{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:43:30Z","timestamp":1770018210915,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T00:00:00Z","timestamp":1321315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2011.51","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T16:58:59Z","timestamp":1321376339000},"page":"e52-e52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome"],"prefix":"10.1038","volume":"1","author":[{"given":"J","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Lenartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Huys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Daumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Woopen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hunsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Maarouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Klosterk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,11,15]]},"reference":[{"key":"BFtp201151_CR1","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1056\/NEJMcp1007805","volume":"363","author":"R Kurlan","year":"2010","unstructured":"Kurlan R . Tourette's syndrome. N Engl J Med 2010; 363: 2332\u20132338.","journal-title":"N Engl J Med"},{"key":"BFtp201151_CR2","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S0140-6736(98)05964-9","volume":"353","author":"V Vandewalle","year":"1999","unstructured":"Vandewalle V, van der Linden C, Groenewegen HJ, Caemaert J . Stereotactic treatment of Gilles de la Tourtete syndrome by high frequency stimulation of thalamus. Lancet 1999; 353: 724.","journal-title":"Lancet"},{"key":"BFtp201151_CR3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1136\/jnnp.2004.043273","volume":"76","author":"JL Houeto","year":"2005","unstructured":"Houeto JL, Karachi C, Mallet L, Pillon B, Yelnik J, Mesnage V et al. Tourette's syndrome and deep brain stimulation. J Neurol, Neurosurg Psychiatry 2005; 76: 992\u2013995.","journal-title":"J Neurol, Neurosurg Psychiatry"},{"key":"BFtp201151_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.jpsychores.2009.06.001","volume":"67","author":"M Porta","year":"2009","unstructured":"Porta M, Sassi M, Ali F, Cavanna AE, Servello D . Neurosurgical treatment for Gilles de la Tourette Syndrome: the Italian perspective. J Psychosom Res 2009; 67: 585\u2013590.","journal-title":"J Psychosom Res"},{"key":"BFtp201151_CR5","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1002\/mds.20816","volume":"21","author":"L Ackermans","year":"2006","unstructured":"Ackermans L, Temel Y, Cath D, van der Linden C, Bruggeman R, Kleijer M et al. Deep brain stimulation in Tourette's syndrome: two targets? Mov Disord 2006; 21: 709\u2013713.","journal-title":"Mov Disord"},{"key":"BFtp201151_CR6","first-page":"65","volume":"3","author":"O Vilela Filho","year":"2008","unstructured":"Vilela Filho O, Ragazzo PC, Silva DJ, Souza JT, Oliveira PM, Ribeiro TM . Bilateral GPe-DBS for Tourette's syndrome. Neuro Target 2008; 3: 65.","journal-title":"Neuro Target"},{"key":"BFtp201151_CR7","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s00415-006-0404-8","volume":"254","author":"J Kuhn","year":"2007","unstructured":"Kuhn J, Lenartz D, Mai JK, Huff W, Lee SH, Koulousakis A et al. Deep brain stimulation of the nucleus accumbens and the internal capsule in therapeutically refractory Tourette-syndrome. J Neurol 2007; 254: 963\u2013965.","journal-title":"J Neurol"},{"key":"BFtp201151_CR8","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3171\/2010.8.JNS10312","volume":"113","author":"HA Taba","year":"2010","unstructured":"Taba HA, Wu SS, Foote KD, Hass CJ, Fernandez HH, Malaty IA et al. A closer look at unilateral versus bilateral deep brain stimulation: results of the National Institutes of Health COMPARE cohort. J Neurosurg 2010; 113: 1224\u20131229.","journal-title":"J Neurosurg"},{"key":"BFtp201151_CR9","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/mds.21039","volume":"21","author":"JW Mink","year":"2006","unstructured":"Mink JW, Walkup J, Frey KA, Como P, Cath D, Delong MR et al. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mov Disord 2006; 21: 1831\u20131838.","journal-title":"Mov Disord"},{"key":"BFtp201151_CR10","first-page":"140","volume-title":"Stereotaxy of the Human Brain","author":"R Hassler","year":"1982","unstructured":"Hassler R . Architectonic organization of the thalamic nuclei. In: Waiker AE, Schaltenbrand G (eds). Stereotaxy of the Human Brain. Georg Thieme Verlag: Stuttgart, Germany, 1982 pp 140\u2013180."},{"key":"BFtp201151_CR11","unstructured":"Mai J, Forutan F . Thalamus. In: Mai JK, Paxinos G (eds). The Human Nervous System. Elsevier: San Diego, California, USA (in press), pp 620\u2013679."},{"key":"BFtp201151_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/mds.10137","volume":"17","author":"IA Ilinsky","year":"2002","unstructured":"Ilinsky IA, Kultas-Ilinsky K . Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders. Mov Disord 2002; 17: 9\u201314.","journal-title":"Mov Disord"},{"key":"BFtp201151_CR13","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1001\/archneur.65.7.952","volume":"65","author":"ML Welter","year":"2008","unstructured":"Welter ML, Mallet L, Houeto JL, Karachi C, Czernecki V, Cornu P et al. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol 2008; 65: 952\u2013957.","journal-title":"Arch Neurol"},{"key":"BFtp201151_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.biopsych.2009.06.025","volume":"66","author":"I Vernaleken","year":"2009","unstructured":"Vernaleken I, Kuhn J, Lenartz D, Raptis M, Huff W, Janouschek H et al. Bithalamical deep brain stimulation in Tourette syndrome is associated with reduction in dopaminergic transmission. Biol Psychiatry 2009; 66: 15\u201317.","journal-title":"Biol Psychiatry"},{"key":"BFtp201151_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clineuro.2009.11.006","volume":"112","author":"W Huff","year":"2010","unstructured":"Huff W, Lenartz D, Schormann M, Lee SH, Kuhn J, Koulousakis A et al. Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment \u2013resistant obsessive-compulsive disorder: Outcomes after one year. Clin Neurol Neurosurg 2010; 112: 137\u2013143.","journal-title":"Clin Neurol Neurosurg"},{"key":"BFtp201151_CR16","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.1212\/01.wnl.0000190258.92496.a4","volume":"66","author":"CL Gallagher","year":"2006","unstructured":"Gallagher CL, Garell PC, Montgomery Jr EB . Hemi tics and deep brain stimulation. Neurology 2006; 66: E12.","journal-title":"Neurology"},{"key":"BFtp201151_CR17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S0887-8994(01)00262-4","volume":"25","author":"JW Mink","year":"2001","unstructured":"Mink JW . Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis. Pediatr Neurol 2001; 25: 190\u2013198.","journal-title":"Pediatr Neurol"},{"key":"BFtp201151_CR18","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1227\/01.NEU.0000349764.34211.74","volume":"65","author":"HC Walker","year":"2009","unstructured":"Walker HC, Watts RL, Guthrie S, Wang D, Guthrie BL . Bilateral effects of unilateral subthalamic deep brain stimulation on Parkinson's disease at 1 year. Neurosurgery 2009; 65: 302\u2013310.","journal-title":"Neurosurgery"},{"key":"BFtp201151_CR19","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrn2196","volume":"8","author":"ML Kringelbach","year":"2007","unstructured":"Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ . Translational principles of deep brain stimulation. Nat Rev Neurosci 2007; 8: 623\u2013635.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp201151_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/brain\/awq380","volume":"134","author":"L Ackermans","year":"2011","unstructured":"Ackermans L, Duits A, van der Linden C, Tijssen M, Schruers K, Temel Y et al. Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome. Brain 2011; 134: 32\u2013844.","journal-title":"Brain"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201151","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:37:37Z","timestamp":1672954657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,15]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11]]}},"alternative-id":["BFtp201151"],"URL":"https:\/\/doi.org\/10.1038\/tp.2011.51","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,15]]},"assertion":[{"value":"19 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"CB, DH, JD, CW and SH reported no biomedical financial interests or potential conflicts of interest in this investigation. JK received financial support for DBS studies (not the present investigation) from Medtronic GmbH (Meerbusch, Germany). DL reports having received financial assistance for travel to congresses from Medtronic AG. MM has occasionally received honoraria from Medtronic for lecturing at conferences and consulting. VS disclosed financial support for studies and travel to congresses by lecture fees from Medtronic AG and Advanced Neuromodulation Systems. He also reported to be coholder of patents on desynchronized brain stimulation and joint founder of ANM-GmbH J\u00fclich, a company that intends to develop new stimulators.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}