{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:03:59Z","timestamp":1773371039811,"version":"3.50.1"},"reference-count":108,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":1920,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as a full agonist. The efficacy of anandamide as a TRPV1 agonist is influenced by a succession of factors including receptor reserve, phosphorylation, metabolism and uptake, CB<jats:sub>1<\/jats:sub> receptor activation, voltage, temperature, pH and bovine serum albumin. There are indications that the endocannabinoid system may play a role in the modulation of TRPV1 receptor activation. The activation of TRPV1 receptors by anandamide has potential implications in the treatment of inflammatory, respiratory and cardiovascular disorders. The relative importance of anandamide as a physiological and\/or pathophysiological TRPV1 receptor agonist in comparison to other potential candidates has yet to be revealed.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>140<\/jats:bold>, 790\u2013801. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705467\">10.1038\/sj.bjp.0705467<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705467","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T21:07:59Z","timestamp":1067461679000},"page":"790-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":482,"title":["Anandamide and vanilloid TRPV1 receptors"],"prefix":"10.1111","volume":"140","author":[{"given":"Ruth A","family":"Ross","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.029561"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00601-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00389-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01550.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00145-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03972-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.3.705"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00047-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.10.5044"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62020686.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051280"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043422"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80813-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35082088"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704223"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161191698"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00060-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008555200"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02934-9"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00406.x"},{"key":"e_1_2_5_22_1","first-page":"1127","article-title":"Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro","volume":"36","author":"DE PETROCELLIS L.","year":"1995","journal-title":"Biochem. Mol. Biol. Int."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0339"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01712-0"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00340-9"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0349"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/372686a0"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.1.180"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00040-0"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0844"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-02834.1998"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704931"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730816100"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205797200"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00157-0"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(02)00149-4"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013489"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180300052"},{"key":"e_1_2_5_39_1","first-page":"363","article-title":"Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G\u2010protein\u2010coupled inwardly rectifying K+ channels","volume":"6","author":"HO B.Y.","year":"1999","journal-title":"Receptors Channels"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0346"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122196999"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01591.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.6.1274"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(02)00149-2"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00120-5"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef281"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704950"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00637-2"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-02-00529.1999"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704840"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01059-7"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00449-9"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.6.859"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0359"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704506"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.18.13484"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01223-0"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005722200"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3869"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704220"},{"key":"e_1_2_5_62_1","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1523\/JNEUROSCI.23-08-03136.2003","article-title":"Presynaptic facilitation of glutamatergic synapses to dopaminergic neurones of the rat substantia nigra by endogenous stimulation of vanilloid receptors","volume":"23","author":"MARINELLI S.","year":"2003","journal-title":"J. Neurosci."},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022863"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705003"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00314-5"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0402.105372"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043893"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1105"},{"key":"e_1_2_5_69_1","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid subtype 1 (VR1), and VR1\u2010like immunoreactivity in the central nervous system of the rat and human","volume":"97","author":"MEZEY E.","year":"2000","journal-title":"Proc. Nat. Acad. U.S.A."},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01309-7"},{"key":"e_1_2_5_71_1","first-page":"65","article-title":"Dual effect of anandamide on nociceptive primary sensory neurones","volume":"2002","author":"NAGY I.","year":"2002","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-08765.1999"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200104200"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101607200"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201551200"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041095"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0355"},{"key":"e_1_2_5_78_1","volume-title":"Esteve Foundation Symposium X. Inverse Agonism","author":"PERTWEE R.G.","year":"2003"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0341"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01602-3"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050121"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01153-0"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02086-6"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00258-9"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0362"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00213-3"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704904"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00135-0"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.900"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703850"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00122-3"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152002699"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703050"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00901-3"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704732"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01123-2"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)02022-9"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1309\/7AYY-VVH1-GQT5-J4R2"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0602-852"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-01104.2001"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703906"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020818q"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00813.x"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0361"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701199"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00370-5"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90154-7"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04503-7"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/22761"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705467","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0705467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:22:14Z","timestamp":1697196134000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0705467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1038\/sj.bjp.0705467"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0705467","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}