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Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. We compared the efficacy of FFP (F group) with that of FFP plus fibrinogen concentrate (F\u2009+\u2009F group) in massive obstetric haemorrhage. In this retrospective study, we compared the medical charts (2004\u20132016) of 137 patients with &lt;150\u2009mg\/dl fibrinogen treated with F\u2009+\u2009F (n\u2009=\u200947; after August 2009) or F (n\u2009=\u200956; before August 2009). Although fibrinogen concentrate was only administered in severe cases, the FFP\/red blood cell concentrate (RCC) ratio was significantly lower in the F\u2009+\u2009F group than in the F group. A sub-group analysis of cases requiring \u226518 RCC units showed that the F\u2009+\u2009F group received significantly less FFP than the F group (40.2\u2009\u00b1\u200919.6 versus 53.4\u2009\u00b1\u200918.5 units; <jats:italic>P<\/jats:italic>\u2009=\u20090.047) and showed significantly less pulmonary oedema (24.0% vs 57.1%; P\u2009&lt;\u20090.05) in the absence of any significant differences in pre-transfusion coagulation, estimated blood loss, or RCC transfusion volume. Administration of fibrinogen concentrate increased the rate of fibrinogen supplementation five-fold and reduced FFP dosage, the FFP\/RCC ratio, and the incidence of pulmonary oedema.<\/jats:p>","DOI":"10.1038\/srep46749","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T09:35:39Z","timestamp":1493026539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["The Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia"],"prefix":"10.1038","volume":"7","author":[{"given":"Shigetaka","family":"Matsunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Takai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Era","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"BFsrep46749_CR1","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","volume":"2","author":"L Say","year":"2014","unstructured":"Say, L. et al. 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