{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:46:55Z","timestamp":1767152815048,"version":"build-2238731810"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Membrane-bound proteases are essential for epidermal integrity. Human airway trypsin-like protease 4 (HAT-L4) is a type II transmembrane serine protease. Currently, its biochemical property, cellular distribution and physiological function remain unknown. Here we examined HAT-L4 expression and function\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . In Western analysis, HAT-L4 expressed in transfected CHO cells appeared as a 48-kDa protein. Flow cytometry confirmed HAT-L4 expression on the cell surface with the expected membrane topology. RT-PCR and immunostaining experiments indicated that HAT-L4 was expressed in epithelial cells and exocrine glands in tissues including skin, esophagus, trachea, tongue, eye, bladder, testis and uterus. In the skin, HAT-L4 expression was abundant in keratinocytes and sebaceous glands. We generated HAT-L4 knockout mice by disrupting the\n                    <jats:italic>Tmprss11f<\/jats:italic>\n                    gene encoding HAT-L4. HAT-L4 knockout mice were viable and fertile. No defects were found in HAT-L4 knockout mice in hair growth, wound healing, water repulsion and body temperature regulation. Compared with wild-type controls, HAT-L4-deficient newborn mice had greater body fluid loss and higher mortality in a trans-epidermal body fluid loss test. In metabolic studies, HAT-L4-deficient adult mice drank water more frequently than wild-type controls did. These results indicate that HAT-L4 is important in epidermal barrier function to prevent body fluid loss.\n                  <\/jats:p>","DOI":"10.1038\/srep45262","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:12:36Z","timestamp":1490335956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss"],"prefix":"10.1038","volume":"7","author":[{"given":"Zhiwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yae","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningzheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"BFsrep45262_CR1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrm2120","volume":"8","author":"CM Overall","year":"2007","unstructured":"Overall, C. 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M. & Wu, Q. Type II transmembrane serine proteases. J Biol Chem 284, 23177\u201323181 (2009).","journal-title":"J Biol Chem"},{"key":"BFsrep45262_CR5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1074\/jbc.R000020200","volume":"276","author":"JD Hooper","year":"2001","unstructured":"Hooper, J. D., Clements, J. A., Quigley, J. P. & Antalis, T. M. Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 276, 857\u2013860. (2001).","journal-title":"J Biol Chem"},{"key":"BFsrep45262_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-385504-6.00001-4","volume":"99","author":"TM Antalis","year":"2011","unstructured":"Antalis, T. M., Bugge, T. H. & Wu, Q. Membrane-anchored serine proteases in health and disease. 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A. & List, K. Type II transmembrane serine proteases as potential targets for cancer therapy. Biol Chem(2016).","DOI":"10.1515\/hsz-2016-0131"},{"key":"BFsrep45262_CR10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev-cellbio-092910-154247","volume":"27","author":"R Szabo","year":"2011","unstructured":"Szabo, R. & Bugge, T. H. Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol 27, 213\u2013235 (2011).","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFsrep45262_CR11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2741\/3704","volume":"16","author":"SL Webb","year":"2011","unstructured":"Webb, S. L., Sanders, A. J., Mason, M. D. & Jiang, W. G. Type II transmembrane serine protease (TTSP) deregulation in cancer. 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