{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:29:57Z","timestamp":1768814997062,"version":"3.49.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2014.97","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T13:48:54Z","timestamp":1412689734000},"page":"e457-e457","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["\u03b1CaMKII controls the establishment of cocaine's reinforcing effects in mice and humans"],"prefix":"10.1038","volume":"4","author":[{"given":"A C","family":"Easton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lourdusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Havranek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Solati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Golub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T-K","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Vallada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Laranjeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Desrivi\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G H","family":"Moll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"M\u00f6ssner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kornhuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K P","family":"Giese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B B","family":"Quednow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"BFtp201497_CR1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Annual Report 2012: the State of the Drugs Problem in Europe. Publications Office of the European Union: Luxembourg, 2012."},{"key":"BFtp201497_CR2","unstructured":"Substance Abuse and Mental Health Services Administration (SAMHSA). Results from the 2010 National Survey on Drug Use and Health: Volume I. Summary of National Findings. Substance Abuse and Mental Health Services Administration: Rockville, MD, USA, 2011."},{"key":"BFtp201497_CR3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.addbeh.2013.10.019","volume":"39","author":"RR Abdalla","year":"2014","unstructured":"Abdalla RR, Madruga CS, Ribeiro M, Pinsky I, Caetano R, Laranjeira R et al. Prevalence of cocaine use in Brazil: data from the II Brazilian National Alcohol and Drugs Survey (BNADS). Add Behav 2014; 39: 297\u2013301.","journal-title":"Add Behav"},{"key":"BFtp201497_CR4","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1017\/S0033291708004510","volume":"39","author":"MD Glantz","year":"2009","unstructured":"Glantz MD, Anthony JC, Berglund PA, Degenhardt L, Dierker L, Kalaydjian A et al. Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. Psychol Med 2009; 39: 1365\u20131377.","journal-title":"Psychol Med"},{"key":"BFtp201497_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0893-133X(01)00367-0","volume":"26","author":"FA Wagner","year":"2002","unstructured":"Wagner FA, Anthony JC . From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology 2002; 26: 479\u2013488.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201497_CR6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1017\/S0140525X11000057","volume":"34","author":"CP M\u00fcller","year":"2011","unstructured":"M\u00fcller CP, Schumann G . Drugs as instruments: a new framework for non-addictive psychoactive drug use. Behav Brain Sci 2011; 34: 293\u2013310.","journal-title":"Behav Brain Sci"},{"key":"BFtp201497_CR7","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1176\/appi.ajp.162.8.1414","volume":"162","author":"SE Hyman","year":"2005","unstructured":"Hyman SE . Addiction: a disease of learning and memory. Am J Psychiatry 2005; 162: 1414\u20131422.","journal-title":"Am J Psychiatry"},{"key":"BFtp201497_CR8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.tins.2012.05.003","volume":"35","author":"SJ Coultrap","year":"2012","unstructured":"Coultrap SJ, Bayer KU . CaMKII regulation in information processing and storage. Trends Neurosci 2012; 35: 607\u2013618.","journal-title":"Trends Neurosci"},{"key":"BFtp201497_CR9","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/mp.2012.114","volume":"18","author":"AC Easton","year":"2013","unstructured":"Easton AC, Lourdusamy A, Loth E, Toro R, Giese KP, Kornhuber J et al. CAMK2A polymorphisms predict working memory performance in humans. Mol Psychiatry 2013a; 18: 850\u2013852.","journal-title":"Mol Psychiatry"},{"key":"BFtp201497_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1101\/lm.028449.112","volume":"20","author":"KP Giese","year":"2013","unstructured":"Giese KP, Mizuno K . The roles of protein kinases in learning and memory. Learn Mem 2013; 20: 540\u2013552.","journal-title":"Learn Mem"},{"key":"BFtp201497_CR11","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0022-3565(24)37708-0","volume":"286","author":"RC Pierce","year":"1998","unstructured":"Pierce RC, Quick EA, Reeder DC, Morgan ZR, Kalivas PW . Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine. J Pharmacol Exp Ther 1998; 286: 1171\u20131176.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp201497_CR12","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1124\/jpet.105.097733","volume":"317","author":"L Tang","year":"2006","unstructured":"Tang L, Shukla PK, Wang LX, Wang ZJ . Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca(2+)\/calmodulin-dependent protein kinase II. J Pharmacol Exp Ther 2006; 317: 901\u2013909.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp201497_CR13","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1371\/journal.pcbi.0040002","volume":"4","author":"CY Li","year":"2008","unstructured":"Li CY, Mao X, Wei L . Genes and (common) pathways underlying drug addiction. PLoS Comput Biol 2008; 4: e2.","journal-title":"PLoS Comput Biol"},{"key":"BFtp201497_CR14","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1523\/JNEUROSCI.5192-12.2013","volume":"33","author":"AJ Robison","year":"2013","unstructured":"Robison AJ, Vialou V, Mazei-Robison M, Feng J, Kourrich S, Collins M et al. Behavioral and structural responses to chronic cocaine require a feedforward loop involving DeltaFosB and calcium\/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci 2013; 33: 4295\u20134307.","journal-title":"J Neurosci"},{"key":"BFtp201497_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neulet.2013.01.017","volume":"537","author":"SL White","year":"2013","unstructured":"White SL, Schmidt HD, Vassoler FM, Pierce RC . Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naive rats, but not cocaine-experienced rats. Neurosci Lett 2013; 537: 71\u201376.","journal-title":"Neurosci Lett"},{"key":"BFtp201497_CR16","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/npp.2009.193","volume":"35","author":"L Wang","year":"2010","unstructured":"Wang L, Lv Z, Hu Z, Sheng J, Hui B, Sun J et al. Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology 2010; 35: 913\u2013928.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201497_CR17","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nn2054","volume":"11","author":"SM Anderson","year":"2008","unstructured":"Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE et al. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci 2008; 11: 344\u2013353.","journal-title":"Nat Neurosci"},{"key":"BFtp201497_CR18","doi-asserted-by":"publisher","first-page":"13562","DOI":"10.1523\/JNEUROSCI.2315-11.2011","volume":"31","author":"K Schierberl","year":"2001","unstructured":"Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q et al. Cav1.2 L-type Ca(2)(+) channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. J Neurosci 2001; 31: 13562\u201313575.","journal-title":"J Neurosci"},{"key":"BFtp201497_CR19","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/npp.2013.299","volume":"39","author":"X Liu","year":"2014","unstructured":"Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM et al. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology 2014; 39: 989\u2013999.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201497_CR20","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1126\/science.279.5352.870","volume":"279","author":"KP Giese","year":"1998","unstructured":"Giese KP, Fedorov NB, Filipkowski RK, Silva AJ . Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 1998; 279: 870\u2013873.","journal-title":"Science"},{"key":"BFtp201497_CR21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nn1431","volume":"8","author":"EE Irvine","year":"2005","unstructured":"Irvine EE, Vernon J, Giese KP . AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory. Nat Neurosci 2005; 8: 411\u2013412.","journal-title":"Nat Neurosci"},{"key":"BFtp201497_CR22","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.neuropharm.2011.08.036","volume":"61","author":"AC Easton","year":"2011","unstructured":"Easton AC, Lucchesi W, Schumann G, Giese KP, M\u00fcller CP, Fernandes C et al. alphaCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli. Neuropharmacology 2011; 61: 1424\u20131431.","journal-title":"Neuropharmacology"},{"key":"BFtp201497_CR23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.tins.2006.06.009","volume":"29","author":"EE Irvine","year":"2006","unstructured":"Irvine EE, von Hertzen LS, Plattner F, Giese KP . alphaCaMKII autophosphorylation: a fast track to memory. Trends Neurosci 2006; 29: 459\u2013465.","journal-title":"Trends Neurosci"},{"key":"BFtp201497_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bbr.2013.05.045","volume":"252","author":"AC Easton","year":"2013","unstructured":"Easton AC, Lucchesi W, Mizuno K, Fernandes C, Schumann G, Giese KP et al. alphaCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice. Behav Brain Res 2013b; 252: 72\u201376.","journal-title":"Behav Brain Res"},{"key":"BFtp201497_CR25","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/npp.2013.60","volume":"38","author":"AC Easton","year":"2013","unstructured":"Easton AC, Lucchesi W, Lourdusamy A, Lenz B, Solati J, Golub Y et al. alphaCaMKII autophosphorylation controls the establishment of alcohol drinking behavior. Neuropsychopharmacology 2013c; 38: 1636\u20131647.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp201497_CR26","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/sim.5486","volume":"32","author":"C Feng","year":"2013","unstructured":"Feng C, Wang H, Lu N, Tu XM . Log transformation: application and interpretation in biomedical research. Stat Med 2013; 32: 230\u2013239.","journal-title":"Stat Med"},{"key":"BFtp201497_CR27","volume-title":"The mouse brain in stereotaxic coordinates","author":"KBJ Franklin","year":"1997","unstructured":"Franklin KBJ Paxinos G . The mouse brain in stereotaxic coordinates. Academic Press: San Diego, CA, USA, 1997."},{"key":"BFtp201497_CR28","doi-asserted-by":"publisher","first-page":"21128","DOI":"10.1073\/pnas.1211844110","volume":"109","author":"D Stacey","year":"2012","unstructured":"Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci USA 2012; 109: 21128\u201321133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201497_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2458-6-10","volume":"6","author":"C Guindalini","year":"2006","unstructured":"Guindalini C, Vallada H, Breen G, Laranjeira R . Concurrent crack and powder cocaine users from Sao Paulo: do they represent a different group?. BMC Public Health 2006; 6: 10.","journal-title":"BMC Public Health"},{"key":"BFtp201497_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1590\/S1516-44462000000100004","volume":"22","author":"J Dunn","year":"2000","unstructured":"Dunn J, Laranjeira R . The development of a structured interview to evaluate cocaine use and risk behaviour. Rev Bras Psiquiatr 2000; 22: 11\u201316.","journal-title":"Rev Bras Psiquiatr"},{"key":"BFtp201497_CR31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFtp201497_CR32","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"SB Gabriel","year":"2002","unstructured":"Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al. The structure of haplotype blocks in the human genome. Science 2002; 296: 2225\u20132229.","journal-title":"Science"},{"key":"BFtp201497_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1192\/bjp.bp.112.118091","volume":"203","author":"M Vonmoos","year":"2013","unstructured":"Vonmoos M, Hulka LM, Preller KH, Jenni D, Baumgartner MR, Stohler R et al. Cognitive dysfunctions in recreational and dependent cocaine users: role of attention-deficit hyperactivity disorder, craving and early age at onset. Br J Psychiatry 2013; 203: 35\u201343.","journal-title":"Br J Psychiatry"},{"key":"BFtp201497_CR34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1017\/S0033291713001839","volume":"44","author":"LM Hulka","year":"2014","unstructured":"Hulka LM, Eisenegger C, Preller KH, Vonmoos M, Jenni D, Bendrick K et al. Altered social and non-social decision-making in recreational and dependent cocaine users. Psychol Med 2014; 44: 1015\u20131028.","journal-title":"Psychol Med"},{"key":"BFtp201497_CR35","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/adb.12070","volume":"19","author":"KH Preller","year":"2014","unstructured":"Preller KH, Hulka LM, Vonmoos M, Jenni D, Baumgartner MR, Seifritz E et al. Impaired emotional empathy and related social network deficits in cocaine users. Addict Biol 2014; 19: 452\u2013466.","journal-title":"Addict Biol"},{"key":"BFtp201497_CR36","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/j.1420-9101.2005.00917.x","volume":"18","author":"MC Whitlock","year":"2005","unstructured":"Whitlock MC . Combining probability from independent tests: the weighted Z-method is superior to Fisher\u2019s approach. J Evol Biol 2005; 18: 1368\u20131373.","journal-title":"J Evol Biol"},{"key":"BFtp201497_CR37","volume-title":"Statistical methods for meta-analysis","author":"LV Hedges","year":"1985","unstructured":"Hedges LV Olkin I . Statistical methods for meta-analysis. Academic: New York, NY, USA, 1985."},{"key":"BFtp201497_CR38","first-page":"Unit 7.2","volume":"Chapter 7","author":"A Zapata","year":"2009","unstructured":"Zapata A, Chefer VI, Shippenberg TS . Microdialysis in rodents. Curr Protoc Neurosci 2009; Chapter 7: Unit 7.2.","journal-title":"Curr Protoc Neurosci"},{"key":"BFtp201497_CR39","doi-asserted-by":"publisher","first-page":"7054","DOI":"10.1523\/JNEUROSCI.1529-05.2005","volume":"25","author":"KK Szumlinski","year":"2005","unstructured":"Szumlinski KK, Lominac KD, Oleson EB, Walker JK, Mason A, Dehoff MH et al. Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci 2005; 25: 7054\u20137061.","journal-title":"J Neurosci"},{"key":"BFtp201497_CR40","doi-asserted-by":"publisher","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","volume":"85","author":"G Di Chiara","year":"1988","unstructured":"Di Chiara G, Imperato A . Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 1988; 85: 5274\u20135278.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201497_CR41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00213-008-1296-3","volume":"201","author":"ME Pum","year":"2008","unstructured":"Pum ME, Carey RJ, Huston JP, M\u00fcller CP . Role of medial prefrontal, entorhinal, and occipital 5-HT in cocaine-induced place preference and hyperlocomotion: evidence for multiple dissociations. Psychopharmacology (Berl) 2008; 201: 391\u2013403.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFtp201497_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","volume":"47","author":"TE Robinson","year":"2004","unstructured":"Robinson TE, Kolb B . Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 2004; 47: 33\u201346.","journal-title":"Neuropharmacology"},{"key":"BFtp201497_CR43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/bjp.2008.77","volume":"154","author":"MJ Thomas","year":"2008","unstructured":"Thomas MJ, Kalivas PW, Shaham Y . Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol 2008; 154: 327\u2013342.","journal-title":"Br J Pharmacol"},{"key":"BFtp201497_CR44","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.1523\/JNEUROSCI.6391-11.2012","volume":"32","author":"S Kourrich","year":"2012","unstructured":"Kourrich S, Klug JR, Mayford M, Thomas MJ . AMPAR-independent effect of striatal alphaCaMKII promotes the sensitization of cocaine reward. J Neurosci 2012; 32: 6578\u20136586.","journal-title":"J Neurosci"},{"key":"BFtp201497_CR45","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.tips.2013.01.004","volume":"34","author":"JP Huston","year":"2013","unstructured":"Huston JP, Silva MA, Topic B, M\u00fcller CP . What's conditioned in conditioned place preference?. Trends Pharmacol Sci 2013; 34: 162\u2013166.","journal-title":"Trends Pharmacol Sci"},{"key":"BFtp201497_CR46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.46867\/C4D01M","volume":"14","author":"OM Carvalho","year":"2001","unstructured":"Carvalho OM, Silva AJ, Balleine BW . Evidence of selective learning deficits on tests of pavlovian and instrumental conditioning in alpha-CaMKII T286A mutant mice. Int J Comp Psychol 2001; 14: 161\u2013174.","journal-title":"Int J Comp Psychol"},{"key":"BFtp201497_CR47","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0166-4328(99)00022-4","volume":"101","author":"WJ McBride","year":"1999","unstructured":"McBride WJ, Murphy JM, Ikemoto S . Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res 1999; 101: 129\u2013152.","journal-title":"Behav Brain Res"},{"key":"BFtp201497_CR48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.tips.2004.12.007","volume":"26","author":"AN Samaha","year":"2005","unstructured":"Samaha AN, Robinson TE . Why does the rapid delivery of drugs to the brain promote addiction?. Trends Pharmacol Sci 2005; 26: 82\u201387.","journal-title":"Trends Pharmacol Sci"},{"key":"BFtp201497_CR49","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1001\/jama.1996.03540190052029","volume":"276","author":"DK Hatsukami","year":"1996","unstructured":"Hatsukami DK, Fischman MW . Crack cocaine and cocaine hydrochloride. Are the differences myth or reality?. JAMA 1996; 276: 1580\u20131588.","journal-title":"JAMA"},{"key":"BFtp201497_CR50","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/35081080","volume":"411","author":"KU Bayer","year":"2001","unstructured":"Bayer KU, De Koninck P, Leonard AS, Hell JW, Schulman H . Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 2001; 411: 801\u2013805.","journal-title":"Nature"},{"key":"BFtp201497_CR51","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1523\/JNEUROSCI.22-11-04406.2002","volume":"22","author":"JC Poncer","year":"2002","unstructured":"Poncer JC, Esteban JA, Malinow R . Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+\/calmodulin-dependent protein kinase II. J Neurosci 2002; 22: 4406\u20134411.","journal-title":"J Neurosci"},{"key":"BFtp201497_CR52","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/35004052","volume":"2","author":"I Dzhura","year":"2000","unstructured":"Dzhura I, Wu Y, Colbran RJ, Balser JR, Anderson ME . Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat Cell Biol 2000; 2: 173\u2013177.","journal-title":"Nat Cell Biol"},{"key":"BFtp201497_CR53","doi-asserted-by":"crossref","first-page":"9542","DOI":"10.1016\/S0021-9258(19)76576-4","volume":"263","author":"LC Griffith","year":"1988","unstructured":"Griffith LC, Schulman H . The multifunctional Ca2+\/calmodulin-dependent protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase. J Biol Chem 1988; 263: 9542\u20139549.","journal-title":"J Biol Chem"},{"key":"BFtp201497_CR54","doi-asserted-by":"publisher","first-page":"29627","DOI":"10.1074\/jbc.M112.367219","volume":"287","author":"T Steinkellner","year":"2012","unstructured":"Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S et al. Ca(2+)\/calmodulin-dependent protein kinase IIalpha (alphaCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. J Biol Chem 2012; 287: 29627\u201329635.","journal-title":"J Biol Chem"},{"key":"BFtp201497_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(02)02271-0","volume":"933","author":"D Sutoo","year":"2002","unstructured":"Sutoo D, Akiyama K, Yabe K . Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium\/calmodulin-dependent protein kinase II in a triple stained slice of rat brain. Brain Res 2002; 933: 1\u201311.","journal-title":"Brain Res"},{"key":"BFtp201497_CR56","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.1073\/pnas.95.13.7699","volume":"95","author":"I Sora","year":"1998","unstructured":"Sora I, Wichems C, Takahashi N, Li XF, Zeng Z, Revay R et al. Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA 1998; 95: 7699\u20137704.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201497_CR57","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.neuropharm.2006.10.002","volume":"52","author":"CP M\u00fcller","year":"2007","unstructured":"M\u00fcller CP, De Souza Silva MA, Huston JP . Double dissociating effects of sensory stimulation and cocaine on serotonin activity in the occipital and temporal cortices. Neuropharmacology 2007a; 52: 854\u2013862.","journal-title":"Neuropharmacology"},{"key":"BFtp201497_CR58","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.pneurobio.2007.01.001","volume":"81","author":"CP M\u00fcller","year":"2007","unstructured":"M\u00fcller CP, Carey RJ, Huston JP, De Souza Silva MA . Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Prog Neurobiol 2007b; 81: 133\u2013178.","journal-title":"Prog Neurobiol"},{"key":"BFtp201497_CR59","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00213-007-0791-2","volume":"193","author":"M Pum","year":"2007","unstructured":"Pum M, Carey RJ, Huston JP, M\u00fcller CP . Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats. Psychopharmacology (Berl) 2007; 193: 375\u2013390.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFtp201497_CR60","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1111\/j.1471-4159.2007.04855.x","volume":"103","author":"DM Kuhn","year":"2007","unstructured":"Kuhn DM, Sakowski SA, Geddes TJ, Wilkerson C, Haycock JW . Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. J Neurochem 2007; 103: 1567\u20131573.","journal-title":"J Neurochem"},{"key":"BFtp201497_CR61","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1017\/S0317167100032480","volume":"18","author":"HA Robertson","year":"1991","unstructured":"Robertson HA, Paul ML, Moratalla R, Graybiel AM . Expression of the immediate early gene c-fos in basal ganglia: induction by dopaminergic drugs. Can J Neurol Sci 1991; 18: 380\u2013383.","journal-title":"Can J Neurol Sci"},{"key":"BFtp201497_CR62","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0022-3565(25)39533-9","volume":"267","author":"RV Bhat","year":"1993","unstructured":"Bhat RV, Baraban JM . Activation of transcription factor genes in striatum by cocaine\u2014role of both serotonin and dopamine systems. J Pharmacol Exp Therap 1993; 267: 496\u2013505.","journal-title":"J Pharmacol Exp Therap"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp201497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201497","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T01:35:44Z","timestamp":1746408944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["BFtp201497"],"URL":"https:\/\/doi.org\/10.1038\/tp.2014.97","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]},"assertion":[{"value":"2 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}