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However, human studies have not yet provided consistent findings analogous to the animal literature, possibly because parental care in humans is likely intermingled with parental overprotection, as suggested by the optimal parenting theory. Here, we tested the hypothesis that the effect of parental care on offspring hippocampal volume varies as a function of parental overprotection with a large cohort of young adult participants (<jats:italic>N<\/jats:italic>\u2009=\u2009257). Consistent with some previous human studies, we found that parental care in childhood alone had little association with the hippocampal volume in adulthood. However, when parental overprotection was low, parental care was positively correlated with offspring hippocampal volume, whereas there was no association between parental care and offspring hippocampal volume when parental overprotection was high. Thus, an interaction exists between parental care and overprotection in human\u2019s hippocampal development, which contributes to the elucidation of the complex relationship between brain structure and environmental factors.<\/jats:p>","DOI":"10.1038\/srep46429","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T09:42:27Z","timestamp":1491990147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of parental care on offspring hippocampal volume in young adults varies as a function of overprotection"],"prefix":"10.1038","volume":"7","author":[{"given":"Yinan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"BFsrep46429_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.2044-8341.1979.tb02487.x","volume":"52","author":"G Parker","year":"1979","unstructured":"Parker, G., Tupling, H. & Brown, L. 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