{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:43:16Z","timestamp":1749012196686},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2013.122","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T14:47:11Z","timestamp":1390920431000},"page":"e353-e353","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The \u03b1-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder"],"prefix":"10.1038","volume":"4","author":[{"given":"K P","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H R","family":"Kranzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Z","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L A","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gelernter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"BFtp2013122_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE . Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593\u2013602.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2013122_CR2","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","volume":"158","author":"JM Hettema","year":"2001","unstructured":"Hettema JM, Neale MC, Kendler KS . A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001; 158: 1568\u20131578.","journal-title":"Am J Psychiatry"},{"key":"BFtp2013122_CR3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1001\/archpsyc.62.2.182","volume":"62","author":"JM Hettema","year":"2005","unstructured":"Hettema JM, Prescott CA, Myers JM, Neale MC, Kendler KS . The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 2005; 62: 182\u2013189.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2013122_CR4","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","volume":"381","author":"JW Smoller","year":"2013","unstructured":"Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI et al. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371\u20131379.","journal-title":"Lancet"},{"key":"BFtp2013122_CR5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00439-008-0501-0","volume":"123","author":"Y Yu","year":"2008","unstructured":"Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA et al. Substance dependence low-density whole genome association study in two distinct American populations. Hum Genet 2008; 123: 495\u2013506.","journal-title":"Hum Genet"},{"key":"BFtp2013122_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1001\/archgenpsychiatry.2008.538","volume":"66","author":"LA Farrer","year":"2009","unstructured":"Farrer LA, Kranzler HR, Yu Y, Weiss RD, Brady KT, Anton R et al. Association of variants in MANEA with cocaine-related behaviors. Arch Gen Psychiatry 2009; 66: 267\u2013274.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2013122_CR7","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1093\/hmg\/ddr167","volume":"20","author":"E Kuokkanen","year":"2011","unstructured":"Kuokkanen E, Riise Stensland HM, Smith W, Kjeldsen Buvang E, Van Nguyen L, Nilssen O et al. Molecular and cellular characterization of novel {alpha}-mannosidosis mutations. Hum Mol Genet 2011; 20: 2651\u20132661.","journal-title":"Hum Mol Genet"},{"key":"BFtp2013122_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-2350-10-84","volume":"10","author":"F Sabourdy","year":"2009","unstructured":"Sabourdy F, Labauge P, Stensland HM, Nieto M, Garces VL, Renard D et al. A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant. BMC Med Genet 2009; 10: 84.","journal-title":"BMC Med Genet"},{"key":"BFtp2013122_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature10423","volume":"478","author":"H Najmabadi","year":"2011","unstructured":"Najmabadi H, Hu H, Garshasbi M, Zemojtel T, Abedini SS, Chen W et al. Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature 2011; 478: 57\u201363.","journal-title":"Nature"},{"key":"BFtp2013122_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ajhg.2011.06.006","volume":"89","author":"MA Rafiq","year":"2011","unstructured":"Rafiq MA, Kuss AW, Puettmann L, Noor A, Ramiah A, Ali G et al. Mutations in the Alpha 1,2-Mannosidase Gene, MAN1B1, Cause Autosomal-Recessive Intellectual Disability. Am J Hum Genet 2011; 89: 176\u2013182.","journal-title":"Am J Hum Genet"},{"key":"BFtp2013122_CR11","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/j.1365-2788.2005.00765.x","volume":"49","author":"D Malm","year":"2005","unstructured":"Malm D, Pantel J, Linaker OM . Psychiatric symptoms in alpha-mannosidosis. J Intellect Disabil Res 2005; 49: 865\u2013871.","journal-title":"J Intellect Disabil Res"},{"key":"BFtp2013122_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00115-004-1720-9","volume":"76","author":"U Seidl","year":"2005","unstructured":"Seidl U, Giesel FL, Cantz M, Schmidbauer M, Schroder J, Pantel J . Unusual course of alpha-mannosidosis with symptoms of paranoid-hallucinatory psychosis. Nervenarzt 2005; 76: 335\u2013338.","journal-title":"Nervenarzt"},{"key":"BFtp2013122_CR13","first-page":"35","volume":"8","author":"BL Stegelmeier","year":"1999","unstructured":"Stegelmeier BL, James LF, Panter KE, Ralphs MH, Gardner DR, Molyneux RJ et al. The pathogenesis and toxicokinetics of locoweed (Astragalus and Oxytropis spp.) poisoning in livestock. J Nat Toxins 1999; 8: 35\u201345.","journal-title":"J Nat Toxins"},{"key":"BFtp2013122_CR14","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1016\/S0021-9258(18)34274-1","volume":"257","author":"DR Tulsiani","year":"1982","unstructured":"Tulsiani DR, Harris TM, Touster O . Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II. J Biol Chem 1982; 257: 7936\u20137939.","journal-title":"J Biol Chem"},{"key":"BFtp2013122_CR15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature10524","volume":"478","author":"C Colantuoni","year":"2011","unstructured":"Colantuoni C, Lipska BK, Ye T, Hyde TM, Tao R, Leek JT et al. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 2011; 478: 519\u2013523.","journal-title":"Nature"},{"key":"BFtp2013122_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.drugalcdep.2005.04.005","volume":"80","author":"A Pierucci-Lagha","year":"2005","unstructured":"Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A et al. Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug Alcohol Depend 2005; 80: 303\u2013312.","journal-title":"Drug Alcohol Depend"},{"key":"BFtp2013122_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.drugalcdep.2007.04.014","volume":"91","author":"A Pierucci-Lagha","year":"2007","unstructured":"Pierucci-Lagha A, Gelernter J, Chan G, Arias A, Cubells JF, Farrer L et al. Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA). Drug Alcohol Depend 2007; 91: 85\u201390.","journal-title":"Drug Alcohol Depend"},{"key":"BFtp2013122_CR18","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1001\/jama.2010.608","volume":"303","author":"P Roy-Byrne","year":"2010","unstructured":"Roy-Byrne P, Craske MG, Sullivan G, Rose RD, Edlund MJ, Lang AJ et al. Delivery of evidence-based treatment for multiple anxiety disorders in primary care: a randomized controlled trial. JAMA 2010; 303: 1921\u20131928.","journal-title":"JAMA"},{"issue":"Suppl 20","key":"BFtp2013122_CR19","first-page":"22","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59 ((Suppl 20)): 22\u201333, quiz 34-57.","journal-title":"J Clin Psychiatry"},{"key":"BFtp2013122_CR20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","volume":"155","author":"JK Pritchard","year":"2000","unstructured":"Pritchard JK, Stephens M, Donnelly P . Inference of population structure using multilocus genotype data. Genetics 2000; 155: 945\u2013959.","journal-title":"Genetics"},{"key":"BFtp2013122_CR21","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D . Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904\u2013909.","journal-title":"Nat Genet"},{"key":"BFtp2013122_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/gepi.20070","volume":"28","author":"BZ Yang","year":"2005","unstructured":"Yang BZ, Zhao H, Kranzler HR, Gelernter J . Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. Genet Epidemiol 2005; 28: 302\u2013312.","journal-title":"Genet Epidemiol"},{"issue":"1","key":"BFtp2013122_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/mp.2013.145","volume":"19","author":"J Gelernter","year":"2013","unstructured":"Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH et al. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Mol Psychiatry advance online publication, 29 October 2013; doi: 10.1038\/mp.2013.145.","journal-title":"Molecular Psychiatry"},{"issue":"1","key":"BFtp2013122_CR24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.biopsych.2013.08.034","volume":"76","author":"Joel Gelernter","year":"2014","unstructured":"Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H et al. Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways. Biol Psychiatry 2013; advance online publication; doi: 10.1016\/j.biopsych.2013.08.034.","journal-title":"Biological Psychiatry"},{"issue":"6","key":"BFtp2013122_CR25","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/mp.2013.99","volume":"19","author":"J Gelernter","year":"2013","unstructured":"Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR et al. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Mol Psychiatry advance online publication, 20 August 2013; doi: 10.1038\/mp.2013.99.","journal-title":"Molecular Psychiatry"},{"key":"BFtp2013122_CR26","first-page":"644","volume":"23","author":"JR Gonzalez","year":"2007","unstructured":"Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X et al. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 2007; 23: 644\u2013645.","journal-title":"Bioinformatics"},{"key":"BFtp2013122_CR27","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","volume":"24","author":"AD Johnson","year":"2008","unstructured":"Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI . SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008; 24: 2938\u20132939.","journal-title":"Bioinformatics"},{"key":"BFtp2013122_CR28","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nature10808","volume":"482","author":"JF Degner","year":"2012","unstructured":"Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, Pickrell JK et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 2012; 482: 390\u2013394.","journal-title":"Nature"},{"key":"BFtp2013122_CR29","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nature09267","volume":"466","author":"H Guo","year":"2010","unstructured":"Guo H, Ingolia NT, Weissman JS, Bartel DP . Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010; 466: 835\u2013840.","journal-title":"Nature"},{"key":"BFtp2013122_CR30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/mp.2008.15","volume":"14","author":"KP Jensen","year":"2009","unstructured":"Jensen KP, Covault J, Conner TS, Tennen H, Kranzler HR, Furneaux HM . A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry 2009; 14: 381\u2013389.","journal-title":"Mol Psychiatry"},{"key":"BFtp2013122_CR31","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1073\/pnas.1111482109","volume":"109","author":"AJ Thompson","year":"2012","unstructured":"Thompson AJ, Williams RJ, Hakki Z, Alonzi DS, Wennekes T, Gloster TM et al. Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase. Proc Natl Acad Sci USA 2012; 109: 781\u2013786.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2013122_CR32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pbb.2006.02.005","volume":"83","author":"R Kalayasiri","year":"2006","unstructured":"Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT et al. Self-reported paranoia during laboratory \"binge\" cocaine self-administration in humans. Pharmacol Biochem Behav 2006; 83: 249\u2013256.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFtp2013122_CR33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.eurpsy.2011.06.012","volume":"28","author":"C Roncero","year":"2011","unstructured":"Roncero C, Daigre C, Gonzalvo B, Valero S, Castells X, Grau-Lopez L et al. Risk factors for cocaine-induced psychosis in cocaine-dependent patients. Eur Psychiatry 2011; 28: 141\u2013146.","journal-title":"Eur Psychiatry"},{"key":"BFtp2013122_CR34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","volume":"51","author":"RC Kessler","year":"1994","unstructured":"Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 8\u201319.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2013122_CR35","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/da.20492","volume":"25","author":"JW Smoller","year":"2008","unstructured":"Smoller JW, Gardner-Schuster E, Misiaszek M . Genetics of anxiety: would the genome recognize the DSM? Depress Anxiety 2008; 25: 368\u2013377.","journal-title":"Depress Anxiety"},{"key":"BFtp2013122_CR36","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/da.20623","volume":"26","author":"JW Smoller","year":"2009","unstructured":"Smoller JW, Block SR, Young MM . Genetics of anxiety disorders: the complex road from DSM to DNA. Depress Anxiety 2009; 26: 965\u2013975.","journal-title":"Depress Anxiety"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp2013122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp2013122","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2013122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T22:20:04Z","timestamp":1672957204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2013122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1]]}},"alternative-id":["BFtp2013122"],"URL":"https:\/\/doi.org\/10.1038\/tp.2013.122","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]},"assertion":[{"value":"6 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Although not directly relevant to the work presented here, Henry R Kranzler has been a paid consultant for Alkermes, Lundbeck, Roche, Pfizer and Lilly. He also reports associations with Lilly, Janssen, Schering Plough, Lundbeck, Alkermes, GlaxoSmithKline, Abbott and Johnson & Johnson, as these companies provide support to the American Society of Clinical Psychopharmacology\u2019s Alcohol Clinical Trials Initiative (ACTIVE) and Dr Kranzler receives support from ACTIVE. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}