{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:37:13Z","timestamp":1788259033786,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T00:00:00Z","timestamp":1308614400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2011.13","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T13:43:19Z","timestamp":1308663799000},"page":"e11-e11","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hostility in adolescents and adults: a genome-wide association study of the Young Finns"],"prefix":"10.1038","volume":"1","author":[{"given":"P","family":"Merjonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Keltikangas-J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jokela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-P","family":"Lyytik\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pulkki-R\u00e5back","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Elovainio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ripatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Viikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Palotie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O T","family":"Raitakari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"BFtp201113_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0191-8869(89)90206-7","volume":"10","author":"ER Greenglass","year":"1989","unstructured":"Greenglass ER, Julkunen J . Construct validity and sex differences in Cook-Medley hostility. Person Individ Diff 1989; 10: 209\u2013218.","journal-title":"Person Individ Diff"},{"key":"BFtp201113_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.schres.2007.03.027","volume":"94","author":"M Soyka","year":"2007","unstructured":"Soyka M, Graz C, Bottlender R, Dirschedl P, Schoech H . Clinical correlates of later violence and criminal offences in schizophrenia. Schizophr Res 2007; 94: 89\u201398.","journal-title":"Schizophr Res"},{"key":"BFtp201113_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0920-9964(03)00049-5","volume":"69","author":"A Abu-Akel","year":"2004","unstructured":"Abu-Akel A, Abushua\u2019leh K . \u2018Theory of mind\u2019 in violent and nonviolent patients with paranoid schizophrenia. Schizophr Res 2004; 69: 46\u201353.","journal-title":"Schizophr Res"},{"key":"BFtp201113_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s12144-999-1029-8","volume":"18","author":"D Vandervoort","year":"1999","unstructured":"Vandervoort D . Quality of social support in mental and physical health. Curr Psychol 1999; 18: 205\u2013222.","journal-title":"Curr Psychol"},{"key":"BFtp201113_CR5","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.socscimed.2006.03.036","volume":"63","author":"T Heponiemi","year":"2006","unstructured":"Heponiemi T, Elovainio M, Kivim\u00e4ki M, Pulkki L, Puttonen S, Keltikangas-J\u00e4rvinen L . The longitudinal effects of social support and hostility on depressive tendencies. Soc Sci Med 2006; 63: 1374\u20131382.","journal-title":"Soc Sci Med"},{"key":"BFtp201113_CR6","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.jacc.2008.11.044","volume":"53","author":"Y Chida","year":"2009","unstructured":"Chida Y, Steptoe A . The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol 2009; 53: 936\u2013946.","journal-title":"J Am Coll Cardiol"},{"key":"BFtp201113_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1037\/0033-2909.119.2.322","volume":"119","author":"TQ Miller","year":"1996","unstructured":"Miller TQ, Smith TW, Turner CW, Guijarro ML, Hallet AJ . A meta-analytic review of research on hostility and physical health. Psychol Bull 1996; 119: 322\u2013348.","journal-title":"Psychol Bull"},{"key":"BFtp201113_CR8","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1161\/01.CIR.99.16.2192","volume":"99","author":"A Rozanski","year":"1999","unstructured":"Rozanski A, Blumenthal JA, Kaplan J . Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999; 99: 2192\u20132217.","journal-title":"Circulation"},{"key":"BFtp201113_CR9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1475-6811.2010.01321.x","volume":"18","author":"P Merjonen","year":"2011","unstructured":"Merjonen P, Pulkki-R\u00e5back L, Lipsanen J, Lehtim\u00e4ki T, Rontu R, Viikari J et al. Development of adulthood hostile attitudes: childhood environment and serotonin receptor gene interactions. Pers Relationship 2011; 18: 184\u2013197.","journal-title":"Pers Relationship"},{"key":"BFtp201113_CR10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1375\/twin.9.5.637","volume":"9","author":"YM Hur","year":"2006","unstructured":"Hur YM . Nonadditive genetic effects on hostility in South Korean adolescent and young adult twins. Twin Res Hum Genet 2006; 9: 637\u2013641.","journal-title":"Twin Res Hum Genet"},{"key":"BFtp201113_CR11","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s10519-005-9025-8","volume":"36","author":"I Rebollo","year":"2006","unstructured":"Rebollo I, Boomsma DI . Genetic analysis of anger: genetic dominance or competitive sibling interaction. Behav Genet 2006; 36: 216\u2013228.","journal-title":"Behav Genet"},{"key":"BFtp201113_CR12","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0006-3223(96)00257-0","volume":"41","author":"EF Coccaro","year":"1997","unstructured":"Coccaro EF, Bergeman CS, Kavoussi RJ, Seroczynski AD . Heritability of aggression and irritability: a twin study of the Buss-Durkee aggression scales in adult male subjects. Biol Psychiatry 1997; 41: 273\u2013284.","journal-title":"Biol Psychiatry"},{"key":"BFtp201113_CR13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/sj.mp.4001447","volume":"9","author":"SS Knox","year":"2004","unstructured":"Knox SS, Wilk JB, Zhang Y, Weidner G, Ellison RC . A genome scan for hostility: the National Heart, Lung, and Blood Institute Family Heart Study. Mol Psychiatry 2004; 9: 124\u2013126.","journal-title":"Mol Psychiatry"},{"key":"BFtp201113_CR14","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0191-8869(96)00146-8","volume":"21","author":"JP Gustavsson","year":"1996","unstructured":"Gustavsson JP, Pedersen NL, Asberg M, Schalling D . Exploration into the sources of individual differences in aggression-, hostility- and anger-related (AHA) personality traits. Pers Individ Diff 1996; 21: 1067\u20131071.","journal-title":"Pers Individ Diff"},{"key":"BFtp201113_CR15","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1093\/ije\/dym225","volume":"37","author":"OT Raitakari","year":"2008","unstructured":"Raitakari OT, Juonala M, R\u00f6nnemaa T, Keltikangas-J\u00e4rvinen L, R\u00e4s\u00e4nen L, Pietik\u00e4inen M et al. Cohort profile: the Cardiovascular Risk in Young Finns Study. Int J Epidemiol 2008; 37: 1220\u20131226.","journal-title":"Int J Epidemiol"},{"key":"BFtp201113_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1177\/001316445801800109","volume":"18","author":"AL Comrey","year":"1958","unstructured":"Comrey AL . A factor analysis of items on the MMPI paranoia scale. Educ Psychol Meas 1958; 18: 99\u2013107.","journal-title":"Educ Psychol Meas"},{"key":"BFtp201113_CR17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1177\/001316445701700413","volume":"17","author":"AL Comrey","year":"1957","unstructured":"Comrey AL . A factor analysis of items on the MMPI hysteria scale. Educ Psychol Meas 1957; 17: 586\u2013592.","journal-title":"Educ Psychol Meas"},{"key":"BFtp201113_CR18","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/1097-4679(197710)33:4<981::AID-JCLP2270330412>3.0.CO;2-0","volume":"33","author":"LR Derogatis","year":"1977","unstructured":"Derogatis LR, Cleary PA . Confirmation of the dimensional structure of the SCL-90: a study in construct validation. J Clin Psychol 1977; 33: 981\u2013989.","journal-title":"J Clin Psychol"},{"key":"BFtp201113_CR19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1037\/h0046900","volume":"21","author":"AH Buss","year":"1957","unstructured":"Buss AH, Durkee A . An inventory for assessing different kinds of hostility. J Consult Psychol 1957; 21: 343\u2013349.","journal-title":"J Consult Psychol"},{"key":"BFtp201113_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10865-007-9131-6","volume":"31","author":"P Merjonen","year":"2008","unstructured":"Merjonen P, Pulkki-R\u00e5back L, Puttonen S, Keskivaara P, Juonala M, Telama R et al. Anger is associated with subclinical atherosclerosis in low SES but not in higher SES men and women. The Cardiovascular Risk in Young Finns Study. J Behav Med 2008; 31: 35\u201344.","journal-title":"J Behav Med"},{"key":"BFtp201113_CR21","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1093\/bioinformatics\/btm443","volume":"23","author":"YY Teo","year":"2007","unstructured":"Teo YY, Inouye M, Small KS, Gwilliam R, Deloukas P, Kwiatkowski DP et al. A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics 2007; 23: 2741\u20132746.","journal-title":"Bioinformatics"},{"key":"BFtp201113_CR22","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFtp201113_CR23","first-page":"2290","volume":"S79","author":"Y Li","year":"2006","unstructured":"Li Y, Abecasis GR . Mach 1.0: rapid haplotype reconstruction and missing genotype inference. Am J Hum Genet 2006; S79: 2290.","journal-title":"Am J Hum Genet"},{"key":"BFtp201113_CR24","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1093\/bioinformatics\/btm108","volume":"23","author":"YS Aulchenko","year":"2007","unstructured":"Aulchenko YS, Ripke S, Isaacs A, van Duijn CM . GenABEL: an R library for genome-wide association analysis. Bioinformatics 2007; 23: 1294\u20131296.","journal-title":"Bioinformatics"},{"key":"BFtp201113_CR25","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biopsycho.2010.07.018","volume":"85","author":"KJH Verweij","year":"2010","unstructured":"Verweij KJH, Zietsch BP, Medland SE, Gordon SD, Benyamin B, Nyholt DR et al. A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. Biol Psychol 2010; 85: 306\u2013317.","journal-title":"Biol Psychol"},{"key":"BFtp201113_CR26","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/mp.2008.113","volume":"15","author":"A Terracciano","year":"2010","unstructured":"Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F et al. Genome-wide association scan for five major dimensions of personality. Mol Psychiatry 2010; 15: 647\u2013656.","journal-title":"Mol Psychiatry"},{"key":"BFtp201113_CR27","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1001\/archpsyc.65.6.649","volume":"65","author":"NR Wray","year":"2008","unstructured":"Wray NR, Middeldorp CM, Birley AJ, Gordon SD, Sullivan PF, Visscher PM et al. Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Arch Gen Psychiatry 2008; 65: 649\u2013658.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201113_CR28","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/sj.mp.4002061","volume":"13","author":"CM Middeldorp","year":"2008","unstructured":"Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJ, Posthuma D et al. Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Mol Psychiatry 2008; 13: 84\u201389.","journal-title":"Mol Psychiatry"},{"key":"BFtp201113_CR29","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"PR Burton","year":"2007","unstructured":"Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661\u2013678.","journal-title":"Nature"},{"key":"BFtp201113_CR30","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1126\/science.1133427","volume":"314","author":"T Sj\u00f6blom","year":"2006","unstructured":"Sj\u00f6blom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314: 268\u2013274.","journal-title":"Science"},{"key":"BFtp201113_CR31","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1182\/blood-2004-09-3605","volume":"105","author":"J Schultess","year":"2005","unstructured":"Schultess J, Danielewski O, Smolenski AP . Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 2005; 105: 3185\u20133192.","journal-title":"Blood"},{"key":"BFtp201113_CR32","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/sj.mp.4001012","volume":"7","author":"JA Badner","year":"2002","unstructured":"Badner JA, Gershon ES . Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7: 405\u2013411.","journal-title":"Mol Psychiatry"},{"key":"BFtp201113_CR33","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1007\/s00018-008-7576-6","volume":"65","author":"MA Westin","year":"2008","unstructured":"Westin MA, Hunt MC, Alexson SE . Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes. Cell Mol Life Sci 2008; 65: 982\u2013990.","journal-title":"Cell Mol Life Sci"},{"key":"BFtp201113_CR34","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1469-7610.2006.01612.x","volume":"47","author":"JT Nigg","year":"2006","unstructured":"Nigg JT . Temperament and developmental psychopathology. J Child Psychol Psychiatry 2006; 47: 395\u2013422.","journal-title":"J Child Psychol Psychiatry"},{"key":"BFtp201113_CR35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U","volume":"81","author":"CR Cloninger","year":"1998","unstructured":"Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V et al. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am J Med Genet 1998; 81: 313\u2013317.","journal-title":"Am J Med Genet"},{"key":"BFtp201113_CR36","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.biopsych.2010.06.030","volume":"68","author":"A Terracciano","year":"2010","unstructured":"Terracciano A, Tanaka T, Sutin AR, Sanna S, Deiana B, Lai S et al. Genome-wide association scan of trait depression. Biol Psychiatry 2010; 68: 811\u2013817.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"BFtp201113_CR37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/mp.2010.12","volume":"16","author":"A A E Vinkhuyzen","year":"2010","unstructured":"de Moor MHM, Costa PT, Terracciano A, Krueger RF, de Geus EJC, Toshiko T et al. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry; e-pub ahead of print 21 December 2010; doi:10.1038\/mp.2010.128 (in press).","journal-title":"Molecular Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:29:27Z","timestamp":1672954167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,21]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6]]}},"alternative-id":["BFtp201113"],"URL":"https:\/\/doi.org\/10.1038\/tp.2011.13","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,21]]},"assertion":[{"value":"6 May 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}