{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:03:39Z","timestamp":1762671819471},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2012.48","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T14:35:13Z","timestamp":1337697313000},"page":"e119-e119","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients"],"prefix":"10.1038","volume":"2","author":[{"given":"T","family":"Teraishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Sasayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kunugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"BFtp201248_CR1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/schbul\/sbp006","volume":"35","author":"OD Howes","year":"2009","unstructured":"Howes OD, Kapur S . The dopamine hypothesis of schizophrenia: version III\u2014the final common pathway. Schizophr Bull 2009; 35: 549\u2013562.","journal-title":"Schizophr Bull"},{"key":"BFtp201248_CR2","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1177\/026988119901300405","volume":"13","author":"M Laruelle","year":"1999","unstructured":"Laruelle M, Abi-Dargham A . Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies. J Psychopharmacol 1999; 13: 358\u2013371.","journal-title":"J Psychopharmacol"},{"key":"BFtp201248_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00005053-196007000-00009","volume":"131","author":"AM Poisner","year":"1960","unstructured":"Poisner AM . Serum phenylalanine in schizophrenia: biochemical genetic aspects. J Nerv Ment Dis 1960; 131: 74\u201376.","journal-title":"J Nerv Ment Dis"},{"key":"BFtp201248_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0165-1781(90)90003-N","volume":"34","author":"ML Rao","year":"1990","unstructured":"Rao ML, Gross G, Strebel B, Br\u00e4unig P, Huber G, Klosterk\u00f6tter J . Serum amino acids, central monoamines, and hormones in drug-naive, drug-free, and neuroleptic-treated schizophrenic patients and healthy subjects. Psychiatry Res 1990; 34: 243\u2013257.","journal-title":"Psychiatry Res"},{"key":"BFtp201248_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0920-9964(94)00080-R","volume":"14","author":"J Wei","year":"1995","unstructured":"Wei J, Xu H, Ramchand CN, Hemmings GP . Low concentrations of serum tyrosine in neuroleptic-free schizophrenics with an early onset. Schizophr Res 1995; 14: 257\u2013260.","journal-title":"Schizophr Res"},{"key":"BFtp201248_CR6","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0006-3223(87)90163-6","volume":"22","author":"MA Reveley","year":"1987","unstructured":"Reveley MA, De Belleroche J, Recordati A, Hirsch SR . Increased CSF amino acids and ventricular enlargement in schizophrenia: a preliminary study. Biol Psychiatry 1987; 22: 413\u2013420.","journal-title":"Biol Psychiatry"},{"key":"BFtp201248_CR7","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1001\/archpsyc.1983.01790060047006","volume":"40","author":"SG Potkin","year":"1983","unstructured":"Potkin SG, Cannon-Spoor HE, DeLisi LE, Neckers LM, Wyatt RJ . Plasma phenylalanine, tyrosine, and tryptophan in schizophrenia. Arch Gen Psychiatry 1983; 40: 749\u2013752.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201248_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-3223(91)90168-L","volume":"30","author":"R O\u2032Reilly","year":"1991","unstructured":"O\u2032Reilly R, Davis BA, Durden DA, Thorpe L, Machnee H, Boulton AA . Plasma phenylethylamine in schizophrenic patients. Biol Psychiatry 1991; 30: 145\u2013150.","journal-title":"Biol Psychiatry"},{"key":"BFtp201248_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1017\/S1461145799001522","volume":"2","author":"PA Janssen","year":"1999","unstructured":"Janssen PA, Leysen JE, Megens AA, Awouters FH . Does phenylethylamine act as an endogenous amphetamine in some patients? Int J Neuropsychopharmacol 1999; 2: 229\u2013240.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp201248_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/bj3110353","volume":"311","author":"S Hufton","year":"1995","unstructured":"Hufton S, Jennings I, Cotton R . Structure and function of the aromatic amino acid hydroxylases. Biochem J 1995; 311: 353\u2013366.","journal-title":"Biochem J"},{"key":"BFtp201248_CR11","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1073\/pnas.97.3.1242","volume":"97","author":"N Moller","year":"2000","unstructured":"Moller N, Meek S, Bigelow M, Andrews J, Nair K . The kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans: a metabolic role of the kidney. Proc Natl Acad Sci USA 2000; 97: 1242\u20131246.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201248_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/mgme.1999.2922","volume":"68","author":"H Erlandsen","year":"1999","unstructured":"Erlandsen H, Stevens RC . The structural basis of phenylketonuria. Mol Genet Metab 1999; 68: 103\u2013125.","journal-title":"Mol Genet Metab"},{"key":"BFtp201248_CR13","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1002\/humu.20526","volume":"28","author":"CR Scriver","year":"2007","unstructured":"Scriver CR . The PAH gene, phenylketonuria, and a paradigm shift. Hum Mutat 2007; 28: 831\u2013845.","journal-title":"Hum Mutat"},{"key":"BFtp201248_CR14","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1007\/PL00014370","volume":"159","author":"R Surtees","year":"2000","unstructured":"Surtees R, Blau N . The neurochemistry of phenylketonuria. Eur J Pediatr 2000; 159: S109\u2013S113.","journal-title":"Eur J Pediatr"},{"key":"BFtp201248_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0140-6736(01)04897-8","volume":"226","author":"LS Penrose","year":"1935","unstructured":"Penrose LS . Inheritance of phenylpyruvic amentia (phenylketonuria). Lancet 1935; 226: 192\u2013194.","journal-title":"Lancet"},{"key":"BFtp201248_CR16","first-page":"337","volume":"177","author":"F Vogel","year":"1985","unstructured":"Vogel F . Phenotypic deviations in heterozygotes of phenylketonuria (PKU). Prog Clin Biol Res 1985; 177: 337\u2013349.","journal-title":"Prog Clin Biol Res"},{"key":"BFtp201248_CR17","first-page":"554","volume":"8","author":"LI Kuznetsova","year":"1974","unstructured":"Kuznetsova LI . Frequency and phenotypic manifestations of schizophrenia in the parents of patients with phenylketonuria. Sov Genet 1974; 8: 554\u2013555.","journal-title":"Sov Genet"},{"key":"BFtp201248_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/ajmg.1320480108","volume":"48","author":"J Sobell","year":"1993","unstructured":"Sobell J, Heston L, Sommer S . Novel association approach for determining the genetic predisposition to schizophrenia: case-control resource and testing of a candidate gene. Am J Med Genet 1993; 48: 28\u201335.","journal-title":"Am J Med Genet"},{"key":"BFtp201248_CR19","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/ajmg.10606","volume":"114","author":"HM Chao","year":"2002","unstructured":"Chao HM, Richardson MA . Aromatic amino acid hydroxylase genes and schizophrenia. Am J Med Genet 2002; 114: 626\u2013630.","journal-title":"Am J Med Genet"},{"key":"BFtp201248_CR20","first-page":"95","volume":"36","author":"MA Richardson","year":"1999","unstructured":"Richardson MA, Guttler F, Guldberg P, Reilly M, Suckow R, Read L et al. Phenylalanine hydroxylase gene mutation associated with schizophrenia and African-American ethnic status. Schizophr Res 1999b; 36: 95, (abstract).","journal-title":"Schizophr Res"},{"issue":"Suppl 1","key":"BFtp201248_CR21","first-page":"S41","volume":"4","author":"MA Richardson","year":"1999","unstructured":"Richardson MA, Guttler F, Guldberg P, Read L, Clelland J, Chao H et al. Functional and psychiatric associations of the phenylalanine hydroxylase gene. Molecular Psychiatry 1999; 4 (Suppl 1): S41, (abstract 41).","journal-title":"Molecular Psychiatry"},{"key":"BFtp201248_CR22","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0006-3223(02)01528-7","volume":"53","author":"MA Richardson","year":"2003","unstructured":"Richardson MA, Read LL, Clelland JD, Chao HM, Reilly MA, Romstad A et al. Phenylalanine hydroxylase gene in psychiatric patients: screening and functional assay of mutations. Biol Psychiatry 2003; 53: 543\u2013553.","journal-title":"Biol Psychiatry"},{"key":"BFtp201248_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s00439-006-0190-5","volume":"120","author":"D Li","year":"2006","unstructured":"Li D, He L . Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia. Hum Genet 2006; 120: 22\u201330.","journal-title":"Hum Genet"},{"key":"BFtp201248_CR24","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/ajmg.b.30862","volume":"150B","author":"ME Talkowski","year":"2009","unstructured":"Talkowski ME, McClain L, Allen T, Bradford LD, Calkins M, Edwards N et al. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 560\u2013569.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201248_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.schres.2009.02.009","volume":"109","author":"SE Bergen","year":"2009","unstructured":"Bergen SE, Fanous AH, Walsh D, O\u2032Neill FA, Kendler KS . Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features. Schizophr Res 2009; 109: 94\u201397.","journal-title":"Schizophr Res"},{"key":"BFtp201248_CR26","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/(SICI)1097-4547(19981201)54:5<691::AID-JNR14>3.0.CO;2-F","volume":"54","author":"Y Xu","year":"1998","unstructured":"Xu Y, Stokes A, Roskoski RJ, Vrana K . Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase. J Neurosci Res 1998; 54: 691\u2013697.","journal-title":"J Neurosci Res"},{"key":"BFtp201248_CR27","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/BF00500085","volume":"332","author":"G Laschinski","year":"1986","unstructured":"Laschinski G, Kittner B, Br\u00e4utigam M . Direct inhibition of tyrosine hydroxylase from PC-12 cells by catechol derivatives. Naunyn Schmiedebergs Arch Pharmacol 1986; 332: 346\u2013350.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"BFtp201248_CR28","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev.biochem.68.1.355","volume":"68","author":"P Fitzpatrick","year":"1999","unstructured":"Fitzpatrick P . Tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem 1999; 68: 355\u2013381.","journal-title":"Annu Rev Biochem"},{"key":"BFtp201248_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psychres.2008.10.024","volume":"176","author":"L Liu","year":"2010","unstructured":"Liu L, Jia F, Yuan G, Chen Z, Yao J, Li H et al. Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis. Psychiatry Res 2010; 176: 1\u20137.","journal-title":"Psychiatry Res"},{"key":"BFtp201248_CR30","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/(SICI)1096-8628(19980907)81:5<388::AID-AJMG7>3.0.CO;2-P","volume":"81","author":"H Ishiguro","year":"1998","unstructured":"Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H et al. Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism. Am J Med Genet 1998; 81: 388\u2013396.","journal-title":"Am J Med Genet"},{"key":"BFtp201248_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/(SICI)1096-8628(19980328)81:2<131::AID-AJMG2>3.0.CO;2-Z","volume":"81","author":"H Kunugi","year":"1998","unstructured":"Kunugi H, Kawada Y, Hattori M, Ueki A, Otsuka M, Nanko S . Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease. Am J Med Genet 1998; 81: 131\u2013133.","journal-title":"Am J Med Genet"},{"key":"BFtp201248_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10256019908234077","volume":"35","author":"K de Meer","year":"1999","unstructured":"de Meer K, Roef M, Kulik W, Jakobs C . In vivo research with stable isotopes in biochemistry, nutrition and clinical medicine: an overview. Isotopes Environ Health Stud 1999; 35: 19\u201337.","journal-title":"Isotopes Environ Health Stud"},{"key":"BFtp201248_CR33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1203\/00006450-199710000-00002","volume":"42","author":"E Treacy","year":"1997","unstructured":"Treacy E, Delente J, Elkas G, Carter K, Lambert M, Waters P et al. Analysis of phenylalanine hydroxylase genotypes and hyperphenylalaninemia phenotypes using L-[1-13C]phenylalanine oxidation rates in vivo: a pilot study. Pediatr Res 1997; 42: 430\u2013435.","journal-title":"Pediatr Res"},{"key":"BFtp201248_CR34","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1056\/NEJMoa021654","volume":"347","author":"AC Muntau","year":"2002","unstructured":"Muntau AC, R\u00f6schinger W, Habich M, Demmelmair H, Hoffmann B, Sommerhoff CP et al. Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria. N Engl J Med 2002; 347: 2122\u20132132.","journal-title":"N Engl J Med"},{"key":"BFtp201248_CR35","first-page":"16","volume":"12","author":"S Yamashita","year":"2002","unstructured":"Yamashita S, Kajiwara M, Naruse H, Ohshima A, Higuchi T . 13C-Phenylalanine breath breath test using an infrared spectroscopy for detection of metabolic changes in depressive disorder. 13C medicine 2002; 12: 16\u201317.","journal-title":"13C medicine"},{"key":"BFtp201248_CR36","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn American Psychiatric Press: Washington DC, 1994."},{"issue":"Suppl 20","key":"BFtp201248_CR37","first-page":"22","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59 (Suppl 20): 22\u201333.","journal-title":"J Clin Psychiatry"},{"key":"BFtp201248_CR38","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/j.1440-1819.2005.01408.x","volume":"59","author":"T Otsubo","year":"2005","unstructured":"Otsubo T, Tanaka K, Koda R, Shinoda J, Sano N, Tanaka S et al. Reliability and validity of Japanese version of the Mini-International Neuropsychiatric Interview. Psychiatry Clin Neurosci 2005; 59: 517\u2013526.","journal-title":"Psychiatry Clin Neurosci"},{"key":"BFtp201248_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0165-7208(97)80149-3","volume-title":"Stable isotopes in pharmaceutical research","author":"TR Brown","year":"1997","unstructured":"Brown TR . Isotope effect: implications for pharmaceutical investigations. In: Brown TR (ed). Stable isotopes in pharmaceutical research. Elsevier Science Publishers: Amsterdam, 1997 pp 13\u201318."},{"key":"BFtp201248_CR40","first-page":"625","volume":"51","author":"J Fulenwider","year":"1978","unstructured":"Fulenwider J, Nordlinger B, Faraj B, Ivey G, Rudman D . Deranged tyrosine metabolism in cirrhosis. Yale J Biol Med 1978; 51: 625\u2013633.","journal-title":"Yale J Biol Med"},{"key":"BFtp201248_CR41","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/sj.bjp.0706948","volume":"149","author":"R Zucchi","year":"2006","unstructured":"Zucchi R, Chiellini G, Scanlan TS, Grandy DK . Trace amine-associated receptors and their ligands. Br J Pharmacol 2006; 149: 967\u2013978.","journal-title":"Br J Pharmacol"},{"key":"BFtp201248_CR42","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1158\/1078-0432.CCR-03-0374","volume":"10","author":"LK Mattison","year":"2004","unstructured":"Mattison LK, Ezzeldin H, Carpenter M, Modak A, Johnson MR, Diasio RB . Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. Clin Cancer Res 2004; 10: 2652\u20132658.","journal-title":"Clin Cancer Res"},{"key":"BFtp201248_CR43","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1203\/01.PDR.0000141520.06524.51","volume":"56","author":"Y Okano","year":"2004","unstructured":"Okano Y, Hase Y, Kawajiri M, Nishi Y, Inui K, Sakai N et al. In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Pediatr Res 2004; 56: 714\u2013719.","journal-title":"Pediatr Res"},{"key":"BFtp201248_CR44","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1248\/cpb.46.1330","volume":"46","author":"T Ishii","year":"1998","unstructured":"Ishii T, Takatori K, Iida K, Higuchi T, Ohshima A, Naruse H et al. Optimum conditions for the 13C-phenylalanine breath test. Chem Pharm Bull 1998; 46: 1330\u20131332.","journal-title":"Chem Pharm Bull"},{"key":"BFtp201248_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261\u2013276.","journal-title":"Schizophr Bull"},{"key":"BFtp201248_CR46","volume-title":"Equivalent Dose of Psychotropics","author":"A Inagaki","year":"1999","unstructured":"Inagaki A, Inada T, Fujii Y, Yagi G, Yoshio T, Nakamura H et al. Equivalent Dose of Psychotropics. Seiwa Shoten: Tokyo, Japan, 1999."},{"key":"BFtp201248_CR47","unstructured":"American Psychiatric Association. Practice Guidelines for the Treatment of Patients with Schizophrenia. American Psychiatric Press: Washington DC, 1997."},{"key":"BFtp201248_CR48","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/jnr.10281","volume":"69","author":"CG Wakade","year":"2002","unstructured":"Wakade CG, Mahadik SP, Waller JL, Chiu FC . Atypical neuroleptics stimulate neurogenesis in adult rat brain. J Neurosci Res 2002; 69: 72\u201379.","journal-title":"J Neurosci Res"},{"key":"BFtp201248_CR49","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/sj.npp.1300449","volume":"29","author":"HD Wang","year":"2004","unstructured":"Wang HD, Dunnavant FD, Jarman T, Deutch AY . Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Neuropsychopharmacology 2004; 29: 1230\u20131238.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201248_CR50","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000026566","volume":"39","author":"U Schmitt","year":"1999","unstructured":"Schmitt U, Dahmen N, Fischer V, Weigmann H, Rao ML, Reuss S et al. Chronic oral haloperidol and clozapine in rats: a behavioral evaluation. Neuropsychobiology 1999; 39: 86\u201391.","journal-title":"Neuropsychobiology"},{"key":"BFtp201248_CR51","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1192\/bjp.147.3.276","volume":"147","author":"L Bjerkenstedt","year":"1985","unstructured":"Bjerkenstedt L, Edman G, Hagenfeldt L, Sedvall G, Wiesel FA . Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls. Br J Psychiatry 1985; 147: 276\u2013282.","journal-title":"Br J Psychiatry"},{"key":"BFtp201248_CR52","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1248\/cpb.49.1507","volume":"49","author":"T Ishii","year":"2001","unstructured":"Ishii T, Furube M, Hirano S, Takatori K, Iida K, Kajiwara M . Evaluation of 13C-phenylalanine and 13C-tyrosine breath tests for the measurement of hepatocyte functional capacity in patients with liver cirrhosis. Chem Pharm Bull 2001; 49: 1507\u20131511.","journal-title":"Chem Pharm Bull"},{"key":"BFtp201248_CR53","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0022-4804(03)00135-5","volume":"112","author":"Y Ishii","year":"2003","unstructured":"Ishii Y, Suzuki S, Kohno T, Aoki M, Ito A, Takayama T et al. L-[1-13C] phenylalanine breath test reflects phenylalanine hydroxylase activity of the whole liver. J Surg Res 2003; 112: 38\u201342.","journal-title":"J Surg Res"},{"key":"BFtp201248_CR54","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s10545-008-0946-2","volume":"32","author":"FJ van Spronsen","year":"2009","unstructured":"van Spronsen FJ, Hoeksma M, Reijngoud DJ . Brain dysfunction in phenylketonuria: is phenylalanine toxicity the only possible cause? J Inherit Metab Dis 2009; 32: 46\u201351.","journal-title":"J Inherit Metab Dis"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201248","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:49:38Z","timestamp":1672955378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,22]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5]]}},"alternative-id":["BFtp201248"],"URL":"https:\/\/doi.org\/10.1038\/tp.2012.48","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,22]]},"assertion":[{"value":"23 December 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}