{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:10:12Z","timestamp":1768518612348,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5215","license":[{"start":{"date-parts":[[1969,10,1]],"date-time":"1969-10-01T00:00:00Z","timestamp":-7948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1969,10]]},"DOI":"10.1038\/224117a0","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T11:09:24Z","timestamp":1152184164000},"page":"117-120","source":"Crossref","is-referenced-by-count":150,"title":["Lest I Forget Thee, Glutathione \u2026"],"prefix":"10.1038","volume":"224","author":[{"given":"E. M.","family":"KOSOWER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. S.","family":"KOSOWER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF224117a0_CR1","first-page":"1683","volume":"106","author":"J de Rey-Pailhade","year":"1888","unstructured":"de Rey-Pailhade, J., CR Acad. Sci., 106, 1683 (1888).","journal-title":"CR Acad. Sci."},{"key":"BF224117a0_CR2","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1042\/bj0150286","volume":"15","author":"FG Hopkins","year":"1921","unstructured":"Hopkins, F. G., Biochem. J., 15, 286 (1921).","journal-title":"Biochem. J."},{"key":"BF224117a0_CR3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)77063-4","volume":"84","author":"NW Pirie","year":"1929","unstructured":"Pirie, N. W., and Pinhey, K. G., J. Biol. Chem., 84, 321 (1929).","journal-title":"J. Biol. Chem."},{"key":"BF224117a0_CR4","unstructured":"Glutathione (edit. by Colowick, S., et al.) (Academic Press, New York, 1954)."},{"key":"BF224117a0_CR5","unstructured":"Glutathione (edit. by Crook, E. M.), Biochem. Soc. Symp. No. 17, (Cambridge University Press, 1959)."},{"key":"BF224117a0_CR6","first-page":"253","volume-title":"The Enzymes","author":"WE Knox","year":"1960","unstructured":"Knox, W. E., in The Enzymes (edit. by Boyer, P. D., Lardy, H., and Myrback, K.), 2, 253 (Academic Press, New York, 1960)."},{"key":"BF224117a0_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0006-291X(65)90602-9","volume":"20","author":"NS Kosower","year":"1965","unstructured":"Kosower, N. S., Vanderhoff, G. A., Kosower, E. M., and Huang, P-k. C., Biochem. Biophys. Res. Commun., 20, 469 (1965).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF224117a0_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0304-4165(69)90002-6","volume":"192","author":"NS Kosower","year":"1969","unstructured":"Kosower, N. S., Song, K. R., and Kosower, E. M., Biochim. Biophys. Acta, 192, 1 (1969).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF224117a0_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/0304-4165(69)90003-8","volume":"192","author":"NS Kosower","year":"1969","unstructured":"Kosower, N. S., Song, K. R., Kosower, E. M., and Correa, W., Biochim. Biophys. Acta, 192, 8 (1969).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF224117a0_CR10","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1021\/ja01011a027","volume":"90","author":"P-kC Huang","year":"1968","unstructured":"Huang, P-k. C., and Kosower, E. M., J. Amer. Chem. Soc. 90, 2354, 2362, 2367 (1968).","journal-title":"J. Amer. Chem. Soc."},{"key":"BF224117a0_CR11","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1021\/ja01037a023","volume":"91","author":"EM Kosower","year":"1969","unstructured":"Kosower, E. M., Huang, P-k. C., and Tsuji, T., J. Amer. Chem. Soc., 91, 2325 (1969).","journal-title":"J. Amer. Chem. Soc."},{"key":"BF224117a0_CR12","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1038\/1821675a0","volume":"182","author":"H Takahashi","year":"1958","unstructured":"Takahashi, H., Murai, T., and Sasaki, T., Nature, 182, 1675 (1958).","journal-title":"Nature"},{"key":"BF224117a0_CR13","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0926-6585(66)90010-0","volume":"126","author":"A Karlin","year":"1966","unstructured":"Karlin, A., and Bartels, E., Biochim. Biophys. Acta, 126, 525 (1966).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF224117a0_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0006-3495(66)86686-9","volume":"6","author":"F HuneeusCox","year":"1966","unstructured":"HuneeusCox, F., Fernandez, H., and Smith, B. H., Biophys. J., 6, 675 (1966).","journal-title":"Biophys. J."},{"key":"BF224117a0_CR15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0014-2999(68)90007-1","volume":"4","author":"EX Albuquerque","year":"1968","unstructured":"Albuquerque, E. X., Sokoll, M. D., Sonesson, B., and Thesleff, S., Europ. J. Pharmacol., 4, 40 (1968).","journal-title":"Europ. J. Pharmacol."},{"key":"BF224117a0_CR16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/0005-2744(67)90039-3","volume":"139","author":"A Karlin","year":"1967","unstructured":"Karlin, A., Biochim. Biophys. Acta, 139, 358 (1967).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF224117a0_CR17","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1073\/pnas.60.2.668","volume":"60","author":"A Karlin","year":"1968","unstructured":"Karlin, A., and Winnik, M., Proc. US Nat. Acad. Sci., 60, 668 (1968).","journal-title":"Proc. US Nat. Acad. Sci."},{"key":"BF224117a0_CR18","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1126\/science.164.3886.1420","volume":"164","author":"I Silman","year":"1969","unstructured":"Silman, I., and Karlin, A., Science, 164, 1420 (1969).","journal-title":"Science"},{"key":"BF224117a0_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/222583a0","volume":"222","author":"R Galun","year":"1969","unstructured":"Galun, R., and Margalit, J., Nature, 222, 583 (1969).","journal-title":"Nature"},{"key":"BF224117a0_CR20","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1126\/science.142.3600.1674","volume":"142","author":"R Galun","year":"1963","unstructured":"Galun, R., Avi-Dor, Y., and Bar-Zeev, M., Science, 142, 1674 (1963).","journal-title":"Science"},{"key":"BF224117a0_CR21","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/0022-1910(68)90175-3","volume":"14","author":"R Galun","year":"1968","unstructured":"Galun, R., and Kindler, S. H., J. Insect Physiol., 14, 1409 (1968).","journal-title":"J. Insect Physiol."},{"key":"BF224117a0_CR22","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1007\/BF02147811","volume":"24","author":"R Galun","year":"1968","unstructured":"Galun, R., and Kindler, S. H., Experientia, 24, 1140 (1968).","journal-title":"Experientia"},{"key":"BF224117a0_CR23","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1126\/science.161.3840.434","volume":"161","author":"HM Lenhoff","year":"1968","unstructured":"Lenhoff, H. M., Science, 161, 434 (1968).","journal-title":"Science"},{"key":"BF224117a0_CR24","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0014-4827(69)90017-2","volume":"56","author":"JW Harris","year":"1969","unstructured":"Harris, J. W., Exp. Cell. Res., 56, 299 (1969).","journal-title":"Exp. Cell. Res."},{"key":"BF224117a0_CR25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/0006-291X(66)90505-5","volume":"25","author":"DV Richmond","year":"1966","unstructured":"Richmond, D. V., and Somers, E., Biochem. Biophys. Res. Commun., 25, 657 (1966).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF224117a0_CR26","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/recl.19680870712","volume":"87","author":"CW Pluijgers","year":"1968","unstructured":"Pluijgers, C. W., Berg, J., Sijpersteijn, A. K., Tempel, A., and Verloop, A., Rec. Trav. Chim., 87, 833 (1968).","journal-title":"Rec. Trav. Chim."},{"key":"BF224117a0_CR27","first-page":"250","volume-title":"The Cell","author":"D Mazia","year":"1961","unstructured":"Mazia, D., in The Cell (edit. by Brachet, J., and Mirsky, A.), 3, 250, 355 (Academic Press, 1961)."},{"key":"BF224117a0_CR28","first-page":"289","volume":"15","author":"JW Harris","year":"1969","unstructured":"Harris, J. W., Painter, R. B., and Hohn, G. M., Int. J. Rad. Biol., 15, 289 (1969).","journal-title":"Int. J. Rad. Biol."},{"key":"BF224117a0_CR29","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1042\/bj1110603","volume":"111","author":"KR Harrap","year":"1969","unstructured":"Harrap, K. R., Jackson, R. C., and Hill, B. T., Biochem. J., 111, 603 (1969).","journal-title":"Biochem. J."},{"key":"BF224117a0_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1073\/pnas.62.1.30","volume":"62","author":"RI Henkin","year":"1969","unstructured":"Henkin, R. I., and Bradley, D. F., Proc. US Nat. Acad. Sci., 62, 30 (1969).","journal-title":"Proc. US Nat. Acad. Sci."},{"key":"BF224117a0_CR31","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1365-2141.1969.tb00435.x","volume":"16","author":"S Piomelli","year":"1969","unstructured":"Piomelli, S., and Siniscalco, M., Brit. J. Haematol., 16, 537 (1969).","journal-title":"Brit. J. Haematol."},{"key":"BF224117a0_CR32","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1001\/jama.1952.72930340027010c","volume":"149","author":"RS Hockwald","year":"1952","unstructured":"Hockwald, R. S., Arnold, J., Clayman, C. B., and Alving, A. S., J. Amer. Med. Assoc., 149, 1568 (1952); Beutler, E., Pharmacol. Rev., 21, 73 (1969).","journal-title":"J. Amer. Med. Assoc."},{"key":"BF224117a0_CR33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1749-6632.1965.tb12257.x","volume":"123","author":"PA Marks","year":"1965","unstructured":"Marks, P. A., and Banks, J., Ann. NY Acad. Sci., 123, 198 (1965).","journal-title":"Ann. NY Acad. Sci."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/224117a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/224117a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/224117a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T19:04:27Z","timestamp":1638385467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/224117a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,10]]},"references-count":33,"journal-issue":{"issue":"5215","published-print":{"date-parts":[[1969,10]]}},"alternative-id":["BF224117a0"],"URL":"https:\/\/doi.org\/10.1038\/224117a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,10]]}}}