{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:11:30Z","timestamp":1770963090276,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1038\/ng1197-292","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T11:17:48Z","timestamp":1153480668000},"page":"292-297","source":"Crossref","is-referenced-by-count":301,"title":["A novel gene involved in zinc transport is deficient in the lethal milk mouse"],"prefix":"10.1038","volume":"17","author":[{"given":"Liping","family":"Huang","sequence":"first","affiliation":[]},{"given":"Jane","family":"Gitschier","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFng1197292_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","volume":"73","author":"BL Vallee","year":"1993","unstructured":"Vallee, B.L. & Falchuk, K.H. The biochemical basis of zinc physiology. Physiol. Rev. 73, 79\u2013118 (1993).","journal-title":"Physiol. Rev."},{"key":"BFng1197292_CR2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/j.1460-2075.1995.tb07042.x","volume":"14","author":"RD Palmiter","year":"1995","unstructured":"Palmiter, R.D. & Findley, S.D. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBOJ. 14, 639\u2013649 (1995).","journal-title":"EMBOJ."},{"key":"BFng1197292_CR3","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/j.1460-2075.1996.tb00527.x","volume":"15","author":"RD Palmiter","year":"1996","unstructured":"Palmiter, R.D., Cole, T.B. & Findley, S.D., ZnT2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 15, 1784\u20131791 (1996).","journal-title":"EMBO J."},{"key":"BFng1197292_CR4","doi-asserted-by":"publisher","first-page":"14934","DOI":"10.1073\/pnas.93.25.14934","volume":"93","author":"RD Palmiter","year":"1996","unstructured":"Palmiter, R.D., Cole, T.B., Quaife, C.J. & Findley, S.D., ZnT3, a putative transporter of zinc into synaptic vesicles. Proc. Natl. Acad. Sci. USA 93, 14934\u201314939 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1197292_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/BF00261172","volume":"219","author":"A Kamizono","year":"1989","unstructured":"Kamizono, A., Nishizawa, M., Y, Murata,, K. & Kimura,, A. Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharamyces cerevisiae . Mol. Gen. Genet. 219, 161\u2013167 (1989).","journal-title":"Mol. Gen. Genet."},{"key":"BFng1197292_CR6","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1128\/MCB.12.9.3678","volume":"12","author":"DS Conklin","year":"1992","unstructured":"Conklin, D.S., McMaster, J.A., Culbertson, M.R. & Kung, C. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 3678\u20133688 (1992).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1197292_CR7","doi-asserted-by":"publisher","first-page":"7351","DOI":"10.1073\/pnas.86.19.7351","volume":"86","author":"DH Nies","year":"1989","unstructured":"Nies, D.H., Nies, A., Chu, L. & Silver, S. Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus. Proc. Nat. Acad. Sci. USA 86, 7351\u20137355 (1989).","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"BFng1197292_CR8","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1073\/pnas.93.6.2454","volume":"93","author":"H Zhao","year":"1996","unstructured":"Zhao, H. & Hide, D. The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc. Natl. Acad. Sci. USA 93, 2454\u20132458 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1197292_CR9","first-page":"23202","volume-title":"Saccharomyces cervisiae","author":"H Zhao","year":"1996","unstructured":"Zhao, H. & Eide, D. The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cervisiae. J. Biol. Chem. 271, 23202\u201323210 (1996)."},{"key":"BFng1197292_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/BF02024322","volume":"149","author":"JP van Wouwe,","year":"1989","unstructured":"van Wouwe,, J.P. Clinical and laboratory diagnosis of acrodermatitis enteropathica. Eur. J. Pediatr. 149, 2\u20138 (1989).","journal-title":"Eur. J. Pediatr."},{"key":"BFng1197292_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1126\/science.619449","volume":"199","author":"JE Piletz","year":"1978","unstructured":"Piletz, J.E. & Ganschow, R.E. Zinc deficiency in murine milk underlies expression of the lethal milk (Im) mutation. Science 199, 181\u2013183 (1978).","journal-title":"Science"},{"key":"BFng1197292_CR12","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1093\/jn\/122.6.1214","volume":"122","author":"ML Ackland","year":"1992","unstructured":"Ackland, M.L. & Mercer, J.F.B. The murine mutation, lethal milk, results in production of zinc-deficient milk. J. Nutrition 122, 1214\u20131218 (1992).","journal-title":"J. Nutrition"},{"key":"BFng1197292_CR13","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1093\/jn\/122.11.2233","volume":"122","author":"DY Lee","year":"1992","unstructured":"Lee, D.Y., Shay, N.F. & Cousins, R.J. Altered zinc metabolism occurs in murine lethal milk syndrome. J. Nutrition 122, 2233\u20132238 (1992).","journal-title":"J. Nutrition"},{"key":"BFng1197292_CR14","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/oxfordjournals.jhered.a109990","volume":"75","author":"LC Erway","year":"1984","unstructured":"Erway, L.C. & Grider, A. Zinc metabolism in lethal milk mice: otolith, lactation, and aging effects. J. Heredity 75, 480\u2013484 (1984).","journal-title":"J. Heredity"},{"key":"BFng1197292_CR15","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/ajcn\/31.4.560","volume":"31","author":"JE Piletz","year":"1978","unstructured":"Piletz, J.E. & Ganschow, R.E. Lethal milk mutations results in dietary zinc deficiency in nursing mice. Am. J. Clin. Nutr. 31, 560\u2013562 (1978).","journal-title":"Am. J. Clin. Nutr."},{"key":"BFng1197292_CR16","first-page":"30","volume":"41","author":"MM Dickie","year":"1969","unstructured":"Dickie, M.M., Mouse News Letter 41, 30 (1969).","journal-title":"Mouse News Letter"},{"key":"BFng1197292_CR17","first-page":"32","volume":"49","author":"MC Green","year":"1973","unstructured":"Green, M.C. & Sweet, H.O., News Letter 49, 32 (1973).","journal-title":"News Letter"},{"key":"BFng1197292_CR18","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.74.1927.569","volume":"74","author":"E Roberts","year":"1931","unstructured":"Roberts, E. A new mutation in the house mouse (Mus musculus). Science 74, 569 (1931).","journal-title":"Science"},{"key":"BFng1197292_CR19","first-page":"S51","volume":"6,","author":"LD Siracusa","year":"1996","unstructured":"Siracusa, L.D., Morgan, J.L., Fisher, J.K., Abbott, C.M. & Peters, J. Mouse chromosome 2. Mamm. Genome 6,, S51\u2013S63 (1996).","journal-title":"Mamm. Genome"},{"key":"BFng1197292_CR20","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/BF00373326","volume":"14","author":"PJ Robinson","year":"1981","unstructured":"Robinson, P.J. et al. Location of the mouse \u03b22-microglobulin gene B2m determined by linkage analysis. Immunogenetics 14, 449\u2013452 (1981).","journal-title":"Immunogenetics"},{"key":"BFng1197292_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/ng0992-80","volume":"2","author":"RA White","year":"1992","unstructured":"White, R.A. et al. The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. Nature Genet. 2, 80\u201383 (1992).","journal-title":"Nature Genet."},{"key":"BFng1197292_CR22","first-page":"550a","volume":"7","author":"B Gwynn","year":"1996","unstructured":"Gwynn, B., Ciciotte, S., Korsgren, C., Cohen, C.M. & Peters, L.L. Genetic mapping distinguishes the gene encoding protein 4.2 from the mouse platelet storage pool deficiency mutation pallid. Mol. Biol. Cell 7, 550a (1996).","journal-title":"Mol. Biol. Cell"},{"key":"BFng1197292_CR23","unstructured":"Lyon, M.F. & Searle, A.G. Variants and Strains of the Laboratory Mouse (Oxford University Press, Oxford, UK, 1989)."},{"key":"BFng1197292_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.bb.23.060194.001123","volume":"23","author":"G von Heijne,","year":"1994","unstructured":"von Heijne,, G. Membrane proteins: from sequence to structure. Annu. Rev. Biophys. Biomol. Struct. 23, 167\u2013192 (1994).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFng1197292_CR25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0012-1606(72)90178-9","volume":"27","author":"N Purichia","year":"1972","unstructured":"Purichia, N. & Erway, L.C. Effects of dichlorophenamide, zinc, and manganese on otolith development in mice. Dev. Biol. 27, 395\u2013405 (1972).","journal-title":"Dev. Biol."},{"key":"BFng1197292_CR26","first-page":"309","volume":"10","author":"Y Kuramoto","year":"1991","unstructured":"Kuramoto, Y., Igarashi, Y. & Tagami, H. Acquired zinc deficiency in breast-fed infants. Semin. Dermatol. 10, 309\u2013312 (1991).","journal-title":"Semin. Dermatol."},{"key":"BFng1197292_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1525-1470.1988.tb00877.x","volume":"5","author":"MT Glover","year":"1988","unstructured":"Glover, M.T. & Atherton, D.J. Transient zinc deficiency in two full-term breast-fed siblings associated with low maternal breast milk zinc concentration. Pediatr. Dermatol. 5, 10\u201313 (1988).","journal-title":"Pediatr. Dermatol."},{"key":"BFng1197292_CR28","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.836589","volume":"195","author":"CD Eckhert","year":"1977","unstructured":"Eckhert, C.D., Sloan, M.V., Duncan, J.R. & LS.Zinc binding: a difference between human and bovine milk. Science 195, 789 (1977).","journal-title":"Science"},{"key":"BFng1197292_CR29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0140-6736(74)91772-3","volume":"II","author":"EJ Moynahan","year":"1974","unstructured":"Moynahan, E.J. Acrodermatitis enteropahtic: a lethal inherited human zinc-deficiency disorder. Lancet II, 399\u2013400 (1974).","journal-title":"Lancet"},{"key":"BFng1197292_CR30","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1093\/hmg\/5.10.1619","volume":"5","author":"MB Theophilos","year":"1996","unstructured":"Theophilos, M.B., Cox, D.W. & Mercer, J.F.B. The toxic milk mouse is a murine model of Wilson disease. Hum. Mol. Genet. 5, 1619\u20131624 (1996).","journal-title":"Hum. Mol. Genet."},{"key":"BFng1197292_CR31","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1093\/nar\/18.10.2887","volume":"18","author":"J Riley","year":"1990","unstructured":"Riley, J. et al. A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acid Res. 18, 2887\u20132890 (1990).","journal-title":"Nucleic Acid Res."},{"key":"BFng1197292_CR32","first-page":"6.10.1","volume-title":"Protocols in Molecular Biology","author":"DD Chaplin","year":"1994","unstructured":"Chaplin, D.D. & Brownstein, B.H., Protocols in Molecular Biology (ed. Janssen, K.) 6.10.1\u20136.10.9 (John Wiley & Sons, New York, 1994)."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1197-292","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1197-292.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1197-292.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T21:20:08Z","timestamp":1684444808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1197-292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["BFng1197292"],"URL":"https:\/\/doi.org\/10.1038\/ng1197-292","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}