{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:01:26Z","timestamp":1785207686799,"version":"3.55.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.15","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T13:40:44Z","timestamp":1396359644000},"page":"e377-e377","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines"],"prefix":"10.1038","volume":"4","author":[{"given":"S","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R E","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Slattery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wynne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tippett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Melnyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"BFtp201415_CR1","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC, USA, 1994."},{"key":"BFtp201415_CR2","first-page":"1","volume":"58","author":"Autism and Developmental Disabilities Monitoring Network Surveillance Year Principal Investigators, Centers for Disease Control and Prevention","year":"2009","unstructured":"Autism and Developmental Disabilities Monitoring Network Surveillance Year Principal Investigators, Centers for Disease Control and Prevention Prevalence of autism spectrum disorders\u2014Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ 2009; 58: 1\u201320.","journal-title":"MMWR Surveill Summ"},{"key":"BFtp201415_CR3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/mp.2010.136","volume":"17","author":"DA Rossignol","year":"2012","unstructured":"Rossignol DA, Frye RE . Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry 2012; 17: 290\u2013314.","journal-title":"Mol Psychiatry"},{"key":"BFtp201415_CR4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0014-4800(77)90010-7","volume":"27","author":"BA Fowler","year":"1977","unstructured":"Fowler BA, Woods JS . Ultrastructural and biochemical changes in renal mitochondria during chronic oral methyl mercury exposure: the relationship to renal function. Exp Mol Pathol 1977; 27: 403\u2013412.","journal-title":"Exp Mol Pathol"},{"key":"BFtp201415_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1006\/taap.1999.8652","volume":"157","author":"BJ Shenker","year":"1999","unstructured":"Shenker BJ, Guo TL, O I, Shapiro IM . Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve. Toxicol Appl Pharmacol 1999; 157: 23\u201335.","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFtp201415_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1146\/annurev.nutr.17.1.37","volume":"17","author":"RA Goyer","year":"1997","unstructured":"Goyer RA . Toxic and essential metal interactions. Annu Rev Nutr 1997; 17: 37\u201350.","journal-title":"Annu Rev Nutr"},{"key":"BFtp201415_CR7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/978-1-4615-0667-6_38","volume":"500","author":"J Pourahmad","year":"2001","unstructured":"Pourahmad J, Mihajlovic A, O\u2019Brien PJ . Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury. Adv Exp Med Biol 2001; 500: 249\u2013252.","journal-title":"Adv Exp Med Biol"},{"key":"BFtp201415_CR8","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.4049\/jimmunol.165.5.2703","volume":"165","author":"TS Hiura","year":"2000","unstructured":"Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave JC, Nel AE . The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol 2000; 165: 2703\u20132711.","journal-title":"J Immunol"},{"key":"BFtp201415_CR9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1046\/j.1471-4159.2001.00022.x","volume":"76","author":"PW Wong","year":"2001","unstructured":"Wong PW, Garcia EF, Pessah IN . ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. J Neurochem 2001; 76: 450\u2013463.","journal-title":"J Neurochem"},{"key":"BFtp201415_CR10","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1471-4159.2006.04333.x","volume":"100","author":"TB Sherer","year":"2007","unstructured":"Sherer TB, Richardson JR, Testa CM, Seo BB, Panov AV, Yagi T et al. Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson\u2019s disease. J Neurochem 2007; 100: 1469\u20131479.","journal-title":"J Neurochem"},{"key":"BFtp201415_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00213961","volume":"28","author":"T Yamano","year":"1995","unstructured":"Yamano T, Morita S . Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes II. Arch Environ Contam Toxicol 1995; 28: 1\u20137.","journal-title":"Arch Environ Contam Toxicol"},{"key":"BFtp201415_CR12","doi-asserted-by":"publisher","first-page":"21134","DOI":"10.1074\/jbc.M801954200","volume":"283","author":"L Samavati","year":"2008","unstructured":"Samavati L, Lee I, Mathes I, Lottspeich F, Huttemann M . Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem 2008; 283: 21134\u201321144.","journal-title":"J Biol Chem"},{"key":"BFtp201415_CR13","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1128\/MCB.00287-06","volume":"27","author":"UD Vempati","year":"2007","unstructured":"Vempati UD, Diaz F, Barrientos A, Narisawa S, Mian AM, Millan JL et al. Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release. Mol Cell Biol 2007; 27: 1771\u20131783.","journal-title":"Mol Cell Biol"},{"key":"BFtp201415_CR14","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1161\/01.CIR.0000055318.09997.1F","volume":"107","author":"N Suematsu","year":"2003","unstructured":"Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T et al. Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 2003; 107: 1418\u20131423.","journal-title":"Circulation"},{"key":"BFtp201415_CR15","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.neuroscience.2007.08.028","volume":"149","author":"S Vali","year":"2007","unstructured":"Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK et al. Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson\u2019s disease: a dynamic model. Neuroscience 2007; 149: 917\u2013930.","journal-title":"Neuroscience"},{"key":"BFtp201415_CR16","doi-asserted-by":"publisher","first-page":"G7","DOI":"10.1152\/ajpcell.1997.273.1.C7","volume":"273","author":"JC Fernandez-Checa","year":"1997","unstructured":"Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, Mari M et al. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol 1997; 273: G7\u201317.","journal-title":"Am J Physiol"},{"key":"BFtp201415_CR17","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","volume":"68","author":"J Hallmayer","year":"2011","unstructured":"Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 2011; 68: 1095\u20131102.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201415_CR18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/mp.2011.165","volume":"17","author":"DA Rossignol","year":"2012","unstructured":"Rossignol DA, Frye RE . A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012; 17: 389\u2013401.","journal-title":"Mol Psychiatry"},{"key":"BFtp201415_CR19","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/ajmg.b.30366","volume":"141B","author":"SJ James","year":"2006","unstructured":"James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 947\u2013956.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201415_CR20","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1096\/fj.08-128926","volume":"23","author":"SJ James","year":"2009","unstructured":"James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J 2009; 23: 2374\u20132383.","journal-title":"FASEB J"},{"key":"BFtp201415_CR21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10803-011-1260-7","volume":"42","author":"S Melnyk","year":"2012","unstructured":"Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ et al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord 2012; 42: 367\u2013377.","journal-title":"J Autism Dev Disord"},{"key":"BFtp201415_CR22","doi-asserted-by":"publisher","first-page":"e134","DOI":"10.1038\/tp.2012.61","volume":"2","author":"S Rose","year":"2012","unstructured":"Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE et al. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry 2012; 2: e134.","journal-title":"Transl Psychiatry"},{"key":"BFtp201415_CR23","first-page":"986519","volume":"2012","author":"S Rose","year":"2012","unstructured":"Rose S, Melnyk S, Trusty TA, Pavliv O, Seidel L, Li J et al. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Res Treat 2012; 2012: 986519.","journal-title":"Autism Res Treat"},{"key":"BFtp201415_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/jhg.2012.123","volume":"58","author":"JH Oh","year":"2013","unstructured":"Oh JH, Kim YJ, Moon S, Nam HY, Jeon JP, Lee JH et al. Genotype instability during long-term subculture of lymphoblastoid cell lines. J Human Genet 2013; 58: 16\u201320.","journal-title":"J Human Genet"},{"key":"BFtp201415_CR25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1186\/1471-2164-13-477","volume":"13","author":"D Nickles","year":"2012","unstructured":"Nickles D, Madireddy L, Yang S, Khankhanian P, Lincoln S, Hauser SL et al. In depth comparison of an individual\u2019s DNA and its lymphoblastoid cell line using whole genome sequencing. BMC Genomics 2012; 13: 477.","journal-title":"BMC Genomics"},{"key":"BFtp201415_CR26","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.freeradbiomed.2010.01.015","volume":"48","author":"BP Dranka","year":"2010","unstructured":"Dranka BP, Hill BG, Darley-Usmar VM . Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radic Biol Med 2010; 48: 905\u2013914.","journal-title":"Free Radic Biol Med"},{"key":"BFtp201415_CR27","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S0955-2863(99)00033-9","volume":"10","author":"S Melnyk","year":"1999","unstructured":"Melnyk S, Pogribna M, Pogribny I, Hine RJ, James SJ . A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem 1999; 10: 490\u2013497.","journal-title":"J Nutr Biochem"},{"key":"BFtp201415_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH . Random-effects models for longitudinal data. Biometrics 1982; 38: 963\u2013974.","journal-title":"Biometrics"},{"key":"BFtp201415_CR29","first-page":"841","volume":"77","author":"JH Ward","year":"1963","unstructured":"Ward JH . Hierarchical grouping to optimize an objective function. J Am Stat Soc 1963; 77: 841\u2013847.","journal-title":"J Am Stat Soc"},{"key":"BFtp201415_CR30","volume-title":"Cluster Analyses for Applications","author":"M Anderberg","year":"1973","unstructured":"Anderberg M . Cluster Analyses for Applications. Academic Press: New York, NY, USA, 1973."},{"key":"BFtp201415_CR31","doi-asserted-by":"publisher","first-page":"192503","DOI":"10.1155\/2012\/192503","volume":"2012","author":"C Desler","year":"2012","unstructured":"Desler C, Hansen TL, Frederiksen JB, Marcker ML, Singh KK, Juel Rasmussen L . Is there a link between mitochondrial reserve respiratory capacity and aging? J Aging Res 2012; 2012: 192503.","journal-title":"J Aging Res"},{"key":"BFtp201415_CR32","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.cbi.2010.12.002","volume":"191","author":"BE Sansbury","year":"2011","unstructured":"Sansbury BE, Jones SP, Riggs DW, Darley-Usmar VM, Hill BG . Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. Chem Biol Interact 2011; 191: 288\u2013295.","journal-title":"Chem Biol Interact"},{"key":"BFtp201415_CR33","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1042\/BST0371385","volume":"37","author":"DG Nicholls","year":"2009","unstructured":"Nicholls DG . Spare respiratory capacity, oxidative stress and excitotoxicity. Biochem Soc Trans 2009; 37: 1385\u20131388.","journal-title":"Biochem Soc Trans"},{"key":"BFtp201415_CR34","doi-asserted-by":"publisher","first-page":"7310","DOI":"10.1523\/JNEUROSCI.0212-07.2007","volume":"27","author":"N Yadava","year":"2007","unstructured":"Yadava N, Nicholls DG . Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. J Neurosci 2007; 27: 7310\u20137317.","journal-title":"J Neurosci"},{"key":"BFtp201415_CR35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1042\/BJ20090934","volume":"424","author":"BG Hill","year":"2009","unstructured":"Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar VM . Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J 2009; 424: 99\u2013107.","journal-title":"Biochem J"},{"key":"BFtp201415_CR36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000327682","volume":"17","author":"L Schmaal","year":"2011","unstructured":"Schmaal L, Berk L, Hulstijn KP, Cousijn J, Wiers RW, van den Brink W . Efficacy of N-acetylcysteine in the treatment of nicotine dependence: a double-blind placebo-controlled pilot study. Eur Addict Res 2011; 17: 211\u2013216.","journal-title":"Eur Addict Res"},{"key":"BFtp201415_CR37","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nrn1428","volume":"5","author":"LM Boulanger","year":"2004","unstructured":"Boulanger LM, Shatz CJ . Immune signalling in neural development, synaptic plasticity and disease. Nat Rev Neurosci 2004; 5: 521\u2013531.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp201415_CR38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1503\/jpn.100057","volume":"36","author":"O Dean","year":"2011","unstructured":"Dean O, Giorlando F, Berk M . N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci 2011; 36: 78\u201386.","journal-title":"J Psychiatry Neurosci"},{"key":"BFtp201415_CR39","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1001\/archgenpsychiatry.2009.60","volume":"66","author":"JE Grant","year":"2009","unstructured":"Grant JE, Odlaug BL, Kim SW . N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry 2009; 66: 756\u2013763.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp201415_CR40","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1212\/WNL.57.8.1515","volume":"57","author":"JC Adair","year":"2001","unstructured":"Adair JC, Knoefel JE, Morgan N . Controlled trial of N-acetylcysteine for patients with probable Alzheimer\u2019s disease. Neurology 2001; 57: 1515\u20131517.","journal-title":"Neurology"},{"key":"BFtp201415_CR41","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.nbd.2011.12.031","volume":"45","author":"YH Hsiao","year":"2012","unstructured":"Hsiao YH, Kuo JR, Chen SH, Gean PW . Amelioration of social isolation-triggered onset of early Alzheimer\u2019s disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model. Neurobiol Dis 2012; 45: 1111\u20131120.","journal-title":"Neurobiol Dis"},{"key":"BFtp201415_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cbi.2009.06.003","volume":"181","author":"R Gonzalez","year":"2009","unstructured":"Gonzalez R, Ferrin G, Hidalgo AB, Ranchal I, Lopez-Cillero P, Santos-Gonzalez M et al. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem Biol Interact 2009; 181: 95\u2013106.","journal-title":"Chem Biol Interact"},{"key":"BFtp201415_CR43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000213502","volume":"30","author":"HT Kuo","year":"2009","unstructured":"Kuo HT, Lee JJ, Hsiao HH, Chen HW, Chen HC . N-acetylcysteine prevents mitochondria from oxidative injury induced by conventional peritoneal dialysate in human peritoneal mesothelial cells. Am J Nephrol 2009; 30: 179\u2013185.","journal-title":"Am J Nephrol"},{"key":"BFtp201415_CR44","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3233\/JAD-2007-12210","volume":"12","author":"PI Moreira","year":"2007","unstructured":"Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA et al. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 2007; 12: 195\u2013206.","journal-title":"J Alzheimers Dis"},{"key":"BFtp201415_CR45","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/npp.2011.109","volume":"36","author":"DM Otte","year":"2011","unstructured":"Otte DM, Sommersberg B, Kudin A, Guerrero C, Albayram O, Filiou MD et al. N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72\/G30 transgenic mice. Neuropsychopharmacology 2011; 36: 2233\u20132243.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201415_CR46","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.biopsych.2012.01.014","volume":"71","author":"AY Hardan","year":"2012","unstructured":"Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry 2012; 71: 956\u2013961.","journal-title":"Biol Psychiatry"},{"key":"BFtp201415_CR47","first-page":"427","volume":"9","author":"RE Frye","year":"2011","unstructured":"Frye RE, Naviaux RK . Autistic disorder with complex IV overactivity: a new mitochondrial syndrome. J Pediatr Neurol 2011; 9: 427\u2013434.","journal-title":"J Pediatr Neurol"},{"key":"BFtp201415_CR48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/088307380001500601","volume":"15","author":"WD Graf","year":"2000","unstructured":"Graf WD, Marin-Garcia J, Gao HG, Pizzo S, Naviaux RK, Markusic D et al. Autism associated with the mitochondrial DNA G8363A transfer RNA(Lys) mutation. J Child Neurol 2000; 15: 357\u2013361.","journal-title":"J Child Neurol"},{"key":"BFtp201415_CR49","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1042\/BJ20040485","volume":"382","author":"AJ Lambert","year":"2004","unstructured":"Lambert AJ, Brand MD . Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J 2004; 382: 511\u2013517.","journal-title":"Biochem J"},{"key":"BFtp201415_CR50","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.bbabio.2010.02.035","volume":"1797","author":"V Azzu","year":"2010","unstructured":"Azzu V, Jastroch M, Divakaruni AS, Brand MD . The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta 2010; 1797: 785\u2013791.","journal-title":"Biochim Biophys Acta"},{"key":"BFtp201415_CR51","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/bbrc.2001.4577","volume":"282","author":"LX Li","year":"2001","unstructured":"Li LX, Skorpen F, Egeberg K, Jorgensen IH, Grill V . Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells. Biochem Biophys Res Commun 2001; 282: 273\u2013277.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFtp201415_CR52","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbabio.2007.11.006","volume":"1777","author":"TM Giardina","year":"2008","unstructured":"Giardina TM, Steer JH, Lo SZ, Joyce DA . Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages. Biochim Biophys Acta 2008; 1777: 118\u2013129.","journal-title":"Biochim Biophys Acta"},{"key":"BFtp201415_CR53","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1152\/physiol.00046.2010","volume":"26","author":"AS Divakaruni","year":"2011","unstructured":"Divakaruni AS, Brand MD . The regulation and physiology of mitochondrial proton leak. Physiology 2011; 26: 192\u2013205.","journal-title":"Physiology"},{"key":"BFtp201415_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.7156\/v5i3p141","volume":"5","author":"RE Frye","year":"2012","unstructured":"Frye RE . Biomarker of abnormal energy metabolism in children with autism spectrum disorder. N Am J Med Sci 2012; 5: 141\u2013147.","journal-title":"N Am J Med Sci"},{"key":"BFtp201415_CR55","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1001\/jama.2010.1706","volume":"304","author":"C Giulivi","year":"2010","unstructured":"Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I et al. Mitochondrial dysfunction in autism. JAMA 2010; 304: 2389\u20132396.","journal-title":"JAMA"},{"key":"BFtp201415_CR56","first-page":"35","volume":"10","author":"RE Frye","year":"2012","unstructured":"Frye RE . Novel cytochrome b gene mutations causing mitochondrial disease in autism. J Pediatr Neurol 2012; 10: 35\u201340.","journal-title":"J Pediatr Neurol"},{"key":"BFtp201415_CR57","doi-asserted-by":"publisher","first-page":"e220","DOI":"10.1038\/tp.2012.143","volume":"3","author":"RE Frye","year":"2013","unstructured":"Frye RE, Melnyk S, Macfabe DF . Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Transl Psychiatry 2013; 3: e220.","journal-title":"Transl Psychiatry"}],"updated-by":[{"DOI":"10.1038\/tp.2015.29","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000}}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tp201415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tp201415","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T14:47:50Z","timestamp":1716648470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["BFtp201415"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.15","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]},"assertion":[{"value":"6 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}