{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:42:44Z","timestamp":1784745764201,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4986","license":[{"start":{"date-parts":[[1965,5,1]],"date-time":"1965-05-01T00:00:00Z","timestamp":-147398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1965,5]]},"DOI":"10.1038\/206757a0","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:11:38Z","timestamp":1152144698000},"page":"757-761","source":"Crossref","is-referenced-by-count":1388,"title":["Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 \u00c5 Resolution"],"prefix":"10.1038","volume":"206","author":[{"given":"C. C. F.","family":"BLAKE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F.","family":"KOENIG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"MAIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. T.","family":"NORTH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"PHILLIPS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. R.","family":"SARMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF206757a0_CR1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1098\/rspb.1922.0023","volume":"93","author":"A Fleming","year":"1922","unstructured":"Fleming, A., Proc. Roy. Soc., B, 93, 306 (1922).","journal-title":"Proc. Roy. Soc."},{"key":"BF206757a0_CR2","first-page":"68","volume":"78","author":"J Joll\u00e8s","year":"1963","unstructured":"Joll\u00e8s, J., Jauregui-Adell, J., and Joll\u00e8s, P., Biochim. Biophys. Acta, 78, 68 (1963).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF206757a0_CR3","first-page":"3926","volume":"258","author":"P Joll\u00e8s","year":"1964","unstructured":"Joll\u00e8s, P., Jauregui-Adell, J., and Joll\u00e8s, J., C.R. Acad. Sci., Paris, 258, 3926 (1964).","journal-title":"C.R. Acad. Sci., Paris"},{"key":"BF206757a0_CR4","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/S0021-9258(18)67888-3","volume":"238","author":"RE Canfield","year":"1963","unstructured":"Canfield, R. E., J. Biol. Chem., 238, 2698 (1963).","journal-title":"J. Biol. Chem."},{"key":"BF206757a0_CR5","unstructured":"Canfield, R. E., and Liu, A. K., J. Biol. Chem. (in the press)."},{"key":"BF206757a0_CR6","first-page":"13P","volume":"92","author":"JR Brown","year":"1964","unstructured":"Brown, J. R., Biochem. J., 92, 13P (1964).","journal-title":"Biochem. J."},{"key":"BF206757a0_CR7","unstructured":"Johnson, L. N., and Phillips, D. C. (following article)."},{"key":"BF206757a0_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(18)43040-2","volume":"164","author":"G Alderton","year":"1946","unstructured":"Alderton, G., and Fevold, J., J. Biol. Chem., 164, 1 (1946).","journal-title":"J. Biol. Chem."},{"key":"BF206757a0_CR9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1021\/ja01183a007","volume":"70","author":"KJ Palmer","year":"1948","unstructured":"Palmer, K. J., Ballantyre, M., and Galvin, J. A., J. Amer. Chem. Soc., 70, 906 (1948).","journal-title":"J. Amer. Chem. Soc."},{"key":"BF206757a0_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1107\/S0365110X59000238","volume":"12","author":"LK Steinrauf","year":"1959","unstructured":"Steinrauf, L. K., Acta Cryst., 12, 77 (1959).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR11","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/1961173a0","volume":"196","author":"CCF Blake","year":"1962","unstructured":"Blake, C. C. F., Fenn, R. H., North, A. C. T., Phillips, D. C., and Poljak, R. J., Nature, 196, 1173 (1962).","journal-title":"Nature"},{"key":"BF206757a0_CR12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-2836(63)80055-8","volume":"6","author":"KC Holmes","year":"1963","unstructured":"Holmes, K. C., and Leberman, R., J. Mol. Biol., 6, 439 (1963).","journal-title":"J. Mol. Biol."},{"key":"BF206757a0_CR13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-2836(63)80073-X","volume":"6","author":"RJ Poljak","year":"1963","unstructured":"Poljak, R. J., J. Mol. Biol., 6, 244 (1963).","journal-title":"J. Mol. Biol."},{"key":"BF206757a0_CR14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1107\/S0365110X61002394","volume":"14","author":"UW Arndt","year":"1961","unstructured":"Arndt, U. W., and Phillips, D. C., Acta Cryst., 14, 807 (1961).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1088\/0950-7671\/41\/3\/302","volume":"41","author":"DC Phillips","year":"1964","unstructured":"Phillips, D. C., J. Sci. Instrum., 41, 123 (1964).","journal-title":"J. Sci. Instrum."},{"key":"BF206757a0_CR16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1088\/0950-7671\/41\/7\/303","volume":"41","author":"UW Arndt","year":"1964","unstructured":"Arndt, U. W., North, A. C. T., and Phillips, D. C., J. Sci. Instrum., 41, 421 (1964).","journal-title":"J. Sci. Instrum."},{"key":"BF206757a0_CR17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1107\/S0365110X59002274","volume":"12","author":"DM Blow","year":"1959","unstructured":"Blow, D. M., and Crick, F. H. C., Acta Cryst., 12, 794 (1959).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1107\/S0365110X65000488","volume":"18","author":"ACT North","year":"1965","unstructured":"North, A. C. T., Acta Cryst., 18, 212 (1965).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1107\/S0365110X56002552","volume":"9","author":"FHC Crick","year":"1956","unstructured":"Crick, F. H. C., and Magdoff, B. S., Acta Cryst., 9, 901 (1956).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1107\/S0365110X65000233","volume":"18","author":"WC Hamilton","year":"1965","unstructured":"Hamilton, W. C., Rollett, J. S., and Sparks, R. A., Acta Cryst., 18, 129 (1965).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR21","unstructured":"North, A. C. T., Phillips, D. C., and Mathews, F. S. (in preparation)."},{"key":"BF206757a0_CR22","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1107\/S0365110X61003442","volume":"14","author":"RG Hart","year":"1961","unstructured":"Hart, R. G., Acta Cryst., 14, 1188 (1961).","journal-title":"Acta Cryst."},{"key":"BF206757a0_CR23","unstructured":"Blake, C. C. F., Fenn, R. H., and Phillips, D. C. (in preparation)."},{"key":"BF206757a0_CR24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/185422a0","volume":"185","author":"JC Kendrew","year":"1960","unstructured":"Kendrew, J. C., Dickerson, R. E., Strandberg, B. E., Hart, R. G., Davies, D. R., Phillips, D. C., and Shore, V. C., Nature, 185, 422 (1960).","journal-title":"Nature"},{"key":"BF206757a0_CR25","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/190666a0","volume":"190","author":"JC Kendrew","year":"1961","unstructured":"Kendrew, J. C., Watson, H. C., Strandberg, B. E., Dickerson, R. E., Phillips, D. C., and Shore, V. C., Nature, 190, 663 (1961).","journal-title":"Nature"},{"key":"BF206757a0_CR26","first-page":"401","volume":"16","author":"P Urnes","year":"1961","unstructured":"Urnes, P., and Doty, P., Adv. Prot. Chem., 16, 401 (1961).","journal-title":"Adv. Prot. Chem."},{"key":"BF206757a0_CR27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/oxfordjournals.jbchem.a127899","volume":"55","author":"K Hamaguchi","year":"1964","unstructured":"Hamaguchi, K., and Imahori, K., J. Biochem. (Japan), 55, 388 (1964).","journal-title":"J. Biochem."},{"key":"BF206757a0_CR28","first-page":"216","volume":"15","author":"JC Kendrew","year":"1962","unstructured":"Kendrew, J. C., Brookhaven Symp. Quant. Biol., 15, 216 (1962).","journal-title":"Brookhaven Symp. Quant. Biol."},{"key":"BF206757a0_CR29","first-page":"412","volume":"92","author":"NA Kravchenko","year":"1964","unstructured":"Kravchenko, N. A., Kleopina, G. V., and Kaverzneva, E. D., Biochim. Biophys. Acta, 92, 412 (1964).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF206757a0_CR30","first-page":"745","volume":"253","author":"I Bernier","year":"1961","unstructured":"Bernier, I., and Joll\u00e8s, P., C.R. Acad. Sci., Paris, 253, 745 (1961).","journal-title":"C.R. Acad. Sci., Paris"},{"key":"BF206757a0_CR31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0006-3002(62)90213-5","volume":"59","author":"LK Ramachandran","year":"1962","unstructured":"Ramachandran, L. K., and Rao, G. J. S., Biochim. Biophys. Acta, 59, 507 (1962).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF206757a0_CR32","first-page":"625","volume":"92","author":"FJ Hartdegen","year":"1964","unstructured":"Hartdegen, F. J., and Rupley, J. A., Biochim. Biophys. Acta, 92, 625 (1964).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/206757a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/206757a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/206757a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:37:41Z","timestamp":1638405461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/206757a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,5]]},"references-count":32,"journal-issue":{"issue":"4986","published-print":{"date-parts":[[1965,5]]}},"alternative-id":["BF206757a0"],"URL":"https:\/\/doi.org\/10.1038\/206757a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,5]]}}}