{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:34:06Z","timestamp":1783798446461,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Birth asphyxia constitutes a major global public health burden for millions of infants, despite hypothermia therapy. There is a critical need for real time surrogate markers of therapeutic success, to aid in patient selection and\/or modification of interventions in neonatal encephalopathy (NE). This is a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of the dynamic coherence between amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy in NE. NVC coupling is assessed by a wavelet metric estimation of percent time of coherence between NIRS S<jats:sub>ct<\/jats:sub>O<jats:sub>2<\/jats:sub> and aEEG for 78\u2009hours after birth. An abnormal outcome was predefined by a Bayley III score &lt;85 by 18\u201324\u2009m. We observed high coherence, intact NVC, between the oscillations of S<jats:sub>ct<\/jats:sub>O<jats:sub>2<\/jats:sub> and aEEG in the frequency range of 0.00025\u20130.001\u2009Hz in the non-encephalopathic newborns. NVC coherence was significantly decreased in encephalopathic newborns who were cooled vs. non-encephalopathic controls (median IQR 3[2\u20139] vs.36 [33\u201339]; p\u2009&lt;\u20090.01), and was significantly lower in those with abnormal 24 months outcomes relative to those with normal outcomes (median IQR 2[1\u20133] vs 28[19\u201326], p\u2009=\u20090.04). Wavelet coherence analysis of neurovascular coupling in NE may identify infants at risk for abnormal outcomes.<\/jats:p>","DOI":"10.1038\/srep45958","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T10:12:19Z","timestamp":1491819139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Novel Wavelet Real Time Analysis of Neurovascular Coupling in Neonatal Encephalopathy"],"prefix":"10.1038","volume":"7","author":[{"given":"Lina F.","family":"Chalak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Adams-Huet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Vasil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbot","family":"Laptook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tarumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"BFsrep45958_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/jp.2014.67","volume":"34","author":"LF Chalak","year":"2014","unstructured":"Chalak, L. F. et al. Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III. J Perinatol 34, 629\u2013633, doi: 10.1038\/jp.2014.67 (2014).","journal-title":"J Perinatol"},{"key":"BFsrep45958_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.siny.2010.02.003","volume":"15","author":"PS Shah","year":"2010","unstructured":"Shah, P. S. Hypothermia: a systematic review and meta-analysis of clinical trials. Semin Fetal Neonatal Med 15, 238\u2013246, doi: S1744-165X(10)00014-4 10.1016\/j.siny.2010.02.003 (2010).","journal-title":"Semin Fetal Neonatal Med"},{"key":"BFsrep45958_CR3","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMra041996","volume":"351","author":"DM Ferriero","year":"2004","unstructured":"Ferriero, D. M. Neonatal brain injury. N Engl J Med 351, 1985\u20131995, doi: 351\/19\/1985 10.1056\/NEJMra041996 (2004).","journal-title":"N Engl J Med"},{"key":"BFsrep45958_CR4","unstructured":"Dupont, T. L. et al. Short-Term Outcomes of Newborns with Perinatal Acidemia Who are Not Eligible for Systemic Hypothermia Therapy. J Pediatr, doi: S0022-3476(12)00730-5 10.1016\/j.jpeds.2012.06.042 (2012)."},{"key":"BFsrep45958_CR5","doi-asserted-by":"crossref","unstructured":"Murray, D. M., O\u2019Connor, C. M., Ryan, C. A., Korotchikova, I. & Boylan, G. B. Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy. Pediatrics, doi: 10.1542\/peds.2016-0659 (2016).","DOI":"10.1542\/peds.2016-0659"},{"key":"BFsrep45958_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1542\/peds.111.2.351","volume":"111","author":"LF Shalak","year":"2003","unstructured":"Shalak, L. F., Laptook, A. R., Velaphi, S. C. & Perlman, J. M. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics 111, 351\u2013357 (2003).","journal-title":"Pediatrics"},{"key":"BFsrep45958_CR7","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","volume":"365","author":"PD Gluckman","year":"2005","unstructured":"Gluckman, P. D. et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365, 663\u2013670, doi: S014067360517946 10.1016\/S0140-6736(05)17946-X (2005).","journal-title":"Lancet"},{"key":"BFsrep45958_CR8","unstructured":"Higgins, R. D. et al. Hypothermia and Other Treatment Options for Neonatal Encephalopathy: An Executive Summary of the Eunice Kennedy Shriver NICHD Workshop. J Pediatr, doi: S0022-3476(11)00786-4 10.1016\/j.jpeds.2011.08.004 (2011)."},{"key":"BFsrep45958_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fnins.2014.00359","volume":"8","author":"I Kratzer","year":"2014","unstructured":"Kratzer, I., Chip, S. & Vexler, Z. S. Barrier mechanisms in neonatal stroke. Frontiers in neuroscience 8, 359, doi: 10.3389\/fnins.2014.00359 (2014).","journal-title":"Frontiers in neuroscience"},{"key":"BFsrep45958_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.clp.2013.09.004","volume":"41","author":"SE Juul","year":"2014","unstructured":"Juul, S. E. & Ferriero, D. M. Pharmacologic neuroprotective strategies in neonatal brain injury. Clin Perinatol 41, 119\u2013131, doi: 10.1016\/j.clp.2013.09.004 (2014).","journal-title":"Clin Perinatol"},{"key":"BFsrep45958_CR11","doi-asserted-by":"publisher","first-page":"561494","DOI":"10.1155\/2012\/561494","volume":"2012","author":"RM McAdams","year":"2012","unstructured":"McAdams, R. M. & Juul, S. E. The role of cytokines and inflammatory cells in perinatal brain injury. Neurol Res Int 2012, 561494, doi: 10.1155\/2012\/561494 (2012).","journal-title":"Neurol Res Int"},{"key":"BFsrep45958_CR12","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fnins.2015.00040","volume":"9","author":"R Moretti","year":"2015","unstructured":"Moretti, R. et al. Blood-brain barrier dysfunction in disorders of the developing brain. Frontiers in neuroscience 9, 40, doi: 10.3389\/fnins.2015.00040 (2015).","journal-title":"Frontiers in neuroscience"},{"key":"BFsrep45958_CR13","doi-asserted-by":"publisher","first-page":"F201","DOI":"10.1136\/adc.2004.062745","volume":"90","author":"LS de Vries","year":"2005","unstructured":"de Vries, L. S. & Hellstrom-Westas, L. Role of cerebral function monitoring in the newborn. Arch Dis Child Fetal Neonatal Ed 90, F201\u2013207, doi: 90\/3\/F201 10.1136\/adc.2004.062745 (2005).","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFsrep45958_CR14","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1542\/peds.2008-2190","volume":"124","author":"DM Murray","year":"2009","unstructured":"Murray, D. M., Boylan, G. B., Ryan, C. A. & Connolly, S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics 124, e459\u2013467, doi: 10.1542\/peds.2008-2190 (2009).","journal-title":"Pediatrics"},{"key":"BFsrep45958_CR15","doi-asserted-by":"publisher","first-page":"13810","DOI":"10.1038\/srep13810","volume":"5","author":"J Song","year":"2015","unstructured":"Song, J. et al. Early amplitude-integrated electroencephalography predicts brain injury and neurological outcome in very preterm infants. Scientific reports 5, 13810, doi: 10.1038\/srep13810 (2015).","journal-title":"Scientific reports"},{"key":"BFsrep45958_CR16","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1542\/peds.2005-0987","volume":"117","author":"MC Toet","year":"2006","unstructured":"Toet, M. C., Lemmers, P. M., van Schelven, L. J. & van Bel, F. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome. Pediatrics 117, 333\u2013339, doi: 117\/2\/333 10.1542\/peds.2005-0987 (2006).","journal-title":"Pediatrics"},{"key":"BFsrep45958_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/pr.2013.84 pr201384","volume":"74","author":"PM Lemmers","year":"2013","unstructured":"Lemmers, P. M. et al. Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value? Pediatr Res 74, 180\u2013185, doi: 10.1038\/pr.2013.84 pr201384(2013).","journal-title":"Pediatr Res"},{"key":"BFsrep45958_CR18","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1542\/peds.2009-2938","volume":"126","author":"M Thoresen","year":"2010","unstructured":"Thoresen, M., Hellstrom-Westas, L., Liu, X. & de Vries, L. S. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics 126, e131\u2013139, doi: 10.1542\/peds.2009-2938 (2010).","journal-title":"Pediatrics"},{"key":"BFsrep45958_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s00221-006-0388-8","volume":"173","author":"PM Lemmers","year":"2006","unstructured":"Lemmers, P. M., Toet, M., van Schelven, L. J. & van Bel, F. Cerebral oxygenation and cerebral oxygen extraction in the preterm infant: the impact of respiratory distress syndrome. Exp Brain Res 173, 458\u2013467, doi: 10.1007\/s00221-006-0388-8 (2006).","journal-title":"Exp Brain Res"},{"key":"BFsrep45958_CR20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrn3174","volume":"13","author":"MA Yenari","year":"2012","unstructured":"Yenari, M. A. & Han, H. S. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nature reviews. Neuroscience 13, 267\u2013278, doi: 10.1038\/nrn3174 (2012).","journal-title":"Nature reviews. Neuroscience"},{"key":"BFsrep45958_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1161\/01.STR.26.1.74","volume":"26","author":"RB Panerai","year":"1995","unstructured":"Panerai, R. B., Kelsall, A. W., Rennie, J. M. & Evans, D. H. Cerebral autoregulation dynamics in premature newborns. Stroke 26, 74\u201380 (1995).","journal-title":"Stroke"},{"key":"BFsrep45958_CR22","doi-asserted-by":"publisher","first-page":"v","DOI":"10.1016\/j.conb.2015.01.016","volume":"31","author":"G Buzsaki","year":"2015","unstructured":"Buzsaki, G. & Freeman, W. Editorial overview: brain rhythms and dynamic coordination. Current opinion in neurobiology 31, v\u2013ix, doi: 10.1016\/j.conb.2015.01.016 (2015).","journal-title":"Current opinion in neurobiology"},{"key":"BFsrep45958_CR23","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1038\/jcbfm.2015.166","volume":"35","author":"DC Zhu","year":"2015","unstructured":"Zhu, D. C., Tarumi, T., Khan, M. A. & Zhang, R. Vascular coupling in resting-state fMRI: evidence from multiple modalities. J Cereb Blood Flow Metab 35, 1910\u20131920, doi: 10.1038\/jcbfm.2015.166 (2015).","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFsrep45958_CR24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pediatrneurol.2015.11.010","volume":"55","author":"LF Chalak","year":"2016","unstructured":"Chalak, L. F., Tian, F., Tarumi, T. & Zhang, R. Cerebral Hemodynamics in Asphyxiated Newborns Undergoing Hypothermia Therapy: Pilot Findings Using a Multiple-Time-Scale Analysis. Pediatr Neurol 55, 30\u201336, doi: 10.1016\/j.pediatrneurol.2015.11.010 (2016).","journal-title":"Pediatr Neurol"},{"key":"BFsrep45958_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.nicl.2016.01.020","volume":"11","author":"F Tian","year":"2016","unstructured":"Tian, F., Tarumi, T., Liu, H., Zhang, R. & Chalak, L. Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy. NeuroImage. Clinical 11, 124\u2013132, doi: 10.1016\/j.nicl.2016.01.020 (2016).","journal-title":"NeuroImage. Clinical"},{"key":"BFsrep45958_CR26","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1126\/science.1099745","volume":"304","author":"G Buzsaki","year":"2004","unstructured":"Buzsaki, G. & Draguhn, A. Neuronal oscillations in cortical networks. Science 304, 1926\u20131929, doi: 10.1126\/science.1099745 (2004).","journal-title":"Science"},{"key":"BFsrep45958_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3181\/00379727-199-43340B","volume":"199","author":"WM Armstead","year":"1992","unstructured":"Armstead, W. M. & Leffler, C. W. Neurohumoral regulation of the cerebral circulation. Proc Soc Exp Biol Med 199, 149\u2013157 (1992).","journal-title":"Proc Soc Exp Biol Med"},{"key":"BFsrep45958_CR28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.neuroimage.2007.04.002","volume":"36","author":"N Roche-Labarbe","year":"2007","unstructured":"Roche-Labarbe, N., Wallois, F., Ponchel, E., Kongolo, G. & Grebe, R. Coupled oxygenation oscillation measured by NIRS and intermittent cerebral activation on EEG in premature infants. Neuroimage 36, 718\u2013727, doi: 10.1016\/j.neuroimage.2007.04.002 (2007).","journal-title":"Neuroimage"},{"key":"BFsrep45958_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nn980","volume":"6","author":"M Zonta","year":"2003","unstructured":"Zonta, M. et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature neuroscience 6, 43\u201350, doi: 10.1038\/nn980 (2003).","journal-title":"Nature neuroscience"},{"key":"BFsrep45958_CR30","first-page":"161","volume":"2","author":"OB Paulson","year":"1990","unstructured":"Paulson, O. B., Strandgaard, S. & Edvinsson, L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2, 161\u2013192 (1990).","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"BFsrep45958_CR31","doi-asserted-by":"crossref","unstructured":"Astrup, J. et al. Evidence against H+ and K+ as main factors for the control of cerebral blood flow: a microelectrode study. Ciba Foundation symposium, 313\u2013337 (1978).","DOI":"10.1002\/9780470720370.ch16"},{"key":"BFsrep45958_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1152\/japplphysiol.00938.2005","volume":"100","author":"RC Koehler","year":"2006","unstructured":"Koehler, R. C., Gebremedhin, D. & Harder, D. R. Role of astrocytes in cerebrovascular regulation. Journal of applied physiology 100, 307\u2013317, doi: 10.1152\/japplphysiol.00938.2005 (2006).","journal-title":"Journal of applied physiology"},{"key":"BFsrep45958_CR33","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1073\/pnas.83.4.1140","volume":"83","author":"PT Fox","year":"1986","unstructured":"Fox, P. T. & Raichle, M. E. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83, 1140\u20131144 (1986).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep45958_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1113\/jphysiol.1890.sp000321","volume":"11","author":"CS Roy","year":"1890","unstructured":"Roy, C. S. & Sherrington, C. S. On the Regulation of the Blood-supply of the Brain. J Physiol 11, 85\u2013158 117 (1890).","journal-title":"J Physiol"},{"key":"BFsrep45958_CR35","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1161\/01.STR.18.4.771","volume":"18","author":"R Aaslid","year":"1987","unstructured":"Aaslid, R. Visually evoked dynamic blood flow response of the human cerebral circulation. Stroke 18, 771\u2013775 (1987).","journal-title":"Stroke"},{"key":"BFsrep45958_CR36","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1073\/pnas.0437938100","volume":"100","author":"A Sirota","year":"2003","unstructured":"Sirota, A., Csicsvari, J., Buhl, D. & Buzsaki, G. Communication between neocortex and hippocampus during sleep in rodents. Proc Natl Acad Sci USA 100, 2065\u20132069, doi: 10.1073\/pnas.0437938100 (2003).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep45958_CR37","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1203\/pdr.0b013e318045be99","volume":"61","author":"MA Franceschini","year":"2007","unstructured":"Franceschini, M. A. et al. Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatric Research 61, 546\u2013551, doi: 10.1203\/pdr.0b013e318045be99 (2007).","journal-title":"Pediatric Research"},{"key":"BFsrep45958_CR38","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/WNP.0b013e31823e96d7","volume":"28","author":"RA Shellhaas","year":"2011","unstructured":"Shellhaas, R. A. et al. The American Clinical Neurophysiology Society\u2019s Guideline on Continuous Electroencephalography Monitoring in Neonates. J Clin Neurophysiol 28, 611\u2013617, doi: 10.1097\/WNP.0b013e31823e96d7 (2011).","journal-title":"J Clin Neurophysiol"},{"key":"BFsrep45958_CR39","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.siny.2006.07.010","volume":"11","author":"G Greisen","year":"2006","unstructured":"Greisen, G. Is near-infrared spectroscopy living up to its promises? Semin Fetal Neonatal Med 11, 498\u2013502, doi: S1744-165X(06)00077-1 10.1016\/j.siny.2006.07.010 (2006).","journal-title":"Semin Fetal Neonatal Med"},{"key":"BFsrep45958_CR40","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1109\/TBME.2014.2323131","volume":"61","author":"L Faes","year":"2014","unstructured":"Faes, L., Marinazzo, D., Montalto, A. & Nollo, G. Lag-specific transfer entropy as a tool to assess cardiovascular and cardiorespiratory information transfer. IEEE Trans Biomed Eng 61, 2556\u20132568, doi: 10.1109\/TBME.2014.2323131 (2014).","journal-title":"IEEE Trans Biomed Eng"},{"key":"BFsrep45958_CR41","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353, 1574\u20131584, doi: 353\/15\/1574 10.1056\/NEJMcps050929 (2005).","journal-title":"N Engl J Med"},{"key":"BFsrep45958_CR42","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","volume":"33","author":"HB Sarnat","year":"1976","unstructured":"Sarnat, H. B. & Sarnat, M. S. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33, 696\u2013705 (1976).","journal-title":"Arch Neurol"},{"key":"BFsrep45958_CR43","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1001\/jama.2014.16058","volume":"312","author":"S Shankaran","year":"2014","unstructured":"Shankaran, S. et al. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA 312, 2629\u20132639, doi: 10.1001\/jama.2014.16058 (2014).","journal-title":"JAMA"},{"key":"BFsrep45958_CR44","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.siny.2006.07.011","volume":"11","author":"L Hellstrom-Westas","year":"2006","unstructured":"Hellstrom-Westas, L. & Rosen, I. Continuous brain-function monitoring: state of the art in clinical practice. Semin Fetal Neonatal Med 11, 503\u2013511, doi: S1744-165X(06)00078-3 10.1016\/j.siny.2006.07.011 (2006).","journal-title":"Semin Fetal Neonatal Med"},{"key":"BFsrep45958_CR45","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.pediatrneurol.2009.05.002","volume":"41","author":"M El-Dib","year":"2009","unstructured":"El-Dib, M., Chang, T., Tsuchida, T. N. & Clancy, R. R. Amplitude-integrated electroencephalography in neonates. Pediatr Neurol 41, 315\u2013326, doi: 10.1016\/j.pediatrneurol.2009.05.002 (2009).","journal-title":"Pediatr Neurol"},{"key":"BFsrep45958_CR46","doi-asserted-by":"publisher","first-page":"561","DOI":"10.5194\/npg-11-561-2004","volume":"11","author":"A Grinsted","year":"2004","unstructured":"Grinsted, A., Moore, J. C. & Jevrejeva, S. Application of the cross wavelet transform and wavelet coherence to geophysical time series. Nonlinear Proc Geoph 11, 561\u2013566 (2004).","journal-title":"Nonlinear Proc Geoph"},{"key":"BFsrep45958_CR47","doi-asserted-by":"crossref","unstructured":"Tian, F. T. T., Liu, H., Zhang, R. & Chalak, L. Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy. Neuroimage clinical(In Press 2015).","DOI":"10.1364\/CANCER.2016.JW3A.36"},{"key":"BFsrep45958_CR48","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1175\/1520-0442(1999)012<2679:Icitem>2.0.Co;2","volume":"12","author":"C Torrence","year":"1999","unstructured":"Torrence, C. & Webster, P. J. Interdecadal changes in the ENSO-monsoon system. J Climate 12, 2679\u20132690, doi: 10.1175\/1520-0442(1999)012&lt;2679:Icitem&gt;2.0.Co;2(1999).","journal-title":"J Climate"},{"key":"BFsrep45958_CR49","doi-asserted-by":"publisher","first-page":"016707","DOI":"10.1103\/PhysRevE.75.016707","volume":"75","author":"D Maraun","year":"2007","unstructured":"Maraun, D., Kurths, J. & Holschneider, M. Nonstationary Gaussian processes in wavelet domain: synthesis, estimation, and significance testing. Phys Rev E Stat Nonlin Soft Matter Phys 75, 016707, doi: 10.1103\/PhysRevE.75.016707 (2007).","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"BFsrep45958_CR50","doi-asserted-by":"publisher","first-page":"F398","DOI":"10.1136\/archdischild-2011-301524","volume":"97","author":"S Shankaran","year":"2012","unstructured":"Shankaran, S. et al. Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 97, F398\u2013404, doi: 10.1136\/archdischild-2011-301524 (2012).","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFsrep45958_CR51","doi-asserted-by":"crossref","unstructured":"Jary, S., Whitelaw, A., Walloe, L. & Thoresen, M. Comparison of Bayley-2 and Bayley-3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia. Dev Med Child Neurol, doi: 10.1111\/dmcn.12208 (2013).","DOI":"10.1111\/dmcn.12208"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep45958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep45958","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/srep45958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/srep45958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T23:34:40Z","timestamp":1671838480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep45958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,5,31]]}},"alternative-id":["BFsrep45958"],"URL":"https:\/\/doi.org\/10.1038\/srep45958","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]},"assertion":[{"value":"9 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45958"}}