{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:03:22Z","timestamp":1776827002778,"version":"3.51.2"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2017.175","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T13:42:08Z","timestamp":1502804528000},"page":"e1206-e1206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse"],"prefix":"10.1038","volume":"7","author":[{"given":"T","family":"Seredenina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sorce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F R","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-J","family":"Ma Mulone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Plastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Aguzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Jaquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K-H","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"BFtp2017175_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pnpbp.2016.09.004","volume":"72","author":"J Data-Franco","year":"2017","unstructured":"Data-Franco J, Singh A, Popovic D, Ashton M, Berk M, Vieta E et al. Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology. Prog Neuro-psychopharmacol Biol Psychiatry 2017; 72: 73\u201386.","journal-title":"Prog Neuro-psychopharmacol Biol Psychiatry"},{"key":"BFtp2017175_CR2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2174\/138955711795906941","volume":"11","author":"TA Kato","year":"2011","unstructured":"Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y et al. Anti-Inflammatory properties of antipsychotics via microglia modulations: are antipsychotics a 'fire extinguisher' in the brain of schizophrenia? Mini Rev Med Chem 2011; 11: 565\u2013574.","journal-title":"Mini Rev Med Chem"},{"key":"BFtp2017175_CR3","doi-asserted-by":"crossref","unstructured":"Romano A, Serviddio G, Calcagnini S, Villani R, Giudetti AM, Cassano T et al. Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal. Free Radic Biol Med 2017.","DOI":"10.1016\/j.freeradbiomed.2016.12.046"},{"key":"BFtp2017175_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1503\/jpn.090083","volume":"35","author":"Y Che","year":"2010","unstructured":"Che Y, Wang JF, Shao L, Young T . Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness. J Psychiatry Neurosci 2010; 35: 296\u2013302.","journal-title":"J Psychiatry Neurosci"},{"key":"BFtp2017175_CR5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/jnc.12316","volume":"127","author":"AC Andreazza","year":"2013","unstructured":"Andreazza AC, Wang JF, Salmasi F, Shao L, Young LT . Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder. J Neurochem 2013; 127: 552\u2013561.","journal-title":"J Neurochem"},{"key":"BFtp2017175_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jad.2008.04.013","volume":"111","author":"AC Andreazza","year":"2008","unstructured":"Andreazza AC, Kauer-Sant'anna M, Frey BN, Bond DJ, Kapczinski F, Young LT et al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 2008; 111: 135\u2013144.","journal-title":"J Affect Disord"},{"key":"BFtp2017175_CR7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pnpbp.2012.07.013","volume":"39","author":"M Raffa","year":"2012","unstructured":"Raffa M, Barhoumi S, Atig F, Fendri C, Kerkeni A, Mechri A . Reduced antioxidant defense systems in schizophrenia and bipolar I disorder. Prog Neuro-psychopharmacol Biol Psychiatry 2012; 39: 371\u2013375.","journal-title":"Prog Neuro-psychopharmacol Biol Psychiatry"},{"key":"BFtp2017175_CR8","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1089\/ars.2010.3463","volume":"15","author":"R Gysin","year":"2011","unstructured":"Gysin R, Kraftsik R, Boulat O, Bovet P, Conus P, Comte-Krieger E et al. Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia. Antioxid Redox Signal 2011; 15: 2003\u20132010.","journal-title":"Antioxid Redox Signal"},{"key":"BFtp2017175_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1017\/S1461145710000805","volume":"14","author":"JW Gawryluk","year":"2011","unstructured":"Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT . Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders. Int J Neuropsychopharmacol 2011; 14: 123\u2013130.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFtp2017175_CR10","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1089\/ars.2012.4858","volume":"18","author":"A Kulak","year":"2013","unstructured":"Kulak A, Steullet P, Cabungcal JH, Werge T, Ingason A, Cuenod M et al. Redox dysregulation in the pathophysiology of schizophrenia and bipolar disorder: insights from animal models. Antioxid Redox Signal 2013; 18: 1428\u20131443.","journal-title":"Antioxid Redox Signal"},{"key":"BFtp2017175_CR11","doi-asserted-by":"publisher","first-page":"16621","DOI":"10.1073\/pnas.0706778104","volume":"104","author":"R Gysin","year":"2007","unstructured":"Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P et al. Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence. Proc Natl Acad Sci USA 2007; 104: 16621\u201316626.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2017175_CR12","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1086\/507566","volume":"79","author":"M Tosic","year":"2006","unstructured":"Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F et al. Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 2006; 79: 586\u2013592.","journal-title":"Am J Hum Genet"},{"key":"BFtp2017175_CR13","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.1046\/j.1460-9568.2000.00229.x","volume":"12","author":"KQ Do","year":"2000","unstructured":"Do KQ, Trabesinger AH, Kirsten-Kruger M, Lauer CJ, Dydak U, Hell D et al. Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci 2000; 12: 3721\u20133728.","journal-title":"Eur J Neurosci"},{"key":"BFtp2017175_CR14","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1089\/ars.2013.5703","volume":"20","author":"Z Nayernia","year":"2014","unstructured":"Nayernia Z, Jaquet V, Krause KH . New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal 2014; 20: 2815\u20132837.","journal-title":"Antioxid Redox Signal"},{"key":"BFtp2017175_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fnins.2015.00249","volume":"9","author":"L Scheuing","year":"2015","unstructured":"Scheuing L, Chiu CT, Liao HM, Chuang DM . Antidepressant mechanism of ketamine: perspective from preclinical studies. Front Neurosci 2015; 9: 249.","journal-title":"Front Neurosci"},{"key":"BFtp2017175_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.tips.2013.01.001","volume":"34","author":"M Berk","year":"2013","unstructured":"Berk M, Malhi GS, Gray LJ, Dean OM . The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol Sci 2013; 34: 167\u2013177.","journal-title":"Trends Pharmacol Sci"},{"issue":"7","key":"BFtp2017175_CR17","doi-asserted-by":"publisher","first-page":"research0034.1","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"Jo Vandesompele","year":"2002","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3.","journal-title":"Genome Biology"},{"key":"BFtp2017175_CR18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1182\/blood.V73.6.1686.1686","volume":"73","author":"AJ Verhoeven","year":"1989","unstructured":"Verhoeven AJ, Bolscher BG, Meerhof LJ, van Zwieten R, Keijer J, Weening RS et al. Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils. Blood 1989; 73: 1686\u20131694.","journal-title":"Blood"},{"key":"BFtp2017175_CR19","doi-asserted-by":"publisher","first-page":"e1004531","DOI":"10.1371\/journal.ppat.1004531","volume":"10","author":"S Sorce","year":"2014","unstructured":"Sorce S, Nuvolone M, Keller A, Falsig J, Varol A, Schwarz P et al. The role of the NADPH oxidase NOX2 in prion pathogenesis. PLoS Pathog 2014; 10: e1004531.","journal-title":"PLoS Pathog"},{"key":"BFtp2017175_CR20","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 2014; 34: 11929\u201311947.","journal-title":"J Neurosci"},{"key":"BFtp2017175_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2016.05.016","volume":"97","author":"T Seredenina","year":"2016","unstructured":"Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC et al. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biol Med 2016; 97: 95\u2013108.","journal-title":"Free Radical Biol Med"},{"key":"BFtp2017175_CR22","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1126\/science.1148045","volume":"318","author":"MM Behrens","year":"2007","unstructured":"Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL et al. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 2007; 318: 1645\u20131647.","journal-title":"Science"},{"key":"BFtp2017175_CR23","doi-asserted-by":"publisher","first-page":"13957","DOI":"10.1523\/JNEUROSCI.4457-08.2008","volume":"28","author":"MM Behrens","year":"2008","unstructured":"Behrens MM, Ali SS, Dugan LL . Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J Neurosci 2008; 28: 13957\u201313966.","journal-title":"J Neurosci"},{"key":"BFtp2017175_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0079-6123(06)58001-X","volume":"158","author":"MJ Webster","year":"2006","unstructured":"Webster MJ . Tissue preparation and banking. Prog Brain Res 2006; 158: 3\u201314.","journal-title":"Prog Brain Res"},{"key":"BFtp2017175_CR25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1034\/j.1600-0609.2000.065006407.x","volume":"65","author":"JB Burritt","year":"2000","unstructured":"Burritt JB, Fritel GN, Dahan I, Pick E, Roos D, Jesaitis AJ . Epitope identification for human neutrophil flavocytochrome b monoclonals 48 and 449. Eur J Haematol 2000; 65: 407\u2013413.","journal-title":"Eur J Haematol"},{"key":"BFtp2017175_CR26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/cei.12202","volume":"175","author":"D Roos","year":"2014","unstructured":"Roos D, de Boer M . Molecular diagnosis of chronic granulomatous disease. Clin Exp Immunol 2014; 175: 139\u2013149.","journal-title":"Clin Exp Immunol"},{"key":"BFtp2017175_CR27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s004010000284","volume":"101","author":"M Mittelbronn","year":"2001","unstructured":"Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R . Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol 2001; 101: 249\u2013255.","journal-title":"Acta Neuropathol"},{"key":"BFtp2017175_CR28","first-page":"331","volume":"20","author":"TA Kato","year":"2013","unstructured":"Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y et al. Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry. Curr Med Chem 2013; 20: 331\u2013344.","journal-title":"Curr Med Chem"},{"key":"BFtp2017175_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0006-8993(03)03364-X","volume":"988","author":"F Serrano","year":"2003","unstructured":"Serrano F, Kolluri NS, Wientjes FB, Card JP, Klann E . NADPH oxidase immunoreactivity in the mouse brain. Brain Res 2003; 988: 193\u2013198.","journal-title":"Brain Res"},{"key":"BFtp2017175_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","volume":"8","author":"JE Le Belle","year":"2011","unstructured":"Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD et al. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner. Cell Stem Cell 2011; 8: 59\u201371.","journal-title":"Cell Stem Cell"},{"key":"BFtp2017175_CR31","doi-asserted-by":"publisher","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","volume":"113","author":"ML Bennett","year":"2016","unstructured":"Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci USA 2016; 113: E1738\u2013E1746.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2017175_CR32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nchembio.497","volume":"7","author":"BC Dickinson","year":"2011","unstructured":"Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ . Nox2 redox signaling maintains essential cell populations in the brain. Nat Chem Biol 2011; 7: 106\u2013112.","journal-title":"Nat Chem Biol"},{"key":"BFtp2017175_CR33","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.celrep.2016.12.066","volume":"18","author":"JM Spaethling","year":"2017","unstructured":"Spaethling JM, Na YJ, Lee J, Ulyanova AV, Baltuch GH, Bell TJ et al. Primary cell culture of live neurosurgically resected aged adult human brain cells and single cell transcriptomics. Cell Rep 2017; 18: 791\u2013803.","journal-title":"Cell Rep"},{"key":"BFtp2017175_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12974-016-0503-0","volume":"13","author":"J Rustenhoven","year":"2016","unstructured":"Rustenhoven J, Aalderink M, Scotter EL, Oldfield RL, Bergin PS, Mee EW et al. TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function. J Neuroinflamm 2016; 13: 37.","journal-title":"J Neuroinflamm"},{"key":"BFtp2017175_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/18715265112129990032","volume":"13","author":"J Suvisaari","year":"2013","unstructured":"Suvisaari J, Mantere O . Inflammation theories in psychotic disorders: a critical review. Infect Disord Drug Targets 2013; 13: 59\u201370.","journal-title":"Infect Disord Drug Targets"},{"key":"BFtp2017175_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.schres.2014.06.021","volume":"176","author":"P Steullet","year":"2016","unstructured":"Steullet P, Cabungcal JH, Monin A, Dwir D, O'Donnell P, Cuenod M et al. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a \"central hub\" in schizophrenia pathophysiology? Schizophr Res 2016; 176: 41\u201351.","journal-title":"Schizophr Res"},{"key":"BFtp2017175_CR37","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1089\/ars.2012.4907","volume":"18","author":"X Wang","year":"2013","unstructured":"Wang X, Pinto-Duarte A, Sejnowski TJ, Behrens MM . How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia. Antioxid Redox Signal 2013; 18: 1444\u20131462.","journal-title":"Antioxid Redox Signal"},{"key":"BFtp2017175_CR38","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1007\/s00018-007-7079-x","volume":"64","author":"G Rosenberg","year":"2007","unstructured":"Rosenberg G . The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci 2007; 64: 2090\u20132103.","journal-title":"Cell Mol Life Sci"},{"key":"BFtp2017175_CR39","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.nbd.2010.08.024","volume":"41","author":"HM Gibbons","year":"2011","unstructured":"Gibbons HM, Smith AM, Teoh HH, Bergin PM, Mee EW, Faull RL et al. Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures. Neurobiol Dis 2011; 41: 96\u2013103.","journal-title":"Neurobiol Dis"},{"key":"BFtp2017175_CR40","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.neuroscience.2006.02.065","volume":"140","author":"M Dragunow","year":"2006","unstructured":"Dragunow M, Greenwood JM, Cameron RE, Narayan PJ, O'Carroll SJ, Pearson AG et al. Valproic acid induces caspase 3-mediated apoptosis in microglial cells. Neuroscience 2006; 140: 1149\u20131156.","journal-title":"Neuroscience"},{"key":"BFtp2017175_CR41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0306-3623(85)90210-1","volume":"16","author":"C Almodovar-Cuevas","year":"1985","unstructured":"Almodovar-Cuevas C, Navarro-Ruiz A, Bastidas-Ramirez BE, Mora-Navarro MR, Garzon P . Valproic acid effects on leukocytes and platelets of Sprague\u2013Dawley rats. Gen Pharmacol 1985; 16: 423\u2013426.","journal-title":"Gen Pharmacol"},{"key":"BFtp2017175_CR42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12888-016-0732-x","volume":"16","author":"KJ Oedegaard","year":"2016","unstructured":"Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH et al. The pharmacogenomics of bipolar disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry 2016; 16: 129.","journal-title":"BMC Psychiatry"},{"key":"BFtp2017175_CR43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1124\/jpet.116.234476","volume":"358","author":"Y Nakagawa","year":"2016","unstructured":"Nakagawa Y, Chiba K . Involvement of neuroinflammation during brain development in social cognitive deficits in autism spectrum disorder and schizophrenia. J Pharmacol Exp Ther 2016; 358: 504\u2013515.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFtp2017175_CR44","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2010.03.055","volume":"141","author":"SK Chen","year":"2010","unstructured":"Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G et al. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 2010; 141: 775\u2013785.","journal-title":"Cell"},{"key":"BFtp2017175_CR45","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nrn3722","volume":"15","author":"M Prinz","year":"2014","unstructured":"Prinz M, Priller J . Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 2014; 15: 300\u2013312.","journal-title":"Nat Rev Neurosci"},{"key":"BFtp2017175_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.brainres.2014.11.032","volume":"1617","author":"PM Bilimoria","year":"2015","unstructured":"Bilimoria PM, Stevens B . Microglia function during brain development: new insights from animal models. Brain Res 2015; 1617: 7\u201317.","journal-title":"Brain Res"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp2017175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017175","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/tp.2017.175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T17:03:02Z","timestamp":1671728582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2017175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"alternative-id":["BFtp2017175"],"URL":"https:\/\/doi.org\/10.1038\/tp.2017.175","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]},"assertion":[{"value":"20 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"VJ and KHK hold shares in Genkyotex SA, a company developing NOX inhibitors. The remaining authors declare no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}