{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:53:07Z","timestamp":1776271987150,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunological and inflammatory reactions have been suggested to have a role in the development of schizophrenia, a hypothesis that has recently been supported by genetic data. The aim of our study was to perform an unbiased search for autoantibodies in patients with a first psychotic episode, and to explore the association between any seroreactivity and the development of a Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) disorder characterized by chronic or relapsing psychotic symptoms. We collected plasma samples from 53 patients when they were treated for their first-episode psychosis, and 41 non-psychotic controls, after which the patients were followed for a mean duration of 7 years. Thirty patients were diagnosed with schizophrenia, delusional disorder, schizoaffective disorder, bipolar disorder or a long-term unspecified nonorganic psychosis during follow-up, whereas 23 patients achieved complete remission. At the end of follow-up, plasma samples were analyzed for IgG reactivity to 2304 fragments of human proteins using a multiplexed affinity proteomic technique. Eight patient samples showed autoreactivity to the N-terminal fragment of the PAGE (P antigen) protein family (PAGE2B\/PAGE2\/PAGE5), whereas no such autoreactivity was seen among the controls. PAGE autoreactivity was associated with a significantly increased risk of being diagnosed with schizophrenia during follow-up (odds ratio 6.7, relative risk 4.6). An immunohistochemistry analysis using antisera raised against the N-terminal fragment stained an unknown extracellular target in human cortical brain tissue. Our findings suggest that autoreactivity to the N-terminal portion of the PAGE protein family is associated with schizophrenia in a subset of patients with first-episode psychosis.<\/jats:p>","DOI":"10.1038\/tp.2017.160","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T13:41:51Z","timestamp":1500990111000},"page":"e1177-e1177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis"],"prefix":"10.1038","volume":"7","author":[{"given":"A","family":"Zandian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wing\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sj\u00f6stedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D X","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Just","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Uhl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Schwenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"H\u00e4ggmark-M\u00e5nberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Norbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Owe-Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A A","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"BFtp2017160_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1155\/2013\/510402","volume":"35","author":"CS Weickert","year":"2013","unstructured":"Weickert CS, Weickert TW, Pillai A, Buckley PF . Biomarkers in schizophrenia: a brief conceptual consideration. Dis Markers 2013; 35: 3\u20139.","journal-title":"Dis Markers"},{"key":"BFtp2017160_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.biopsych.2016.07.014","volume":"81","author":"OD Howes","year":"2016","unstructured":"Howes OD, McCutcheon R, Owen MJ, Murray RM . The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry 2016; 81: 9\u201320.","journal-title":"Biol Psychiatry"},{"key":"BFtp2017160_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomics C","year":"2014","unstructured":"Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511: 421\u2013427.","journal-title":"Nature"},{"key":"BFtp2017160_CR4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1176\/appi.ajp.2013.13010086","volume":"171","author":"ME Benros","year":"2014","unstructured":"Benros ME, Pedersen MG, Rasmussen H, Eaton WW, Nordentoft M, Mortensen PB . A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis. Am J Psychiatry 2014; 171: 218\u2013226.","journal-title":"Am J Psychiatry"},{"key":"BFtp2017160_CR5","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1093\/schbul\/sbu054","volume":"40","author":"C Sellgren","year":"2014","unstructured":"Sellgren C, Frisell T, Lichtenstein P, Landen M, Askling J . The association between schizophrenia and rheumatoid arthritis: a nationwide population-based Swedish study on intraindividual and familial risks. Schizophr Bull 2014; 40: 1552\u20131559.","journal-title":"Schizophr Bull"},{"key":"BFtp2017160_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1440-1711.2005.01305.x","volume":"83","author":"AL Jones","year":"2005","unstructured":"Jones AL, Mowry BJ, Pender MP, Greer JM . Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? Immunol Cell Biol 2005; 83: 9\u201317.","journal-title":"Immunol Cell Biol"},{"key":"BFtp2017160_CR7","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1592\/phco.28.6.730","volume":"28","author":"CA Goldsmith","year":"2008","unstructured":"Goldsmith CA, Rogers DP . The case for autoimmunity in the etiology of schizophrenia. Pharmacotherapy 2008; 28: 730\u2013741.","journal-title":"Pharmacotherapy"},{"key":"BFtp2017160_CR8","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1007\/BF01776787","volume":"16","author":"H Lehmann-Facius","year":"1937","unstructured":"Lehmann-Facius H . Uber die liquordiagnose der schizophrenien. Klin Wochenschr 1937; 16: 1646\u20131648.","journal-title":"Klin Wochenschr"},{"key":"BFtp2017160_CR9","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s00415-010-5788-9","volume":"258","author":"MS Zandi","year":"2011","unstructured":"Zandi MS, Irani SR, Lang B, Waters P, Jones PB, McKenna P et al. Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 2011; 258: 686\u2013688.","journal-title":"J Neurol"},{"key":"BFtp2017160_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ana.24189","volume":"76","author":"L Dahm","year":"2014","unstructured":"Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S et al. Seroprevalence of autoantibodies against brain antigens in health and disease. Anna Neurol 2014; 76: 82\u201394.","journal-title":"Anna Neurol"},{"key":"BFtp2017160_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261\u2013276.","journal-title":"Schizophr Bull"},{"key":"BFtp2017160_CR12","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.pnpbp.2011.03.012","volume":"35","author":"B Owe-Larsson","year":"2011","unstructured":"Owe-Larsson B, Ekdahl K, Edbom T, Osby U, Karlsson H, Lundberg C et al. Increased plasma levels of thioredoxin-1 in patients with first episode psychosis and long-term schizophrenia. Progr Neuropsychopharmacol Biol Psychiatry 2011; 35: 1117\u20131121.","journal-title":"Progr Neuropsychopharmacol Biol Psychiatry"},{"key":"BFtp2017160_CR13","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/path.2440","volume":"216","author":"F Ponten","year":"2008","unstructured":"Ponten F, Jirstrom K, Uhlen M . The Human Protein Atlas\u2014a tool for pathology. J Pathol 2008; 216: 387\u2013393.","journal-title":"J Pathol"},{"key":"BFtp2017160_CR14","doi-asserted-by":"publisher","first-page":"4327","DOI":"10.1002\/pmic.200500072","volume":"5","author":"P Nilsson","year":"2005","unstructured":"Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC et al. Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling. Proteomics 2005; 5: 4327\u20134337.","journal-title":"Proteomics"},{"key":"BFtp2017160_CR15","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1074\/mcp.M112.026757","volume":"12","author":"B Ayoglu","year":"2013","unstructured":"Ayoglu B, Haggmark A, Khademi M, Olsson T, Uhlen M, Schwenk JM et al. Autoantibody profiling in multiple sclerosis using arrays of human protein fragments. Mol Cell Proteomics 2013; 12: 2657\u20132672.","journal-title":"Mol Cell Proteomics"},{"key":"BFtp2017160_CR16","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.neuropharm.2005.09.013","volume":"50","author":"S Ganzinelli","year":"2006","unstructured":"Ganzinelli S, Borda T, Sterin-Borda L . Regulation of m1 muscarinic receptors and nNOS mRNA levels by autoantibodies from schizophrenic patients. Neuropharmacology 2006; 50: 362\u2013371.","journal-title":"Neuropharmacology"},{"key":"BFtp2017160_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nri2529","volume":"9","author":"B Diamond","year":"2009","unstructured":"Diamond B, Huerta PT, Mina-Osorio P, Kowal C, Volpe BT . Losing your nerves? Maybe it's the antibodies. Nat Rev Immunol 2009; 9: 449\u2013456.","journal-title":"Nat Rev Immunol"},{"key":"BFtp2017160_CR18","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jns.2011.08.024","volume":"312","author":"P Loukaides","year":"2012","unstructured":"Loukaides P, Schiza N, Pettingill P, Palazis L, Vounou E, Vincent A et al. Morvan's syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex. J Neurol Sci 2012; 312: 52\u201356.","journal-title":"J Neurol Sci"},{"key":"BFtp2017160_CR19","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/art.23218","volume":"58","author":"JG Hanly","year":"2008","unstructured":"Hanly JG, Urowitz MB, Siannis F, Farewell V, Gordon C, Bae SC et al. Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study. Arthritis Rheum 2008; 58: 843\u2013853.","journal-title":"Arthritis Rheum"},{"key":"BFtp2017160_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1053\/beha.2000.0061","volume":"13","author":"AS Schneider","year":"2000","unstructured":"Schneider AS . Triosephosphate isomerase deficiency: historical perspectives and molecular aspects. Baillieres Best Pract Res Clin Haematol 2000; 13: 119\u2013140.","journal-title":"Baillieres Best Pract Res Clin Haematol"},{"key":"BFtp2017160_CR21","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1212\/WNL.0b013e3181dad590","volume":"74","author":"A Kimura","year":"2010","unstructured":"Kimura A, Kanoh Y, Sakurai T, Koumura A, Yamada M, Hayashi Y et al. Antibodies in patients with neuropsychiatric systemic lupus erythematosus. Neurology 2010; 74: 1372\u20131379.","journal-title":"Neurology"},{"key":"BFtp2017160_CR22","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1191\/0961203305lu2150rr","volume":"14","author":"T Eber","year":"2005","unstructured":"Eber T, Chapman J, Shoenfeld Y . Anti-ribosomal P-protein and its role in psychiatric manifestations of systemic lupus erythematosus: myth or reality? Lupus 2005; 14: 571\u2013575.","journal-title":"Lupus"},{"key":"BFtp2017160_CR23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1192\/bjp.169.5.555","volume":"169","author":"DB Pritchard","year":"1996","unstructured":"Pritchard DB, Harris B . Aspects of perinatal psychiatric illness. Br J Psychiatry 1996; 169: 555\u2013562.","journal-title":"Br J Psychiatry"},{"key":"BFtp2017160_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/08916934.2016.1183655","volume":"49","author":"A Haggmark-Manberg","year":"2016","unstructured":"Haggmark-Manberg A, Zandian A, Forsstrom B, Khademi M, Lima Bomfim I, Hellstrom C et al. Autoantibody targets in vaccine-associated narcolepsy. Autoimmunity 2016; 49: 421\u2013433.","journal-title":"Autoimmunity"},{"key":"BFtp2017160_CR25","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1073\/pnas.1518553113","volume":"113","author":"B Ayoglu","year":"2016","unstructured":"Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sjoberg R et al. Anoctamin 2 identified as an autoimmune target in multiple sclerosis. Proc Natl Acad Sci USA 2016; 113: 2188\u20132193.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2017160_CR26","doi-asserted-by":"publisher","first-page":"e96403","DOI":"10.1371\/journal.pone.0096403","volume":"9","author":"B Ayoglu","year":"2014","unstructured":"Ayoglu B, Szarka E, Huber K, Orosz A, Babos F, Magyar A et al. Bead arrays for antibody and complement profiling reveal joint contribution of antibody isotypes to C3 deposition. PLoS ONE 2014; 9: e96403.","journal-title":"PLoS ONE"},{"key":"BFtp2017160_CR27","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1021\/acs.jproteome.6b00916","volume":"16","author":"A Zandian","year":"2017","unstructured":"Zandian A, Forsstrom B, Haggmark-Manberg A, Schwenk JM, Uhlen M, Nilsson P et al. Whole-proteome peptide microarrays for profiling autoantibody repertoires within multiple sclerosis and narcolepsy. J Proteome Res 2017; 16: 1300\u20131314.","journal-title":"J Proteome Res"},{"key":"BFtp2017160_CR28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nbt0698-562","volume":"16","author":"P Berglund","year":"1998","unstructured":"Berglund P, Smerdou C, Fleeton MN, Tubulekas I, Liljestrom P . Enhancing immune responses using suicidal DNA vaccines. Nat Biotechnol 1998; 16: 562\u2013565.","journal-title":"Nat Biotechnol"},{"key":"BFtp2017160_CR29","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1128\/JVI.06535-11","volume":"86","author":"ML Knudsen","year":"2012","unstructured":"Knudsen ML, Mbewe-Mvula A, Rosario M, Johansson DX, Kakoulidou M, Bridgeman A et al. Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine. J Virol 2012; 86: 4082\u20134090.","journal-title":"J Virol"},{"key":"BFtp2017160_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/protein\/gzr058","volume":"25","author":"AA Gilmartin","year":"2012","unstructured":"Gilmartin AA, Lamp B, Rumenapf T, Persson MA, Rey FA, Krey T . High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells. Protein Eng Des Sel 2012; 25: 59\u201366.","journal-title":"Protein Eng Des Sel"},{"key":"BFtp2017160_CR31","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhlen","year":"2015","unstructured":"Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A et al. Tissue-based map of the human proteome. Science 2015; 347: 1260419.","journal-title":"Science"},{"key":"BFtp2017160_CR32","first-page":"e3620","volume":"63","author":"C Kampf","year":"2012","unstructured":"Kampf C, Olsson I, Ryberg U, Sj\u00f6stedt E, Ponten F . Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. J Vis Exp 2012; 63: e3620.","journal-title":"J Vis Exp"},{"key":"BFtp2017160_CR33","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang JH, Zhang Z, Miller W et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25: 3389\u20133402.","journal-title":"Nucleic Acids Res"},{"key":"BFtp2017160_CR34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","volume":"5","author":"R Ihaka","year":"1996","unstructured":"Ihaka R, Gentleman R . R: a language for data analysis and graphics. J Comput Graph Stat 1996; 5: 299\u2013314.","journal-title":"J Comput Graph Stat"},{"key":"BFtp2017160_CR35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.autrev.2013.12.002","volume":"13","author":"OJ Calixto","year":"2014","unstructured":"Calixto OJ, Anaya JM . Socioeconomic status. The relationship with health and autoimmune diseases. Autoimmun Rev 2014; 13: 641\u2013654.","journal-title":"Autoimmun Rev"},{"key":"BFtp2017160_CR36","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ebiom.2017.04.002","volume":"18","author":"R Hilker","year":"2017","unstructured":"Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM et al. Is an early age at illness onset in schizophrenia associated with increased genetic susceptibility? Analysis of data from the Nationwide Danish Twin Register. EBioMedicine 2017; 18: 320\u2013326.","journal-title":"EBioMedicine"},{"key":"BFtp2017160_CR37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","volume":"160","author":"P Brodin","year":"2015","unstructured":"Brodin P, Jojic V, Gao T, Bhattacharya S, Angel CJ, Furman D et al. Variation in the Human Immune System Is Largely Driven by Non-Heritable. Cell 2015; 160: 37\u201347.","journal-title":"Cell"},{"key":"BFtp2017160_CR38","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nature08186","volume":"460","author":"H Stefansson","year":"2009","unstructured":"Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D et al. Common variants conferring risk of schizophrenia. Nature 2009; 460: 744\u2013747.","journal-title":"Nature"},{"key":"BFtp2017160_CR39","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1399-0039.2007.00997.x","volume":"71","author":"MF Gjerstorff","year":"2008","unstructured":"Gjerstorff MF, Ditzel HJ . An overview of the GAGE cancer\/testis antigen family with the inclusion of newly identified members. Tissue Antigens 2008; 71: 187\u2013192.","journal-title":"Tissue Antigens"},{"key":"BFtp2017160_CR40","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nature11405","volume":"489","author":"MJ Hawrylycz","year":"2012","unstructured":"Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 2012; 489: 391\u2013399.","journal-title":"Nature"},{"key":"BFtp2017160_CR41","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nrn2722","volume":"10","author":"AR Jones","year":"2009","unstructured":"Jones AR, Overly CC, Sunkin SM . The Allen Brain Atlas: 5 years and beyond. Nat Rev Neurosci 2009; 10: 821\u2013828.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp2017160_CR42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/ncpneuro0033","volume":"1","author":"C Buckley","year":"2005","unstructured":"Buckley C, Vincent A . Autoimmune channelopathies. Nat Clin Pract Neurol 2005; 1: 22\u201333.","journal-title":"Nat Clin Pract Neurol"},{"key":"BFtp2017160_CR43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.1179220","volume":"190","author":"KV Toyka","year":"1975","unstructured":"Toyka KV, Brachman DB, Pestronk A, Kao I . Myasthenia gravis: passive transfer from man to mouse. Science 1975; 190: 397\u2013399.","journal-title":"Science"},{"key":"BFtp2017160_CR44","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1084\/jem.20050304","volume":"202","author":"VA Lennon","year":"2005","unstructured":"Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR . IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005; 202: 473\u2013477.","journal-title":"J Exp Med"},{"key":"BFtp2017160_CR45","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/nyas.12118","volume":"1283","author":"M Mitsdoerffer","year":"2013","unstructured":"Mitsdoerffer M, Kuchroo V, Korn T . Immunology of neuromyelitis optica: a T cell-B cell collaboration. Ann N Y Acad Sci 2013; 1283: 57\u201366.","journal-title":"Ann N Y Acad Sci"},{"key":"BFtp2017160_CR46","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0162-3109(97)00037-4","volume":"37","author":"I Leykin","year":"1997","unstructured":"Leykin I, Mayer R, Shinitzky M . Short and long-term immunosuppressive effects of clozapine and haloperidol. Immunopharmacology 1997; 37: 75\u201386.","journal-title":"Immunopharmacology"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp2017160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/tp.2017.160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:38:25Z","timestamp":1719344305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2017160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["BFtp2017160"],"URL":"https:\/\/doi.org\/10.1038\/tp.2017.160","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]},"assertion":[{"value":"25 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}