{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:15:50Z","timestamp":1791350150877,"version":"4.3.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.91","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T13:43:17Z","timestamp":1410874997000},"page":"e441-e441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury"],"prefix":"10.1038","volume":"4","author":[{"given":"E M","family":"Mitsis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Riggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kostakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Machac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Delman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"D\u2019Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Naidich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Aloysi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Seibyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S T","family":"DeKosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Marek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P R","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"BFtp201491_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1227\/01.NEU.0000163407.92769.ED","volume":"57","author":"BI Omalu","year":"2005","unstructured":"Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH et al. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 2005; 57: 128\u2013134, discussion 130\u2013134.","journal-title":"Neurosurgery"},{"key":"BFtp201491_CR2","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1227\/01.NEU.0000245601.69451.27","volume":"59","author":"BI Omalu","year":"2006","unstructured":"Omalu BI, DeKosky ST, Hamilton RL, Minster RL, Kamboh MI, Shakir AM et al. Chronic traumatic encephalopathy in a national football league player: part II. Neurosurgery 2006; 59: 1086\u20131092, discussion 1092\u20131083.","journal-title":"Neurosurgery"},{"key":"BFtp201491_CR3","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1001\/jamaneurol.2014.367","volume":"71","author":"P Shahim","year":"2014","unstructured":"Shahim P, Tegner Y, Wilson DH, Randall J, Skillback T, Pazooki D et al. Blood biomarkers for brain injury in concussed professional ice hockey players. JAMA Neurol 2014; 71: 684\u2013692.","journal-title":"JAMA Neurol"},{"key":"BFtp201491_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1939-3938.2010.01078.x","volume":"6","author":"BI Omalu","year":"2010","unstructured":"Omalu BI, Fitzsimmons RP, Hammers J, Bailes J . Chronic traumatic encephalopathy in a professional American wrestler. J Forensic Nurs 2010; 6: 130\u2013136.","journal-title":"J Forensic Nurs"},{"key":"BFtp201491_CR5","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.neubiorev.2012.02.013","volume":"36","author":"TM Sivanandam","year":"2012","unstructured":"Sivanandam TM, Thakur MK . Traumatic brain injury: a risk factor for Alzheimer's disease. Neurosci Biobehav Rev 2012; 36: 1376\u20131381.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFtp201491_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrneurol.2013.29","volume":"9","author":"DH Smith","year":"2013","unstructured":"Smith DH, Johnson VE, Stewart W . Chronic neuropathologies of single and repetitive TBI: substrates of dementia?. Nat Rev Neurol 2013; 9: 211\u2013221.","journal-title":"Nat Rev Neurol"},{"key":"BFtp201491_CR7","first-page":"300","volume":"38","author":"L Goodwin","year":"2006","unstructured":"Goodwin L . Dementia pugilistica. J Insur Med 2006; 38: 300\u2013302.","journal-title":"J Insur Med"},{"key":"BFtp201491_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1227\/NEU.0b013e318212bc7b","volume":"69","author":"B Omalu","year":"2011","unstructured":"Omalu B, Bailes J, Hamilton RL, Kamboh MI, Hammers J, Case M et al. Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes. Neurosurgery 2011; 69: 173\u2013183.","journal-title":"Neurosurgery"},{"key":"BFtp201491_CR9","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","author":"AC McKee","year":"2009","unstructured":"McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68: 709\u2013735.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFtp201491_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/brain\/aws307","volume":"136","author":"AC McKee","year":"2013","unstructured":"McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136: 43\u201364.","journal-title":"Brain"},{"key":"BFtp201491_CR11","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1365-2990.2011.01186.x","volume":"37","author":"A Costanza","year":"2011","unstructured":"Costanza A, Weber K, Gandy S, Bouras C, Hof PR, Giannakopoulos P et al. Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathol Appl Neurobiol 2011; 37: 570\u2013584.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"BFtp201491_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF00304630","volume":"85","author":"PR Hof","year":"1992","unstructured":"Hof PR, Bouras C, Bu\u00e9e L, Delacourte A, Perl DP, Morrison JH et al. Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathol 1992; 85: 23\u201330.","journal-title":"Acta Neuropathol"},{"key":"BFtp201491_CR13","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrneurol.2013.36","volume":"9","author":"ST DeKosky","year":"2013","unstructured":"DeKosky ST, Blennow K, Ikonomovic MD, Gandy S . Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nat Rev Neurol 2013; 9: 192\u2013200.","journal-title":"Nat Rev Neurol"},{"key":"BFtp201491_CR14","doi-asserted-by":"publisher","first-page":"S460","DOI":"10.1016\/j.pmrj.2011.08.008","volume":"3","author":"RA Stern","year":"2011","unstructured":"Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC et al. Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. PM R 2011; 3: S460\u2013S467.","journal-title":"PM R"},{"key":"BFtp201491_CR15","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1212\/WNL.0b013e3182a55f7f","volume":"81","author":"RA Stern","year":"2013","unstructured":"Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO et al. Clinical presentation of chronic traumatic encephalopathy. Neurology 2013; 81: 1122\u20131129.","journal-title":"Neurology"},{"key":"BFtp201491_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1750-1326-9-10","volume":"9","author":"EM Mitsis","year":"2014","unstructured":"Mitsis EM, Bender HA, Kostakoglu L, Machac J, Martin J, Woehr JL et al. A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition. Mol Neurodegen 2014; 9: 10.","journal-title":"Mol Neurodegen"},{"key":"BFtp201491_CR17","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/ana.23650","volume":"72","author":"SM Landau","year":"2012","unstructured":"Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS et al. Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol 2012; 72: 578\u2013586.","journal-title":"Ann Neurol"},{"key":"BFtp201491_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1023\/A:1009068804787","volume":"10","author":"TC Lye","year":"2000","unstructured":"Lye TC, Shores EA . Traumatic brain injury as a risk factor for Alzheimer's disease: a review. Neuropsychol Rev 2000; 10: 115\u2013129.","journal-title":"Neuropsychol Rev"},{"key":"BFtp201491_CR19","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jalz.2012.11.008","volume":"9","author":"CF Xia","year":"2013","unstructured":"Xia CF, Arteaga J, Chen G, Gangadharmath U, Gomez LF, Kasi D et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement 2013; 9: 666\u2013676.","journal-title":"Alzheimers Dement"},{"key":"BFtp201491_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00259-012-2237-2","volume":"40","author":"A Nordberg","year":"2013","unstructured":"Nordberg A, Carter SF, Rinne J, Drzezga A, Brooks DJ, Vandenberghe R et al. A European multicentre PET study of fibrillar amyloid in Alzheimer's disease. Eur J Nucl Med Mol Imaging 2013; 40: 104\u2013114.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"BFtp201491_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/hbm.10123","volume":"19","author":"A Hammers","year":"2003","unstructured":"Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 2003; 19: 224\u2013247.","journal-title":"Hum Brain Mapp"},{"key":"BFtp201491_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1939-3938.2009.01064.x","volume":"6","author":"BI Omalu","year":"2010","unstructured":"Omalu BI, Hamilton RL, Kamboh MI, DeKosky ST, Bailes J . Chronic traumatic encephalopathy (CTE) in a National Football League Player: case report and emerging medicolegal practice questions. J Forensic Nurs 2010; 6: 40\u201346.","journal-title":"J Forensic Nurs"},{"key":"BFtp201491_CR23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/PAF.0b013e3181ca7f35","volume":"31","author":"BI Omalu","year":"2010","unstructured":"Omalu BI, Bailes J, Hammers JL, Fitzsimmons RP . Chronic traumatic encephalopathy, suicides and parasuicides in professional American athletes: the role of the forensic pathologist. Am J Forensic Med Pathol 2010; 31: 130\u2013132.","journal-title":"Am J Forensic Med Pathol"},{"key":"BFtp201491_CR24","doi-asserted-by":"crossref","unstructured":"Gandy S . Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. Mol Neurodegen (Under Revision) 2014.","DOI":"10.1186\/1750-1326-9-37"},{"key":"BFtp201491_CR25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1227\/01.NEU.0000175725.75780.DD","volume":"57","author":"KM Guskiewicz","year":"2005","unstructured":"Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Cantu RC, Randolph C et al. Association between recurrent concussion and late-life cognitive impairment in retired professional football players. Neurosurgery 2005; 57: 719\u2013726.","journal-title":"Neurosurgery"},{"key":"BFtp201491_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/2051-5960-2-24","volume":"2","author":"H Ling","year":"2014","unstructured":"Ling H, Kara E, Revesz T, Lees AJ, Plant GT, Martino D et al. Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer. Acta Neuropathol Commun 2014; 2: 24.","journal-title":"Acta Neuropathol Commun"},{"key":"BFtp201491_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1001\/jamaneurol.2013.4847","volume":"71","author":"YT Hong","year":"2014","unstructured":"Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C et al. Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 2014; 71: 23\u201331.","journal-title":"JAMA Neurol"},{"key":"BFtp201491_CR28","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1001\/archneur.64.4.541","volume":"64","author":"ST DeKosky","year":"2007","unstructured":"DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RS et al. Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol 2007; 64: 541\u2013544.","journal-title":"Arch Neurol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp201491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201491","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T22:16:08Z","timestamp":1672956968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,16]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9]]}},"alternative-id":["BFtp201491"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.91","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,16]]},"assertion":[{"value":"9 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}