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This study investigated the effect of acute exercise on adolescents with BD and healthy control subjects (HC) to test for positive or negative consequences on neural response during an executive task. Fifty adolescents (mean age 16.54\u00b11.47 years, 56% female, 30 with BD) completed an attention and response inhibition task before and after 20\u2009min of recumbent cycling at ~70% of age-predicted maximum heart rate. 3\u2009T functional magnetic resonance imaging data were analyzed in a whole brain voxel-wise analysis and as regions of interest (ROI), examining Go and NoGo response events. In the whole brain analysis of Go trials, exercise had larger effect in BD vs HC throughout ventral prefrontal cortex, amygdala and hippocampus; the profile of these effects was of greater disengagement after exercise. Pre-exercise ROI analysis confirmed this 'deficit in deactivation' for BDs in rostral ACC and found an activation deficit on NoGo errors in accumbens. Pre-exercise accumbens NoGo error activity correlated with depression symptoms and Go activity with mania symptoms; no correlations were present after exercise. Performance was matched to controls and results survived a series of covariate analyses. This study provides evidence that acute aerobic exercise transiently changes neural response during an executive task among adolescents with BD, and that pre-exercise relationships between symptoms and neural response are absent after exercise. Acute aerobic exercise constitutes a biological probe that may provide insights regarding pathophysiology and treatment of BD.<\/jats:p>","DOI":"10.1038\/tp.2016.85","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T13:51:06Z","timestamp":1463493066000},"page":"e814-e814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder"],"prefix":"10.1038","volume":"6","author":[{"given":"A W S","family":"Metcalfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"MacIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Korczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B I","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"BFtp201685_CR1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1176\/appi.ajp.163.2.286","volume":"163","author":"MN Pavuluri","year":"2006","unstructured":"Pavuluri MN, Schenkel LS, Aryal S, Harral EM, Hill SK, Herbener ES et al. 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