{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:02:57Z","timestamp":1788346977221,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.48","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T13:46:31Z","timestamp":1404222391000},"page":"e407-e407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates"],"prefix":"10.1038","volume":"4","author":[{"given":"L L","family":"Howell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Nye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Voll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sunahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F I","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"BFtp201448_CR1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1128\/AEM.66.3.904-908.2000","volume":"66","author":"MM Bresler","year":"2000","unstructured":"Bresler MM, Rosser SJ, Basran A, Bruce NC . Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. Appl Environ Microbiol 2000; 66: 904\u2013908.","journal-title":"Appl Environ Microbiol"},{"key":"BFtp201448_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nsb742","volume":"9","author":"NA Larsen","year":"2002","unstructured":"Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA et al. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol 2002; 9: 17\u201321.","journal-title":"Nat Struct Biol"},{"key":"BFtp201448_CR3","doi-asserted-by":"publisher","first-page":"12297","DOI":"10.1021\/bi026131p","volume":"41","author":"JM Turner","year":"2002","unstructured":"Turner JM, Larsen NA, Basran A, Barbas CF 3rd, Bruce NC et al. Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry 2002; 41: 12297\u201312307.","journal-title":"Biochemistry"},{"key":"BFtp201448_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1124\/jpet.108.150029","volume":"331","author":"GT Collins","year":"2009","unstructured":"Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG et al. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. J Pharmacol Exp Ther 2009; 331: 445\u2013455.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp201448_CR5","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1124\/mol.106.025999","volume":"70","author":"ZD Cooper","year":"2006","unstructured":"Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA et al. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol 2006; 70: 1885\u20131891.","journal-title":"Mol Pharmacol"},{"key":"BFtp201448_CR6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1124\/mol.108.049486","volume":"75","author":"D Gao","year":"2009","unstructured":"Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW et al. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol Pharmacol 2009; 75: 318\u2013323.","journal-title":"Mol Pharmacol"},{"key":"BFtp201448_CR7","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/npp.2010.242","volume":"36","author":"GT Collins","year":"2011","unstructured":"Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW et al. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology 2011; 36: 1047\u20131059.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201448_CR8","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.annemergmed.2008.09.023","volume":"54","author":"EM Jutkiewicz","year":"2009","unstructured":"Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH . A bacterial cocaine esterase protects against cocaine- induced epileptogenic activity and lethality. Ann Emerg Med 2009; 54: 409\u2013420.","journal-title":"Ann Emerg Med"},{"key":"BFtp201448_CR9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.pbb.2008.03.032","volume":"90","author":"HL Kimmel","year":"2008","unstructured":"Kimmel HL, Negus SS, Wilcox KM, Ewing SB, Stehouwer J, Goodman MM et al. Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. Pharmacol Biochem Behav 2008; 90: 453\u2013462.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFtp201448_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pbb.2006.12.006","volume":"86","author":"HL Kimmel","year":"2007","unstructured":"Kimmel HL, O'Connor JA, Carroll FI, Howell LL . Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. Pharmacol Biochem Behav 2007; 86: 45\u201354.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFtp201448_CR11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/syn.21536","volume":"66","author":"HL Kimmel","year":"2012","unstructured":"Kimmel HL, Nye JA, Voll R, Stehouwer J, Goodman MM, Votaw JR, Carroll FI, Howell LL . Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys. Synapse 2012; 66: 501\u2013508.","journal-title":"Synapse"},{"key":"BFtp201448_CR12","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1124\/mol.111.074997","volume":"80","author":"D Narasimhan","year":"2011","unstructured":"Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J et al. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Mol Pharmacol 2011; 80: 1056\u20131065.","journal-title":"Mol Pharmacol"},{"key":"BFtp201448_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)07246-1","volume":"3","author":"SS Kety","year":"1951","unstructured":"Kety SS . The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 1951; 3: 1\u201341.","journal-title":"Pharmacol Rev"},{"key":"BFtp201448_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/01.RES.44.1.127","volume":"44","author":"M Reivich","year":"1979","unstructured":"Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T et al. The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 1979; 44: 127\u2013137.","journal-title":"Circ Res"},{"key":"BFtp201448_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/ana.410150302","volume":"15","author":"MA Mintun","year":"1984","unstructured":"Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ . A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15: 217\u2013227.","journal-title":"Ann Neurol"},{"key":"BFtp201448_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00004647-199601000-00005","volume":"16","author":"AA Lammertsma","year":"1996","unstructured":"Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ et al. Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab 1996; 16: 42\u201352.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFtp201448_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/syn.10068","volume":"44","author":"JR Votaw","year":"2002","unstructured":"Votaw JR, Howell LL, Martarello L, Hoffman JM, Kilts CD, Lindsey KP et al. Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT. Synapse 2002; 44: 203\u2013210.","journal-title":"Synapse"},{"key":"BFtp201448_CR18","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","volume":"27","author":"RB Innis","year":"2007","unstructured":"Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 2007; 27: 1533\u20131539.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFtp201448_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ccc.2012.07.003","volume":"28","author":"JL Zimmerman","year":"2012","unstructured":"Zimmerman JL . Cocaine intoxication. Crit Care Clin 2012; 28: 517\u2013526.","journal-title":"Crit Care Clin"},{"key":"BFtp201448_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.amjcard.2012.10.022","volume":"111","author":"NP Arora","year":"2013","unstructured":"Arora NP, Berk WA, Aaron CK, Williams KA . Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol 2013; 111: 445\u2013447.","journal-title":"Am J Cardiol"},{"key":"BFtp201448_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4155\/fmc.11.190","volume":"4","author":"DA Gorelick","year":"2012","unstructured":"Gorelick DA . Pharmacokinetic strategies for treatment of drug overdose and addiction. Future Med Chem 2012; 4: 227\u2013243.","journal-title":"Future Med Chem"},{"key":"BFtp201448_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1124\/jpet.111.186049","volume":"340","author":"RL Brim","year":"2012","unstructured":"Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D et al. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. J Pharmacol Exp Ther 2012; 340: 83\u201395.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp201448_CR23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1124\/jpet.112.194639","volume":"342","author":"GT Collins","year":"2012","unstructured":"Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK et al. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. J Pharmacol Exp Ther 2012; 342: 205\u2013213.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp201448_CR24","doi-asserted-by":"publisher","first-page":"e1002610","DOI":"10.1371\/journal.pcbi.1002610","volume":"8","author":"F Zheng","year":"2012","unstructured":"Zheng F, Zhan CG . Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse. PLoS Comput Biol 2012; 8: e1002610.","journal-title":"PLoS Comput Biol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp201448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201448","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T16:12:57Z","timestamp":1746288777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7]]}},"alternative-id":["BFtp201448"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.48","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]},"assertion":[{"value":"14 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}