{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:14:11Z","timestamp":1790273651014,"version":"4.1.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.106","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T13:42:05Z","timestamp":1413294125000},"page":"e466-e466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism"],"prefix":"10.1038","volume":"4","author":[{"given":"I","family":"Tsilioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Dodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-1050","authenticated-orcid":false,"given":"A I","family":"Petra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Taliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moon-Fanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Shuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Theoharides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"BFtp2014106_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1203\/PDR.0b013e31819e7203","volume":"65","author":"E Fombonne","year":"2009","unstructured":"Fombonne E . Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65: 591\u2013598.","journal-title":"Pediatr Res"},{"key":"BFtp2014106_CR2","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1542\/peds.2007-2361","volume":"120","author":"CP Johnson","year":"2007","unstructured":"Johnson CP, Myers SM . Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007; 120: 1183\u20131215.","journal-title":"Pediatrics"},{"key":"BFtp2014106_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/B978-0-444-52002-9.00023-1","volume":"106","author":"J McPartland","year":"2012","unstructured":"McPartland J, Volkmar FR . Autism and related disorders. Handb Clin Neurol 2012; 106: 407\u2013418.","journal-title":"Handb Clin Neurol"},{"key":"BFtp2014106_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nrg2346","volume":"9","author":"BS Abrahams","year":"2008","unstructured":"Abrahams BS, Geschwind DH . Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008; 9: 341\u2013355.","journal-title":"Nat Rev Genet"},{"key":"BFtp2014106_CR5","doi-asserted-by":"publisher","first-page":"12102","DOI":"10.1073\/pnas.96.21.12102","volume":"96","author":"M Hornig","year":"1999","unstructured":"Hornig M, Weissenbock H, Horscroft N, Lipkin WI . An infection-based model of neurodevelopmental damage. Proc Natl Acad Sci USA 1999; 96: 12102\u201312107.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2014106_CR6","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1073\/pnas.1202556109","volume":"109","author":"EY Hsiao","year":"2012","unstructured":"Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH . Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proc Natl Acad Sci USA 2012; 109: 12776\u201312781.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2014106_CR7","doi-asserted-by":"publisher","first-page":"d6238","DOI":"10.1136\/bmj.d6238","volume":"343","author":"S Blenner","year":"2011","unstructured":"Blenner S, Reddy A, Augustyn M . Diagnosis and management of autism in childhood. BMJ 2011; 343: d6238.","journal-title":"BMJ"},{"key":"BFtp2014106_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neuro.2007.09.010","volume":"29","author":"R Deth","year":"2008","unstructured":"Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M . How environmental and genetic factors combine to cause autism: a redox\/methylation hypothesis. NeuroToxicol 2008; 29: 190\u2013201.","journal-title":"NeuroToxicol"},{"key":"BFtp2014106_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/WCO.0b013e328336a01f","volume":"23","author":"MR Herbert","year":"2010","unstructured":"Herbert MR . Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010; 23: 103\u2013110.","journal-title":"Curr Opin Neurol"},{"key":"BFtp2014106_CR10","doi-asserted-by":"publisher","first-page":"e360","DOI":"10.1038\/tp.2014.4","volume":"4","author":"DA Rossignol","year":"2014","unstructured":"Rossignol DA, Genuis SJ, Frye RE . Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 2014; 4: e360.","journal-title":"Transl Psychiatry"},{"key":"BFtp2014106_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/1362361311425916","volume":"16","author":"KE Lanni","year":"2012","unstructured":"Lanni KE, Schupp CW, Simon D, Corbett BA . Verbal ability, social stress, and anxiety in children with autistic disorder. Autism 2012; 16: 123\u2013138.","journal-title":"Autism"},{"issue":"Suppl 1","key":"BFtp2014106_CR12","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1542\/peds.2009-1878C","volume":"125","author":"T Buie","year":"2010","unstructured":"Buie T, Campbell DB, Fuchs GJ III, Furuta GT, Levy J, Vandewater J et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010; 125 (Suppl 1): S1\u2013S18.","journal-title":"Pediatrics"},{"key":"BFtp2014106_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pediatrneurol.2005.03.014","volume":"33","author":"AW Zimmerman","year":"2005","unstructured":"Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A et al. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol 2005; 33: 195\u2013201.","journal-title":"Pediatr Neurol"},{"key":"BFtp2014106_CR14","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/mp.2011.165","volume":"17","author":"DA Rossignol","year":"2012","unstructured":"Rossignol DA, Frye RE . A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012; 17: 389\u2013401.","journal-title":"Mol Psychiatry"},{"key":"BFtp2014106_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/WCO.0b013e3283373514","volume":"23","author":"P Goines","year":"2010","unstructured":"Goines P, Van de Water J . The immune system's role in the biology of autism. Curr Opin Neurol 2010; 23: 111\u2013117.","journal-title":"Curr Opin Neurol"},{"key":"BFtp2014106_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/1721727X1301100103","volume":"11","author":"S Tete'","year":"2013","unstructured":"Tete' S, Varvara G, Murmura G, Saggini A, Maccauro G, Rosati M et al. Impact of immunity in autism spectrum disorders. Eur J Inflamm 2013; 11: 23\u201331.","journal-title":"Eur J Inflamm"},{"key":"BFtp2014106_CR17","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1542\/peds.2008-2445","volume":"124","author":"HO Atladottir","year":"2009","unstructured":"Atladottir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 2009; 124: 687\u2013694.","journal-title":"Pediatrics"},{"key":"BFtp2014106_CR18","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1517\/14656560903107789","volume":"10","author":"TC Theoharides","year":"2009","unstructured":"Theoharides TC, Kempuraj D, Redwood L . Autism: an emerging 'neuroimmune disorder' in search of therapy. Expert Opin Pharmacother 2009; 10: 2127\u20132143.","journal-title":"Expert Opin Pharmacother"},{"key":"BFtp2014106_CR19","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.clinthera.2013.04.009","volume":"35","author":"TC Theoharides","year":"2013","unstructured":"Theoharides TC . Is a subtype of autism \u2018allergy of the brain\u2019? Clin Ther 2013; 35: 584\u2013591.","journal-title":"Clin Ther"},{"key":"BFtp2014106_CR20","first-page":"731935","volume":"2013","author":"BS Gadad","year":"2013","unstructured":"Gadad BS, Hewitson L, Young KA, German DC . Neuropathology and animal models of autism: genetic and environmental factors. Autism Res Treat 2013; 2013: 731935.","journal-title":"Autism Res Treat"},{"key":"BFtp2014106_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev-genom-091212-153431","volume":"14","author":"G Huguet","year":"2013","unstructured":"Huguet G, Ey E, Bourgeron T . The genetic landscapes of autism spectrum disorders. Annu Rev Genomics Hum Genet 2013; 14: 191\u2013213.","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"BFtp2014106_CR22","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrd4102","volume":"12","author":"A Ghosh","year":"2013","unstructured":"Ghosh A, Michalon A, Lindemann L, Fontoura P, Santarelli L . Drug discovery for autism spectrum disorder: challenges and opportunities. Nat Rev Drug Discov 2013; 12: 777\u2013790.","journal-title":"Nat Rev Drug Discov"},{"key":"BFtp2014106_CR23","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/joim.12113","volume":"274","author":"C Ecker","year":"2013","unstructured":"Ecker C, Spooren W, Murphy D . Developing new pharmacotherapies for autism. J Intern Med 2013; 274: 308\u2013320.","journal-title":"J Intern Med"},{"key":"BFtp2014106_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","volume":"176","author":"SS Moy","year":"2007","unstructured":"Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP et al. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 2007; 176: 4\u201320.","journal-title":"Behav Brain Res"},{"key":"BFtp2014106_CR25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.1149801","volume":"318","author":"JN Crawley","year":"2007","unstructured":"Crawley JN . Medicine. Testing hypotheses about autism. Science 2007; 318: 56\u201357.","journal-title":"Science"},{"key":"BFtp2014106_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1601-183X.2007.00330.x","volume":"7","author":"HG McFarlane","year":"2008","unstructured":"McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN . Autism-like behavioral phenotypes in BTBR T+tf\/J mice. Genes Brain Behav 2008; 7: 152\u2013163.","journal-title":"Genes Brain Behav"},{"key":"BFtp2014106_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/aur.22","volume":"1","author":"KK Chadman","year":"2008","unstructured":"Chadman KK, Gong S, Scattoni ML, Boltuck SE, Gandhy SU, Heintz N et al. Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. Autism Res 2008; 1: 147\u2013158.","journal-title":"Autism Res"},{"key":"BFtp2014106_CR28","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/npp.2009.201","volume":"35","author":"JL Silverman","year":"2009","unstructured":"Silverman JL, Tolu SS, Barkan CL, Crawley JN . Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2009; 35: 976\u2013989.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp2014106_CR29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fncel.2014.00058","volume":"8","author":"S Banerjee","year":"2014","unstructured":"Banerjee S, Riordan M, Bhat MA . Genetic aspects of autism spectrum disorders: insights from animal models. Front Cell Neurosci 2014; 8: 58.","journal-title":"Front Cell Neurosci"},{"key":"BFtp2014106_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.bbr.2013.05.047","volume":"251","author":"M Wohr","year":"2013","unstructured":"Wohr M, Scattoni ML . Behavioural methods used in rodent models of autism spectrum disorders: current standards and new developments. Behav Brain Res 2013; 251: 5\u201317.","journal-title":"Behav Brain Res"},{"key":"BFtp2014106_CR31","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","volume":"24","author":"P Boksa","year":"2010","unstructured":"Boksa P . Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav Immun 2010; 24: 881\u2013897.","journal-title":"Brain Behav Immun"},{"key":"BFtp2014106_CR32","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1038\/tp.2012.24","volume":"2","author":"KA Garbett","year":"2012","unstructured":"Garbett KA, Hsiao EY, Kalman S, Patterson PH, Mirnics K . Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl Psychiatry 2012; 2: e98.","journal-title":"Transl Psychiatry"},{"key":"BFtp2014106_CR33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbr.2006.08.023","volume":"176","author":"MH Lewis","year":"2007","unstructured":"Lewis MH, Tanimura Y, Lee LW, Bodfish JW . Animal models of restricted repetitive behavior in autism. Behav Brain Res 2007; 176: 66\u201374.","journal-title":"Behav Brain Res"},{"key":"BFtp2014106_CR34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0166-4328(03)00115-3","volume":"145","author":"JP Garner","year":"2003","unstructured":"Garner JP, Meehan CL, Mench JA . Stereotypies in caged parrots, schizophrenia and autism: evidence for a common mechanism. Behav Brain Res 2003; 145: 125\u2013134.","journal-title":"Behav Brain Res"},{"key":"BFtp2014106_CR35","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1292\/jvms.59.397","volume":"59","author":"Y Uchida","year":"1997","unstructured":"Uchida Y, Dodman N, DeNapoli J, Aronson L . Characterization and treatment of 20 canine dominance aggression cases. J Vet Med Sci 1997; 59: 397\u2013399.","journal-title":"J Vet Med Sci"},{"key":"BFtp2014106_CR36","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2460\/javma.1993.202.05.758","volume":"202","author":"NH Dodman","year":"1993","unstructured":"Dodman NH, Bronson R, Gliatto J . Tail chasing in a bull terrier. J Am Vet Med Assoc 1993; 202: 758\u2013760.","journal-title":"J Am Vet Med Assoc"},{"key":"BFtp2014106_CR37","doi-asserted-by":"publisher","first-page":"883","DOI":"10.2460\/javma.238.7.883","volume":"238","author":"AA Moon-Fanelli","year":"2010","unstructured":"Moon-Fanelli AA, Dodman NH, Famula TR, Cottam N . Characteristics of compulsive tail chaing and associated risk factors in bull terriers. J Am Vet Med Assoc 2010; 238: 883\u2013889.","journal-title":"J Am Vet Med Assoc"},{"key":"BFtp2014106_CR38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1742-2094-7-48","volume":"7","author":"A Angelidou","year":"2010","unstructured":"Angelidou A, Francis K, Vasiadi M, Alysandratos K-D, Zhang B, Theoharides A et al. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflam 2010; 7: 48.","journal-title":"J Neuroinflam"},{"key":"BFtp2014106_CR39","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1016\/S0021-9258(19)43429-7","volume":"248","author":"R Carraway","year":"1973","unstructured":"Carraway R, Leeman SE . The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 1973; 248: 6854\u20136861.","journal-title":"J Biol Chem"},{"key":"BFtp2014106_CR40","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/MED.0b013e3283419052","volume":"18","author":"WC Mustain","year":"2011","unstructured":"Mustain WC, Rychahou PG, Evers BM . The role of neurotensin in physiologic and pathologic processes. Curr Opin Endocrinol Diabetes Obes 2011; 18: 75\u201382.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"BFtp2014106_CR41","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000234057","volume":"80","author":"DE Cochrane","year":"1986","unstructured":"Cochrane DE, Boucher W, Bibb P . Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin. Int Arch Allergy Appl Immunol 1986; 80: 225\u2013230.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"BFtp2014106_CR42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1210\/endo.139.1.5660","volume":"139","author":"TC Theoharides","year":"1998","unstructured":"Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E et al. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its pro-inflammatory effects. Endocrinology 1998; 139: 403\u2013413.","journal-title":"Endocrinology"},{"key":"BFtp2014106_CR43","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1006\/brbi.1998.0541","volume":"13","author":"LK Singh","year":"1999","unstructured":"Singh LK, Pang X, Alexacos N, Letourneau R, Theoharides TC . Acute immobilization stress triggers skin mast cell degranulation via corticotropin-releasing hormone, neurotensin and substance P: a link to neurogenic skin disorders. Brain Behav Immunity 1999; 13: 225\u2013239.","journal-title":"Brain Behav Immunity"},{"key":"BFtp2014106_CR44","doi-asserted-by":"publisher","first-page":"7759","DOI":"10.1073\/pnas.0602210103","volume":"103","author":"J Donelan","year":"2006","unstructured":"Donelan J, Boucher W, Papadopoulou N, Lytinas M, Papaliodis D, Theoharides TC . Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proc Natl Acad Sci USA 2006; 103: 7759\u20137764.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2014106_CR45","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1210\/jc.2003-030377","volume":"88","author":"R Crompton","year":"2003","unstructured":"Crompton R, Clifton VL, Bisits AT, Read MA, Smith R, Wright IM . Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways. J Clin Endocrinol Metab 2003; 88: 5427\u20135432.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFtp2014106_CR46","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1210\/er.2012-1092","volume":"34","author":"AT Slominski","year":"2013","unstructured":"Slominski AT, Zmijewski MA, Zbytek B, Tobin DJ, Theoharides TC, Rivier J . Key role of CRF in the skin stress response system. Endocr Rev 2013; 34: 827\u2013884.","journal-title":"Endocr Rev"},{"key":"BFtp2014106_CR47","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.clinthera.2013.04.006","volume":"35","author":"A Taliou","year":"2013","unstructured":"Taliou A, Zintzaras E, Lykouras L, Francis K . An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther 2013; 35: 592\u2013602.","journal-title":"Clin Ther"},{"key":"BFtp2014106_CR48","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/S0028-3908(00)00060-5","volume":"39","author":"A Fassio","year":"2000","unstructured":"Fassio A, Evans G, Grisshammer R, Bolam JP, Mimmack M, Emson PC . Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Neuropharmacology 2000; 39: 1430\u20131442.","journal-title":"Neuropharmacology"},{"key":"BFtp2014106_CR49","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0006-8993(85)90948-5","volume":"358","author":"M Goedert","year":"1985","unstructured":"Goedert M, Lightman SL, Mantyh PW, Hunt SP, Emson PC . Neurotensin-like immunoreactivity and neurotensin receptors in the rat hypothalamus and in the neurointermediate lobe of the pituitary gland. Brain Res 1985; 358: 59\u201369.","journal-title":"Brain Res"},{"key":"BFtp2014106_CR50","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1016\/j.peptides.2005.12.016","volume":"27","author":"D Zhao","year":"2006","unstructured":"Zhao D, Pothoulakis C . Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides 2006; 27: 2434\u20132444.","journal-title":"Peptides"},{"key":"BFtp2014106_CR51","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1523\/JNEUROSCI.23-04-01198.2003","volume":"23","author":"S Martin","year":"2003","unstructured":"Martin S, Vincent JP, Mazella J . Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci 2003; 23: 1198\u20131205.","journal-title":"J Neurosci"},{"key":"BFtp2014106_CR52","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1742-2094-7-58","volume":"7","author":"A Ghanizadeh","year":"2010","unstructured":"Ghanizadeh A . Targeting neurotensin as a potential novel approach for the treatment of autism. J Neuroinflammation 2010; 7: 58.","journal-title":"J Neuroinflammation"},{"key":"BFtp2014106_CR53","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1113\/jphysiol.1982.sp014080","volume":"323","author":"R Carraway","year":"1982","unstructured":"Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ . Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol 1982; 323: 403\u2013414.","journal-title":"J Physiol"},{"key":"BFtp2014106_CR54","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","volume":"1822","author":"TC Theoharides","year":"2010","unstructured":"Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B et al. Mast cells and inflammation. Biochim Biophys Acta 2010; 1822: 21\u201333.","journal-title":"Biochim Biophys Acta"},{"key":"BFtp2014106_CR55","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.coi.2009.09.009","volume":"21","author":"M Metz","year":"2009","unstructured":"Metz M, Maurer M . Innate immunity and allergy in the skin. Curr Opin Immunol 2009; 21: 687\u2013693.","journal-title":"Curr Opin Immunol"},{"key":"BFtp2014106_CR56","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.2007.00528.x","volume":"217","author":"JP Kinet","year":"2007","unstructured":"Kinet JP . The essential role of mast cells in orchestrating inflammation. Immunol Rev 2007; 217: 5\u20137.","journal-title":"Immunol Rev"},{"key":"BFtp2014106_CR57","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1177\/039463201302600303","volume":"26","author":"S Frydas","year":"2013","unstructured":"Frydas S, Varvara G, Murmura G, Saggini A, Caraffa A, Antinolfi P et al. Impact of capsaicin on mast cell inflammation. Int J Immunopathol Pharmacol 2013; 26: 597\u2013600.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"BFtp2014106_CR58","doi-asserted-by":"publisher","first-page":"e48934","DOI":"10.1371\/journal.pone.0048934","volume":"7","author":"KD Alysandratos","year":"2012","unstructured":"Alysandratos KD, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H et al. Neurotensin and CRH interactions augment human mast cell activation. PLoS One 2012; 7: e48934.","journal-title":"PLoS One"},{"key":"BFtp2014106_CR59","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.tips.2004.09.007","volume":"25","author":"TC Theoharides","year":"2004","unstructured":"Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P . Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci 2004; 25: 563\u2013568.","journal-title":"Trends Pharmacol Sci"},{"key":"BFtp2014106_CR60","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.it.2005.10.002","volume":"27","author":"R Paus","year":"2006","unstructured":"Paus R, Theoharides TC, Arck PC . Neuroimmunoendocrine circuitry of the 'brain-skin connection'. Trends Immunol 2006; 27: 32\u201339.","journal-title":"Trends Immunol"},{"key":"BFtp2014106_CR61","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1365-2133.2008.08958.x","volume":"160","author":"A Slominski","year":"2009","unstructured":"Slominski A . On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol 2009; 160: 229\u2013232.","journal-title":"Br J Dermatol"},{"issue":"Suppl 7","key":"BFtp2014106_CR62","first-page":"33","volume":"60","author":"M Larauche","year":"2009","unstructured":"Larauche M, Kiank C, Tache Y . Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications. J Physiol Pharmacol 2009; 60 (Suppl 7): 33\u201346.","journal-title":"J Physiol Pharmacol"},{"key":"BFtp2014106_CR63","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1210\/en.2003-0851","volume":"145","author":"A Slominski","year":"2004","unstructured":"Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz J, Wortsman J . Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 2004; 145: 941\u2013950.","journal-title":"Endocrinology"},{"key":"BFtp2014106_CR64","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000069516","volume":"130","author":"M Lytinas","year":"2003","unstructured":"Lytinas M, Kempuraj D, Huang M, Boucher W, Esposito P, Theoharides TC . Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists. Int Arch Allergy Immunol 2003; 130: 224\u2013231.","journal-title":"Int Arch Allergy Immunol"},{"key":"BFtp2014106_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(99)01855-7","volume":"849","author":"JJ Rozniecki","year":"1999","unstructured":"Rozniecki JJ, Dimitriadou V, Lambracht-Hall M, Pang X, Theoharides TC . Morphological and functional demonstration of rat dura mast cell-neuron interactions in vitro and in vivo. Brain Res 1999; 849: 1\u201315.","journal-title":"Brain Res"},{"key":"BFtp2014106_CR66","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/0016-5085(89)90627-6","volume":"97","author":"RH Stead","year":"1989","unstructured":"Stead RH, Dixon MF, Bramwell NH, Riddell RH, Bienenstock J . Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 1989; 97: 575\u2013585.","journal-title":"Gastroenterology"},{"key":"BFtp2014106_CR67","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/sj.jid.5700153","volume":"126","author":"J Donelan","year":"2006","unstructured":"Donelan J, Marchand J, Kempuraj D, Papadopoulou N, Theoharides TC . Perifollicular and perivascular mouse skin mast cells express corticotropin-releasing hormone receptor. J Inv Dermatol 2006; 126: 929\u2013932.","journal-title":"J Inv Dermatol"},{"key":"BFtp2014106_CR68","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0165-5728(96)00178-6","volume":"72","author":"K Karalis","year":"1997","unstructured":"Karalis K, Louis JM, Bae D, Hilderbrand H, Majzoub JA . CRH and the immune system. J Neuroimmunol 1997; 72: 131\u2013136.","journal-title":"J Neuroimmunol"},{"key":"BFtp2014106_CR69","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1210\/en.2003-0805","volume":"145","author":"D Kempuraj","year":"2004","unstructured":"Kempuraj D, Papadopoulou NG, Lytinas M, Huang M, Kandere-Grzybowska K, Madhappan B et al. Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells. Endocrinology 2004; 145: 43\u201348.","journal-title":"Endocrinology"},{"key":"BFtp2014106_CR70","doi-asserted-by":"publisher","first-page":"7665","DOI":"10.4049\/jimmunol.174.12.7665","volume":"174","author":"J Cao","year":"2005","unstructured":"Cao J, Papadopoulou N, Kempuraj D, Boucher WS, Sugimoto K, Cetrulo CL et al. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 2005; 174: 7665\u20137675.","journal-title":"J Immunol"},{"key":"BFtp2014106_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2003.10.041","volume":"146","author":"TC Theoharides","year":"2004","unstructured":"Theoharides TC, Cochrane DE . Critical role of mast cells in inflammatory diseases and the effect of acute stress. J Neuroimmunol 2004; 146: 1\u201312.","journal-title":"J Neuroimmunol"},{"key":"BFtp2014106_CR72","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00130832-200502000-00006","volume":"5","author":"RJ Wright","year":"2005","unstructured":"Wright RJ, Cohen RT, Cohen S . The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 2005; 5: 23\u201329.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"BFtp2014106_CR73","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.iac.2005.02.007","volume":"25","author":"MJ Slattery","year":"2005","unstructured":"Slattery MJ . Psychiatric comorbidity associated with atopic disorders in children and adolescents. Immunol Allergy Clin North Am 2005; 25: 407\u2013420, viii.","journal-title":"Immunol Allergy Clin North Am"},{"key":"BFtp2014106_CR74","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1097\/01.PSY.0000088620.66211.B1","volume":"65","author":"A Stauder","year":"2003","unstructured":"Stauder A, Kovacs M . Anxiety symptoms in allergic patients: identification and risk factors. Psychosom Med 2003; 65: 816\u2013823.","journal-title":"Psychosom Med"},{"key":"BFtp2014106_CR75","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/aur.151","volume":"3","author":"R Sacco","year":"2010","unstructured":"Sacco R, Curatolo P, Manzi B, Militerni R, Bravaccio C, Frolli A et al. Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Res 2010; 3: 237\u2013252.","journal-title":"Autism Res"},{"key":"BFtp2014106_CR76","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1001\/jamapsychiatry.2014.179","volume":"71","author":"S Goh","year":"2014","unstructured":"Goh S, Dong Z, Zhang Y, Dimauro S, Peterson BS . Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging. JAMA Psychiatry 2014; 71: 665\u2013671.","journal-title":"JAMA Psychiatry"},{"key":"BFtp2014106_CR77","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/jmg.2010.079426","volume":"48","author":"AT Pagnamenta","year":"2010","unstructured":"Pagnamenta AT, Khan H, Walker S, Gerrelli D, Wing K, Bonaglia MC et al. Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability. J Med Genet 2010; 48: 48\u201354.","journal-title":"J Med Genet"},{"key":"BFtp2014106_CR78","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nature07999","volume":"459","author":"K Wang","year":"2009","unstructured":"Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 2009; 459: 528\u2013533.","journal-title":"Nature"},{"key":"BFtp2014106_CR79","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","volume":"52","author":"EJ Middleton","year":"2000","unstructured":"Middleton EJ, Kandaswami C, Theoharides TC . The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000; 52: 673\u2013751.","journal-title":"Pharmacol Rev"},{"key":"BFtp2014106_CR80","first-page":"955","volume":"27","author":"SK Kritas","year":"2013","unstructured":"Kritas SK, Saggini A, Varvara G, Murmura G, Caraffa A, Antinolfi P et al. Luteolin inhibits mast cell-mediated allergic inflammation. J Biol Regul Homeost Agents 2013; 27: 955\u2013959.","journal-title":"J Biol Regul Homeost Agents"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp2014106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2014106","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2014106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:10:28Z","timestamp":1746418228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2014106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,14]]},"references-count":80,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["BFtp2014106"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.106","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,14]]},"assertion":[{"value":"1 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}