{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:21:51Z","timestamp":1783686111267,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth are at high risk. Few studies have evaluated the role of exposure to maternal depression or child behavior in relation to TL in children. We assessed early-childhood exposures to maternal depression from birth to the age of 5 years and child behavior from ages 3\u20135 years in a cohort of Latino children in relation to child leukocyte TL at ages 4 and 5 years. Children who had oppositional defiant behavior at 3, 4 or 5 years had shorter TL than those without by ~450 base pairs (<jats:italic>P<\/jats:italic>&lt;0.01). In multivariate analyses, independent predictors for shorter TL at 4 and 5 years of age included oppositional defiant disorder at 3, 4 or 5 years (<jats:italic>\u03b2<\/jats:italic>=\u2212359.25, 95% CI \u2212633.84 to 84.66; <jats:italic>P<\/jats:italic>=0.01), exposure to maternal clinical depression at 3 years of age (<jats:italic>\u03b2<\/jats:italic>=\u2212363.99, 95% CI \u2212651.24 to 764.74; <jats:italic>P<\/jats:italic>=0.01), shorter maternal TL (<jats:italic>\u03b2<\/jats:italic>=502.92, 95% CI 189.21\u2013816.63) and younger paternal age at the child\u2019s birth (<jats:italic>\u03b2<\/jats:italic>=24.63, 95% CI 1.14\u201348.12). Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age. Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression. Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.<\/jats:p>","DOI":"10.1038\/tp.2015.71","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T13:45:29Z","timestamp":1434462329000},"page":"e581-e581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children"],"prefix":"10.1038","volume":"5","author":[{"given":"J M","family":"Wojcicki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Heyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Elwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shiboski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Epel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"BFtp201571_CR1","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1002\/anie.201002387","volume":"49","author":"EH Blackburn","year":"2010","unstructured":"Blackburn EH . Telomeres and telomerase: the means to the end (Nobel lecture). Angew Chem Int Ed Engl 2010; 49: 7405\u20137421.","journal-title":"Angew Chem Int Ed Engl"},{"key":"BFtp201571_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/MCO.0b013e32834121b1","volume":"14","author":"MA Shammas","year":"2011","unstructured":"Shammas MA . Telomeres, lifestyle, cancer and aging. Curr Opin Clin Nutr Metab Care 2011; 14: 28\u201334.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"BFtp201571_CR3","doi-asserted-by":"publisher","first-page":"e112483","DOI":"10.1371\/journal.pone.0112483","volume":"9","author":"P Willeit","year":"2014","unstructured":"Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A et al. Leukocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature \u2013based meta-analysis. PLoS One 2014; 9: e112483.","journal-title":"PLoS One"},{"key":"BFtp201571_CR4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/obr.12126","volume":"15","author":"A Muezzinler","year":"2014","unstructured":"Muezzinler A, Zaineddin AK, Brenner H . Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis. Obes Rev 2014; 15: 192\u2013201.","journal-title":"Obes Rev"},{"key":"BFtp201571_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.psyneuen.2005.08.011","volume":"31","author":"ES Epel","year":"2006","unstructured":"Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE et al. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 2006; 31: 277\u2013287.","journal-title":"Psychoneuroendocrinology"},{"key":"BFtp201571_CR6","doi-asserted-by":"publisher","first-page":"49053","DOI":"10.1016\/j.bbi.2012.11.009","volume":"28","author":"C Garcia-Rizo","year":"2013","unstructured":"Garcia-Rizo C, Fernandez-Egea E, Miller BJ, Oliveira C, Justicia A, Griffith JK et al. Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-na\u00efve patients with depression. Brain Behav Immun 2013; 28: 49053.","journal-title":"Brain Behav Immun"},{"key":"BFtp201571_CR7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/mp.2013.151","volume":"19","author":"JE Verhoeven","year":"2014","unstructured":"Verhoeven JE, Revesz D, Epel ES, Lin J, Wolkowitz OM, Penninx BW . Major depressive disorder and accelerated cellular aging: results from a large Psychiatric Cohort Study. Mol Psychiatry 2014; 19: 895\u2013901.","journal-title":"Mol Psychiatry"},{"key":"BFtp201571_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/da.20686","volume":"27","author":"OM Walkowitz","year":"2010","unstructured":"Walkowitz OM, Epel ES, Reus VI, Mellon SH . Depression gets old fast: do stress and depression accelerate cell aging. Depress Anxiety 2010; 27: 327\u2013328.","journal-title":"Depress Anxiety"},{"key":"BFtp201571_CR9","doi-asserted-by":"publisher","first-page":"e17837","DOI":"10.1371\/journal.pone.0017837","volume":"6","author":"OM Walkowitz","year":"2011","unstructured":"Walkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y et al. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress- preliminary findings. PLoS One 2011; 6: e17837.","journal-title":"PLoS One"},{"key":"BFtp201571_CR10","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1182\/blood.V97.3.700","volume":"97","author":"FJ Plunkett","year":"2001","unstructured":"Plunkett FJ, Soares MV, Annels N, Hislop A, Ivory K, Lowdell M et al. The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection. Blood 2001; 97: 700\u2013707.","journal-title":"Blood"},{"key":"BFtp201571_CR11","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.4049\/jimmunol.0903442","volume":"184","author":"PJ Van der Berg","year":"2010","unstructured":"Van der Berg PJ, Griffiths SJ, Young SL, Macaulay R, Bemelman FJ, Jackson S et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 2010; 184: 3417\u20133423.","journal-title":"J Immunol"},{"key":"BFtp201571_CR12","doi-asserted-by":"publisher","first-page":"e64762","DOI":"10.1371\/journal.pone.0064762","volume":"8","author":"KH Ladwig","year":"2013","unstructured":"Ladwig KH, Brockhaus AC, Baumert J, Lukaschek K, Emeny RT, Kruse J et al. Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the populatin-based KORA F4 study. PLoS One 2013; 8: e64762.","journal-title":"PLoS One"},{"key":"BFtp201571_CR13","doi-asserted-by":"publisher","first-page":"30R","DOI":"10.1203\/pdr.0b013e31804575f7","volume":"61","author":"DC Dolinoy","year":"2007","unstructured":"Dolinoy DC, Das R, Weidman JR, Jirtle RL . Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatr Res 2007; 61: 30R\u201337R.","journal-title":"Pediatr Res"},{"key":"BFtp201571_CR14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4161\/epi.3.2.6034","volume":"3","author":"TF Oberlander","year":"2008","unstructured":"Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM . Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 3: 96\u2013106.","journal-title":"Epigenetics"},{"key":"BFtp201571_CR15","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.biopsych.2008.11.028","volume":"65","author":"TL Roth","year":"2009","unstructured":"Roth TL, Lubin FD, Funk AJ, Swealt JD . Lasting epigenetic influence of early-life adversity on the BDHNF gene. Biol Psychiatry 2009; 65: 760\u201309.","journal-title":"Biol Psychiatry"},{"key":"BFtp201571_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.biopsych.2009.08.014","volume":"67","author":"AR Tyrka","year":"2010","unstructured":"Tyrka AR, Rice LH, Kao HT, Porton B, Marsella SA, Carpenter LL . Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress son cellular aging. Biol Psychiatry 2010; 67: 531\u2013534.","journal-title":"Biol Psychiatry"},{"key":"BFtp201571_CR17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.biopsych.2011.01.035","volume":"70","author":"A O\u2019Donovan","year":"2011","unstructured":"O\u2019Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S et al. Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry 2011; 70: 465\u2013471.","journal-title":"Biol Psychiatry"},{"key":"BFtp201571_CR18","doi-asserted-by":"publisher","first-page":"5944","DOI":"10.1073\/pnas.1404293111","volume":"111","author":"C Mitchell","year":"2014","unstructured":"Mitchell C, Hobcraft J, McLanahan SS, Siegel SR, Berg A, Brooks-Gunn J et al. Social disadvantage, genetic sensitivity, and children\u2019s telomere length. Proc Natl Acad Sci USA 2014; 111: 5944\u20135949.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201571_CR19","doi-asserted-by":"publisher","first-page":"e10826","DOI":"10.1371\/journal.pone.0010826","volume":"5","author":"L Kananen","year":"2010","unstructured":"Kananen L, Surakka I, Pirkola S, Suvisaari J, Loongvist J, Peltonen L et al. Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One 2010; 5: e10826.","journal-title":"PLoS One"},{"key":"BFtp201571_CR20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/mp.2012.32","volume":"18","author":"I Shalev","year":"2013","unstructured":"Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A et al. Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry 2013; 18: 576\u2013581.","journal-title":"Mol Psychiatry"},{"key":"BFtp201571_CR21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/mp.2011.53","volume":"17","author":"SS Drury","year":"2012","unstructured":"Drury SS, Theall K, Gleason MM, Smyke AT, Vivo De, Wong JY et al. Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry 2012; 17: 719\u2013727.","journal-title":"Mol Psychiatry"},{"key":"BFtp201571_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.socscimed.2013.02.030","volume":"85","author":"KP Theall","year":"2013","unstructured":"Theall KP, Brett ZH, Shirtcliff EA, Dunn EC, Drury SS . Neighborhood disorder and telomeres: connecting children\u2019s exposure to community level stress and cellular response. Soc Sci Med 2013; 85: 50\u201358.","journal-title":"Soc Sci Med"},{"key":"BFtp201571_CR23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1017\/S0954579413000011","volume":"25","author":"A Asok","year":"2013","unstructured":"Asok A, Bernard K, Roth TL, Rosen JB, Dozier M . Parental responsiveness moderates the association between early-life stress and reduced telomere length. Dev Psychopathol 2013; 25: 577\u2013585.","journal-title":"Dev Psychopathol"},{"key":"BFtp201571_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1097\/PSY.0b013e318229acfc","volume":"73","author":"CH Kroenke","year":"2011","unstructured":"Kroenke CH, Epel E, Adler N, Bush NR, Obradovic J, Lin J et al. Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosom Med 2011; 73: 533\u2013540.","journal-title":"Psychosom Med"},{"key":"BFtp201571_CR25","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.1073\/pnas.95.10.5607","volume":"95","author":"RW Frenck Jr","year":"1998","unstructured":"Frenck RW Jr, Blackburn EH, Shannon KM . The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 1998; 95: 5607\u20135610.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp201571_CR26","first-page":"513","volume":"26","author":"A Feder","year":"2009","unstructured":"Feder A, Alonso A, Tang M, Liriano W, Warner V, Pilowsky D et al. Children of low-income depressed mothers: psychiatric disorders and social adjustment. Depress Anxiety 2009; 26: 513\u2013520.","journal-title":"Depress Anxiety"},{"key":"BFtp201571_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0165-0327(02)00301-4","volume":"78","author":"MM Weissman","year":"2004","unstructured":"Weissman MM, Feder A, Pilowsky DJ, Olfson M, Fuentes M, Blanco C et al. Depressed mothers coming to primary care: maternal reports of problems with their children. J Affect Disord 2004; 78: 93\u2013100.","journal-title":"J Affect Disord"},{"key":"BFtp201571_CR28","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1176\/ajp.2006.163.6.1001","volume":"163","author":"MW Weissman","year":"2006","unstructured":"Weissman MW, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, Verdeli H . Offspring of depressed parents: 20 years later. Am J Psychiatry 2006; 163: 1001\u20131008.","journal-title":"Am J Psychiatry"},{"key":"BFtp201571_CR29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1080\/15374416.2013.836451","volume":"43","author":"RP Breaux","year":"2014","unstructured":"Breaux RP, Harvey EA, Lugo-Candelas CI . The role of parent psychopathology in the development of preschool children with behavior problems. J Clin Chid Adolesc Psychol 2014; 43: 777\u2013790.","journal-title":"J Clin Chid Adolesc Psychol"},{"key":"BFtp201571_CR30","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cpr.2009.12.008","volume":"30","author":"ER Anderson","year":"2010","unstructured":"Anderson ER, Mayes LC . Race\/ethnicity and internalizing disorders in youth: a review. Clin Psychol Rev 2010; 30: 338\u2013348.","journal-title":"Clin Psychol Rev"},{"key":"BFtp201571_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1037\/a0033817","volume":"50","author":"U Orth","year":"2014","unstructured":"Orth U, Robins RW, Widaman KF, Conger RD . Is low self-esteem a risk factor for depression? Findings from a longitudinal study of mexican-origin youth. Dev Psychol 2014; 50: 622\u2013633.","journal-title":"Dev Psychol"},{"key":"BFtp201571_CR32","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","volume":"30","author":"RM Cawthon","year":"2002","unstructured":"Cawthon RM . Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30: e47.","journal-title":"Nucleic Acids Res"},{"key":"BFtp201571_CR33","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1093\/nar\/gkn1027","volume":"37","author":"RM Cawthon","year":"2009","unstructured":"Cawthon RM . Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009; 37: e21.","journal-title":"Nucleic Acids Res"},{"key":"BFtp201571_CR34","doi-asserted-by":"publisher","first-page":"e16737","DOI":"10.1371\/journal.pone.0016737","volume":"6","author":"JM Wojcicki","year":"2011","unstructured":"Wojcicki JM, Holbrook K, Lustig RH, Epel E, Caughey AB, Munoz RF et al. Chronic maternal depression is associated with reduced weight gain in Latino infants from birth 2 years of age. PLoS One 2011; 6: e16737.","journal-title":"PLoS One"},{"key":"BFtp201571_CR35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1177\/0890334410396510","volume":"27","author":"JM Wojcicki","year":"2011","unstructured":"Wojcicki JM, Holbrook K, Lustig RH, Caughey AB, Munoz RF, Heyman MB . Infant formula, tea and water supplementation of Latino infants at 4-6 weeks postpartum. J Hum Lact 2011; 27: 122\u2013130.","journal-title":"J Hum Lact"},{"key":"BFtp201571_CR36","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s10900-013-9781-y","volume":"39","author":"S Verstraete","year":"2014","unstructured":"Verstraete S, Heyman MB, Wojcicki JM . Breastfeeding offers protection against obesity in children of recently immigrated Latina women. J Community Health 2014; 39: 480\u2013486.","journal-title":"J Community Health"},{"key":"BFtp201571_CR37","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1192\/bjp.150.6.782","volume":"150","author":"JL Cox","year":"1987","unstructured":"Cox JL, Holden JM, Sagovsky R . Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150: 782\u2013786.","journal-title":"Br J Psychiatry"},{"key":"BFtp201571_CR38","doi-asserted-by":"crossref","unstructured":"Radloff LS . The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977; 385\u2013401.","DOI":"10.1177\/014662167700100306"},{"key":"BFtp201571_CR39","first-page":"22","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan DV, Lecruibier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22\u201333.","journal-title":"J Clin Psychiatry"},{"key":"BFtp201571_CR40","unstructured":"Achenbach TM, Rescorla LA . Manual for the ASEBA Preschool Forms and Profiles Burlington, VT, USA: University of Vermont, Research Center for Children, Youth, & Families, 2000."},{"key":"BFtp201571_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5402\/2012\/408694","volume":"2012","author":"L Albores-Gallo","year":"2012","unstructured":"Albores-Gallo L, Roldan Ceballos O, Villareal-Valdes G . M-CHAT Mexican version validity and reliability and some cultural considerations. ISRN Neurol 2012; 2012: 1\u20137.","journal-title":"ISRN Neurol"},{"key":"BFtp201571_CR42","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1080\/15374410701444363","volume":"36","author":"MY Ivanova","year":"2007","unstructured":"Ivanova MY, Dobrean A, Dopfner M, Erol N, Fombonne E, Fonseca AC et al. Testing the 8-syndrome structure of the child behavior checklist in 30 societies. J Clin Child Adolesc Psychol 2007; 36: 405\u2013417.","journal-title":"J Clin Child Adolesc Psychol"},{"key":"BFtp201571_CR43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1037\/a0020761","volume":"15","author":"K Imai","year":"2010","unstructured":"Imai K, Keele L, Tingley D . A general approach to causal mediation analysis. Psychol Methods. 2010; 15: 309\u2013334.","journal-title":"Psychol Methods."},{"key":"BFtp201571_CR44","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/mp.2014.119","volume":"20","author":"IH Gotlib","year":"2014","unstructured":"Gotlib IH, LeMoult J, Colich NL, Foland-Ross LC, Hallmayer J, Joormann J et al. Telomere length and cortisol reactivity in children of depressed mothers. Mol Psychiatry 2014; 20: 615\u2013620.","journal-title":"Mol Psychiatry"},{"key":"BFtp201571_CR45","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1017\/S1461145714000698","volume":"17","author":"A Szebeni","year":"2014","unstructured":"Szebeni A, Szebeni K, DiPeri T, Chandley MJ, Crawford JD, Stockmeier CA et al. Shortened telomere length in white matter oligodendrocytes in major depression: potential role of oxidative stress. Int J Neuropsychopharmacol 2014; 17: 1579\u20131589.","journal-title":"Int J Neuropsychopharmacol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp201571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201571","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp201571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T09:50:07Z","timestamp":1672912207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp201571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,16]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6]]}},"alternative-id":["BFtp201571"],"URL":"https:\/\/doi.org\/10.1038\/tp.2015.71","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,16]]},"assertion":[{"value":"29 January 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JL is a consultant to Telomere Diagnostics Inc., formerly Telomere Health, and owns stock in the company, and the company did not play any role in this research. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}