{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:56:52Z","timestamp":1789016212411,"version":"build-2803163510"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2012.77","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T13:43:44Z","timestamp":1344951824000},"page":"e150-e150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":225,"title":["Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF\u2009) after acute psychosocial stress"],"prefix":"10.1038","volume":"2","author":[{"given":"E","family":"Unternaehrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Luers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dempster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Staehli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Hellhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Meinlschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"BFtp201277_CR1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.mppsy.2008.10.006","volume":"7","author":"S Docherty","year":"2008","unstructured":"Docherty S, Mill J . Epigenetic mechanisms as mediators of environmental risks for psychiatric disorders. Psychiatry 2008; 7: 500\u2013506.","journal-title":"Psychiatry"},{"key":"BFtp201277_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.socscimed.2011.09.036","volume":"74","author":"S Toyokawa","year":"2012","unstructured":"Toyokawa S, Uddin M, Koenen KC, Galea S . How does the social environment \u2018get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology. Soc Sci Med 2012; 74: 67\u201374.","journal-title":"Soc Sci Med"},{"key":"BFtp201277_CR3","unstructured":"National Institute of Mental Health. National Institute of Mental Health Strategic Plan 2008."},{"key":"BFtp201277_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jcp.20280","volume":"204","author":"MI Scarano","year":"2005","unstructured":"Scarano MI, Strazzullo M, Matarazzo MR, D'Esposito M . DNA methylation 40 years later: Its role in human health and disease. J Cell Physiol 2005; 204: 21\u201335.","journal-title":"J Cell Physiol"},{"key":"BFtp201277_CR5","first-page":"147","volume":"13","author":"M Fuchikami","year":"2010","unstructured":"Fuchikami M, Morinobu S, Segawa M, Yamawaki S . DNA methylation profiles of the BDNF gene in patients with major depression. Int J Neuropsychopharmacol 2010; 13: 147.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp201277_CR6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.biopsycho.2009.12.003","volume":"83","author":"CA Olsson","year":"2010","unstructured":"Olsson CA, Foley DL, Parkinson-Bates M, Byrnes G, McKenzie M, Patton GC et al. Prospects for epigenetic research within cohort studies of psychological disorder: a pilot investigation of a peripheral cell marker of epigenetic risk for depression. Biol Psychol 2010; 83: 159\u2013165.","journal-title":"Biol Psychol"},{"key":"BFtp201277_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jad.2010.12.004","volume":"131","author":"A Rotter","year":"2011","unstructured":"Rotter A, Asemann R, Decker A, Kornhuber J, Biermann T . Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder. J Affect Disord 2011; 131: 186\u2013192.","journal-title":"J Affect Disord"},{"key":"BFtp201277_CR8","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1017\/S0033291710001674","volume":"41","author":"M Uddin","year":"2011","unstructured":"Uddin M, Koenen KC, Aiello AE, Wildman DE . de los Santos R, Galea S. Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample. Psychol Med 2011; 41: 997\u20131007.","journal-title":"Psychol Med"},{"key":"BFtp201277_CR9","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/sj.mp.4001992","volume":"12","author":"J Mill","year":"2007","unstructured":"Mill J, Petronis A . Molecular studies of major depressive disorder: the epigenetic perspective. Mol Psychiatry 2007; 12: 799\u2013814.","journal-title":"Mol Psychiatry"},{"key":"BFtp201277_CR10","first-page":"S37","volume":"9","author":"HM Abdolmaleky","year":"2006","unstructured":"Abdolmaleky HM . Reelin hypermethylation in schizophrenia and beyond. Int J Neuropsychopharmacol 2006; 9: S37.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp201277_CR11","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/ajmg.b.31192","volume":"156B","author":"M Ghadirivasfi","year":"2011","unstructured":"Ghadirivasfi M, Nohesara S, Ahmadkhaniha HR, Eskandari MR, Mostafavi S, Thiagalingam S et al. Hypomethylation of the serotonin receptor type-2A gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet Part B 2011; 156B: 536\u2013545.","journal-title":"Am J Med Genet Part B"},{"key":"BFtp201277_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/sj.mp.4002001","volume":"13","author":"G Kuratomi","year":"2008","unstructured":"Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N et al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry 2008; 13: 429\u2013441.","journal-title":"Mol Psychiatry"},{"key":"BFtp201277_CR13","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.ajhg.2008.01.008","volume":"82","author":"J Mill","year":"2008","unstructured":"Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008; 82: 696\u2013711.","journal-title":"Am J Hum Genet"},{"key":"BFtp201277_CR14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.jpsychires.2006.08.006","volume":"41","author":"M Shimabukuro","year":"2007","unstructured":"Shimabukuro M, Sasaki T, Imamura A, Tsujita T, Fuke C, Umekage T et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J Psychiatr Res 2007; 41: 1042\u20131046.","journal-title":"J Psychiatr Res"},{"key":"BFtp201277_CR15","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.1093\/hmg\/ddr416","volume":"20","author":"EL Dempster","year":"2011","unstructured":"Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet 2011; 20: 4786\u20134796.","journal-title":"Hum Mol Genet"},{"key":"BFtp201277_CR16","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/ajmg.b.31212","volume":"156B","author":"AK Smith","year":"2011","unstructured":"Smith AK, Conneely KN, Kilaru V, Mercer KB, Weiss TE, Bradley B et al. Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet 2011; 156B: 700\u2013708.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201277_CR17","doi-asserted-by":"publisher","first-page":"9470","DOI":"10.1073\/pnas.0910794107","volume":"107","author":"M Uddin","year":"2010","unstructured":"Uddin M, Aiello AE, Wildman DE, Koenen KC, Pawelec G, de Los Santos R et al. Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci U S A 2010; 107: 9470\u20139475.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFtp201277_CR18","doi-asserted-by":"publisher","first-page":"R138","DOI":"10.1093\/hmg\/ddl213","volume":"2","author":"NC Schanen","year":"2006","unstructured":"Schanen NC . Epigenetics of autism spectrum disorders. Hum Mol Genet 2006; 2: R138\u2013R150.","journal-title":"Hum Mol Genet"},{"key":"BFtp201277_CR19","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1096\/fj.10-154484","volume":"24","author":"A Nguyen","year":"2010","unstructured":"Nguyen A, Rauch TA, Pfeifer GP, Hu VW . Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J 2010; 24: 3036\u20133051.","journal-title":"FASEB J"},{"key":"BFtp201277_CR20","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/eat.20745","volume":"43","author":"H Frieling","year":"2010","unstructured":"Frieling H, Romer KD, Scholz S, Mittelbach F, Wilhelm J, De Zwaan M et al. Epigenetic dysregulation of dopaminergic genes in eating disorders. Int J Eat Disord 2010; 43: 577\u2013583.","journal-title":"Int J Eat Disord"},{"key":"BFtp201277_CR21","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1038\/sj.npp.1301662","volume":"33","author":"H Frieling","year":"2008","unstructured":"Frieling H, Bleich S, Otten J, Romer KD, Kornhuber J, de Zwaan M et al. Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity. Neuropsychopharmacology 2008; 33: 2605\u20132609.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201277_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1360-0443.2010.03321.x","volume":"106","author":"CC Wong","year":"2011","unstructured":"Wong CC, Mill J, Fernandes C . Drugs and addiction: an introduction to epigenetics. Addiction 2011; 106: 480\u2013489.","journal-title":"Addiction"},{"key":"BFtp201277_CR23","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nm.2305","volume":"17","author":"M Rodriguez-Paredes","year":"2011","unstructured":"Rodriguez-Paredes M, Esteller M . Cancer epigenetics reaches mainstream oncology. Nat Med 2011; 17: 330\u2013339.","journal-title":"Nat Med"},{"key":"BFtp201277_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1467-8624.2009.01381.x","volume":"81","author":"MJ Meaney","year":"2010","unstructured":"Meaney MJ . Epigenetics and the biological definition of gene x environment interactions. Child Dev 2010; 81: 41\u201379.","journal-title":"Child Dev"},{"key":"BFtp201277_CR25","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","volume":"277","author":"D Liu","year":"1997","unstructured":"Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 1997; 277: 1659\u20131662.","journal-title":"Science"},{"key":"BFtp201277_CR26","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nn.2270","volume":"12","author":"PO McGowan","year":"2009","unstructured":"McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342\u2013348.","journal-title":"Nat Neurosci"},{"key":"BFtp201277_CR27","doi-asserted-by":"publisher","first-page":"9055","DOI":"10.1523\/JNEUROSCI.1424-08.2008","volume":"28","author":"BR Mueller","year":"2008","unstructured":"Mueller BR, Bale TL . Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci 2008; 28: 9055\u20139065.","journal-title":"J Neurosci"},{"issue":"7","key":"BFtp201277_CR28","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1038\/tp.2011.21","volume":"1","author":"K M Radtke","year":"2011","unstructured":"Radtke KM, Ruf M, Gunter HM, Dohrmann K, Schauer M, Meyer A et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 2011; 1.","journal-title":"Translational Psychiatry"},{"key":"BFtp201277_CR29","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nn1276","volume":"7","author":"ICG Weaver","year":"2004","unstructured":"Weaver ICG, Cervoni N, Champagne FA, D\u2019Alessio AC, Sharma SS et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847\u2013854.","journal-title":"Nat Neurosci"},{"key":"BFtp201277_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4161\/epi.3.2.6034","volume":"3","author":"TF Oberlander","year":"2008","unstructured":"Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM . Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 3: 97\u2013106.","journal-title":"Epigenetics"},{"key":"BFtp201277_CR31","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/nn.2436","volume":"12","author":"D Spengler","year":"2009","unstructured":"Spengler D, Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009; 12: 1559\u2013U1108.","journal-title":"Nat Neurosci"},{"key":"BFtp201277_CR32","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.biopsych.2008.11.028","volume":"65","author":"TL Roth","year":"2009","unstructured":"Roth TL, Lubin FD, Funk AJ, Sweatt JD . Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009; 65: 760\u2013769.","journal-title":"Biol Psychiatry"},{"key":"BFtp201277_CR33","doi-asserted-by":"publisher","first-page":"10604","DOI":"10.1073\/pnas.0500398102","volume":"102","author":"MF Fraga","year":"2005","unstructured":"Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestart ML et al. Epigenetic differences arise during the lifetime of monozygotic twins. P Natl Acad Sci USA 2005; 102: 10604\u201310609.","journal-title":"P Natl Acad Sci USA"},{"key":"BFtp201277_CR34","doi-asserted-by":"publisher","first-page":"516","DOI":"10.4161\/epi.5.6.12226","volume":"5","author":"CC Wong","year":"2010","unstructured":"Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A et al. A longitudinal study of epigenetic variation in twins. Epigenetics 2010; 5: 516\u2013526.","journal-title":"Epigenetics"},{"key":"BFtp201277_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0079-6123(02)39014-9","volume":"139","author":"ID Neumann","year":"2002","unstructured":"Neumann ID . Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis. Prog Brain Res 2002; 139: 147\u2013162.","journal-title":"Prog Brain Res"},{"key":"BFtp201277_CR36","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/sj.npp.1301276","volume":"32","author":"VA Vaidya","year":"2007","unstructured":"Vaidya VA, Nair A, Vadodaria KC, Banerjee SB, Benekareddy M, Dias BG et al. Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Neuropsychopharmacology 2007; 32: 1504\u20131519.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201277_CR37","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0006-3223(03)00465-7","volume":"54","author":"M Heinrichs","year":"2003","unstructured":"Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U . Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 2003; 54: 1389\u20131398.","journal-title":"Biol Psychiatry"},{"key":"BFtp201277_CR38","doi-asserted-by":"publisher","first-page":"21437","DOI":"10.1073\/pnas.0909579106","volume":"106","author":"SM Rodrigues","year":"2009","unstructured":"Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D . Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA 2009; 106: 21437\u201321441.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201277_CR39","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0306-4530(97)00045-0","volume":"22","author":"I Liberzon","year":"1997","unstructured":"Liberzon I, Young EA . Effects of stress and glucocorticoids on CNS oxytocin receptor binding. Psychoneuroendocrinology 1997; 22: 411\u2013422.","journal-title":"Psychoneuroendocrinology"},{"key":"BFtp201277_CR40","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.biopsych.2006.09.007","volume":"61","author":"G Meinlschmidt","year":"2007","unstructured":"Meinlschmidt G, Heim C . Sensitivity to intranasal oxytocin in adult men with early parental separation. Biol Psychiat 2007; 61: 1109\u20131111.","journal-title":"Biol Psychiat"},{"key":"BFtp201277_CR41","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.biopsycho.2011.04.003","volume":"87","author":"KM Grewen","year":"2011","unstructured":"Grewen KM, Light KC . Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress. Biol Psychol 2011; 87: 340\u2013349.","journal-title":"Biol Psychol"},{"key":"BFtp201277_CR42","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1590\/S0100-879X2000000600003","volume":"33","author":"J Gutkowska","year":"2000","unstructured":"Gutkowska J, Jankowski M, Mukaddam-Daher S, McCann SM . Oxytocin is a cardiovascular hormone. Braz J Med Biol Res 2000; 33: 625\u2013633.","journal-title":"Braz J Med Biol Res"},{"key":"BFtp201277_CR43","doi-asserted-by":"crossref","unstructured":"Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 2009; 7.","DOI":"10.1186\/1741-7015-7-62"},{"key":"BFtp201277_CR44","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/08977190410001723308","volume":"22","author":"DK Binder","year":"2004","unstructured":"Binder DK, Scharfman HE . Brain-derived neurotrophic factor. Growth Factors 2004; 22: 123\u2013131.","journal-title":"Growth Factors"},{"key":"BFtp201277_CR45","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1126\/science.270.5236.593","volume":"270","author":"H Thoenen","year":"1995","unstructured":"Thoenen H . Neurotrophins and neuronal plasticity. Science 1995; 270: 593\u2013598.","journal-title":"Science"},{"key":"BFtp201277_CR46","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1084\/jem.189.5.865","volume":"189","author":"M Kerschensteiner","year":"1999","unstructured":"Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WEF et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? J Exp Med 1999; 189: 865\u2013870.","journal-title":"J Exp Med"},{"key":"BFtp201277_CR47","doi-asserted-by":"crossref","unstructured":"Boulle F, van den Hove DL, Jakob SB, Rutten BP, Hamon M, van Os J et al. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry 2011.","DOI":"10.1038\/mp.2011.107"},{"key":"BFtp201277_CR48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0165-1781(02)00005-7","volume":"109","author":"F Karege","year":"2002","unstructured":"Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM . Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiat Res 2002; 109: 143\u2013148.","journal-title":"Psychiat Res"},{"key":"BFtp201277_CR49","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.pnpbp.2009.04.018","volume":"33","author":"L Dell'Osso","year":"2009","unstructured":"Dell'Osso L, Carmassi C, Del Debbio A, Dell'Osso MC, Bianchi C, da Pozzo E et al. Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. Prog Neuro-Psychoph 2009; 33: 899\u2013902.","journal-title":"Prog Neuro-Psychoph"},{"key":"BFtp201277_CR50","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.neubiorev.2008.03.011","volume":"33","author":"I Branchi","year":"2009","unstructured":"Branchi I . The mouse communal nest: Investigating the epigenetic influences of the early social environment on brain and behavior development. Neurosci Biobehav Rev 2009; 33: 551\u2013559.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFtp201277_CR51","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.biopsych.2006.01.005","volume":"60","author":"I Branchi","year":"2006","unstructured":"Branchi I, D'Andrea I, Fiore M, Di Fausto V, Aloe L, Alleva E . Early social enrichment shapes social behavior and nerve growth factor and brain-derived neurotrophic factor levels in the adult mouse brain. Biol Psychiatry 2006; 60: 690\u2013696.","journal-title":"Biol Psychiatry"},{"key":"BFtp201277_CR52","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1111\/j.1460-9568.2007.05522.x","volume":"25","author":"M Lippmann","year":"2007","unstructured":"Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM . Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 2007; 25: 3091\u20133098.","journal-title":"Eur J Neurosci"},{"key":"BFtp201277_CR53","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/77702","volume":"3","author":"MJ Meaney","year":"2000","unstructured":"Meaney MJ, Liu D, Diorio J, Day JC, Francis DD . Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nat Neurosci 2000; 3: 799\u2013806.","journal-title":"Nat Neurosci"},{"key":"BFtp201277_CR54","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.pbb.2006.11.021","volume":"85","author":"J Gronli","year":"2006","unstructured":"Gronli J, Bramham C, Murison R, Kanhema T, Fiske E, Bjorvatn B et al. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol Biochem Behav 2006; 85: 842\u2013849.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFtp201277_CR55","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1460-9568.2010.07508.x","volume":"33","author":"F Gomez-Pinilla","year":"2011","unstructured":"Gomez-Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G . Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. Eur J Neurosci 2011; 33: 383\u2013390.","journal-title":"Eur J Neurosci"},{"key":"BFtp201277_CR56","doi-asserted-by":"publisher","first-page":"10576","DOI":"10.1523\/JNEUROSCI.1786-08.2008","volume":"28","author":"FD Lubin","year":"2008","unstructured":"Lubin FD, Roth TL, Sweatt JD . Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci 2008; 28: 10576\u201310586.","journal-title":"J Neurosci"},{"key":"BFtp201277_CR57","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1254\/jphs.91.267","volume":"91","author":"K Yamada","year":"2003","unstructured":"Yamada K, Nabeshima T . Brain-derived neurotrophic factor\/TrkB signaling in memory processes. J Pharmacol Sci 2003; 91: 267\u2013270.","journal-title":"J Pharmacol Sci"},{"key":"BFtp201277_CR58","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000119004","volume":"28","author":"C Kirschbaum","year":"1993","unstructured":"Kirschbaum C, Pirke KM, Hellhammer DH . The Trier social stress test\u2014a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993; 28: 76\u201381.","journal-title":"Neuropsychobiology"},{"key":"BFtp201277_CR59","first-page":"105","volume":"64","author":"SS Dickerson","year":"2002","unstructured":"Dickerson SS, Kemeny ME . Acute stressors and cortisol reactivity: a meta-analytic review. Psychosom Med 2002; 64: 105\u2013105.","journal-title":"Psychosom Med"},{"key":"BFtp201277_CR60","unstructured":"Hautzinger M, Bailer M . ADS: Allgemeine Depressions Skala. Beltz Test: Weinheim 1993; 3, Einheitenpp."},{"key":"BFtp201277_CR61","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1006\/bbrc.2001.6024","volume":"289","author":"C Kusui","year":"2001","unstructured":"Kusui C, Kimura T, Ogita K, Nakamura H, Matsumura Y, Koyama M et al. DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochem Biophys Res Commun 2001; 289: 681\u2013686.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFtp201277_CR62","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","volume":"90","author":"P Pruunsild","year":"2007","unstructured":"Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T . Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics 2007; 90: 397\u2013406.","journal-title":"Genomics"},{"key":"BFtp201277_CR63","volume-title":"Multilevel and Longitudinal Modeling with IBM SPSS","author":"RH Heck","year":"2010","unstructured":"Heck RH, Thomas SL, Tabata LN . Multilevel and Longitudinal Modeling with IBM SPSS. Routledge: New York, 2010 343 pp."},{"key":"BFtp201277_CR64","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/ije\/dyq154","volume":"41","author":"ZZ Zhu","year":"2010","unstructured":"Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol 2010; 41: 126\u2013139.","journal-title":"Int J Epidemiol"},{"key":"BFtp201277_CR65","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.4049\/jimmunol.154.10.5511","volume":"154","author":"FS Dhabhar","year":"1995","unstructured":"Dhabhar FS, Miller AH, McEwen BS, Spencer RL . Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms. J Immunol 1995; 154: 5511\u20135527.","journal-title":"J Immunol"},{"key":"BFtp201277_CR66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0165-1781(98)00141-3","volume":"85","author":"HR Eriksen","year":"1999","unstructured":"Eriksen HR, Olff M, Murison R, Ursin H . The time dimension in stress responses: relevance for survival and health. Psychiatry Res 1999; 85: 39\u201350.","journal-title":"Psychiatry Res"},{"key":"BFtp201277_CR67","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0196-9781(97)00209-X","volume":"18","author":"AIV Favaretto","year":"1997","unstructured":"Favaretto AIV, Ballejo GO, AlbuquerqueAraujo WIC, Gutkowska J, AntunesRodrigues J, McCann SM . Oxytocin releases atrial natriuretic peptide from rat atria in vitro that exerts negative inotropic and chronotropic action. Peptides 1997; 18: 1377\u20131381.","journal-title":"Peptides"},{"key":"BFtp201277_CR68","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.1073\/pnas.110137497","volume":"97","author":"M Jankowski","year":"2000","unstructured":"Jankowski M, Wang DH, Hajjar F, Mukaddam-Daher S, McCann SM, Gutkowska J . Oxytocin and its receptors ar synthesized in the rat vasculature. Proc Natl Acad Sci USA 2000; 97: 6207\u20136211.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201277_CR69","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1371\/journal.pone.0023881","volume":"6","author":"M Fuchikami","year":"2011","unstructured":"Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N et al. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. Plos One 2011; 6: 8.","journal-title":"Plos One"},{"key":"BFtp201277_CR70","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neubiorev.2010.01.010","volume":"35","author":"P Foley","year":"2010","unstructured":"Foley P, Kirschbaum C . Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings. Neurosci Biobehav Rev 2010; 35: 91\u201396.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFtp201277_CR71","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.biopsych.2010.03.029","volume":"69","author":"R Pidsley","year":"2011","unstructured":"Pidsley R, Mill J . Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry 2011; 69: 146\u2013156.","journal-title":"Biol Psychiatry"},{"key":"BFtp201277_CR72","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/FPC.0b013e32833eecbc","volume":"21","author":"V Yuferov","year":"2011","unstructured":"Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A et al. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenet Genomics 2011; 21: 185\u2013196.","journal-title":"Pharmacogenet Genomics"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201277","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:41:26Z","timestamp":1672954886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,14]]},"references-count":72,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["BFtp201277"],"URL":"https:\/\/doi.org\/10.1038\/tp.2012.77","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,14]]},"assertion":[{"value":"9 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}