{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:31:25Z","timestamp":1787290285864,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1038\/tpj.2014.19","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T10:00:10Z","timestamp":1398765610000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Associations between functional polymorphisms in the NF\u03baB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease"],"prefix":"10.1038","volume":"14","author":[{"given":"S","family":"Bank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Burisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Roug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Galsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Y","family":"Turino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Brodersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B K","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Avlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T B","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V \u00d8","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Frydenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Nex\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-9320","authenticated-orcid":false,"given":"J","family":"Sode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,29]]},"reference":[{"key":"BFtpj201419_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJMra020831","volume":"347","author":"DK Podolsky","year":"2002","unstructured":"Podolsky DK . Inflammatory bowel disease. N Engl J Med 2002; 347: 417\u2013429.","journal-title":"N Engl J Med"},{"key":"BFtpj201419_CR2","unstructured":"http:\/\/www.bu.edu\/nf-kb\/gene-resources\/target-genes\/ ."},{"key":"BFtpj201419_CR3","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1007\/s00018-008-8064-8","volume":"65","author":"L Verstrepen","year":"2008","unstructured":"Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R . TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci 2008; 65: 2964\u20132978.","journal-title":"Cell Mol Life Sci"},{"key":"BFtpj201419_CR4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/clinchem\/47.7.1297","volume":"47","author":"M Komatsu","year":"2001","unstructured":"Komatsu M, Kobayashi D, Saito K, Furuya D, Yagihashi A, Araake H et al. Tumor necrosis factor-alpha in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR. Clin Chem 2001; 47: 1297\u20131301.","journal-title":"Clin Chem"},{"key":"BFtpj201419_CR5","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1023\/A:1018895500721","volume":"42","author":"S Dionne","year":"1997","unstructured":"Dionne S, Hiscott J, D'Agata I, Duhaime A, Seidman EG . Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci 1997; 42: 1557\u20131566.","journal-title":"Dig Dis Sci"},{"key":"BFtpj201419_CR6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/MCG.0b013e31828a6e93","volume":"47","author":"NK Meena","year":"2013","unstructured":"Meena NK, Verma R, Verma N, Ahuja V, Paul J . TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis. J Clin Gastroenterol 2013; 47: 773\u2013780.","journal-title":"J Clin Gastroenterol"},{"key":"BFtpj201419_CR7","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/0161-5890(93)90106-L","volume":"30","author":"DM Knight","year":"1993","unstructured":"Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 1993; 30: 1443\u20131453.","journal-title":"Mol Immunol"},{"key":"BFtpj201419_CR8","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1056\/NEJMoa050516","volume":"353","author":"P Rutgeerts","year":"2005","unstructured":"Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462\u20132476.","journal-title":"N Engl J Med"},{"key":"BFtpj201419_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/sj.tpj.6500091","volume":"2","author":"S Mascheretti","year":"2002","unstructured":"Mascheretti S, Hampe J, Kuhbacher T, Herfarth H, Krawczak M, Folsch UR et al. Pharmacogenetic investigation of the TNF\/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab. Pharmacogenomics J 2002; 2: 127\u2013136.","journal-title":"Pharmacogenomics J"},{"key":"BFtpj201419_CR10","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1136\/gut.2003.018515","volume":"53","author":"T Ljung","year":"2004","unstructured":"Ljung T, Karlen P, Schmidt D, Hellstrom PM, Lapidus A, Janczewska I et al. Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County. Gut 2004; 53: 849\u2013853.","journal-title":"Gut"},{"key":"BFtpj201419_CR11","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.cgh.2008.05.010","volume":"6","author":"S Caspersen","year":"2008","unstructured":"Caspersen S, Elkjaer M, Riis L, Pedersen N, Mortensen C, Jess T et al. Infliximab for inflammatory bowel disease in Denmark 1999-2005: clinical outcome and follow-up evaluation of malignancy and mortality. Clin Gastroenterol Hepatol 2008; 6: 1212\u20131217.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFtpj201419_CR12","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1111\/j.1572-0241.2000.03363.x","volume":"95","author":"RD Cohen","year":"2000","unstructured":"Cohen RD, Tsang JF, Hanauer SB . Infliximab in Crohn's disease: first anniversary clinical experience. Am J Gastroenterol 2000; 95: 3469\u20133477.","journal-title":"Am J Gastroenterol"},{"key":"BFtpj201419_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1089\/gtmb.2012.0429","volume":"17","author":"S Bank","year":"2013","unstructured":"Bank S, Nexo BA, Andersen V, Vogel U, Andersen PS . High-quality and -quantity DNA extraction from frozen archival blood clots for genotyping of single-nucleotide polymorphisms. Genet Test Mol Biomarkers 2013; 17: 501\u2013503.","journal-title":"Genet Test Mol Biomarkers"},{"key":"BFtpj201419_CR14","unstructured":"http:\/\/pngu.mgh.harvard.edu\/\u223cpurcell\/gpc\/ ."},{"key":"BFtpj201419_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/01.sla.0000262788.67171.3f","volume":"246","author":"W Gu","year":"2007","unstructured":"Gu W, Shan YA, Zhou J, Jiang DP, Zhang L, Du DY et al. Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2. Ann Surg 2007; 246: 151\u2013158.","journal-title":"Ann Surg"},{"key":"BFtpj201419_CR16","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00439-011-0962-4","volume":"129","author":"SJ Bielinski","year":"2011","unstructured":"Bielinski SJ, Hall JL, Pankow JS, Boerwinkle E, Matijevic-Aleksic N, He M et al. Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the Atherosclerosis Risk in Communities MRI Study. Hum Genet 2011; 129: 655\u2013662.","journal-title":"Hum Genet"},{"key":"BFtpj201419_CR17","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","volume":"20","author":"M Baldini","year":"1999","unstructured":"Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD . A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20: 976\u2013983.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFtpj201419_CR18","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00109-009-0479-7","volume":"87","author":"J Mertens","year":"2009","unstructured":"Mertens J, Bregadze R, Mansur A, Askar E, Bickeboller H, Ramadori G et al. Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity. J Mol Med (Berl) 2009; 87: 815\u2013824.","journal-title":"J Mol Med (Berl)"},{"key":"BFtpj201419_CR19","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1136\/ard.2006.065961","volume":"66","author":"K Tao","year":"2007","unstructured":"Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y et al. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. Ann Rheum Dis 2007; 66: 905\u2013909.","journal-title":"Ann Rheum Dis"},{"key":"BFtpj201419_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/1475-2875-11-168","volume":"11","author":"AH Omar","year":"2012","unstructured":"Omar AH, Yasunami M, Yamazaki A, Shibata H, Ofori MF, Akanmori BD et al. Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study. Malar J 2012; 11: 168.","journal-title":"Malar J"},{"key":"BFtpj201419_CR21","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.4049\/jimmunol.1002864","volume":"186","author":"SA Thair","year":"2011","unstructured":"Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Wellman H et al. A single nucleotide polymorphism in NF-kappaB inducing kinase is associated with mortality in septic shock. J Immunol 2011; 186: 2321\u20132328.","journal-title":"J Immunol"},{"key":"BFtpj201419_CR22","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/ng1331","volume":"36","author":"JC Knight","year":"2004","unstructured":"Knight JC, Keating BJ, Kwiatkowski DP . Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. Nat Genet 2004; 36: 394\u2013399.","journal-title":"Nat Genet"},{"key":"BFtpj201419_CR23","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/j.1365-2222.2005.02265.x","volume":"35","author":"O Migita","year":"2005","unstructured":"Migita O, Noguchi E, Koga M, Jian Z, Shibasaki M, Migita T et al. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy 2005; 35: 790\u2013796.","journal-title":"Clin Exp Allergy"},{"key":"BFtpj201419_CR24","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1002\/art.27589","volume":"62","author":"W Tan","year":"2010","unstructured":"Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA et al. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arthritis Rheum 2010; 62: 2864\u20132875.","journal-title":"Arthritis Rheum"},{"key":"BFtpj201419_CR25","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1046\/j.1523-1747.2000.00001.x","volume":"114","author":"W Kaluza","year":"2000","unstructured":"Kaluza W, Reuss E, Grossmann S, Hug R, Schopf RE, Galle PR et al. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism. J Invest Dermatol 2000; 114: 1180\u20131183.","journal-title":"J Invest Dermatol"},{"key":"BFtpj201419_CR26","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/hmg\/ddi469","volume":"15","author":"H Chen","year":"2006","unstructured":"Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006; 15: 519\u2013529.","journal-title":"Hum Mol Genet"},{"key":"BFtpj201419_CR27","first-page":"708","volume":"28","author":"LM Elsby","year":"2010","unstructured":"Elsby LM, Orozco G, Denton J, Worthington J, Ray DW, Donn RP . Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis. Clin Exp Rheumatol 2010; 28: 708\u2013714.","journal-title":"Clin Exp Rheumatol"},{"key":"BFtpj201419_CR28","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0198-8859(00)00167-1","volume":"61","author":"V Pravica","year":"2000","unstructured":"Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV . A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 2000; 61: 863\u2013866.","journal-title":"Hum Immunol"},{"key":"BFtpj201419_CR29","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.schres.2012.06.031","volume":"140","author":"M Yoshida","year":"2012","unstructured":"Yoshida M, Shiroiwa K, Mouri K, Ishiguro H, Supriyanto I, Ratta-Apha W et al. Haplotypes in the expression quantitative trait locus of interleukin-1beta gene are associated with schizophrenia. Schizophr Res 2012; 140: 185\u2013191.","journal-title":"Schizophr Res"},{"key":"BFtpj201419_CR30","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1373\/clinchem.2007.098608","volume":"54","author":"AJ Smith","year":"2008","unstructured":"Smith AJ, D'Aiuto F, Palmen J, Cooper JA, Samuel J, Thompson S et al. Association of serum interleukin-6 concentration with a functional IL6 -6331T&gt;C polymorphism. Clin Chem 2008; 54: 841\u2013850.","journal-title":"Clin Chem"},{"key":"BFtpj201419_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cyto.2007.05.001","volume":"38","author":"H Lind","year":"2007","unstructured":"Lind H, Haugen A, Zienolddiny S . Differential binding of proteins to the IL1B -31 T\/C polymorphism in lung epithelial cells. Cytokine 2007; 38: 43\u201348.","journal-title":"Cytokine"},{"key":"BFtpj201419_CR32","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/SHK.0b013e3181cc0a8e","volume":"33","author":"AQ Wen","year":"2010","unstructured":"Wen AQ, Gu W, Wang J, Feng K, Qin L, Ying C et al. Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma. Shock 2010; 33: 576\u2013582.","journal-title":"Shock"},{"key":"BFtpj201419_CR33","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/sj.gene.6364393","volume":"8","author":"S Rafiq","year":"2007","unstructured":"Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN et al. Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun 2007; 8: 344\u2013351.","journal-title":"Genes Immun"},{"key":"BFtpj201419_CR34","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/sj.gene.6364414","volume":"8","author":"S Rafiq","year":"2007","unstructured":"Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN et al. A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun 2007; 8: 552\u2013559.","journal-title":"Genes Immun"},{"key":"BFtpj201419_CR35","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00228-012-1389-0","volume":"69","author":"D Lacruz-Guzman","year":"2013","unstructured":"Lacruz-Guzman D, Torres-Moreno D, Pedrero F, Romero-Cara P, Garcia-Tercero I, Trujillo-Santos J et al. Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn's disease and ulcerative colitis. Eur J Clin Pharmacol 2013; 69: 431\u2013438.","journal-title":"Eur J Clin Pharmacol"},{"key":"BFtpj201419_CR36","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s15010-013-0444-9","volume":"41","author":"F Zhang","year":"2013","unstructured":"Zhang F, Gao XD, Wu WW, Gao Y, Zhang YW, Wang SP . Polymorphisms in toll-like receptors 2, 4 and 5 are associated with Legionella pneumophila infection. Infection 2013; 41: 941\u2013948.","journal-title":"Infection"},{"key":"BFtpj201419_CR37","doi-asserted-by":"publisher","first-page":"e26229","DOI":"10.1371\/journal.pone.0026229","volume":"6","author":"JL Espinoza","year":"2011","unstructured":"Espinoza JL, Takami A, Nakata K, Onizuka M, Kawase T, Akiyama H et al. A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PLoS One 2011; 6: e26229.","journal-title":"PLoS One"},{"key":"BFtpj201419_CR38","doi-asserted-by":"publisher","first-page":"e24370","DOI":"10.1371\/journal.pone.0024370","volume":"6","author":"A Gast","year":"2011","unstructured":"Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A et al. Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival. PLoS One 2011; 6: e24370.","journal-title":"PLoS One"},{"key":"BFtpj201419_CR39","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1084\/jem.20031220","volume":"198","author":"TR Hawn","year":"2003","unstructured":"Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003; 198: 1563\u20131572.","journal-title":"J Exp Med"},{"key":"BFtpj201419_CR40","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/ng1391","volume":"36","author":"D Guo","year":"2004","unstructured":"Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet 2004; 36: 837\u2013841.","journal-title":"Nat Genet"},{"key":"BFtpj201419_CR41","doi-asserted-by":"publisher","first-page":"e21726","DOI":"10.1371\/journal.pone.0021726","volume":"6","author":"S Song","year":"2011","unstructured":"Song S, Chen D, Lu J, Liao J, Luo Y, Yang Z et al. NFkappaB1 and NFkappaBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PLoS One 2011; 6: e21726.","journal-title":"PLoS One"},{"key":"BFtpj201419_CR42","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.lfs.2011.02.016","volume":"88","author":"S Wang","year":"2011","unstructured":"Wang S, Zhang M, Zeng Z, Tian L, Wu K, Chu J et al. IkappaBalpha polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control study. Life Sci 2011; 88: 792\u2013797.","journal-title":"Life Sci"},{"key":"BFtpj201419_CR43","doi-asserted-by":"publisher","first-page":"H2320","DOI":"10.1152\/ajpheart.00186.2007","volume":"293","author":"JY Park","year":"2007","unstructured":"Park JY, Farrance IK, Fenty NM, Hagberg JM, Roth SM, Mosser DM et al. NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. Am J Physiol Heart Circ Physiol 2007; 293: H2320\u2013H2327.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFtpj201419_CR44","doi-asserted-by":"publisher","first-page":"9113","DOI":"10.1128\/MCB.20.24.9113-9119.2000","volume":"20","author":"IA Udalova","year":"2000","unstructured":"Udalova IA, Richardson A, Denys A, Smith C, Ackerman H, Foxwell B et al. Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region. Mol Cell Biol 2000; 20: 9113\u20139119.","journal-title":"Mol Cell Biol"},{"key":"BFtpj201419_CR45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1365-3083.2006.01786.x","volume":"64","author":"K Lv","year":"2006","unstructured":"Lv K, Chen R, Cai Q, Fang M, Sun S . Effects of a single nucleotide polymorphism on the expression of human tumor necrosis factor-alpha. Scand J Immunol 2006; 64: 164\u2013169.","journal-title":"Scand J Immunol"},{"key":"BFtpj201419_CR46","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1038\/ejhg.2009.80","volume":"17","author":"M Karimi","year":"2009","unstructured":"Karimi M, Goldie LC, Cruickshank MN, Moses EK, Abraham LJ . A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of -308 TNF polymorphism function using a novel integrated reporter system. Eur J Hum Genet 2009; 17: 1454\u20131462.","journal-title":"Eur J Hum Genet"},{"key":"BFtpj201419_CR47","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.humimm.2011.02.004","volume":"72","author":"GB Wang","year":"2011","unstructured":"Wang GB, Li CR, Yang J, Wen PQ, Jia SL . A regulatory polymorphism in promoter region of TNFR1 gene is associated with Kawasaki disease in Chinese individuals. Hum Immunol 2011; 72: 451\u2013457.","journal-title":"Hum Immunol"},{"key":"BFtpj201419_CR48","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.4049\/jimmunol.1002402","volume":"186","author":"ED Carrol","year":"2011","unstructured":"Carrol ED, Payton A, Payne D, Miyajima F, Chaponda M, Mankhambo LA et al. The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1. J Immunol 2011; 186: 2329\u20132335.","journal-title":"J Immunol"},{"key":"BFtpj201419_CR49","doi-asserted-by":"publisher","first-page":"R15","DOI":"10.1186\/ar3239","volume":"13","author":"SK Wallis","year":"2011","unstructured":"Wallis SK, Cooney LA, Endres JL, Lee MJ, Ryu J, Somers EC et al. A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis. Arthritis Res Ther 2011; 13: R15.","journal-title":"Arthritis Res Ther"},{"key":"BFtpj201419_CR50","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s00018-002-8448-0","volume":"59","author":"LE Rees","year":"2002","unstructured":"Rees LE, Wood NA, Gillespie KM, Lai KN, Gaston K, Mathieson PW . The interleukin-10-1082 G\/A polymorphism: allele frequency in different populations and functional significance. Cell Mol Life Sci 2002; 59: 560\u2013569.","journal-title":"Cell Mol Life Sci"},{"key":"BFtpj201419_CR51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1471-2350-11-82","volume":"11","author":"V Andersen","year":"2010","unstructured":"Andersen V, Ernst A, Christensen J, Ostergaard M, Jacobsen BA, Tjonneland A et al. The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study. BMC Med Genet 2010; 11: 82.","journal-title":"BMC Med Genet"},{"key":"BFtpj201419_CR52","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1128\/IAI.05242-11","volume":"79","author":"M Oosting","year":"2011","unstructured":"Oosting M, ter HH, van de Veerdonk FL, Sturm P, Kullberg BJ, van der Meer JW et al. Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease. Infect Immun 2011; 79: 4681\u20134687.","journal-title":"Infect Immun"},{"key":"BFtpj201419_CR53","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00439-006-0194-1","volume":"120","author":"R Shah","year":"2006","unstructured":"Shah R, Hurley CK, Posch PE . A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C &gt; T). Hum Genet 2006; 120: 461\u2013469.","journal-title":"Hum Genet"},{"key":"BFtpj201419_CR54","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1002\/art.23728","volume":"58","author":"SN Kariuki","year":"2008","unstructured":"Kariuki SN, Crow MK, Niewold TB . The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus. Arthritis Rheum 2008; 58: 2818\u20132823.","journal-title":"Arthritis Rheum"},{"key":"BFtpj201419_CR55","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/j.1442-200X.2010.03195.x","volume":"52","author":"Y Aoyagi","year":"2010","unstructured":"Aoyagi Y, Nagata S, Kudo T, Fujii T, Wada M, Chiba Y et al. Peroxisome proliferator-activated receptor gamma 2 mutation may cause a subset of ulcerative colitis. Pediatr Int 2010; 52: 729\u2013734.","journal-title":"Pediatr Int"},{"key":"BFtpj201419_CR56","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jaci.2009.07.044","volume":"124","author":"Y Hitomi","year":"2009","unstructured":"Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol 2009; 124: 779\u2013785.","journal-title":"J Allergy Clin Immunol"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/tpj201419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tpj201419","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/tpj201419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:47:27Z","timestamp":1684622847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/tpj201419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,29]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["BFtpj201419"],"URL":"https:\/\/doi.org\/10.1038\/tpj.2014.19","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,29]]},"assertion":[{"value":"21 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}