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Clinical studies with the genetic data are often limited in sample sizes. Drug response obtained from self-reports may offer an alternative approach to conduct a study with much larger sample size. Using the phenotype data collected from 23andMe \u2018Antidepressant Efficacy and Side Effects\u2019 survey and genotype data from 23andMe\u2019s research participants, we conducted genome-wide association study (GWAS) on subjects of European ancestry using four groups of phenotypes (a) non-treatment-resistant depression (<jats:italic>n<\/jats:italic>=7795) vs treatment-resistant depression (TRD, <jats:italic>n<\/jats:italic>=1311), (b) selective serotonin reuptake inhibitors (SSRI) responders (<jats:italic>n<\/jats:italic>=6348) vs non-responders (<jats:italic>n<\/jats:italic>=3340), (c) citalopram\/escitalopram responders (<jats:italic>n<\/jats:italic>=2963) vs non-responders (<jats:italic>n<\/jats:italic>=2005), and (d) norepinephrine\u2013dopamine reuptake inhibitor (NDRI, bupropion) responders (<jats:italic>n<\/jats:italic>=2675) vs non-responders (<jats:italic>n<\/jats:italic>=1861). Each of these subgroups was also compared with controls (<jats:italic>n<\/jats:italic> ~ 190\u2009000). The most significant association was from bupropion responders vs non-responders analysis. Variant rs1908557 (<jats:italic>P<\/jats:italic>=2.6 \u00d7 10<jats:sup>\u22128<\/jats:sup>, OR=1.35) passed the conventional genome-wide significance threshold (<jats:italic>P<\/jats:italic>=5 \u00d7 10<jats:sup>\u22128<\/jats:sup>) and was located within the intron of human spliced expressed sequence tags in chromosome 4. Gene sets associated with long-term depression, circadian rhythm and vascular endothelial growth factor (VEGF) pathway were enriched in the bupropion analysis. No single-nucleotide polymorphism passed genome-wide significance threshold in other analyses. The heritability estimates for each response group compared with controls were between 0.15 and 0.25, consistent with the known heritability for major depressive disorder.<\/jats:p>","DOI":"10.1038\/tp.2016.171","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T13:48:05Z","timestamp":1473774485000},"page":"e889-e889","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response"],"prefix":"10.1038","volume":"6","author":[{"given":"Q S","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Seabrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Drevets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V A","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"BFtp2016171_CR1","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1001\/archgenpsychiatry.2009.95","volume":"66","author":"M Ising","year":"2009","unstructured":"Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S et al. 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All authors may be shareholders in Johnson & Johnson, which is the parent company of the Janssen companies. QSL, GRS, WCD and VAN declare that except for income received from their primary employer, no financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional service, and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest. CT is an employee of 23andMe.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}