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Their preclinical investigations are mostly based on genetically-engineered animals. Despite their interest, these models are often based on high level of disease-related protein expression, thus questioning their relevance to human pathology and calling for the alternate use of ecological models. In the past few years,\n                    <jats:italic>Octodon degus<\/jats:italic>\n                    has emerged as a promising animal model displaying age-dependent Alzheimer\u2019s disease-related pathology. As neurodegenerative-related proteins often co-deposit in the brain of patients, we assessed the occurrence of \u03b1-synuclein-related pathology in this model using state-of-the-art immunohistochemistry and biochemistry. Despite our efforts and in contrast with previously published results, our study argues against the use of\n                    <jats:italic>Octodon degus<\/jats:italic>\n                    as a suitable natural model of neurodegenerative disorder as we failed to identify either Parkinson\u2019s disease- or Alzheimer\u2019s disease-related brain pathologies.\n                  <\/jats:p>","DOI":"10.1038\/srep45831","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T08:22:38Z","timestamp":1491294158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model"],"prefix":"10.1038","volume":"7","author":[{"given":"Mathieu","family":"Bourdenx","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Dovero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Thiolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dehay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"BFsrep45831_CR1","doi-asserted-by":"crossref","unstructured":"Bourdenx, M. et al. 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