{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:16:52Z","timestamp":1773735412293,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,9]]},"DOI":"10.1038\/2063","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:54Z","timestamp":1027673034000},"page":"1073-1077","source":"Crossref","is-referenced-by-count":516,"title":["Expression of heme oxygenase-1 can determine cardiac xenograft survival"],"prefix":"10.1038","volume":"4","author":[{"given":"M.P.","family":"Soares","sequence":"first","affiliation":[]},{"given":"Y.","family":"Lin","sequence":"additional","affiliation":[]},{"given":"J.","family":"Anrather","sequence":"additional","affiliation":[]},{"given":"E.","family":"Csizmadia","sequence":"additional","affiliation":[]},{"given":"K.","family":"Takigami","sequence":"additional","affiliation":[]},{"given":"K.","family":"Sato","sequence":"additional","affiliation":[]},{"given":"S.T.","family":"Grey","sequence":"additional","affiliation":[]},{"given":"R.B.","family":"Colvin","sequence":"additional","affiliation":[]},{"given":"A.M.","family":"Choi","sequence":"additional","affiliation":[]},{"given":"K.D.","family":"Poss","sequence":"additional","affiliation":[]},{"given":"F.H.","family":"Bach","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnm0998_1073_CR1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0167-5699(96)10024-4","volume":"17","author":"FH Bach","year":"1996","unstructured":"Bach, F.H., Winkler, H., Ferran, C., Hancock, W.W. & Robson, S.C. Delayed xenograft rejection. Immunol. Today 17, 379\u2013384 ( 1996).","journal-title":"Immunol. Today"},{"key":"BFnm0998_1073_CR2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm0995-869","volume":"1","author":"FH Bach","year":"1995","unstructured":"Bach, F.H. et al. Barriers to xenotransplantation. Nature Med. 1, 869\u2013873 (1995).","journal-title":"Nature Med."},{"key":"BFnm0998_1073_CR3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00007890-199411270-00001","volume":"58","author":"ML Blakely","year":"1994","unstructured":"Blakely, M.L. et al. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58, 1059\u20131066 (1994).","journal-title":"Transplantation"},{"key":"BFnm0998_1073_CR4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/00007890-199711150-00005","volume":"64","author":"T Kobayashi","year":"1997","unstructured":"Kobayashi, T. et al. Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy. Transplantation 64 , 1255\u20131261 (1997).","journal-title":"Transplantation"},{"key":"BFnm0998_1073_CR5","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1172\/JCI2134","volume":"101","author":"SS Lin","year":"1998","unstructured":"Lin, S.S. et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J. Clin. Invest. 101, 1745\u20131756 (1998).","journal-title":"J. Clin. Invest."},{"key":"BFnm0998_1073_CR6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nm0298-173","volume":"4","author":"YA Lin","year":"1998","unstructured":"Lin, Y.A. et al. Induction of specific transplantation tolerance across xenogeneic barriers in the t-independent immune compartment. Nature Med. 4, 173\u2013180 (1998).","journal-title":"Nature Med."},{"key":"BFnm0998_1073_CR7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nm0297-196","volume":"3","author":"FH Bach","year":"1997","unstructured":"Bach, F.H. et al. Accommodation of vascularized xenografts: expression of \"protective genes\" by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3, 196\u2013204 ( 1997).","journal-title":"Nature Med."},{"key":"BFnm0998_1073_CR8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00007890-199209000-00004","volume":"54","author":"R Hasan","year":"1992","unstructured":"Hasan, R. et al. Evidence that long-term survival of concordant xenografts is achieved by inhibition of antispecies antibody production. Transplantation 54, 408\u2013413 ( 1992).","journal-title":"Transplantation"},{"key":"BFnm0998_1073_CR9","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/00007890-199805150-00012","volume":"65","author":"N Koyamada","year":"1998","unstructured":"Koyamada, N. et al. Transient complement inhibition plus T cell immunossupression induce long-term survival of mouse to rat cardiac xenografts. Transplantation 65, 1210\u20131215 (1998).","journal-title":"Transplantation"},{"key":"BFnm0998_1073_CR10","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.4049\/jimmunol.160.8.4114","volume":"160","author":"T Miyatake","year":"1998","unstructured":"Miyatake, T. et al. Complement fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection. J. Immunol. 160, 4114\u20134123 (1998).","journal-title":"J. Immunol."},{"key":"BFnm0998_1073_CR11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI119634","volume":"100","author":"K Ishikawa","year":"1997","unstructured":"Ishikawa, K., Navab, M., Leitinger, N., Fogelman, A.M. & Lusis, A.J. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J. Clin. Invest. 100, 1209\u20131216 ( 1997).","journal-title":"J. Clin. Invest."},{"key":"BFnm0998_1073_CR12","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss, K.D. & Tonegawa, S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Natl. Acad. Sci. USA 94, 10925\u201310930 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0998_1073_CR13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","volume":"235","author":"R Stocker","year":"1987","unstructured":"Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N. & Ames, B.N. Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043 \u20131046 (1987).","journal-title":"Science"},{"key":"BFnm0998_1073_CR14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","volume":"2","author":"D Willis","year":"1996","unstructured":"Willis, D., Moore, A.R., Frederick, R. & Willoughby, D.A. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nature Med. 2, 87\u201390 (1996).","journal-title":"Nature Med."},{"key":"BFnm0998_1073_CR15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"MD Maines","year":"1997","unstructured":"Maines, M.D. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 517\u2013 554 (1997).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"BFnm0998_1073_CR16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1073\/pnas.88.3.688","volume":"88","author":"RS Eisenstein","year":"1991","unstructured":"Eisenstein, R.S., Garcia, M.D., Pettingell, W. & Munro, H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA 88, 688\u2013692 (1991).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0998_1073_CR17","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1016\/S0021-9258(18)42292-2","volume":"267","author":"AJ Opipari","year":"1992","unstructured":"Opipari, A.J., Hu, H.M., Yabkowitz, R. & Dixit, V.M. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem. 267, 12424\u201312427 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFnm0998_1073_CR18","first-page":"257","volume":"77","author":"MR Slowik","year":"1997","unstructured":"Slowik, M.R. et al. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways. Lab. Invest. 77, 257\u2013267 (1997).","journal-title":"Lab. Invest."},{"key":"BFnm0998_1073_CR19","doi-asserted-by":"crossref","first-page":"27201","DOI":"10.1074\/jbc.271.44.27201","volume":"271","author":"A Karsan","year":"1996","unstructured":"Karsan, A., Yee, E. & Harlan, J.M. Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. J. Biol. Chem. 271, 27201\u201327204 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFnm0998_1073_CR20","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1182\/blood.V91.7.2249","volume":"91","author":"C Ferran","year":"1998","unstructured":"Ferran, C. et al. A20 Inhibits NF-kB activation in endothelial cells without sensitizing to apoptosis. Blood 91, 2249 \u20132258 (1998).","journal-title":"Blood"},{"key":"BFnm0998_1073_CR21","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0092-8674(89)90944-6","volume":"58","author":"GH Wong","year":"1989","unstructured":"Wong, G.H., Elwell, J.H., Oberley, L.W. & Goeddel, D.V. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58, 923\u2013 931 (1989).","journal-title":"Cell"},{"key":"BFnm0998_1073_CR22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0952-7915(94)90107-4","volume":"6","author":"J Chen","year":"1994","unstructured":"Chen, J., Shinkai, Y., Young, F. & Alt, F.W. Probing immune functions in RAG-deficient mice. Curr. Opin. Immunol. 6, 313\u2013319 (1994).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnm0998_1073_CR23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.15.1.8679227","volume":"15","author":"AM Choi","year":"1996","unstructured":"Choi, A.M. & Alam, J. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15, 9\u201319 (1996).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFnm0998_1073_CR24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","volume":"15","author":"TM Buttke","year":"1994","unstructured":"Buttke, T.M. & Sandstrom, P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7\u2013 10 (1994).","journal-title":"Immunol. Today"},{"key":"BFnm0998_1073_CR25","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","volume":"267","author":"G Balla","year":"1992","unstructured":"Balla, G. et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J. Biol. Chem. 267, 18148\u2013 18153 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFnm0998_1073_CR26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0167-5699(96)10028-1","volume":"17","author":"W Parker","year":"1996","unstructured":"Parker, W. et al. Transplantation of discordant xenografts: a challenge revisited. Immunol. Today 17, 373\u2013 378 (1996).","journal-title":"Immunol. Today"},{"key":"BFnm0998_1073_CR27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-065X.1994.tb00875.x","volume":"141","author":"JL Platt","year":"1994","unstructured":"Platt, J.L. A perspective on xenograft rejection and accommodation. Immunol. Rev. 141, 127\u2013149 ( 1994).","journal-title":"Immunol. Rev."},{"key":"BFnm0998_1073_CR28","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1073\/pnas.92.18.8378","volume":"92","author":"C Lozada","year":"1995","unstructured":"Lozada, C. et al. Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1. Proc. Natl. Acad. Sci. USA 92, 8378\u2013 8382 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0998_1073_CR29","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss, K.D. & Tonegawa, S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. USA 94, 10919\u201310924 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0998_1073_CR30","doi-asserted-by":"crossref","first-page":"10393","DOI":"10.1073\/pnas.93.19.10393","volume":"93","author":"PJ Lee","year":"1996","unstructured":"Lee, P.J., Alam, J., Wiegand, G.W. & Choi, A.M. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Natl. Acad. Sci. USA 93, 10393\u201310398 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0998_1073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0998_1073","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0998_1073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T23:42:47Z","timestamp":1682034167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0998_1073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["BFnm0998_1073"],"URL":"https:\/\/doi.org\/10.1038\/2063","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}