{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:57:27Z","timestamp":1768294647254,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2013.28","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T13:39:28Z","timestamp":1367329168000},"page":"e254-e254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["A single gene defect causing claustrophobia"],"prefix":"10.1038","volume":"3","author":[{"given":"A","family":"El-Kordi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"K\u00e4stner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Grube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Klugmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Begemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hammerschmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Stepniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Patzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"de Monasterio-Schrader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Strenzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Fl\u00fcgge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H B","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K-A","family":"Nave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ehrenreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"BFtp201328_CR1","doi-asserted-by":"publisher","first-page":"17196","DOI":"10.1073\/pnas.0504262102","volume":"102","author":"J Alfonso","year":"2005","unstructured":"Alfonso J, Fernandez ME, Cooper B, Flugge G, Frasch AC . The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium\/spine formation. Proc Natl Acad Sci USA 2005; 102: 17196\u201317201.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201328_CR2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1089\/scd.2008.0215","volume":"18","author":"H Michibata","year":"2009","unstructured":"Michibata H, Okuno T, Konishi N, Kyono K, Wakimoto K, Aoki K et al. Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells. Stem Cells Dev 2009; 18: 629\u2013639.","journal-title":"Stem Cells Dev"},{"key":"BFtp201328_CR3","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/S0006-291X(02)02284-2","volume":"297","author":"S Mukobata","year":"2002","unstructured":"Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y et al. M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation. Biochem Biophys Res Commun 2002; 297: 722\u2013728.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFtp201328_CR4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/j.1460-9568.2004.03178.x","volume":"19","author":"J Alfonso","year":"2004","unstructured":"Alfonso J, Pollevick GD, Van Der Hart MG, Flugge G, Fuchs E, Frasch AC . Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus. Eur J Neurosci 2004; 19: 659\u2013666.","journal-title":"Eur J Neurosci"},{"key":"BFtp201328_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrn1683","volume":"6","author":"ER de Kloet","year":"2005","unstructured":"de Kloet ER, Joels M, Holsboer F . Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005; 6: 463\u2013475.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp201328_CR6","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<829::AID-JNR19>3.0.CO;2-W","volume":"50","author":"S Forss-Petter","year":"1997","unstructured":"Forss-Petter S, Werner H, Berger J, Lassmann H, Molzer B, Schwab MH et al. Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. J Neurosci Res 1997; 50: 829\u2013843.","journal-title":"J Neurosci Res"},{"key":"BFtp201328_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/neu.480230108","volume":"23","author":"C Lagenaur","year":"1992","unstructured":"Lagenaur C, Kunemund V, Fischer G, Fushiki S, Schachner M . Monoclonal M6 antibody interferes with neurite extension of cultured neurons. J Neurobiol 1992; 23: 71\u201388.","journal-title":"J Neurobiol"},{"key":"BFtp201328_CR8","doi-asserted-by":"publisher","first-page":"7920","DOI":"10.1523\/JNEUROSCI.16-24-07920.1996","volume":"16","author":"M Jung","year":"1996","unstructured":"Jung M, Sommer I, Schachner M, Nave KA . Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice. J Neurosci 1996; 16: 7920\u20137929.","journal-title":"J Neurosci"},{"key":"BFtp201328_CR9","doi-asserted-by":"crossref","unstructured":"El-Kordi A, Winkler D, Hammerschmidt K, K\u00e4stner A, Krueger D, Ronnenberg A et al. Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism. Behav Brain Res 2013 (e-pub ahead of print).","DOI":"10.1016\/j.bbr.2012.11.016"},{"key":"BFtp201328_CR10","first-page":"506","volume":"42","author":"GB Jaissle","year":"2001","unstructured":"Jaissle GB, May CA, Reinhard J, Kohler K, Fauser S, Lutjen-Drecoll E et al. Evaluation of the rhodopsin knockout mouse as a model of pure cone function. Invest Ophthalmol Vis Sci 2001; 42: 506\u2013513.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFtp201328_CR11","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.steroids.2009.06.009","volume":"74","author":"EA Al-Dujaili","year":"2009","unstructured":"Al-Dujaili EA, Mullins LJ, Bailey MA, Andrew R, Kenyon CJ . Physiological and pathophysiological applications of sensitive ELISA methods for urinary deoxycorticosterone and corticosterone in rodents. Steroids 2009; 74: 938\u2013944.","journal-title":"Steroids"},{"key":"BFtp201328_CR12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bbr.2009.05.030","volume":"204","author":"B Adamcio","year":"2009","unstructured":"Adamcio B, Havemann-Reinecke U, Ehrenreich H . Chronic psychosocial stress in the absence of social support induces pathological pre-pulse inhibition in mice. Behav Brain Res 2009; 204: 246\u2013249.","journal-title":"Behav Brain Res"},{"key":"BFtp201328_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/BF00427564","volume":"81","author":"JT Winslow","year":"1983","unstructured":"Winslow JT, Miczek KA . Habituation of aggression in mice: pharmacological evidence of catecholaminergic and serotonergic mediation. Psychopharmacology (Berl) 1983; 81: 286\u2013291.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFtp201328_CR14","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature09938","volume":"473","author":"BK Attwood","year":"2011","unstructured":"Attwood BK, Bourgognon JM, Patel S, Mucha M, Schiavon E, Skrzypiec AE et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature 2011; 473: 372\u2013375.","journal-title":"Nature"},{"key":"BFtp201328_CR15","unstructured":"APA. Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV). American Psychiatric Association: Washington, DC, 1994."},{"key":"BFtp201328_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-244X-10-91","volume":"10","author":"K Ribbe","year":"2010","unstructured":"Ribbe K, Friedrichs H, Begemann M, Grube S, Papiol S, K\u00e4stner A et al. The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients. BMC Psychiatry 2010; 10: 91.","journal-title":"BMC Psychiatry"},{"key":"BFtp201328_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0887-6185(01)00064-0","volume":"15","author":"AS Radomsky","year":"2001","unstructured":"Radomsky AS, Rachman S, Thordarson DS, McIsaac HK, Teachman BA . The Claustrophobia Questionnaire. J Anxiety Disord 2001; 15: 287\u2013297.","journal-title":"J Anxiety Disord"},{"key":"BFtp201328_CR18","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition","author":"MB First","year":"2002","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBWRL . Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I\/P) Biometrics Research, New York State Psychiatric Institute: New York, 2002."},{"key":"BFtp201328_CR19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0887-6185(93)90025-G","volume":"7","author":"S Rachmann","year":"1993","unstructured":"Rachmann S, Taylor S . Analyses of claustrophobia. J Anxiety Disord 1993; 7: 281\u2013291.","journal-title":"J Anxiety Disord"},{"key":"BFtp201328_CR20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/BF00844886","volume":"13","author":"LC Kilborn","year":"1990","unstructured":"Kilborn LC, Labbe EE . Magnetic resonance imaging scanning procedures: development of phobic response during scan and at one-month follow-up. J Behav Med 1990; 13: 391\u2013401.","journal-title":"J Behav Med"},{"key":"BFtp201328_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1023\/A:1018717016680","volume":"21","author":"HK McIsaac","year":"1998","unstructured":"McIsaac HK, Thordarson DS, Shafran R, Rachman S, Poole G . Claustrophobia and the magnetic resonance imaging procedure. J Behav Med 1998; 21: 255\u2013268.","journal-title":"J Behav Med"},{"key":"BFtp201328_CR22","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/ng1479","volume":"36","author":"EB Binder","year":"2004","unstructured":"Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Putz B et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 2004; 36: 1319\u20131325.","journal-title":"Nat Genet"},{"key":"BFtp201328_CR23","doi-asserted-by":"publisher","first-page":"e16883","DOI":"10.1371\/journal.pone.0016883","volume":"6","author":"SH Scharf","year":"2011","unstructured":"Scharf SH, Liebl C, Binder EB, Schmidt MV, Muller MB . Expression and regulation of the Fkbp5 gene in the adult mouse brain. PLoS One 2011; 6: e16883.","journal-title":"PLoS One"},{"key":"BFtp201328_CR24","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.physbeh.2012.03.004","volume":"107","author":"ME Bowers","year":"2012","unstructured":"Bowers ME, Choi DC, Ressler KJ . Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. Physiol Behav 2012; 107: 699\u2013710.","journal-title":"Physiol Behav"},{"key":"BFtp201328_CR25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/jmg.2010.086876","volume":"48","author":"J Schumacher","year":"2011","unstructured":"Schumacher J, Kristensen AS, Wendland JR, Nothen MM, Mors O, McMahon FJ . The genetics of panic disorder. J Med Genet 2011; 48: 361\u2013368.","journal-title":"J Med Genet"},{"key":"BFtp201328_CR26","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/jnr.20328","volume":"78","author":"J Alfonso","year":"2004","unstructured":"Alfonso J, Aguero F, Sanchez DO, Flugge G, Fuchs E, Frasch AC et al. Gene expression analysis in the hippocampal formation of tree shrews chronically treated with cortisol. J Neurosci Res 2004; 78: 702\u2013710.","journal-title":"J Neurosci Res"},{"key":"BFtp201328_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1017\/S1740925X0900009X","volume":"4","author":"W M\u00f6bius","year":"2008","unstructured":"M\u00f6bius W, Patzig J, Nave KA, Werner HB . Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection. Neuron Glia Biol 2008; 4: 111\u2013127.","journal-title":"Neuron Glia Biol"},{"key":"BFtp201328_CR28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1006\/mcne.2001.1044","volume":"18","author":"H Werner","year":"2001","unstructured":"Werner H, Dimou L, Klugmann M, Pfeiffer S, Nave KA . Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes. Mol Cell Neurosci 2001; 18: 593\u2013605.","journal-title":"Mol Cell Neurosci"},{"key":"BFtp201328_CR29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0896-6273(93)90147-J","volume":"11","author":"Y Yan","year":"1993","unstructured":"Yan Y, Lagenaur C, Narayanan V . Molecular cloning of M6: identification of a PLP\/DM20 gene family. Neuron 1993; 11: 423\u2013431.","journal-title":"Neuron"},{"key":"BFtp201328_CR30","doi-asserted-by":"crossref","unstructured":"Lisowski P, Wieczorek M, Goscik J, Juszczak GR, Stankiewicz AM, Zwierzchowski L et al. Effects of chronic stress on prefrontal cortex transcriptome in mice displaying different genetic backgrounds. J Mol Neurosci 2012 doi:10.1007\/s12031-012-9850-1.","DOI":"10.1007\/s12031-012-9850-1"},{"key":"BFtp201328_CR31","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/glia.22456","volume":"61","author":"HB Werner","year":"2013","unstructured":"Werner HB, Kr\u00e4mer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y et al. A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia 2013; 61: 567\u2013586.","journal-title":"Glia"},{"key":"BFtp201328_CR32","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1101\/gad.1519207","volume":"21","author":"X Cao","year":"2007","unstructured":"Cao X, Pfaff SL, Gage FH . A functional study of miR-124 in the developing neural tube. Genes Dev 2007; 21: 531\u2013536.","journal-title":"Genes Dev"},{"key":"BFtp201328_CR33","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nn.2294","volume":"12","author":"LC Cheng","year":"2009","unstructured":"Cheng LC, Pastrana E, Tavazoie M, Doetsch F . miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 2009; 12: 399\u2013408.","journal-title":"Nat Neurosci"},{"key":"BFtp201328_CR34","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.mcn.2009.08.009","volume":"42","author":"V Chandrasekar","year":"2009","unstructured":"Chandrasekar V, Dreyer JL . microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. Mol Cell Neurosci 2009; 42: 350\u2013362.","journal-title":"Mol Cell Neurosci"},{"key":"BFtp201328_CR35","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.neuron.2009.05.029","volume":"63","author":"P Rajasethupathy","year":"2009","unstructured":"Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ et al. Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron 2009; 63: 803\u2013817.","journal-title":"Neuron"},{"key":"BFtp201328_CR36","doi-asserted-by":"publisher","first-page":"653","DOI":"10.2214\/ajr.152.3.653-b","volume":"152","author":"D Fishbain","year":"1989","unstructured":"Fishbain D, Goldberg M, Labbe E, Zacher D, Steele-Rosomoff R, Rosomoff H . MR imaging as a trigger for persistent claustrophobia. AJR Am J Roentgenol 1989; 152: 653.","journal-title":"AJR Am J Roentgenol"},{"key":"BFtp201328_CR37","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1523\/JNEUROSCI.4054-05.2006","volume":"26","author":"TI Gudz","year":"2006","unstructured":"Gudz TI, Komuro H, Macklin WB . Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin\/myelin proteolipid protein complex. J Neurosci 2006; 26: 2458\u20132466.","journal-title":"J Neurosci"},{"key":"BFtp201328_CR38","doi-asserted-by":"publisher","first-page":"11743","DOI":"10.1523\/JNEUROSCI.3581-06.2006","volume":"26","author":"EM Kr\u00e4mer-Albers","year":"2006","unstructured":"Kr\u00e4mer-Albers EM, Gehrig-Burger K, Thiele C, Trotter J, Nave KA . Perturbed interactions of mutant proteolipid protein\/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia. J Neurosci 2006; 26: 11743\u201311752.","journal-title":"J Neurosci"},{"key":"BFtp201328_CR39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1471-4159.2011.07252.x","volume":"119","author":"C Scorticati","year":"2011","unstructured":"Scorticati C, Formoso K, Frasch AC . Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts. J Neurochem 2011; 119: 521\u2013531.","journal-title":"J Neurochem"},{"key":"BFtp201328_CR40","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/cr.2008.71","volume":"18","author":"YJ Liang","year":"2008","unstructured":"Liang YJ, Wu DF, Stumm R, Hollt V, Koch T . Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway. Cell Res 2008; 18: 768\u2013779.","journal-title":"Cell Res"},{"key":"BFtp201328_CR41","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1096\/fj.08-108175","volume":"22","author":"Q Wu","year":"2008","unstructured":"Wu Q, Law PY, Wei LN, Loh HH . Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3\u2032 untranslated region: a role for microRNA23b. Faseb J 2008; 22: 4085\u20134095.","journal-title":"Faseb J"},{"key":"BFtp201328_CR42","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1176\/appi.ajp.2009.09050617","volume":"167","author":"RA Bryant","year":"2010","unstructured":"Bryant RA, O\u2019Donnell ML, Creamer M, McFarlane AC, Clark CR, Silove D . The psychiatric sequelae of traumatic injury. Am J Psychiatry 2010; 167: 312\u2013320.","journal-title":"Am J Psychiatry"},{"key":"BFtp201328_CR43","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12031-008-9092-4","volume":"37","author":"AW Fjorback","year":"2009","unstructured":"Fjorback AW, Muller HK, Wiborg O . Membrane glycoprotein M6B interacts with the human serotonin transporter. J Mol Neurosci 2009; 37: 191\u2013200.","journal-title":"J Mol Neurosci"},{"key":"BFtp201328_CR44","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/gm161","volume":"2","author":"J Schumacher","year":"2010","unstructured":"Schumacher J, Deckert J . Serotonin transporter polymorphisms and panic disorder. Genome Med 2010; 2: 40.","journal-title":"Genome Med"},{"key":"BFtp201328_CR45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/ajmg.b.30667","volume":"147B","author":"MP Boks","year":"2008","unstructured":"Boks MP, Hoogendoorn M, Jungerius BJ, Bakker SC, Sommer IE, Sinke RJ et al. Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 707\u2013711.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201328","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:59:46Z","timestamp":1672955986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4]]}},"alternative-id":["BFtp201328"],"URL":"https:\/\/doi.org\/10.1038\/tp.2013.28","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]},"assertion":[{"value":"21 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}