>\u201d mice generated using 129 embryonic stem cells carry a 129-associated inactivating passenger mutation on the<jats:italic>caspase-11<\/jats:italic>locus, essentially making them deficient in both caspase-1 and caspase-11. The overlapping and unique functions of caspase-1 and caspase-11 are difficult to unravel without additional genetic tools. Here, we generated caspase-1\u2013deficient mouse (<jats:italic>Casp1<\/jats:italic><jats:sup>Null<\/jats:sup>) on the C57BL\/6\u2009J background that expressed caspase-11.<jats:italic>Casp1<\/jats:italic><jats:sup>Null<\/jats:sup>cells did not release IL-1\u03b2 and IL-18 in response to NLRC4 activators<jats:italic>Salmonella<\/jats:italic>Typhimurium and flagellin, canonical or non-canonical NLRP3 activators LPS and ATP,<jats:italic>Escherichia coli, Citrobacter rodentium<\/jats:italic>and transfection of LPS, AIM2 activators<jats:italic>Francisella novicida<\/jats:italic>, mouse cytomegalovirus and DNA, and the infectious agents<jats:italic>Listeria monocytogenes<\/jats:italic>and<jats:italic>Aspergillus fumigatus<\/jats:italic>. We further demonstrated that caspase-1 and caspase-11 differentially contributed to the host defense against<jats:italic>A. fumigatus<\/jats:italic>infection and to endotoxemia.<\/jats:p>","DOI":"10.1038\/srep45126","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T09:28:39Z","timestamp":1490606919000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Differential roles of caspase-1 and caspase-11 in infection and inflammation"],"prefix":"10.1038","volume":"7","author":[{"given":"Si Ming","family":"Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Karki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Briard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gingras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"BFsrep45126_CR1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2004.05.004","volume":"117","author":"F Martinon","year":"2004","unstructured":"Martinon, F. & Tschopp, J. 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