{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:43:35Z","timestamp":1768538615921,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5583","license":[{"start":{"date-parts":[[1976,11,1]],"date-time":"1976-11-01T00:00:00Z","timestamp":215654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1976,11]]},"DOI":"10.1038\/264253a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T20:18:59Z","timestamp":1123100339000},"page":"253-254","source":"Crossref","is-referenced-by-count":93,"title":["Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6"],"prefix":"10.1038","volume":"264","author":[{"given":"PER","family":"TEISBERG","sequence":"first","affiliation":[]},{"given":"INGVAR","family":"\u00c5KESSON","sequence":"additional","affiliation":[]},{"given":"BJORNAR","family":"OLAISEN","sequence":"additional","affiliation":[]},{"suffix":"JR","given":"TOBIAS","family":"GEDDE-DAHL","sequence":"additional","affiliation":[]},{"given":"ERIK","family":"THORSBY","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF264253a0_CR1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.118.3.447","volume":"118","author":"HJ M\u00fcller-Eberhard","year":"1963","unstructured":"M\u00fcller-Eberhard, H. J., and Biro, C. E., J. exp. Med., 118, 447 (1963).","journal-title":"J. exp. Med."},{"key":"BF264253a0_CR2","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1084\/jem.140.5.1324","volume":"140","author":"RD Schreiber","year":"1974","unstructured":"Schreiber, R. D., and M\u00fcller-Eberhard, H. J., J. exp. Med., 140, 1324 (1974).","journal-title":"J. exp. Med."},{"key":"BF264253a0_CR3","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1172\/JCI105904","volume":"47","author":"CA Alper","year":"1968","unstructured":"Alper, C. A., and Propp, R. P., J. clin. Invest., 47, 2181 (1968).","journal-title":"J. clin. Invest."},{"key":"BF264253a0_CR4","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1126\/science.162.3856.905","volume":"162","author":"EA Azen","year":"1968","unstructured":"Azen, E. A., and Smithies, O., Science, 162, 905 (1968).","journal-title":"Science"},{"key":"BF264253a0_CR5","volume-title":"Protides of the Biological Fluids","author":"MJ Hobart","year":"1975","unstructured":"Hobart, M. J., Lachmann, P. J., and Alper, C. A., in Protides of the Biological Fluids, 22 (edit. by Pecters, H.) (Pergamon, Oxford, 1975)."},{"key":"BF264253a0_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1084\/jem.135.1.68","volume":"135","author":"CA Alper","year":"1972","unstructured":"Alper, C. A., Boenisch, T., and Watson, L., J. exp. Med., 135, 68 (1972).","journal-title":"J. exp. Med."},{"key":"BF264253a0_CR7","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1423-0410.1974.tb02433.x","volume":"27","author":"FH Allen Jr","year":"1974","unstructured":"Allen, F. H., Jr, Vox Sang., 27, 382 (1974).","journal-title":"Vox Sang."},{"key":"BF264253a0_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/BF00275141","volume":"30","author":"B Olaisen","year":"1975","unstructured":"Olaisen, B., Teisberg, P., Gedde-Dahl, T., Jr, and Thorsby, E., Hum. Genet, 30, 291 (1975).","journal-title":"Hum. Genet"},{"key":"BF264253a0_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1423-0410.1970.tb01494.x","volume":"19","author":"P Teisberg","year":"1970","unstructured":"Teisberg, P., Vox Sang., 19, 47 (1970).","journal-title":"Vox Sang."},{"key":"BF264253a0_CR10","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1423-0410.1969.tb00414.x","volume":"17","author":"CA Alper","year":"1969","unstructured":"Alper, C. A., and Johnson, A. M., Vox Sang., 17, 445 (1969).","journal-title":"Vox Sang."},{"key":"BF264253a0_CR11","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1172\/JCI106194","volume":"48","author":"SJ Rosenfeld","year":"1969","unstructured":"Rosenfeld, S. J., Ruddy, S., and Austen, K. F., J. clin. Invest., 48, 2283 (1969).","journal-title":"J. clin. Invest."},{"key":"BF264253a0_CR12","first-page":"869","volume":"21","author":"S Bach","year":"1971","unstructured":"Bach, S., Ruddy, S., Maclaren, J. A., and Austen, K. F., Immunology 21, 869 (1971).","journal-title":"Immunology"},{"key":"BF264253a0_CR13","volume-title":"Histocompatibility Testing","author":"C Rittner","year":"1975","unstructured":"Rittner, C., et al., in Histocompatibility Testing (edit. by Kissmeyer-Nielsen, F.) (Munksgaard, Copenhagen, 1975)."},{"key":"BF264253a0_CR14","first-page":"1464","volume":"140","author":"SM Fu","year":"1974","unstructured":"Fu, S. M., Kunkel, H. G., Brusman, H. P., Allen, F. H., and Fotino, M., J. exp. Med, 140, 1464 (1974).","journal-title":"J. exp. Med"},{"key":"BF264253a0_CR15","unstructured":"Merrit, A. D., et al., Third Int. Conf. Human Gene Mapping (edit. by Bergsma, D.) (National Foundation, New York, in the press)."},{"key":"BF264253a0_CR16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/258242a0","volume":"258","author":"PJ Lachmann","year":"1975","unstructured":"Lachmann, P. J., Grennan, D., and Martin, A., Nature, 258, 242 (1975).","journal-title":"Nature"},{"key":"BF264253a0_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/258243a0","volume":"258","author":"B Curman","year":"1975","unstructured":"Curman, B., et al., Nature, 258, 243 (1975).","journal-title":"Nature"},{"key":"BF264253a0_CR18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1399-0004.1974.tb00632.x","volume":"6","author":"T Gedde-Dahl Jr","year":"1974","unstructured":"Gedde-Dahl, T., Jr, Teisberg, P., and Thorsby, E., Clin. Genet., 6, 66 (1974).","journal-title":"Clin. Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/264253a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/264253a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/264253a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T13:32:35Z","timestamp":1706448755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/264253a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,11]]},"references-count":18,"journal-issue":{"issue":"5583","published-print":{"date-parts":[[1976,11]]}},"alternative-id":["BF264253a0"],"URL":"https:\/\/doi.org\/10.1038\/264253a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,11]]}}}