{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:11:00Z","timestamp":1789416660023,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tic disorders affect ~5% of the population and are frequently comorbid with obsessive-compulsive disorder, autism, and attention deficit disorder. Histamine dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (<jats:italic>Hdc<\/jats:italic>) gene represent a promising pathophysiologically grounded model. How alterations in the histamine system lead to tics and other neuropsychiatric pathology, however, remains unclear. We found elevated expression of the histamine H3 receptor in the striatum of <jats:italic>Hdc<\/jats:italic> knockout mice. The H3 receptor has significant basal activity even in the absence of ligand and thus may modulate striatal function in this knockout model. We probed H3R function using specific agonists. The H3 agonists R-aminomethylhistamine (RAMH) and immepip produced behavioral stereotypies in KO mice, but not in controls. H3 agonist treatment elevated intra-striatal dopamine in KO mice, but not in controls. This was associated with elevations in phosphorylation of rpS6, a sensitive marker of neural activity, in the dorsal striatum. We used a novel chemogenetic strategy to demonstrate that this dorsal striatal activity is necessary and sufficient for the development of stereotypy: when RAMH-activated cells in the dorsal striatum were chemogenetically activated (in the absence of RAMH), stereotypy was recapitulated in KO animals, and when they were silenced the ability of RAMH to produce stereotypy was blocked. These results identify the H3 receptor in the dorsal striatum as a contributor to repetitive behavioral pathology.<\/jats:p>","DOI":"10.1038\/tp.2016.290","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T16:51:51Z","timestamp":1485276711000},"page":"e1013-e1013","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders"],"prefix":"10.1038","volume":"7","author":[{"given":"M","family":"Rapanelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Frick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Pogorelov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ohtsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Bito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pittenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"BFtp2016290_CR1","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","volume":"88","author":"HL Haas","year":"2008","unstructured":"Haas HL, Sergeeva OA, Selbach O . Histamine in the nervous system. Physiol Rev 2008; 88: 1183\u20131241.","journal-title":"Physiol Rev"},{"key":"BFtp2016290_CR2","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrn3526","volume":"14","author":"P Panula","year":"2013","unstructured":"Panula P, Nuutinen S . The histaminergic network in the brain: basic organization and role in disease. Nat Rev Neurosci 2013; 14: 472\u2013487.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp2016290_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neubiorev.2014.07.020","volume":"47","author":"EH Schneider","year":"2014","unstructured":"Schneider EH, Neumann D, Seifert R . Modulation of behavior by the histaminergic system: lessons from HDC-, H3R- and H4R-deficient mice. Neurosci Biobehav Rev 2014; 47: 101\u2013121.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFtp2016290_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/WCO.0b013e328344648c","volume":"24","author":"M Bloch","year":"2011","unstructured":"Bloch M, State M, Pittenger C . Recent advances in Tourette syndrome. Curr Opin Neurol 2011; 24: 119\u2013125.","journal-title":"Curr Opin Neurol"},{"key":"BFtp2016290_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neuropharm.2015.08.019","volume":"106","author":"M Rapanelli","year":"2016","unstructured":"Rapanelli M, Pittenger C . Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions. Neuropharmacology 2016; 106: 85\u201390.","journal-title":"Neuropharmacology"},{"key":"BFtp2016290_CR6","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1056\/NEJMoa0907006","volume":"362","author":"AG Ercan-Sencicek","year":"2010","unstructured":"Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE et al. L-histidine decarboxylase and Tourette's syndrome. N Engl J Med 2010; 362: 1901\u20131908.","journal-title":"N Engl J Med"},{"key":"BFtp2016290_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuron.2013.10.052","volume":"81","author":"L Castellan Baldan","year":"2014","unstructured":"Castellan Baldan L, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M et al. Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice. Neuron 2014; 81: 77\u201390.","journal-title":"Neuron"},{"key":"BFtp2016290_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neulet.2015.03.067","volume":"595","author":"M Xu","year":"2015","unstructured":"Xu M, Li L, Ohtsu H, Pittenger C . Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear. Neurosci Lett 2015; 595: 50\u201353.","journal-title":"Neurosci Lett"},{"key":"BFtp2016290_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.biopsych.2011.09.034","volume":"71","author":"TV Fernandez","year":"2012","unstructured":"Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO et al. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry 2012; 71: 392\u2013402.","journal-title":"Biol Psychiatry"},{"key":"BFtp2016290_CR10","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1136\/jmedgenet-2013-101637","volume":"50","author":"I Karagiannidis","year":"2013","unstructured":"Karagiannidis I, Dehning S, Sandor P, Tarnok Z, Rizzo R, Wolanczyk T et al. Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families. Journal of medical genetics 2013; 50: 760\u2013764.","journal-title":"Journal of medical genetics"},{"key":"BFtp2016290_CR11","volume-title":"Tourette Syndrome","author":"L Scahill","year":"2013","unstructured":"Scahill L, Dalsgaard S . Prevalence and methods for population screening. In: Martno D, Leckman JF (eds). Tourette Syndrome. Oxford University Press: New York, NY, USA, 2013."},{"key":"BFtp2016290_CR12","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199796267.001.0001","volume-title":"Tourette Syndrome","author":"D Martino","year":"2013","unstructured":"Martino D, Leckman JF . Tourette Syndrome. Oxford University Press: Oxford ; New York, NY, USA, 2013, p 692."},{"key":"BFtp2016290_CR13","unstructured":"Williams K, Bloch MH, State MW, Pittenger C Neurobiology of Mental Illness. In: Charney DS, Buxbaum JD, Sklar P, Nestler EJ (eds), 4th edn, Oxford University Press: New York, NY, USA, 2013."},{"key":"BFtp2016290_CR14","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.euroneuro.2014.10.007","volume":"24","author":"M Rapanelli","year":"2014","unstructured":"Rapanelli M, Frick LR, Pogorelov V, Ota KT, Abbasi E, Ohtsu H et al. Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome. Eur Neuropsychopharmacol 2014; 24: 1896\u20131906.","journal-title":"Eur Neuropsychopharmacol"},{"key":"BFtp2016290_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35048583","volume":"408","author":"S Morisset","year":"2000","unstructured":"Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H et al. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature 2000; 408: 860\u2013864.","journal-title":"Nature"},{"key":"BFtp2016290_CR16","doi-asserted-by":"publisher","first-page":"15340","DOI":"10.1523\/JNEUROSCI.3144-11.2011","volume":"31","author":"TJ Ellender","year":"2011","unstructured":"Ellender TJ, Huerta-Ocampo I, Deisseroth K, Capogna M, Bolam JP . Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. J Neurosci 2011; 31: 15340\u201315351.","journal-title":"J Neurosci"},{"key":"BFtp2016290_CR17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/j.1472-8206.1994.tb00789.x","volume":"8","author":"E Schlicker","year":"1994","unstructured":"Schlicker E, Malinowska B, Kathmann M, Gothert M . Modulation of neurotransmitter release via histamine H3 heteroreceptors. Fundam Clin Pharmacol 1994; 8: 128\u2013137.","journal-title":"Fundam Clin Pharmacol"},{"key":"BFtp2016290_CR18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neuropharm.2008.05.008","volume":"55","author":"C Ferrada","year":"2008","unstructured":"Ferrada C, Ferre S, Casado V, Cortes A, Justinova Z, Barnes C et al. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. Neuropharmacology 2008; 55: 190\u2013197.","journal-title":"Neuropharmacology"},{"key":"BFtp2016290_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1476-5381.2009.00152.x","volume":"157","author":"C Ferrada","year":"2009","unstructured":"Ferrada C, Moreno E, Casado V, Bongers G, Cortes A, Mallol J et al. Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors. Br J Pharmacol 2009; 157: 64\u201375.","journal-title":"Br J Pharmacol"},{"key":"BFtp2016290_CR20","doi-asserted-by":"publisher","first-page":"5846","DOI":"10.1074\/jbc.M110.161489","volume":"286","author":"E Moreno","year":"2011","unstructured":"Moreno E, Hoffmann H, Gonzalez-Sepulveda M, Navarro G, Casado V, Cortes A et al. Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. J Biol Chem 2011; 286: 5846\u20135854.","journal-title":"J Biol Chem"},{"key":"BFtp2016290_CR21","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1523\/JNEUROSCI.4147-13.2014","volume":"34","author":"E Moreno","year":"2014","unstructured":"Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S et al. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci 2014; 34: 3545\u20133558.","journal-title":"J Neurosci"},{"key":"BFtp2016290_CR22","doi-asserted-by":"publisher","first-page":"21042","DOI":"10.1074\/jbc.M116.731406","volume":"291","author":"M Rapanelli","year":"2016","unstructured":"Rapanelli M, Frick LR, Horn KD, Schwarcz R, Pogorelov V, Nairn AC et al. The histamine H3 receptor differentially modulates MAPK and Akt signaling in striatonigral and striatopallidal neurons. J Biol Chem 2016; 291: 21042\u201321052.","journal-title":"J Biol Chem"},{"key":"BFtp2016290_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0014-5793(01)02663-1","volume":"502","author":"H Ohtsu","year":"2001","unstructured":"Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G et al. Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett 2001; 502: 53\u201356.","journal-title":"FEBS Lett"},{"key":"BFtp2016290_CR24","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/nn.2153","volume":"11","author":"HS Bateup","year":"2008","unstructured":"Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N et al. Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat Neurosci 2008; 11: 932\u2013939.","journal-title":"Nat Neurosci"},{"key":"BFtp2016290_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1461145712000016","volume":"16","author":"V Duric","year":"2013","unstructured":"Duric V, Banasr M, Stockmeier CA, Simen AA, Newton SS, Overholser JC et al. Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects. Int J Neuropsychopharmacol 2013; 16: 69\u201382.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp2016290_CR26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cell.2005.05.012","volume":"122","author":"JM Beaulieu","year":"2005","unstructured":"Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG . An Akt\/beta-arrestin 2\/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005; 122: 261\u2013273.","journal-title":"Cell"},{"key":"BFtp2016290_CR27","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.1073\/pnas.0307921101","volume":"101","author":"JM Beaulieu","year":"2004","unstructured":"Beaulieu JM, Sotnikova TD, Yao WD, Kockeritz L, Woodgett JR, Gainetdinov RR et al. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci USA 2004; 101: 5099\u20135104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2016290_CR28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.283.5400.397","volume":"283","author":"RR Gainetdinov","year":"1999","unstructured":"Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG . Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283: 397\u2013401.","journal-title":"Science"},{"key":"BFtp2016290_CR29","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1038\/npp.2008.223","volume":"34","author":"X Guo","year":"2009","unstructured":"Guo X, Hamilton PJ, Reish NJ, Sweatt JD, Miller CA, Rumbaugh G . Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. Neuropsychopharmacology 2009; 34: 1659\u20131672.","journal-title":"Neuropsychopharmacology"},{"key":"BFtp2016290_CR30","volume-title":"The Mouse Brain in Stereotaxic Coordinates, Compact","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Franklin KBJ . The Mouse Brain in Stereotaxic Coordinates, Compact 2nd edn., Elsevier Academic Press: Amsterdam ; Boston, CA, USA, 2004."},{"key":"BFtp2016290_CR31","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1073\/pnas.1419533112","volume":"112","author":"M Xu","year":"2015","unstructured":"Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M et al. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Pro Natl Acad Sci USA 2015; 112: 893\u2013898.","journal-title":"Pro Natl Acad Sci USA"},{"key":"BFtp2016290_CR32","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nmeth.2559","volume":"10","author":"T Kawashima","year":"2013","unstructured":"Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S et al. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 2013; 10: 889\u2013895.","journal-title":"Nat Methods"},{"key":"BFtp2016290_CR33","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/nm964","volume":"9","author":"JD Hommel","year":"2003","unstructured":"Hommel JD, Sears RM, Georgescu D, Simmons DL, DiLeone RJ . Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 2003; 9: 1539\u20131544.","journal-title":"Nat Med"},{"key":"BFtp2016290_CR34","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.neuron.2015.03.065","volume":"86","author":"E Vardy","year":"2015","unstructured":"Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron 2015; 86: 936\u2013946.","journal-title":"Neuron"},{"key":"BFtp2016290_CR35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-neuro-071013-014048","volume":"37","author":"SM Sternson","year":"2014","unstructured":"Sternson SM, Roth BL . Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci 2014; 37: 387\u2013407.","journal-title":"Annu Rev Neurosci"},{"key":"BFtp2016290_CR36","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/484410a","volume":"484","author":"X Liu","year":"2012","unstructured":"Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 2012; 484: 381\u2013385.","journal-title":"Nature"},{"key":"BFtp2016290_CR37","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1126\/science.1214985","volume":"335","author":"AR Garner","year":"2012","unstructured":"Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C et al. Generation of a synthetic memory trace. Science 2012; 335: 1513\u20131516.","journal-title":"Science"},{"key":"BFtp2016290_CR38","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.neuron.2014.09.022","volume":"84","author":"KK Cowansage","year":"2014","unstructured":"Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M . Direct reactivation of a coherent neocortical memory of context. Neuron 2014; 84: 432\u2013441.","journal-title":"Neuron"},{"key":"BFtp2016290_CR39","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1073\/pnas.0610155104","volume":"104","author":"T Matsuda","year":"2007","unstructured":"Matsuda T, Cepko CL . Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci USA 2007; 104: 1027\u20131032.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2016290_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10571-011-9730-1","volume":"32","author":"A Chepkova","year":"2012","unstructured":"Chepkova A, Yanovsky E, Parmentier R, Ohtsu H, Haas HL, Lin JS et al. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice. Cell Mol Neurobiol 2012; 32: 17\u201325.","journal-title":"Cell Mol Neurobiol"},{"key":"BFtp2016290_CR41","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.cell.2012.10.039","volume":"151","author":"ZA Knight","year":"2012","unstructured":"Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW et al. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell 2012; 151: 1126\u20131137.","journal-title":"Cell"},{"key":"BFtp2016290_CR42","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1523\/JNEUROSCI.4783-12.2013","volume":"33","author":"SM Ferguson","year":"2013","unstructured":"Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF . Direct-pathway striatal neurons regulate the retention of decision-making strategies. J Neurosci 2013; 33: 11668\u201311676.","journal-title":"J Neurosci"},{"key":"BFtp2016290_CR43","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neulet.2015.03.067","volume":"595","author":"M Xu","year":"2015","unstructured":"Xu M, Li L, Ohtsu H, Pittenger C . Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show enhanced stereotypy following stress. Neurosci Lett 2015; 595: 50\u201353.","journal-title":"Neurosci Lett"},{"key":"BFtp2016290_CR44","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1101\/lm.67603","volume":"10","author":"E Dere","year":"2003","unstructured":"Dere E, De Souza-Silva MA, Topic B, Spieler RE, Haas HL, Huston JP . Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover. Learn Mem 2003; 10: 510\u2013519.","journal-title":"Learn Mem"},{"key":"BFtp2016290_CR45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neulet.2013.07.026","volume":"552","author":"A Alfaro-Rodriguez","year":"2013","unstructured":"Alfaro-Rodriguez A, Alonso-Spilsbury M, Arch-Tirado E, Gonzalez-Pina R, Arias-Montano JA, Bueno-Nava A . Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study. Neurosci Lett 2013; 552: 5\u20139.","journal-title":"Neurosci Lett"},{"key":"BFtp2016290_CR46","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fnmol.2015.00075","volume":"8","author":"A Biever","year":"2015","unstructured":"Biever A, Valjent E, Puighermanal E . Ribosomal Protein S6 phosphorylation in the nervous system: from regulation to function. Front Mol Neurosci 2015; 8: 75.","journal-title":"Front Mol Neurosci"},{"key":"BFtp2016290_CR47","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.tins.2006.01.001","volume":"29","author":"RL Albin","year":"2006","unstructured":"Albin RL, Mink JW . Recent advances in Tourette syndrome research. Trends Neurosci 2006; 29: 175\u2013182.","journal-title":"Trends Neurosci"},{"key":"BFtp2016290_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbr.2014.05.057","volume":"276","author":"SD McBride","year":"2015","unstructured":"McBride SD, Parker MO . The disrupted basal ganglia and behavioural control: an integrative cross-domain perspective of spontaneous stereotypy. Behav Brain Res 2015; 276: 45\u201358.","journal-title":"Behav Brain Res"},{"key":"BFtp2016290_CR49","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.pnpbp.2016.10.002","volume":"73","author":"M Rapanelli","year":"2016","unstructured":"Rapanelli M . The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry. Prog Neuropsychopharmacol Biol Psychiatry 2016; 73: 36\u201340.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFtp2016290_CR50","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neuroscience.2016.02.074","volume":"324","author":"M Xu","year":"2016","unstructured":"Xu M, Li L, Pittenger C . Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming. Neuroscience 2016; 324: 321\u2013329.","journal-title":"Neuroscience"},{"key":"BFtp2016290_CR51","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1126\/science.1234733","volume":"340","author":"SE Ahmari","year":"2013","unstructured":"Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K et al. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 2013; 340: 1234\u20131239.","journal-title":"Science"},{"key":"BFtp2016290_CR52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0896-6273(01)00564-5","volume":"33","author":"JM Greer","year":"2002","unstructured":"Greer JM, Capecchi MR . Hoxb8 is required for normal grooming behavior in mice. Neuron 2002; 33: 23\u201334.","journal-title":"Neuron"},{"key":"BFtp2016290_CR53","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/nm.2125","volume":"16","author":"SV Shmelkov","year":"2010","unstructured":"Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T et al. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med 2010; 16: 598\u2013602, 1p following 602.","journal-title":"Nat Med"},{"key":"BFtp2016290_CR54","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature06104","volume":"448","author":"JM Welch","year":"2007","unstructured":"Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 2007; 448: 894\u2013900.","journal-title":"Nature"},{"key":"BFtp2016290_CR55","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature09965","volume":"472","author":"J Peca","year":"2011","unstructured":"Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 2011; 472: 437\u2013442.","journal-title":"Nature"},{"key":"BFtp2016290_CR56","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nature09582","volume":"468","author":"HT Chao","year":"2010","unstructured":"Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J et al. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 2010; 468: 263\u2013269.","journal-title":"Nature"},{"key":"BFtp2016290_CR57","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrn.2015.8","volume":"17","author":"AV Kalueff","year":"2016","unstructured":"Kalueff AV, Stewart AM, Song C, Berridge KC, Graybiel AM, Fentress JC . Neurobiology of rodent self-grooming and its value for translational neuroscience. Nat Rev Neurosci 2016; 17: 45\u201359.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp2016290_CR58","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","volume":"167","author":"T Insel","year":"2010","unstructured":"Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 2010; 167: 748\u2013751.","journal-title":"Am J Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp2016290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2016290","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2016290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T16:31:32Z","timestamp":1671726692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2016290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1]]}},"alternative-id":["BFtp2016290"],"URL":"https:\/\/doi.org\/10.1038\/tp.2016.290","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]},"assertion":[{"value":"28 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}