{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:21:21Z","timestamp":1784920881774,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2011.26","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T13:43:43Z","timestamp":1311083023000},"page":"e24-e24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins"],"prefix":"10.1038","volume":"1","author":[{"given":"H","family":"Sugawara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Komori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kazuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Adati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kusumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ishigooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,26]]},"reference":[{"key":"BFtp201126_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1001\/archpsyc.57.8.729","volume":"57","author":"JJ Mann","year":"2000","unstructured":"Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 2000; 57: 729\u2013738.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201126_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.biopsych.2006.05.005","volume":"60","author":"DM Cannon","year":"2006","unstructured":"Cannon DM, Ichise M, Fromm SJ, Nugent AC, Rollis D, Gandhi SK et al. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry 2006; 60: 207\u2013217.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR3","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.biopsych.2007.03.016","volume":"62","author":"DM Cannon","year":"2007","unstructured":"Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS et al. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biol Psychiatry 2007; 62: 870\u2013877.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1399-5618.2010.00800.x","volume":"12","author":"YH Chou","year":"2010","unstructured":"Chou YH, Wang SJ, Lin CL, Mao WC, Lee SM, Liao MH . Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study. Bipolar Disord 2010; 12: 312\u2013318.","journal-title":"Bipolar Disord"},{"key":"BFtp201126_CR5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0006-3223(01)01351-8","volume":"51","author":"T Ichimiya","year":"2002","unstructured":"Ichimiya T, Suhara T, Sudo Y, Okubo Y, Nakayama K, Nankai M et al. Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. Biol Psychiatry 2002; 51: 715\u2013722.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1176\/appi.ajp.163.1.48","volume":"163","author":"RV Parsey","year":"2006","unstructured":"Parsey RV, Hastings RS, Oquendo MA, Hu X, Goldman D, Huang YY et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 2006; 163: 48\u201351.","journal-title":"Am J Psychiatry"},{"key":"BFtp201126_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF01281159","volume":"102","author":"A Heils","year":"1995","unstructured":"Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U et al. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 1995; 102: 247\u2013254.","journal-title":"J Neural Transm Gen Sect"},{"key":"BFtp201126_CR8","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1126\/science.1083968","volume":"301","author":"A Caspi","year":"2003","unstructured":"Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386\u2013389.","journal-title":"Science"},{"key":"BFtp201126_CR9","first-page":"453","volume":"1","author":"DA Collier","year":"1996","unstructured":"Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453\u2013460.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR10","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nn1463","volume":"8","author":"L Pezawas","year":"2005","unstructured":"Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828\u2013834.","journal-title":"Nat Neurosci"},{"key":"BFtp201126_CR11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1001\/archpsyc.62.5.529","volume":"62","author":"KS Kendler","year":"2005","unstructured":"Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B . The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 2005; 62: 529\u2013535.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201126_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.biopsych.2005.07.014","volume":"59","author":"PG Surtees","year":"2006","unstructured":"Surtees PG, Wainwright NW, Willis-Owen SA, Luben R, Day NE, Flint J . Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry 2006; 59: 224\u2013229.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/sj.mp.4002067","volume":"13","author":"R Uher","year":"2008","unstructured":"Uher R, McGuffin P . The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 2008; 13: 131\u2013146.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR14","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","volume":"167","author":"A Caspi","year":"2010","unstructured":"Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE . Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010; 167: 509\u2013527.","journal-title":"Am J Psychiatry"},{"key":"BFtp201126_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/ng1235","volume":"35","author":"C Kakiuchi","year":"2003","unstructured":"Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I et al. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet 2003; 35: 171\u2013175.","journal-title":"Nat Genet"},{"key":"BFtp201126_CR16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/sj.mp.4002001","volume":"13","author":"G Kuratomi","year":"2008","unstructured":"Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N et al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry 2008; 13: 429\u2013441.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR17","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/nature08990","volume":"464","author":"SE Baranzini","year":"2010","unstructured":"Baranzini SE, Mudge J, van Velkinburgh JC, Khankhanian P, Khrebtukova I, Miller NA et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature 2010; 464: 1351\u20131356.","journal-title":"Nature"},{"key":"BFtp201126_CR18","doi-asserted-by":"publisher","first-page":"10604","DOI":"10.1073\/pnas.0500398102","volume":"102","author":"MF Fraga","year":"2005","unstructured":"Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005; 102: 10604\u201310609.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201126_CR19","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/ng.286","volume":"41","author":"ZA Kaminsky","year":"2009","unstructured":"Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 2009; 41: 240\u2013245.","journal-title":"Nat Genet"},{"key":"BFtp201126_CR20","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/ajmg.b.30316","volume":"141B","author":"J Mill","year":"2006","unstructured":"Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I . Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 421\u2013425.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201126_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/oxfordjournals.schbul.a006988","volume":"29","author":"A Petronis","year":"2003","unstructured":"Petronis A, Gottesman II, Kan P, Kennedy JL, Basile VS, Paterson AD et al. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull 2003; 29: 169\u2013178.","journal-title":"Schizophr Bull"},{"key":"BFtp201126_CR22","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/ajmg.b.30616","volume":"147B","author":"A Rosa","year":"2008","unstructured":"Rosa A, Picchioni MM, Kalidindi S, Loat CS, Knight J, Toulopoulou T et al. Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 459\u2013462.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201126_CR23","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/ajmg.a.33271","volume":"152A","author":"L Kaplan","year":"2010","unstructured":"Kaplan L, Foster R, Shen Y, Parry DM, McMaster ML, O\u2019Leary MC et al. Monozygotic twins discordant for neurofibromatosis 1. Am J Med Genet A 2010; 152A: 601\u2013606.","journal-title":"Am J Med Genet A"},{"key":"BFtp201126_CR24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/ng985","volume":"32","author":"S Kondo","year":"2002","unstructured":"Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y et al. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet 2002; 32: 285\u2013289.","journal-title":"Nat Genet"},{"key":"BFtp201126_CR25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/6784","volume":"21","author":"A Sakuntabhai","year":"1999","unstructured":"Sakuntabhai A, Ruiz-Perez V, Carter S, Jacobsen N, Burge S, Monk S et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet 1999; 21: 271\u2013277.","journal-title":"Nat Genet"},{"key":"BFtp201126_CR26","first-page":"253","volume":"36","author":"AT Helderman-van den Enden","year":"1999","unstructured":"Helderman-van den Enden AT, Maaswinkel-Mooij PD, Hoogendoorn E, Willemsen R, Maat-Kievit JA, Losekoot M et al. Monozygotic twin brothers with the fragile X syndrome: different CGG repeats and different mental capacities. J Med Genet 1999; 36: 253\u2013257.","journal-title":"J Med Genet"},{"key":"BFtp201126_CR27","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ajhg.2007.12.011","volume":"82","author":"CE Bruder","year":"2008","unstructured":"Bruder CE, Piotrowski A, Gijsbers AA, Andersson R, Erickson S, Diaz de Stahl T et al. Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet 2008; 82: 763\u2013771.","journal-title":"Am J Hum Genet"},{"key":"BFtp201126_CR28","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/0006-3223(94)00364-9","volume":"37","author":"I Kusumi","year":"1995","unstructured":"Kusumi I, Ohmori T, Kohsaka M, Ito M, Honma H, Koyama T . Chronobiological approach for treatment-resistant rapid cycling affective disorders. Biol Psychiatry 1995; 37: 553\u2013559.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.4161\/epi.6.4.14876","volume":"6","author":"H Sugawara","year":"2011","unstructured":"Sugawara H, Iwamoto K, Bundo M, Ueda J, Ishigooka J, Kato T . Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics 2011; 6: 508\u2013515.","journal-title":"Epigenetics"},{"key":"BFtp201126_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1017\/S1461145708009358","volume":"12","author":"A Hayashi","year":"2009","unstructured":"Hayashi A, Kasahara T, Kametani M, Toyota T, Yoshikawa T, Kato T . Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsychopharmacol 2009; 12: 33\u201343.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp201126_CR31","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1017\/S1461145703003717","volume":"6","author":"T Kato","year":"2003","unstructured":"Kato T, Ishiwata M, Mori K, Washizuka S, Tajima O, Akiyama T et al. Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsychopharmacol 2003; 6: 379\u2013389.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp201126_CR32","doi-asserted-by":"publisher","first-page":"12457","DOI":"10.1073\/pnas.0601180103","volume":"103","author":"WE Johnson","year":"2006","unstructured":"Johnson WE, Li W, Meyer CA, Gottardo R, Carroll JS, Brown M et al. Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci USA 2006; 103: 12457\u201312462.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201126_CR33","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"LC Li","year":"2002","unstructured":"Li LC, Dahiya R . MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002; 18: 1427\u20131431.","journal-title":"Bioinformatics"},{"key":"BFtp201126_CR34","doi-asserted-by":"publisher","first-page":"W170","DOI":"10.1093\/nar\/gkn294","volume":"36","author":"Y Kumaki","year":"2008","unstructured":"Kumaki Y, Oda M, Okano M . QUMA: quantification tool for methylation analysis. Nucleic Acids Res 2008; 36: W170\u2013W175.","journal-title":"Nucleic Acids Res"},{"key":"BFtp201126_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2144\/03351md01","volume":"35","author":"S Colella","year":"2003","unstructured":"Colella S, Shen L, Baggerly KA, Issa JP, Krahe R . Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques 2003; 35: 146\u2013150.","journal-title":"Biotechniques"},{"key":"BFtp201126_CR36","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1086\/503850","volume":"78","author":"XZ Hu","year":"2006","unstructured":"Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006; 78: 815\u2013826.","journal-title":"Am J Hum Genet"},{"key":"BFtp201126_CR37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ajmg.10119","volume":"114","author":"R Kaiser","year":"2002","unstructured":"Kaiser R, Muller-Oerlinghausen B, Filler D, Tremblay PB, Berghofer A, Roots I et al. Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Am J Med Genet 2002; 114: 323\u2013328.","journal-title":"Am J Med Genet"},{"key":"BFtp201126_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/sj.mp.4000821","volume":"6","author":"R Kaiser","year":"2001","unstructured":"Kaiser R, Tremblay PB, Schmider J, Henneken M, Dettling M, Muller-Oerlinghausen B et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry 2001; 6: 179\u2013185.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR39","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1073\/pnas.73.10.3628","volume":"73","author":"N Hozumi","year":"1976","unstructured":"Hozumi N, Tonegawa S . Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA 1976; 73: 3628\u20133632.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201126_CR40","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/archpsyc.64.2.201","volume":"64","author":"MA Oquendo","year":"2007","unstructured":"Oquendo MA, Hastings RS, Huang YY, Simpson N, Ogden RT, Hu XZ et al. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 2007; 64: 201\u2013208.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201126_CR41","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/S0893-133X(01)00310-4","volume":"25","author":"V Arango","year":"2001","unstructured":"Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung S et al. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 2001; 25: 892\u2013903.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201126_CR42","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/sj.mp.4001663","volume":"10","author":"HJ Cho","year":"2005","unstructured":"Cho HJ, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry 2005; 10: 771\u2013781.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/sj.mp.4000334","volume":"2","author":"H Kunugi","year":"1997","unstructured":"Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 1997; 2: 457\u2013462.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR44","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/sj.mp.4001992","volume":"12","author":"J Mill","year":"2007","unstructured":"Mill J, Petronis A . Molecular studies of major depressive disorder: the epigenetic perspective. Mol Psychiatry 2007; 12: 799\u2013814.","journal-title":"Mol Psychiatry"},{"key":"BFtp201126_CR45","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ajmg.b.31028","volume":"153B","author":"SR Beach","year":"2010","unstructured":"Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA . Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 710\u2013713.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201126_CR46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.biopsych.2010.05.008","volume":"68","author":"IMH van","year":"2010","unstructured":"van IMH, Caspers K, Bakermans-Kranenburg MJ, Beach SR, Philibert R . Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol Psychiatry 2010; 68: 405\u2013407.","journal-title":"Biol Psychiatry"},{"key":"BFtp201126_CR47","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/ajmg.b.30414","volume":"144B","author":"R Philibert","year":"2007","unstructured":"Philibert R, Madan A, Andersen A, Cadoret R, Packer H, Sandhu H . Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 101\u2013105.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201126_CR48","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nn1276","volume":"7","author":"IC Weaver","year":"2004","unstructured":"Weaver IC, Cervoni N, Champagne FA, D\u2019Alessio AC, Sharma S, Seckl JR et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847\u2013854.","journal-title":"Nat Neurosci"},{"key":"BFtp201126_CR49","doi-asserted-by":"publisher","first-page":"516","DOI":"10.4161\/epi.5.6.12226","volume":"5","author":"CC Wong","year":"2010","unstructured":"Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A et al. A longitudinal study of epigenetic variation in twins. Epigenetics 2010; 5: 516\u2013526.","journal-title":"Epigenetics"},{"key":"BFtp201126_CR50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4161\/epi.3.2.5938","volume":"3","author":"CM Connor","year":"2008","unstructured":"Connor CM, Akbarian S . DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics 2008; 3: 55\u201358.","journal-title":"Epigenetics"},{"key":"BFtp201126_CR51","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/sj.mp.4001662","volume":"10","author":"T Kato","year":"2005","unstructured":"Kato T, Iwamoto K, Kakiuchi C, Kuratomi G, Okazaki Y . Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders. Mol Psychiatry 2005; 10: 622\u2013630.","journal-title":"Mol Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201126","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:29:55Z","timestamp":1672954195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,26]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,7]]}},"alternative-id":["BFtp201126"],"URL":"https:\/\/doi.org\/10.1038\/tp.2011.26","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,26]]},"assertion":[{"value":"17 June 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}