{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:45:44Z","timestamp":1790376344925,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.35","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T05:11:05Z","timestamp":1436159465000},"page":"e396-e396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Genes associated with the progression of neurofibrillary tangles in Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"4","author":[{"given":"A","family":"Miyashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hatsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tsukie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ogishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Akazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japanese Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"BFtp201435_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E . Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239\u2013259.","journal-title":"Acta Neuropathol"},{"key":"BFtp201435_CR2","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","volume":"71","author":"PT Nelson","year":"2012","unstructured":"Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 2012; 71: 362\u2013381.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFtp201435_CR3","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1073\/pnas.0308512100","volume":"101","author":"EM Blalock","year":"2004","unstructured":"Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW . Incipient Alzheimer\u2019s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA 2004; 101: 2173\u20132178.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201435_CR4","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.neurobiolaging.2006.11.008","volume":"29","author":"B Wilmot","year":"2008","unstructured":"Wilmot B, McWeeney SK, Nixon RR, Montine TJ, Laut J, Harrington CA et al. Translational gene mapping of cognitive decline. Neurobiol Aging 2008; 29: 524\u2013541.","journal-title":"Neurobiol Aging"},{"key":"BFtp201435_CR5","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.neurobiolaging.2007.07.021","volume":"30","author":"V Haroutunian","year":"2009","unstructured":"Haroutunian V, Katsel P, Schmeidler J . Transcriptional vulnerability of brain regions in Alzheimer\u2019s disease and dementia. Neurobiol Aging 2009; 30: 561\u2013573.","journal-title":"Neurobiol Aging"},{"key":"BFtp201435_CR6","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/brain\/awq258","volume":"133","author":"K Bossers","year":"2010","unstructured":"Bossers K, Wirz KT, Meerhoff GF, Essing AH, van Dongen JW, Houba P et al. Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer\u2019s disease. Brain 2010; 133: 3699\u20133723.","journal-title":"Brain"},{"key":"BFtp201435_CR7","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/j.neurobiolaging.2005.08.013","volume":"27","author":"T Dunckley","year":"2006","unstructured":"Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG et al. Gene expression correlates of neurofibrillary tangles in Alzheimer\u2019s disease. Neurobiol Aging 2006; 27: 1359\u20131371.","journal-title":"Neurobiol Aging"},{"key":"BFtp201435_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1440-1789.2004.00571.x","volume":"24","author":"S Murayama","year":"2004","unstructured":"Murayama S, Saito Y . Neuropathological diagnostic criteria for Alzheimer's disease. Neuropathology 2004; 24: 254\u2013260.","journal-title":"Neuropathology"},{"key":"BFtp201435_CR9","first-page":"1013","volume":"62","author":"S Murayama","year":"2010","unstructured":"Murayama S, Saito Y . The present and future of brain bank in Japan. Brain Nerve 2010; 62: 1013\u20131018 (in Japanese).","journal-title":"Brain Nerve"},{"key":"BFtp201435_CR10","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1093\/hmg\/ddl142","volume":"15","author":"R Kuwano","year":"2006","unstructured":"Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M et al. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer\u2019s disease. Hum Mol Genet 2006; 15: 2170\u20132182.","journal-title":"Hum Mol Genet"},{"key":"BFtp201435_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2199-7-3","volume":"7","author":"A Schroeder","year":"2006","unstructured":"Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 2006; 7: 3.","journal-title":"BMC Mol Biol"},{"key":"BFtp201435_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249\u2013264.","journal-title":"Biostatistics"},{"key":"BFtp201435_CR13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y . Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statist Soc Ser B 1995; 57: 289\u2013300.","journal-title":"J Roy Statist Soc Ser B"},{"key":"BFtp201435_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA . Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44\u201357.","journal-title":"Nat Protoc"},{"key":"BFtp201435_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M . KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 1999; 27: 29\u201334.","journal-title":"Nucleic Acids Res"},{"key":"BFtp201435_CR16","doi-asserted-by":"publisher","first-page":"D816","DOI":"10.1093\/nar\/gks1158","volume":"41","author":"A Chatr-Aryamontri","year":"2013","unstructured":"Chatr-Aryamontri A, Breitkreutz BJ, Heinicke S, Boucher L, Winter A, Stark C et al. The BioGRID interaction database: 2013 update. Nucleic Acids Res 2013; 41: D816\u2013D823.","journal-title":"Nucleic Acids Res"},{"key":"BFtp201435_CR17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.2174\/1871527311312050008","volume":"12","author":"MV Guillot-Sestier","year":"2013","unstructured":"Guillot-Sestier MV, Town T . Innate immunity in Alzheimer\u2019s disease: a complex affair. CNS Neurol Disord Drug Targets 2013; 12: 593\u2013607.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFtp201435_CR18","doi-asserted-by":"publisher","first-page":"34088","DOI":"10.1074\/jbc.M111.243907","volume":"286","author":"J Ol\u00e1h","year":"2011","unstructured":"Ol\u00e1h J, Vincze O, Vir\u00f3k D, Simon D, Bozs\u00f3 Z, T\u00f5k\u00e9si N et al. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein\/p25, beta-amyloid, and alpha-synuclein. J Biol Chem 2011; 286: 34088\u201334100.","journal-title":"J Biol Chem"},{"key":"BFtp201435_CR19","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/ajmg.b.32094","volume":"159B","author":"LM Bekris","year":"2012","unstructured":"Bekris LM, Millard S, Lutz F, Li G, Galasko DR, Farlow MR et al. Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer\u2019s disease. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 874\u2013883.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFtp201435_CR20","doi-asserted-by":"publisher","first-page":"940603","DOI":"10.1155\/2013\/940603","volume":"2013","author":"S Mondrag\u00f3n-Rodr\u00edguez","year":"2013","unstructured":"Mondrag\u00f3n-Rodr\u00edguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S . Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease. Oxid Med Cell Longev 2013; 2013: 940603.","journal-title":"Oxid Med Cell Longev"},{"key":"BFtp201435_CR21","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuropharm.2012.08.015","volume":"68","author":"TD Folsom","year":"2013","unstructured":"Folsom TD, Fatemi SH . The involvement of Reelin in neurodevelopmental disorders. Neuropharmacology 2013; 68: 122\u2013135.","journal-title":"Neuropharmacology"},{"key":"BFtp201435_CR22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuroscience.2013.04.042","volume":"246","author":"D Krstic","year":"2013","unstructured":"Krstic D, Pfister S, Notter T, Knuesel I . Decisive role of Reelin signaling during early stages of Alzheimer\u2019s disease. Neuroscience 2013; 246: 108\u2013116.","journal-title":"Neuroscience"},{"key":"BFtp201435_CR23","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/jnen\/63.9.901","volume":"63","author":"L Minghetti","year":"2004","unstructured":"Minghetti L . Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 2004; 63: 901\u2013910.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFtp201435_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.biochi.2010.09.009","volume":"93","author":"S A\u00efd","year":"2011","unstructured":"A\u00efd S, Bosetti F . Targeting cyclooxygenases-1 and -2 in neuroinflammation: therapeutic implications. Biochimie 2011; 93: 46\u201351.","journal-title":"Biochimie"},{"key":"BFtp201435_CR25","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/mp.2011.135","volume":"17","author":"MI Kamboh","year":"2012","unstructured":"Kamboh MI, Barmada MM, Demirci FY, Minster RL, Carrasquillo MM, Pankratz VS et al. Genome-wide association analysis of age-at-onset in Alzheimer\u2019s disease. Mol Psychiatry 2012; 17: 1340\u20131346.","journal-title":"Mol Psychiatry"},{"key":"BFtp201435_CR26","doi-asserted-by":"publisher","first-page":"26668","DOI":"10.1074\/jbc.M113.476689","volume":"288","author":"H Wang","year":"2013","unstructured":"Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S et al. COPS5 (Jab1) Protein increases \u03b2 site processing of amyloid precursor protein and amyloid \u03b2 peptide generation by stabilizing RanBP9 protein levels. J Biol Chem 2013; 288: 26668\u201326677.","journal-title":"J Biol Chem"},{"key":"BFtp201435_CR27","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.bbrc.2011.04.059","volume":"408","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ et al. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochem Biophys Res Commun 2011; 408: 553\u2013558.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFtp201435_CR28","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/nchembio0308-152","volume":"4","author":"C Loenarz","year":"2008","unstructured":"Loenarz C, Schofield CJ . Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol 2008; 4: 152\u2013156.","journal-title":"Nat Chem Biol"},{"key":"BFtp201435_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00394-013-0561-3","volume":"53","author":"A Otaegui-Arrazola","year":"2014","unstructured":"Otaegui-Arrazola A, Amiano P, Elbusto A, Urdaneta E, Mart\u00ednez-Lage P . Diet, cognition, and Alzheimer\u2019s disease: food for thought. Eur J Nutr 2014; 53: 1\u201323.","journal-title":"Eur J Nutr"},{"key":"BFtp201435_CR30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.115.5.991","volume":"115","author":"OC Rodriguez","year":"2002","unstructured":"Rodriguez OC, Cheney RE . Human myosin-Vc is a novel class V myosin expressed in epithelial cells. J Cell Sci 2002; 115: 991\u20131004.","journal-title":"J Cell Sci"},{"key":"BFtp201435_CR31","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1091\/mbc.e08-08-0865","volume":"20","author":"DT Jacobs","year":"2009","unstructured":"Jacobs DT, Weigert R, Grode KD, Donaldson JG, Cheney RE . Myosin Vc is a molecular motor that functions in secretory granule trafficking. Mol Biol Cell 2009; 20: 4471\u20134488.","journal-title":"Mol Biol Cell"},{"key":"BFtp201435_CR32","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00702-010-0426-3","volume":"118","author":"E Gr\u00fcnblatt","year":"2011","unstructured":"Gr\u00fcnblatt E, Bartl J, Riederer P . The link between iron, metabolic syndrome, and Alzheimer\u2019s disease. J Neural Transm 2011; 118: 371\u2013379.","journal-title":"J Neural Transm"},{"key":"BFtp201435_CR33","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1074\/jbc.M805957200","volume":"284","author":"JT Roland","year":"2009","unstructured":"Roland JT, Lapierre LA, Goldenring JR . Alternative splicing in class V myosins determines association with Rab10. J Biol Chem 2009; 284: 1213\u20131223.","journal-title":"J Biol Chem"},{"key":"BFtp201435_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng1943","volume":"39","author":"E Rogaeva","year":"2007","unstructured":"Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007; 39: 168\u2013177.","journal-title":"Nat Genet"},{"key":"BFtp201435_CR35","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1126\/science.315.5810.314","volume":"315","author":"J Marx","year":"2007","unstructured":"Marx J . Molecular biology. Trafficking protein suspected in Alzheimer\u2019s disease. Science 2007; 315: 314.","journal-title":"Science"},{"key":"BFtp201435_CR36","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.4049\/jimmunol.0901518","volume":"183","author":"S Carpenter","year":"2009","unstructured":"Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P et al. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. J Immunol 2009; 183: 3989\u20133995.","journal-title":"J Immunol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp201435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201435","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T17:32:44Z","timestamp":1717954364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["BFtp201435"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.35","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,10]]},"assertion":[{"value":"14 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}