{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:58Z","timestamp":1791296698753,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/tp.2017.180","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T13:42:08Z","timestamp":1502804528000},"page":"e1204-e1204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder"],"prefix":"10.1038","volume":"7","author":[{"given":"H T","family":"Karim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Tudorascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Butters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Aizenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Andreescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"BFtp2017180_CR1","first-page":"29","volume-title":"Chronic Anxiety: Generalized Anxiety Disorder and Mixed Anxiety-Depression","author":"TD Borkovec","year":"1991","unstructured":"Borkovec TD, Shadick RN, Hopkins M . The nature of normal and pathological worry. In: Rappe RM, Barlow DH (eds). Chronic Anxiety: Generalized Anxiety Disorder and Mixed Anxiety-Depression. Guilford: New York, NY, 1991, pp 29\u201351."},{"key":"BFtp2017180_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/da.20493","volume":"25","author":"DS Mennin","year":"2008","unstructured":"Mennin DS, Heimberg RG, Fresco DM, Ritter MR . Is generalized anxiety disorder an anxiety or mood disorder? Considering multiple factors as we ponder the fate of GAD. Depress Anxiety 2008; 25: 289\u2013299.","journal-title":"Depress Anxiety"},{"key":"BFtp2017180_CR3","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/13607863.2011.583621","volume":"15","author":"J Golden","year":"2011","unstructured":"Golden J, Conroy RM, Bruce I, Denihan A, Greene E, Kirby M et al. The spectrum of worry in the community-dwelling elderly. Aging Ment Health 2011; 15: 985\u2013994.","journal-title":"Aging Ment Health"},{"key":"BFtp2017180_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.amjcard.2016.05.041","volume":"118","author":"CA Emdin","year":"2016","unstructured":"Emdin CA, Odutayo A, Wong CX, Tran J, Hsiao AJ, Hunn BH . Meta-analysis of anxiety as a risk factor for cardiovascular disease. Am J Cardiol 2016; 118: 511\u2013519.","journal-title":"Am J Cardiol"},{"key":"BFtp2017180_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1192\/bjp.bp.114.156554","volume":"208","author":"NM Batelaan","year":"2016","unstructured":"Batelaan NM, Seldenrijk A, Bot M, van Balkom AJ, Penninx BW . Anxiety and new onset of cardiovascular disease: critical review and meta-analysis. Br J Psychiatry 2016; 208: 223\u2013231.","journal-title":"Br J Psychiatry"},{"key":"BFtp2017180_CR6","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.jclinepi.2008.08.006","volume":"62","author":"J Denollet","year":"2009","unstructured":"Denollet J, Maas K, Knottnerus A, Keyzer JJ, Pop VJ . Anxiety predicted premature all-cause and cardiovascular death in a 10-year follow-up of middle-aged women. J Clin Epidemiol 2009; 62: 452\u2013456.","journal-title":"J Clin Epidemiol"},{"key":"BFtp2017180_CR7","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1161\/STROKEAHA.113.003741","volume":"45","author":"MJ Lambiase","year":"2014","unstructured":"Lambiase MJ, Kubzansky LD, Thurston RC . Prospective study of anxiety and incident stroke. Stroke 2014; 45: 438\u2013443.","journal-title":"Stroke"},{"key":"BFtp2017180_CR8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1001\/archgenpsychiatry.2010.74","volume":"67","author":"EJ Martens","year":"2010","unstructured":"Martens EJ, de Jonge P, Na B, Cohen BE, Lett H, Whooley MA . Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010; 67: 750\u2013758.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2017180_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1161\/01.CIR.95.4.818","volume":"95","author":"LD Kubzansky","year":"1997","unstructured":"Kubzansky LD, Kawachi I, Spiro A 3rd, Weiss ST, Vokonas PS, Sparrow D . Is worrying bad for your heart? A prospective study of worry and coronary heart disease in the Normative Aging Study. Circulation 1997; 95: 818\u2013824.","journal-title":"Circulation"},{"key":"BFtp2017180_CR10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jagp.2016.05.015","volume":"24","author":"B Gulpers","year":"2016","unstructured":"Gulpers B, Ramakers I, Hamel R, Kohler S, Oude Voshaar R, Verhey F . Anxiety as a predictor for cognitive decline and dementia: a systematic review and meta-analysis. Am J Geriatr Psychiatry 2016; 24: 823\u2013842.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR11","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jagp.2013.01.006","volume":"21","author":"PB Rosenberg","year":"2013","unstructured":"Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG . The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry 2013; 21: 685\u2013695.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR12","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jagp.2012.09.010","volume":"22","author":"C Andreescu","year":"2014","unstructured":"Andreescu C, Teverovsky E, Fu B, Hughes TF, Chang CC, Ganguli M . Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. Am J Geriatr Psychiatry 2014; 22: 274\u2013284.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR13","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.janxdis.2010.04.003","volume":"24","author":"K Yook","year":"2010","unstructured":"Yook K, Kim KH, Suh SY, Lee KS . Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. J Anxiety Disord 2010; 24: 623\u2013628.","journal-title":"J Anxiety Disord"},{"key":"BFtp2017180_CR14","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1001\/archpsyc.65.5.568","volume":"65","author":"CS Monk","year":"2008","unstructured":"Monk CS, Telzer EH, Mogg K, Bradley BP, Mai X, Louro HM et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 2008; 65: 568\u2013576.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2017180_CR15","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jaac.2012.12.010","volume":"52","author":"AK Roy","year":"2013","unstructured":"Roy AK, Fudge JL, Kelly C, Perry JS, Daniele T, Carlisi C et al. Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder. J Am Acad Child Adoles Psychiatry 2013; 52: 290\u20139 e2.","journal-title":"J Am Acad Child Adoles Psychiatry"},{"key":"BFtp2017180_CR16","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.biopsych.2012.04.013","volume":"72","author":"KS Blair","year":"2012","unstructured":"Blair KS, Geraci M, Smith BW, Hollon N, DeVido J, Otero M et al. Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia\/generalized anxiety disorder. Biol Psychiatry 2012; 72: 476\u2013482.","journal-title":"Biol Psychiatry"},{"key":"BFtp2017180_CR17","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1001\/archgenpsychiatry.2009.104","volume":"66","author":"A Etkin","year":"2009","unstructured":"Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD . Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 2009; 66: 1361\u20131372.","journal-title":"Arch Gen Psychiatry"},{"key":"BFtp2017180_CR18","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/da.20799","volume":"28","author":"C Andreescu","year":"2011","unstructured":"Andreescu C, Gross JJ, Lenze E, Edelman KD, Snyder S, Tanase C et al. Altered cerebral blood flow patterns associated with pathologic worry in the elderly. Depress Anxiety 2011; 28: 202\u2013209.","journal-title":"Depress Anxiety"},{"key":"BFtp2017180_CR19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jagp.2014.05.003","volume":"23","author":"C Andreescu","year":"2015","unstructured":"Andreescu C, Sheu LK, Tudorascu D, Gross JJ, Walker S, Banihashemi L et al. Emotion reactivity and regulation in late-life generalized anxiety disorder: functional connectivity at baseline and post-treatment. Am J Geriatr Psychiatry 2015; 23: 200\u2013214.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR20","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jad.2014.06.041","volume":"167","author":"MD Mochcovitch","year":"2014","unstructured":"Mochcovitch MD, da Rocha Freire RC, Garcia RF, Nardi AE . A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis. J Affect Disord 2014; 167: 336\u2013342.","journal-title":"J Affect Disord"},{"key":"BFtp2017180_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1017\/S0033291709005649","volume":"40","author":"E Paulesu","year":"2010","unstructured":"Paulesu E, Sambugaro E, Torti T, Danelli L, Ferri F, Scialfa G et al. Neural correlates of worry in generalized anxiety disorder and in normal controls: a functional MRI study. Psychol Med 2010; 40: 117\u2013124.","journal-title":"Psychol Med"},{"key":"BFtp2017180_CR22","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1162\/jocn_a_00512","volume":"26","author":"J Bijsterbosch","year":"2014","unstructured":"Bijsterbosch J, Smith S, Forster S, John OP, Bishop SJ . Resting state correlates of subdimensions of anxious affect. J Cogn Neurosci 2014; 26: 914\u2013926.","journal-title":"J Cogn Neurosci"},{"key":"BFtp2017180_CR23","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/cercor\/bht248","volume":"25","author":"S Forster","year":"2015","unstructured":"Forster S, Nunez Elizalde AO, Castle E, Bishop SJ . Unraveling the anxious mind: anxiety, worry, and frontal engagement in sustained attention versus off-task processing. Cereb Cortex 2015; 25: 609\u2013618.","journal-title":"Cereb Cortex"},{"key":"BFtp2017180_CR24","volume-title":"Worrying: Perspectives on Theory, Assessment, and Treatment","author":"TD Borkovec","year":"1994","unstructured":"Borkovec TD . The nature, functions, and origins of worry. In: Tallis GDF (ed). Worrying: Perspectives on Theory, Assessment, and Treatment. Wiley & Sons: Sussex, England, 1994."},{"key":"BFtp2017180_CR25","volume-title":"The Meaning of Anxiety","author":"R May","year":"1996","unstructured":"May R . The Meaning of Anxiety. W.W. Norton & Co: New York, NY, 1996."},{"key":"BFtp2017180_CR26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1037\/0021-843X.110.3.413","volume":"110","author":"AM Ruscio","year":"2001","unstructured":"Ruscio AM, Borkovec TD, Ruscio J . A taxometric investigation of the latent structure of worry. J Abnorm Psychol 2001; 110: 413\u2013422.","journal-title":"J Abnorm Psychol"},{"key":"BFtp2017180_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.beth.2009.03.001","volume":"41","author":"BO Olatunji","year":"2010","unstructured":"Olatunji BO, Broman-Fulks JJ, Bergman SM, Green BA, Zlomke KR . A taxometric investigation of the latent structure of worry: dimensionality and associations with depression, anxiety, and stress. Behav Ther 2010; 41: 212\u2013228.","journal-title":"Behav Ther"},{"key":"BFtp2017180_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/gps.3788","volume":"28","author":"DC Goncalves","year":"2013","unstructured":"Goncalves DC, Byrne GJ . Who worries most? Worry prevalence and patterns across the lifespan. Int J Geriatr Psychiatry 2013; 28: 41\u201349.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFtp2017180_CR29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.janxdis.2013.01.008","volume":"27","author":"A Tsypes","year":"2013","unstructured":"Tsypes A, Aldao A, Mennin DS . Emotion dysregulation and sleep difficulties in generalized anxiety disorder. J Anxiety Disord 2013; 27: 197\u2013203.","journal-title":"J Anxiety Disord"},{"key":"BFtp2017180_CR30","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.janxdis.2009.04.006","volume":"23","author":"DS Mennin","year":"2009","unstructured":"Mennin DS, McLaughlin KA, Flanagan TJ . Emotion regulation deficits in generalized anxiety disorder, social anxiety disorder, and their co-occurrence. J Anxiety Disord 2009; 23: 866\u2013871.","journal-title":"J Anxiety Disord"},{"key":"BFtp2017180_CR31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1017\/S0048577201393198","volume":"39","author":"JJ Gross","year":"2002","unstructured":"Gross JJ . Emotion regulation: affective, cognitive, and social consequences. Psychophysiology 2002; 39: 281\u2013291.","journal-title":"Psychophysiology"},{"key":"BFtp2017180_CR32","volume-title":"Handbook of Emotion Regulation","author":"JJ Gross","year":"2007","unstructured":"Gross JJ, Thompson RA . Emotion regulation: conceptual foundations. In: Gross JJ (ed). Handbook of Emotion Regulation. Guilford Press: New York, NY, 2007."},{"key":"BFtp2017180_CR33","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jagp.2014.05.003","volume":"23","author":"C Andreescu","year":"2015","unstructured":"Andreescu C, Sheu LK, Tudorascu D, Gross JJ, Walker S, Banihashemi L et al. Emotion reactivity and regulation in late-life generalized anxiety disorder: functional connectivity at baseline and post-treatment. Am J Geriatr Psychiatry 2015; 23: 200\u2013214.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR34","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.mri.2007.07.003","volume":"26","author":"Z Wang","year":"2008","unstructured":"Wang Z, Aguirre GK, Rao H, Wang J, Fernandez-Seara MA, Childress AR et al. Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx. Magn Reson Imaging 2008; 26: 261\u2013269.","journal-title":"Magn Reson Imaging"},{"key":"BFtp2017180_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0005-7967(90)90135-6","volume":"28","author":"TJ Meyer","year":"1990","unstructured":"Meyer TJ, Miller ML, Metzger RL, Borkovec TD . Development and validation of the Penn State Worry questionnaire. Behav Res Therapy 1990; 28: 487\u2013495.","journal-title":"Behav Res Therapy"},{"key":"BFtp2017180_CR36","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0165-1781(92)90005-N","volume":"41","author":"MD Miller","year":"1992","unstructured":"Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH et al. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 1992; 41: 237\u2013248.","journal-title":"Psychiatry Res"},{"key":"BFtp2017180_CR37","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","volume":"20","author":"C Randolph","year":"1998","unstructured":"Randolph C, Tierney MC, Mohr E, Chase TN . The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998; 20: 310\u2013319.","journal-title":"J Clin Exp Neuropsychol."},{"key":"BFtp2017180_CR38","volume-title":"Delis Kaplan Executive Function System Examiner's Manual","author":"DC Delis","year":"2001","unstructured":"Delis DC, Kaplan E, Kramer JH . Delis Kaplan Executive Function System Examiner's Manual. The Psychological Corporation: San Antonio, TX, 2001."},{"key":"BFtp2017180_CR39","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.mri.2012.05.004","volume":"30","author":"Z Wang","year":"2012","unstructured":"Wang Z . Improving cerebral blood flow quantification for arterial spin labeled perfusion MRI by removing residual motion artifacts and global signal fluctuations. Magn Reson Imaging 2012; 30: 1409\u20131415.","journal-title":"Magn Reson Imaging"},{"key":"BFtp2017180_CR40","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/01.JGP.0000218325.76196.d1","volume":"14","author":"AY Dombrovski","year":"2006","unstructured":"Dombrovski AY, Blakesley-Ball RE, Mulsant BH, Mazumdar S, Houck PR, Szanto K et al. Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age. Am J Geriatr Psychiatry 2006; 14: 550\u2013554.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR41","doi-asserted-by":"publisher","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","volume":"8","author":"M Xia","year":"2013","unstructured":"Xia M, Wang J, He Y . BrainNet Viewer: a network visualization tool for human brain connectomics. PLoS ONE 2013; 8: e68910.","journal-title":"PLoS ONE"},{"key":"BFtp2017180_CR42","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.1073\/pnas.1602413113","volume":"113","author":"A Eklund","year":"2016","unstructured":"Eklund A, Nichols TE, Knutsson H . Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci USA 2016; 113: 7900\u20137905.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFtp2017180_CR43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1017\/S0140525X11000446","volume":"35","author":"KA Lindquist","year":"2012","unstructured":"Lindquist KA, Wager TD, Kober H, Bliss-Moreau E, Barrett LF . The brain basis of emotion: a meta-analytic review. Behav Brain Sci 2012; 35: 121\u2013143.","journal-title":"Behav Brain Sci"},{"key":"BFtp2017180_CR44","doi-asserted-by":"publisher","first-page":"4303","DOI":"10.1002\/hbm.22476","volume":"35","author":"MN Servaas","year":"2014","unstructured":"Servaas MN, Riese H, Ormel J, Aleman A . The neural correlates of worry in association with individual differences in neuroticism. Hum Brain Mapp 2014; 35: 4303\u20134315.","journal-title":"Hum Brain Mapp"},{"key":"BFtp2017180_CR45","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1037\/a0024947","volume":"121","author":"CR Hirsch","year":"2012","unstructured":"Hirsch CR, Hayes S, Mathews A, Perman G, Borkovec T . The extent and nature of imagery during worry and positive thinking in generalized anxiety disorder. J Abnorm Psychol 2012; 121: 238\u2013243.","journal-title":"J Abnorm Psychol"},{"key":"BFtp2017180_CR46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/10615800801998914","volume":"22","author":"E Walkenhorst","year":"2009","unstructured":"Walkenhorst E, Crowe SF . The effect of state worry and trait anxiety on working memory processes in a normal sample. Anxiety Stress Coping 2009; 22: 167\u2013187.","journal-title":"Anxiety Stress Coping"},{"key":"BFtp2017180_CR47","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pscychresns.2015.08.013","volume":"234","author":"C Andreescu","year":"2015","unstructured":"Andreescu C, Mennin D, Tudorascu D, Sheu LK, Walker S, Banihashemi L et al. The many faces of anxiety-neurobiological correlates of anxiety phenotypes. Psychiatry Res 2015; 234: 96\u2013105.","journal-title":"Psychiatry Res"},{"key":"BFtp2017180_CR48","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1162\/jocn.2009.21366","volume":"22","author":"K Vytal","year":"2010","unstructured":"Vytal K, Hamann S . Neuroimaging support for discrete neural correlates of basic emotions: a voxel-based meta-analysis. J Cogn Neurosci 2010; 22: 2864\u20132885.","journal-title":"J Cogn Neurosci"},{"key":"BFtp2017180_CR49","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.neuron.2008.09.006","volume":"59","author":"TD Wager","year":"2008","unstructured":"Wager TD, Davidson ML, Hughes BL, Lindquist MA, Ochsner KN . Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron 2008; 59: 1037\u20131050.","journal-title":"Neuron"},{"key":"BFtp2017180_CR50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00406-014-0510-z","volume":"265","author":"S Opialla","year":"2015","unstructured":"Opialla S, Lutz J, Scherpiet S, Hittmeyer A, Jancke L, Rufer M et al. Neural circuits of emotion regulation: a comparison of mindfulness-based and cognitive reappraisal strategies. Eur Arch Psychiatry Clin Neurosci 2015; 265: 45\u201355.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"BFtp2017180_CR51","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.pscychresns.2015.10.009","volume":"234","author":"K Hilbert","year":"2015","unstructured":"Hilbert K, Pine DS, Muehlhan M, Lueken U, Steudte-Schmiedgen S, Beesdo-Baum K . Gray and white matter volume abnormalities in generalized anxiety disorder by categorical and dimensional characterization. Psychiatry Res 2015; 234: 314\u2013320.","journal-title":"Psychiatry Res"},{"issue":"1","key":"BFtp2017180_CR52","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/0284185116633915","volume":"58","author":"Chung-Man Moon","year":"2016","unstructured":"Moon CM, Yang JC, Jeong GW . Functional neuroanatomy associated with the interaction between emotion and cognition in explicit memory tasks in patients with generalized anxiety disorder. Acta Radiol 2016; 58: 98-106.","journal-title":"Acta Radiologica"},{"key":"BFtp2017180_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/gps.2074","volume":"24","author":"EJ Lenze","year":"2009","unstructured":"Lenze EJ, Wetherell JL . Bringing the bedside to the bench, and then to the community: a prospectus for intervention research in late-life anxiety disorders. Int J Geriatr Psychiatry 2009; 24: 1\u201314.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFtp2017180_CR54","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/JGP.0b013e31818b3f7e","volume":"17","author":"SR Thorp","year":"2009","unstructured":"Thorp SR, Ayers CR, Nuevo R, Stoddard JA, Sorrell JT, Wetherell JL . Meta-analysis comparing different behavioral treatments for late-life anxiety. Am J Geriatr Psychiatry 2009; 17: 105\u2013115.","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFtp2017180_CR55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nrn4044","volume":"16","author":"A Etkin","year":"2015","unstructured":"Etkin A, Buchel C, Gross JJ . The neural bases of emotion regulation. Nat Neurosci 2015; 16: 693\u2013700.","journal-title":"Nat Neurosci"},{"key":"BFtp2017180_CR56","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1080\/02699931.2010.544160","volume":"25","author":"A Gyurak","year":"2011","unstructured":"Gyurak A, Gross JJ, Etkin A . Explicit and implicit emotion regulation: a dual-process framework. Cogn Emot 2011; 25: 400\u2013412.","journal-title":"Cogn Emot"},{"key":"BFtp2017180_CR57","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/da.22377","volume":"32","author":"DS Mennin","year":"2015","unstructured":"Mennin DS, Fresco DM, Ritter M, Heimberg RG . An open trial of emotion regulation therapy for generalized anxiety disorder and cooccurring depression. Depress Anxiety 2015; 32: 614\u2013623.","journal-title":"Depress Anxiety"},{"key":"BFtp2017180_CR58","doi-asserted-by":"publisher","first-page":"8877","DOI":"10.1523\/JNEUROSCI.2063-07.2007","volume":"27","author":"T Johnstone","year":"2007","unstructured":"Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ . Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. J Neurosci 2007; 27: 8877\u20138884.","journal-title":"J Neurosci"},{"key":"BFtp2017180_CR59","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/scan\/nsq103","volume":"7","author":"K McRae","year":"2012","unstructured":"McRae K, Misra S, Prasad AK, Pereira SC, Gross JJ . Bottom-up and top-down emotion generation: implications for emotion regulation. Soc Cogn Affect Neurosci 2012; 7: 253\u2013262.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFtp2017180_CR60","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1192\/bjp.bp.110.090217","volume":"199","author":"MA Butters","year":"2011","unstructured":"Butters MA, Bhalla RK, Andreescu C, Wetherell JL, Mantella R, Begley AE et al. Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder. Br J Psychiatry 2011; 199: 211\u2013218.","journal-title":"Br J Psychiatry"},{"key":"BFtp2017180_CR61","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/bjc.12080","volume":"55","author":"B Miloyan","year":"2016","unstructured":"Miloyan B, Bulley A, Suddendorf T . Episodic foresight and anxiety: Proximate and ultimate perspectives. Br J Clin Psychol 2016; 55: 4\u201322.","journal-title":"Br J Clin Psychol"},{"key":"BFtp2017180_CR62","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/187152711796234943","volume":"10","author":"F Paes","year":"2011","unstructured":"Paes F, Machado S, Arias-Carrion O, Velasques B, Teixeira S, Budde H et al. The value of repetitive transcranial magnetic stimulation (rTMS) for the treatment of anxiety disorders: an integrative review. CNS Neurol Disord Drug Targets 2011; 10: 610\u2013620.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFtp2017180_CR63","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/jmri.20451","volume":"22","author":"JR Ewing","year":"2005","unstructured":"Ewing JR, Cao Y, Knight RA, Fenstermacher JD . Arterial spin labeling: validity testing and comparison studies. J Magn Reson Imaging 2005; 22: 737\u2013740.","journal-title":"J Magn Reson Imaging"},{"key":"BFtp2017180_CR64","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.mri.2007.10.008","volume":"26","author":"JE Perthen","year":"2008","unstructured":"Perthen JE, Bydder M, Restom K, Liu TT . SNR and functional sensitivity of BOLD and perfusion-based fMRI using arterial spin labeling with spiral SENSE at 3T. Magn Reson Imaging 2008; 26: 513\u2013522.","journal-title":"Magn Reson Imaging"}],"updated-by":[{"DOI":"10.1038\/tp.2017.215","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000}}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/tp2017180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017180","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/tp.2017.180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/tp2017180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T17:02:53Z","timestamp":1671728573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tp2017180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":64,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"alternative-id":["BFtp2017180"],"URL":"https:\/\/doi.org\/10.1038\/tp.2017.180","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]},"assertion":[{"value":"28 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}