{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:03:10Z","timestamp":1791928990429,"version":"4.3.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2013.14","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T14:38:00Z","timestamp":1362494280000},"page":"e237-e237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study"],"prefix":"10.1038","volume":"3","author":[{"given":"R E","family":"Frye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"DeLaTorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H B","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Slattery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Melnyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"BFtp201314_CR1","unstructured":"APA. Diagnostic and statistical manual of mental disorders 4th edn. American Psychiatric Association: Washington, DC, USA, 1994."},{"key":"BFtp201314_CR2","first-page":"1","volume":"58","author":"C Rice","year":"2009","unstructured":"Rice C . Prevalence of autism spectrum disorders\u2014Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ 2009; 58: 1\u201320.","journal-title":"MMWR Surveill Summ"},{"key":"BFtp201314_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/GIM.0b013e31815efdd7","volume":"10","author":"GB Schaefer","year":"2008","unstructured":"Schaefer GB, Mendelsohn NJ . Genetics evaluation for the etiologic diagnosis of autism spectrum disorders. Genet Med 2008; 10: 4\u201312.","journal-title":"Genet Med"},{"key":"BFtp201314_CR4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/mp.2010.136","volume":"17","author":"DA Rossignol","year":"2011","unstructured":"Rossignol DA, Frye RE . Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry 2011; 17: 290\u2013314.","journal-title":"Mol Psychiatry"},{"issue":"Suppl 1","key":"BFtp201314_CR5","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1542\/peds.2009-1878C","volume":"125","author":"T Buie","year":"2010","unstructured":"Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010; 125 (Suppl 1): S1\u201318.","journal-title":"Pediatrics"},{"key":"BFtp201314_CR6","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/ajmg.b.30366","volume":"141","author":"SJ James","year":"2006","unstructured":"James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006; 141: 947\u2013956.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201314_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","volume":"25","author":"P Ashwood","year":"2010","unstructured":"Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J . Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2010; 25: 40\u201345.","journal-title":"Brain Behav Immun"},{"key":"BFtp201314_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/mp.2011.165","volume":"17","author":"DA Rossignol","year":"2012","unstructured":"Rossignol DA, Frye RE . A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012; 17: 389\u2013401.","journal-title":"Mol Psychiatry"},{"key":"BFtp201314_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/0883073807307102","volume":"23","author":"X Ming","year":"2008","unstructured":"Ming X, Brimacombe M, Chaaban J, Zimmerman-Bier B, Wagner GC . Autism spectrum disorders: concurrent clinical disorders. J Child Neurol 2008; 23: 6\u201313.","journal-title":"J Child Neurol"},{"key":"BFtp201314_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.nurt.2010.05.004","volume":"7","author":"RE Frye","year":"2010","unstructured":"Frye RE, Huffman LC, Elliott GR . Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics 2010; 7: 241\u2013249.","journal-title":"Neurotherapeutics"},{"key":"BFtp201314_CR11","first-page":"181","volume":"21","author":"H Naruse","year":"1989","unstructured":"Naruse H, Hayashi T, Takesada M, Nakane A, Yamazaki K . [Metabolic changes in aromatic amino acids and monoamines in infantile autism and development of new treatment related to the finding]. No to hattatsu 1989; 21: 181\u2013189.","journal-title":"No to hattatsu"},{"key":"BFtp201314_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2183\/pjab.63.231","volume":"63B","author":"H Naruse","year":"1987","unstructured":"Naruse H, Hayashi T, Takesada M, Nakane A, Yamazaki K . Therapeutic effect of tetrahydrobiopterin in infantile autism. Proc Jpn Acad 1987; 63B: 231\u2013233.","journal-title":"Proc Jpn Acad"},{"key":"BFtp201314_CR13","first-page":"1343","volume":"6","author":"H Naruse","year":"1990","unstructured":"Naruse H, Takesada M, Nagahata M, Kazamatsuri H, Nakane Y, Yamazaki K . An open clinical study of sapropterin hydocloride (R-tetrahydrobiopterin SUN 588) in infantile autism: clinical study using a Rating Scale for Abnormal Behaviors in Children. Rinsho Iyaku 1990; 6: 1343\u20131368.","journal-title":"Rinsho Iyaku"},{"key":"BFtp201314_CR14","first-page":"1859","volume":"6","author":"H Naruse","year":"1990","unstructured":"Naruse H, Takesada M, Nagahata M, Kazamatsuri H, Nakane Y, Yamazaki K . An open clinical study of sapropterin hydrochloride (R-tetrahydrobiopterin SUN 0588) in infantile autism - clinical study using a Rating Scale for Abnormal Behaviors in Children. Rinsho Iyaku 1990; 6: 1859\u20131875.","journal-title":"Rinsho Iyaku"},{"key":"BFtp201314_CR15","first-page":"1877","volume":"6","author":"M Nagahata","year":"1990","unstructured":"Nagahata M, Kazamatsuri H, Naruse H, Yamazaki K, Takesada M, Nakane Y et al. Clinical evaluation of aproterin hydrochloride (R-THBP. SUN 0588) on infantile autism\u2014a multicenter cooperative study. Rinsho Iyaku 1990; 6: 1877\u20131899.","journal-title":"Rinsho Iyaku"},{"key":"BFtp201314_CR16","first-page":"4579","volume":"24","author":"Y Nakane","year":"1990","unstructured":"Nakane Y, Asuo T, Shimogawa S, Fujiwara T, Kawabata Y, Kubota J . Clinical efficacy and effects on physical development of long-term treatment of R-tetrahydrobiopterin (R-THBP, SUN 0588) for autism. Kiso to Rinshou 1990; 24: 4579\u20134598.","journal-title":"Kiso to Rinshou"},{"key":"BFtp201314_CR17","unstructured":"Takesada M, Naruse H, Nagahata M . An open clinical study of aprpterin hydrochloride (R-tetrahydrobiopterin, R-THBP) in infantile autism - clinical effects and long-term follow-up. International Symposium on Neurobiology of Infantile Autism: Tokyo, Japan 1990."},{"key":"BFtp201314_CR18","first-page":"337","volume-title":"Neurobiology of Infantile Autism","author":"Y Nakan","year":"1992","unstructured":"Nakan Y, Naruse H, Hayashi T, Takesada M, Yamazaki K . Clinical effect of R-THBP on Infantile Autism. In: Naruse H, Ornitz E, (eds) Neurobiology of Infantile Autism. Elsevier Science Publishers: New York, NY, USA pp 337\u2013349 1992."},{"key":"BFtp201314_CR19","unstructured":"Naruse H, Hayashi T, Takesada M A preliminary study on clinical effect of tetrahydrobiopterin in infantile autism. Ministry of Health and Welfare; 1985."},{"key":"BFtp201314_CR20","first-page":"1343","volume":"6","author":"H Naruse","year":"1990","unstructured":"Naruse H, Takesada M, Nakane Y, Yamazaki K, Uchiyama T, Kaihara S et al. Clinical evaluation of R-tetrahydrobiopterin (SUN 0588) on infantile autism \u2014 a double-blind comparative study using placebo as a control. Rinsho Iyaku 1990; 6: 1343\u20131368.","journal-title":"Rinsho Iyaku"},{"key":"BFtp201314_CR21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/01.jcp.0000177667.35016.e9","volume":"25","author":"T Danfors","year":"2005","unstructured":"Danfors T, von Knorring AL, Hartvig P, Langstrom B, Moulder R, Stromberg B et al. Tetrahydrobiopterin in the treatment of children with autistic disorder: a double-blind placebo-controlled crossover study. J Clin Psychopharmacol 2005; 25: 485\u2013489.","journal-title":"J Clin Psychopharmacol"},{"key":"BFtp201314_CR22","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1469-8749.1997.tb07437.x","volume":"39","author":"E Fernell","year":"1997","unstructured":"Fernell E, Watanabe Y, Adolfsson I, Tani Y, Bergstrom M, Hartvig P et al. Possible effects of tetrahydrobiopterin treatment in six children with autism\u2014clinical and positron emission tomography data: a pilot study. Dev Med Child Neurol 1997; 39: 313\u2013318.","journal-title":"Dev Med Child Neurol"},{"key":"BFtp201314_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2183\/pjab.63.231","volume":"63","author":"H Naruse","year":"1987","unstructured":"Naruse H, Hayahi I, Takesada M, Nakane Y, Yamazaki K, Noguchi T et al. Therapeutic effect of tetrahydrobiopterin in infantile autism. Proc Jpn Acad 1987; 63: 231\u2013233.","journal-title":"Proc Jpn Acad"},{"issue":"Pt 1","key":"BFtp201314_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3470001","volume":"347","author":"B Thony","year":"2000","unstructured":"Thony B, Auerbach G, Blau N . Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J 2000; 347 (Pt 1): 1\u201316.","journal-title":"Biochem J"},{"key":"BFtp201314_CR25","first-page":"52","volume":"4","author":"RE Frye","year":"2010","unstructured":"Frye RE . Central tetrahydrobiopterin concentration in neurodevelopmental disorders. Front Neurosci 2010; 4: 52.","journal-title":"Front Neurosci"},{"key":"BFtp201314_CR26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0304-3940(94)90586-X","volume":"181","author":"Y Tani","year":"1994","unstructured":"Tani Y, Fernell E, Watanabe Y, Kanai T, Langstrom B . Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients. Neuroscience Lett 1994; 181: 169\u2013172.","journal-title":"Neuroscience Lett"},{"key":"BFtp201314_CR27","volume-title":"Preschool Language Scale","author":"IL Zimmerman","year":"2002","unstructured":"Zimmerman IL, Steiner VG, Pond RE . Preschool Language Scale Fourth Edition Harcourt Assessment: San Antonio, TX, USA, 2002."},{"key":"BFtp201314_CR28","volume-title":"Vineland Adaptive Behavior Scales","author":"S Sparrow","year":"2005","unstructured":"Sparrow S, Cicchetti D, Balla D . Vineland Adaptive Behavior Scales 2nd edn. Pearson Assessments: Bloomington, MN, USA, 2005."},{"key":"BFtp201314_CR29","volume-title":"The Social Responsiveness Scale","author":"JN Constantino","year":"2002","unstructured":"Constantino JN . The Social Responsiveness Scale. Western Psychological Services: Los Angeles, CA, USA, 2002."},{"key":"BFtp201314_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/01688639708403856","volume":"19","author":"SH Landry","year":"1997","unstructured":"Landry SH, Denson SE, Swank PR . Effects of medical risk and socioeconomic status on the rate of change in cognitive and social development for low birth weight children. J Clin Exp Neuropsychol 1997; 19: 261\u2013274.","journal-title":"J Clin Exp Neuropsychol"},{"key":"BFtp201314_CR31","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1037\/a0013030","volume":"44","author":"SH Landry","year":"2008","unstructured":"Landry SH, Smith KE, Swank PR, Guttentag C . A responsive parenting intervention: the optimal timing across early childhood for impacting maternal behaviors and child outcomes. Dev Psychol 2008; 44: 1335\u20131353.","journal-title":"Dev Psychol"},{"key":"BFtp201314_CR32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s10803-010-1024-9","volume":"41","author":"S Bolte","year":"2011","unstructured":"Bolte S, Westerwald E, Holtmann M, Freitag C, Poustka F . Autistic traits and autism spectrum disorders: the clinical validity of two measures presuming a continuum of social communication skills. J Autism Dev Disorders 2011; 41: 66\u201372.","journal-title":"J Autism Dev Disorders"},{"key":"BFtp201314_CR33","first-page":"485","volume":"89","author":"MG Aman","year":"1985","unstructured":"Aman MG, Singh GK, Stewart AW, Field CJ . The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects. Am J Mental Deficits 1985; 89: 485\u2013491.","journal-title":"Am J Mental Deficits"},{"key":"BFtp201314_CR34","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH . Random-effects models for longitudinal data. Biometrics 1982; 38: 963\u2013974.","journal-title":"Biometrics"},{"key":"BFtp201314_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0009-8981(87)90081-7","volume":"167","author":"DW Howells","year":"1987","unstructured":"Howells DW, Hyland K . Direct analysis of tetrahydrobiopterin in cerebrospinal fluid by high-performance liquid chromatography with redox electrochemistry: prevention of autoxidation during storage and analysis. Clinica Chimica Acta; Int J Clin Chem 1987; 167: 23\u201330.","journal-title":"Clinica Chimica Acta; Int J Clin Chem"},{"key":"BFtp201314_CR36","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S0955-2863(99)00033-9","volume":"10","author":"S Melnyk","year":"1999","unstructured":"Melnyk S, Pogribna M, Pogribny I, Hine RJ, James SJ . A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem 1999; 10: 490\u2013497.","journal-title":"J Nutr Biochem"},{"key":"BFtp201314_CR37","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1471-2350-11-108","volume":"11","author":"R Delorme","year":"2010","unstructured":"Delorme R, Betancur C, Scheid I, Anckarsater H, Chaste P, Jamain S et al. Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls. BMC Med Genet 2010; 11: 108.","journal-title":"BMC Med Genet"},{"key":"BFtp201314_CR38","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/ajmg.b.30798","volume":"150B","author":"HW Kim","year":"2009","unstructured":"Kim HW, Cho SC, Kim JW, Cho IH, Kim SA, Park M et al. Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 300\u2013306.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201314_CR39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0009-8981(03)00119-0","volume":"331","author":"S Sogut","year":"2003","unstructured":"Sogut S, Zoroglu SS, Ozyurt H, Yilmaz HR, Ozugurlu F, Sivasli E et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clinica Chimica Acta; Int J Clin Chem 2003; 331: 111\u2013117.","journal-title":"Clinica Chimica Acta; Int J Clin Chem"},{"key":"BFtp201314_CR40","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1055\/s-0032-1301914","volume":"45","author":"MH Tostes","year":"2012","unstructured":"Tostes MH, Teixeira HC, Gattaz WF, Brandao MA, Raposo NR . Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism. Pharmacopsychiatry 2012; 45: 241\u2013243.","journal-title":"Pharmacopsychiatry"},{"key":"BFtp201314_CR41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12011-011-9280-x","volume":"147","author":"MM Essa","year":"2012","unstructured":"Essa MM, Guillemin GJ, Waly MI, Al-Sharbati MM, Al-Farsi YM, Hakkim FL et al. Increased markers of oxidative stress in autistic children of the Sultanate of Oman. Biol Trace Elem Res 2012; 147: 25\u201327.","journal-title":"Biol Trace Elem Res"},{"key":"BFtp201314_CR42","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.cca.2011.02.021","volume":"412","author":"MD Lakshmi Priya","year":"2011","unstructured":"Lakshmi Priya MD, Geetha A . A biochemical study on the level of proteins and their percentage of nitration in the hair and nail of autistic children. Clinica Chimica Acta; Int J Clin Chem 2011; 412: 1036\u20131042.","journal-title":"Clinica Chimica Acta; Int J Clin Chem"},{"key":"BFtp201314_CR43","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10803-011-1260-7","volume":"42","author":"S Melnyk","year":"2012","unstructured":"Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ et al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disorders 2012; 42: 367\u2013377.","journal-title":"J Autism Dev Disorders"},{"key":"BFtp201314_CR44","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/ajmg.b.30366","volume":"141B","author":"SJ James","year":"2006","unstructured":"James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 947\u2013956.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201314_CR45","doi-asserted-by":"publisher","first-page":"e134","DOI":"10.1038\/tp.2012.61","volume":"2","author":"S Rose","year":"2012","unstructured":"Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE et al. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Translational Psychiatry 2012; 2: e134.","journal-title":"Translational Psychiatry"},{"key":"BFtp201314_CR46","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s12311-010-0223-4","volume":"10","author":"EM Sajdel-Sulkowska","year":"2011","unstructured":"Sajdel-Sulkowska EM, Xu M, McGinnis W, Koibuchi N . Brain region-specific changes in oxidative stress and neurotrophin levels in autism spectrum disorders (ASD). Cerebellum 2011; 10: 43\u201348.","journal-title":"Cerebellum"},{"key":"BFtp201314_CR47","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.biopsych.2003.09.001","volume":"55","author":"TL Sweeten","year":"2004","unstructured":"Sweeten TL, Posey DJ, Shankar S, McDougle CJ . High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Biol Psychiatry 2004; 55: 434\u2013437.","journal-title":"Biol Psychiatry"},{"key":"BFtp201314_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1749-6632.2012.06582.x","volume":"1259","author":"J Laranjinha","year":"2012","unstructured":"Laranjinha J, Santos RM, Lourenco CF, Ledo A, Barbosa RM . Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling. Ann N Y Acad Sci 2012; 1259: 10\u201318.","journal-title":"Ann N Y Acad Sci"},{"key":"BFtp201314_CR49","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12035-010-8105-9","volume":"41","author":"GC Brown","year":"2010","unstructured":"Brown GC, Neher JJ . Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010; 41: 242\u2013247.","journal-title":"Mol Neurobiol"},{"key":"BFtp201314_CR50","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-94-007-2869-1_4","volume":"942","author":"P Sarti","year":"2012","unstructured":"Sarti P, Arese M, Forte E, Giuffre A, Mastronicola D . Mitochondria and nitric oxide: chemistry and pathophysiology. Adv Exp Med Biol 2012; 942: 75\u201392.","journal-title":"Adv Exp Med Biol"},{"key":"BFtp201314_CR51","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1096\/fj.08-128926","volume":"23","author":"SJ James","year":"2009","unstructured":"James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J 2009; 23: 2374\u20132383.","journal-title":"FASEB J"},{"key":"BFtp201314_CR52","doi-asserted-by":"crossref","unstructured":"Klaiman C, Huffman L, Elliott GR . Sapropterin as a treatment for Autism Spectrum Disorders: a double-blind, placebo-controlled trial. J Child Adol Psychop 2013 (in press).","DOI":"10.1089\/cap.2012.0127"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201314","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:53:50Z","timestamp":1672955630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,5]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3]]}},"alternative-id":["BFtp201314"],"URL":"https:\/\/doi.org\/10.1038\/tp.2013.14","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,5]]},"assertion":[{"value":"9 October 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr Frye received funding for this trial by Biomarin Pharmaceutical, the manufacture of Kuvan, the form of sapropterin used in this study. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}