{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:05:03Z","timestamp":1790723103999,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2012.84","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T13:42:44Z","timestamp":1347370964000},"page":"e160-e160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder"],"prefix":"10.1038","volume":"2","author":[{"suffix":"Jr","given":"R O","family":"Brady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Renshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Keshavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"\u00d6ng\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"BFtp201284_CR1","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/sj.mp.4001711","volume":"10","author":"C Stork","year":"2005","unstructured":"Stork C, Renshaw PF . Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005; 10: 900\u2013919.","journal-title":"Mol Psychiatry"},{"key":"BFtp201284_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/RMR.0b013e318181e0be","volume":"19","author":"SR Dager","year":"2008","unstructured":"Dager SR, Corrigan NM, Richards TL, Posse S . Research applications of magnetic resonance spectroscopy to investigate psychiatric disorders. Top Magn Reson Imaging 2008; 19: 81\u201396.","journal-title":"Top Magn Reson Imaging"},{"key":"BFtp201284_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0165-0327(93)90097-4","volume":"27","author":"T Kato","year":"1993","unstructured":"Kato T, Takahashi S, Shioiri T, Inubushi T . Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J Affect Disord 1993; 27: 53\u201359.","journal-title":"J Affect Disord"},{"key":"BFtp201284_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","volume":"61","author":"SR Dager","year":"2004","unstructured":"Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 2004; 61: 450\u2013458.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201284_CR5","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2353\/ajpath.2010.081068","volume":"177","author":"AM Cataldo","year":"2010","unstructured":"Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ et al. Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol 2010; 177: 575\u2013585.","journal-title":"Am J Pathol"},{"key":"BFtp201284_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0165-0327(89)90005-0","volume":"17","author":"M Maj","year":"1989","unstructured":"Maj M, Pirozzi R, Starace F . Previous pattern of course of the illness as a predictor of response to lithium prophylaxis in bipolar patients. J Affect Disord 1989; 17: 237\u2013241.","journal-title":"J Affect Disord"},{"key":"BFtp201284_CR7","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1001\/archpsyc.1990.01810240026005","volume":"47","author":"M Tohen","year":"1990","unstructured":"Tohen M, Waternaux CM, Tsuang MT . Outcome in Mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis. Arch Gen Psychiatry 1990; 47: 1106\u20131111.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201284_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.brainresrev.2008.04.005","volume":"59","author":"KN Fountoulakis","year":"2008","unstructured":"Fountoulakis KN, Giannakopoulos P, Kovari E, Bouras C . Assessing the role of cingulate cortex in bipolar disorder: neuropathological, structural and functional imaging data. Brain Res Rev 2008; 59: 9\u201321.","journal-title":"Brain Res Rev"},{"key":"BFtp201284_CR9","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.biopsych.2008.05.014","volume":"64","author":"D Ongur","year":"2008","unstructured":"Ongur D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohen BM et al. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry 2008; 64: 718\u2013726.","journal-title":"Biol Psychiatry"},{"key":"BFtp201284_CR10","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders: SCID-I","author":"MB First","year":"2007","unstructured":"First MB . New York State Psychiatric Institute. Biometrics Research D. Structured Clinical Interview for DSM-IV-TR Axis I Disorders: SCID-I. Biometrics Research Dept., New York State Psychiatric Institutute: New York, NY, 2007."},{"key":"BFtp201284_CR11","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/sj.mp.4002137","volume":"14","author":"RJ Maddock","year":"2009","unstructured":"Maddock RJ, Buonocore MH, Copeland LE, Richards AL . Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study. Mol Psychiatry 2009; 14: 537\u2013545.","journal-title":"Mol Psychiatry"},{"key":"BFtp201284_CR12","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/nbm.1390","volume":"22","author":"JE Jensen","year":"2009","unstructured":"Jensen JE, Licata SC, Ongur D, Friedman SD, Prescot AP, Henry ME et al. Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla. NMR Biomed 2009; 22: 762\u2013769.","journal-title":"NMR Biomed"},{"key":"BFtp201284_CR13","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s00213-003-1440-z","volume":"168","author":"N Michael","year":"2003","unstructured":"Michael N, Erfurth A, Ohrmann P, Gossling M, Arolt V, Heindel W et al. Acute mania is accompanied by elevated glutamate\/glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacology 2003; 168: 344\u2013346.","journal-title":"Psychopharmacology"},{"key":"BFtp201284_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pscychresns.2008.06.002","volume":"172","author":"D Ongur","year":"2009","unstructured":"Ongur D, Prescot AP, Jensen JE, Cohen BM, Renshaw PF . Creatine abnormalities in schizophrenia and bipolar disorder. Psychiatry Res 2009; 172: 44\u201348.","journal-title":"Psychiatry Res"},{"key":"BFtp201284_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1034\/j.1399-5618.2002.02235.x","volume":"4","author":"KM Cecil","year":"2002","unstructured":"Cecil KM, DelBello MP, Morey R, Strakowski SM . Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 2002; 4: 357\u2013365.","journal-title":"Bipolar Disord"},{"key":"BFtp201284_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0165-0327(92)90099-R","volume":"26","author":"T Kato","year":"1992","unstructured":"Kato T, Takahashi S, Shioiri T, Inubushi T . Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 1992; 26: 223\u2013230.","journal-title":"J Affect Disord"},{"key":"BFtp201284_CR17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0925-4927(01)00082-8","volume":"106","author":"A Yildiz","year":"2001","unstructured":"Yildiz A, Sachs GS, Dorer DJ, Renshaw PF . 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis. Psychiatry Res 2001; 106: 181\u2013191.","journal-title":"Psychiatry Res"},{"key":"BFtp201284_CR18","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.pnpbp.2007.04.009","volume":"31","author":"DJ Kim","year":"2007","unstructured":"Kim DJ, Lyoo IK, Yoon SJ, Choi T, Lee B, Kim JE et al. Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1182\u20131188.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3 Part 1","key":"BFtp201284_CR19","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1034\/j.1399-5618.2000.020305.x","volume":"2","author":"T Kato","year":"2000","unstructured":"Kato T, Kato N . Mitochondrial dysfunction in bipolar disorder. Bipolar Disord 2000; 2 (3 Part 1): 180\u2013190.","journal-title":"Bipolar Disord"},{"key":"BFtp201284_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1046\/j.1399-5618.2003.00091.x","volume":"6","author":"RT Joffe","year":"2004","unstructured":"Joffe RT, MacQueen GM, Marriott M, Trevor Young L . A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders. Bipolar Disord 2004; 6: 62\u201366.","journal-title":"Bipolar Disord"},{"key":"BFtp201284_CR21","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1176\/appi.ajp.158.8.1265","volume":"158","author":"JF Goldberg","year":"2001","unstructured":"Goldberg JF, Harrow M, Whiteside JE . Risk for bipolar illness in patients initially hospitalized for unipolar depression. Am J Psychiatry 2001; 158: 1265\u20131270.","journal-title":"Am J Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201284","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:49:13Z","timestamp":1672955353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,9]]}},"alternative-id":["BFtp201284"],"URL":"https:\/\/doi.org\/10.1038\/tp.2012.84","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]},"assertion":[{"value":"25 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr Renshaw is a consultant to Novartis, GlaxoSmithKline and Kyowa Hakko. Dr \u00d6ng\u00fcr is PI on a research contract with Rules Based Medicine Inc. The other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}