{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:05:47Z","timestamp":1761764747380},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5027","license":[{"start":{"date-parts":[[1966,3,1]],"date-time":"1966-03-01T00:00:00Z","timestamp":-121132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1966,3]]},"DOI":"10.1038\/209996a0","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T01:38:15Z","timestamp":1152149895000},"page":"996-1002","source":"Crossref","is-referenced-by-count":48,"title":["Electrophoretic and Functional Heterogeneity of Pepsinogen in Several Species"],"prefix":"10.1038","volume":"209","author":[{"given":"W. B.","family":"HANLEY","sequence":"first","affiliation":[]},{"given":"SAMUEL H.","family":"BOYER","sequence":"additional","affiliation":[]},{"given":"M. A.","family":"NAUGHTON","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF209996a0_CR1","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1152\/physrev.1962.42.4.519","volume":"42","author":"WH Taylor","year":"1962","unstructured":"Taylor, W. H., Physiol. Rev., 42, 519 (1962).","journal-title":"Physiol. Rev."},{"key":"BF209996a0_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1042\/bj0730075","volume":"73","author":"AP Ryle","year":"1959","unstructured":"Ryle, A. P., and Porter, R. R., Biochem. J., 73, 75 (1959).","journal-title":"Biochem. J."},{"key":"BF209996a0_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1042\/bj0750145","volume":"75","author":"AP Ryle","year":"1960","unstructured":"Ryle, A. P., Biochem. J., 75, 145 (1960).","journal-title":"Biochem. J."},{"key":"BF209996a0_CR4","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0021-9258(18)81305-9","volume":"238","author":"J Tang","year":"1963","unstructured":"Tang, J., and Tang, K. I., J. Biol. Chem., 238, 606 (1963).","journal-title":"J. Biol. Chem."},{"key":"BF209996a0_CR5","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0021-9258(18)98151-2","volume":"234","author":"J Tang","year":"1959","unstructured":"Tang, J., Wolf, S., Caputto, R., and Trucco, R. E., J. Biol. Chem., 234, 1174 (1959).","journal-title":"J. Biol. Chem."},{"key":"BF209996a0_CR6","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/ajplegacy.1963.205.6.1099","volume":"205","author":"MJ Seijffers","year":"1963","unstructured":"Seijffers, M. J., Segal, H. L., and Miller, L. L., Amer. J. Physiol., 205, 1099 (1963).","journal-title":"Amer. J. Physiol."},{"key":"BF209996a0_CR7","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1152\/ajplegacy.1963.205.6.1106","volume":"205","author":"MJ Seijffers","year":"1963","unstructured":"Seijffers, M. J., Segal, H. L., and Miller, L. L., Amer. J. Physiol., 205, 1106 (1963).","journal-title":"Amer. J. Physiol."},{"key":"BF209996a0_CR8","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1152\/ajplegacy.1964.206.5.1106","volume":"206","author":"MJ Seijffers","year":"1964","unstructured":"Seijffers, M. J., Segal, H. L., and Miller, L. L., Amer. J. Physiol., 206, 1106 (1964).","journal-title":"Amer. J. Physiol."},{"key":"BF209996a0_CR9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4049\/jimmunol.92.4.579","volume":"92","author":"W Rapp","year":"1964","unstructured":"Rapp, W., Aronson, S. B., Burtin, P., and Grabar, P., J. Immunol., 92, 579 (1964).","journal-title":"J. Immunol."},{"key":"BF209996a0_CR10","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1172\/JCI105072","volume":"43","author":"I Kushner","year":"1964","unstructured":"Kushner, I., Rapp, W., and Burtin, P., J. Clin. Invest., 43, 1983 (1964).","journal-title":"J. Clin. Invest."},{"key":"BF209996a0_CR11","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/188853a0","volume":"188","author":"J Uriel","year":"1960","unstructured":"Uriel, J., Nature, 188, 853 (1960).","journal-title":"Nature"},{"key":"BF209996a0_CR12","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1126\/science.140.3572.1228-a","volume":"140","author":"SH Boyer","year":"1963","unstructured":"Boyer, S. H., Fainer, D. C., and Naughton, M. A., Science, 140, 1228 (1963).","journal-title":"Science"},{"key":"BF209996a0_CR13","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF02231348","volume":"2","author":"ML Sievers","year":"1957","unstructured":"Sievers, M. L., and Fischer, G. L., Amer. J. Dig. Dis. (N. S.), 2, 363 (1957).","journal-title":"Amer. J. Dig. Dis."},{"key":"BF209996a0_CR14","unstructured":"Hanley, W. B., thesis, Univ. Liverpool (1963)."},{"key":"BF209996a0_CR15","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1042\/bj0610629","volume":"61","author":"O Smithies","year":"1955","unstructured":"Smithies, O., Biochem. J., 61, 629 (1955).","journal-title":"Biochem. J."},{"key":"BF209996a0_CR16","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/1801477a0","volume":"180","author":"MD Poulik","year":"1957","unstructured":"Poulik, M. D., Nature, 180, 1477 (1957).","journal-title":"Nature"},{"key":"BF209996a0_CR17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/ajcp\/40.6.588","volume":"40","author":"JC Robinson","year":"1963","unstructured":"Robinson, J. C., and Pierce, J. E., Amer. J. Clin. Path., 40, 588 (1963).","journal-title":"Amer. J. Clin. Path."},{"key":"BF209996a0_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0003-2697(61)90037-9","volume":"2","author":"WL Nelson","year":"1961","unstructured":"Nelson, W. L., Ciaccio, E. I., and Hess, G. P., Anal. Biochem., 2, 39 (1961).","journal-title":"Anal. Biochem."},{"key":"BF209996a0_CR19","unstructured":"Smithies, O., Arch. Biochem. Biophys., Suppl. 1, 125 (1962)."},{"key":"BF209996a0_CR20","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/0003-2697(64)90215-5","volume":"9","author":"AL Koen","year":"1964","unstructured":"Koen, A. L., and Shaw, C. R., Anal. Biochem., 9, 495 (1964).","journal-title":"Anal. Biochem."},{"key":"BF209996a0_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1042\/bj0440126","volume":"44","author":"F Sanger","year":"1949","unstructured":"Sanger, F., Biochem. J., 44, 126 (1949).","journal-title":"Biochem. J."},{"key":"BF209996a0_CR22","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/cber.19540870807","volume":"87","author":"F Reindel","year":"1952","unstructured":"Reindel, F., and Hoppe, W., Chem. Berichte, 87, 1103 (1952).","journal-title":"Chem. Berichte"},{"key":"BF209996a0_CR23","first-page":"37P","volume":"74","author":"GN Atfield","year":"1960","unstructured":"Atfield, G. N., and Morris, C. J. O. R., Biochem. J., 74, 37P (1960).","journal-title":"Biochem. J."},{"key":"BF209996a0_CR24","first-page":"405","volume-title":"Molecular Genetics","author":"C Baglioni","year":"1962","unstructured":"Baglioni, C., in Molecular Genetics, edit. by Taylor, J. H., 1, 405 (Academic Press, New York, 1962)."},{"key":"BF209996a0_CR25","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1101\/SQB.1964.029.01.039","volume":"29","author":"RJ Kossmann","year":"1964","unstructured":"Kossmann, R. J., Fainer, D. C., and Boyer, S. H., Cold Spr. Harb. Symp. Quant. Biol., 29, 375 (1964).","journal-title":"Cold Spr. Harb. Symp. Quant. Biol."},{"key":"BF209996a0_CR26","first-page":"1","volume":"10","author":"GE Perlmann","year":"1955","unstructured":"Perlmann, G. E., Adv. Prot. Chem., 10, 1 (1955).","journal-title":"Adv. Prot. Chem."},{"key":"BF209996a0_CR27","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/0006-3002(62)90253-6","volume":"62","author":"F Sanger","year":"1962","unstructured":"Sanger, F., and Hocquard, E., Biochim. Biophys. Acta, 62, 606 (1962).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF209996a0_CR28","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1042\/bj0710384","volume":"71","author":"WH Taylor","year":"1959","unstructured":"Taylor, W. H., Biochem. J., 71, 384 (1959).","journal-title":"Biochem. J."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/209996a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/209996a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/209996a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T23:28:39Z","timestamp":1683502119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/209996a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,3]]},"references-count":28,"journal-issue":{"issue":"5027","published-print":{"date-parts":[[1966,3]]}},"alternative-id":["BF209996a0"],"URL":"https:\/\/doi.org\/10.1038\/209996a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,3]]}}}