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Initially due to the lacuna of LCC, we modeled the protein through modeller 9.15v and evaluated through servers. Docking studies were performed with the synthesized compounds and resulted two best compounds, i.e.,<jats:bold>5a, 5e<\/jats:bold>showed the best binding energies. The activity of intracellular Ca<jats:sup>2+<\/jats:sup>measurements was performed on two cell lines: A7r5 (rat aortic smooth muscle cells) and SH-SY5Y (human neuroblastoma cells). The 5a and 5e compounds was showing the more specific activity on L-type calcium channels, i.e. A7r5 (IC<jats:sub>50<\/jats:sub>\u2009=\u20090.18\u2009\u00b1\u20090.02 and 0.25\u2009\u00b1\u20090.63\u2009\u03bcg\/ml, respectively) (containing only L-type channels) than SH-SY5Y (i.e. both L-type and T-type channels) (IC<jats:sub>50<\/jats:sub>\u2009=\u20098\u2009\u00b1\u20090.23 and 10\u2009\u00b1\u20090.18\u2009\u03bcg\/ml, respectively) with intracellular calcium mobility similar to amlodipine. Finally, both<jats:italic>in silico<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>results exploring two derivatives 5a and 5e succeeded to treat cadmium toxicity.<\/jats:p>","DOI":"10.1038\/srep45211","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T09:59:09Z","timestamp":1490608749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity"],"prefix":"10.1038","volume":"7","author":[{"given":"Madhu Sudhana","family":"Saddala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kandimalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeepkiran Jangampalli","family":"Adi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainath Sri","family":"Bhashyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha Rani","family":"Asupatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"BFsrep45211_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5012\/jkcs.2013.57.1.99","volume":"57","author":"B Prafulla","year":"2013","unstructured":"Prafulla, B. et al. 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