{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:01:35Z","timestamp":1775106095762,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7174","license":[{"start":{"date-parts":[[2007,12,9]],"date-time":"2007-12-09T00:00:00Z","timestamp":1197158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1038\/nature06483","type":"journal-article","created":{"date-parts":[[2007,12,9]],"date-time":"2007-12-09T13:04:03Z","timestamp":1197205443000},"page":"33-37","source":"Crossref","is-referenced-by-count":522,"title":["A receptor that mediates the post-mating switch in Drosophila reproductive behaviour"],"prefix":"10.1038","volume":"451","author":[{"given":"Nilay","family":"Yapici","sequence":"first","affiliation":[]},{"given":"Young-Joon","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Barry J.","family":"Dickson","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,12,9]]},"reference":[{"key":"BFnature06483_CR1","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/S0960-9822(07)00491-5","volume":"8","author":"BI Arthur","year":"1998","unstructured":"Arthur, B. I., Jallon, J. M., Caflisch, B., Choffat, Y. & Nothiger, R. Sexual behaviour in Drosophila is irreversibly programmed during a critical period. Curr. Biol. 8, 1187\u20131190 (1998)","journal-title":"Curr. Biol."},{"key":"BFnature06483_CR2","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/nn1325","volume":"7","author":"JA Morris","year":"2004","unstructured":"Morris, J. A., Jordan, C. L. & Breedlove, S. M. Sexual differentiation of the vertebrate nervous system. Nature Neurosci. 7, 1034\u20131039 (2004)","journal-title":"Nature Neurosci."},{"key":"BFnature06483_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tree.2005.10.020","volume":"21","author":"PL Munday","year":"2006","unstructured":"Munday, P. L., Buston, P. M. & Warner, R. R. Diversity and flexibility of sex-change strategies in animals. Trends Ecol. Evol. 21, 89\u201395 (2006)","journal-title":"Trends Ecol. Evol."},{"key":"BFnature06483_CR4","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.cell.2005.04.027","volume":"121","author":"E Demir","year":"2005","unstructured":"Demir, E. & Dickson, B. J. fruitless splicing specifies male courtship behavior in Drosophila . Cell 121, 785\u2013794 (2005)","journal-title":"Cell"},{"key":"BFnature06483_CR5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nature03859","volume":"436","author":"DS Manoli","year":"2005","unstructured":"Manoli, D. S. et al. Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436, 395\u2013400 (2005)","journal-title":"Nature"},{"key":"BFnature06483_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev.ento.48.091801.112657","volume":"48","author":"C Gillott","year":"2003","unstructured":"Gillott, C. Male accessory gland secretions: modulators of female reproductive physiology and behavior. Annu. Rev. Entomol. 48, 163\u2013184 (2003)","journal-title":"Annu. Rev. Entomol."},{"key":"BFnature06483_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0092-8674(88)90192-4","volume":"54","author":"PS Chen","year":"1988","unstructured":"Chen, P. S. et al. A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster . Cell 54, 291\u2013298 (1988)","journal-title":"Cell"},{"key":"BFnature06483_CR8","doi-asserted-by":"publisher","first-page":"9923","DOI":"10.1073\/pnas.1631635100","volume":"100","author":"T Chapman","year":"2003","unstructured":"Chapman, T. et al. The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference. Proc. Natl Acad. Sci. USA 100, 9923\u20139928 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR9","doi-asserted-by":"publisher","first-page":"9929","DOI":"10.1073\/pnas.1631700100","volume":"100","author":"H Liu","year":"2003","unstructured":"Liu, H. & Kubli, E. Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster . Proc. Natl Acad. Sci. USA 100, 9929\u20139933 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR10","doi-asserted-by":"publisher","first-page":"R355","DOI":"10.1016\/j.cub.2006.04.025","volume":"16","author":"D Kvitsiani","year":"2006","unstructured":"Kvitsiani, D. & Dickson, B. J. Shared neural circuitry for female and male sexual behaviours in Drosophila . Curr. Biol. 16, R355\u2013R356 (2006)","journal-title":"Curr. Biol."},{"key":"BFnature06483_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nature05954","volume":"448","author":"G Dietzl","year":"2007","unstructured":"Dietzl, G. et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila . Nature 448, 151\u2013156 (2007)","journal-title":"Nature"},{"key":"BFnature06483_CR12","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/ng1312","volume":"36","author":"AL Parks","year":"2004","unstructured":"Parks, A. L. et al. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nature Genet. 36, 288\u2013292 (2004)","journal-title":"Nature Genet."},{"key":"BFnature06483_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0925-4773(97)00031-2","volume":"64","author":"A Santel","year":"1997","unstructured":"Santel, A., Winhauer, T., Blumer, N. & Renkawitz-Pohl, R. The Drosophila don juan (dj) gene encodes a novel sperm specific protein component characterized by an unusual domain of a repetitive amino acid motif. Mech. Dev. 64, 19\u201330 (1997)","journal-title":"Mech. Dev."},{"key":"BFnature06483_CR14","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0022-1910(93)90023-K","volume":"39","author":"T Schmidt","year":"1993","unstructured":"Schmidt, T., Choffat, Y., Klauser, S. & Kubli, E. The Drosophila melanogaster Sex-peptide: a molecular analysis of structure\u2013function relationships. J. Insect Physiol. 39, 361\u2013368 (1993)","journal-title":"J. Insect Physiol."},{"key":"BFnature06483_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1089\/108705702753520341","volume":"7","author":"E Le Poul","year":"2002","unstructured":"Le Poul, E., Hisada, S., Mizuguchi, Y., Dupriez, V. J., Burgeon, E. & Detheux, M. Adaptation of aequorin functional assay to high throughput screening. J. Biomol. Screen. 7, 57\u201365 (2002)","journal-title":"J. Biomol. Screen."},{"key":"BFnature06483_CR16","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0022-1910(99)00038-4","volume":"45","author":"LG Harshman","year":"1999","unstructured":"Harshman, L. G., Loeb, A. M. & Johnson & B. A Ecdysteroid titers in mated and unmated Drosophila melanogaster females. J. Insect Physiol. 45, 571\u2013577 (1999)","journal-title":"J. Insect Physiol."},{"key":"BFnature06483_CR17","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/S0022-1910(96)00070-4","volume":"42","author":"T Chapman","year":"1996","unstructured":"Chapman, T., Choffat, Y., Lucas, W. E., Kubli, E. & Partridge, L. Lack of response to sex-peptide results in increased cost of mating in dunce Drosophila melanogaster females. J. Insect Physiol. 42, 1007\u20131015 (1996)","journal-title":"J. Insect Physiol."},{"key":"BFnature06483_CR18","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/363274a0","volume":"363","author":"BR Conklin","year":"1993","unstructured":"Conklin, B. R., Farfel, Z., Lustig, K. D., Julius, D. & Bourne, H. R. Substitution of three amino acids switches receptor specificity of Gq\u03b1 to that of Gi\u03b1. Nature 363, 274\u2013276 (1993)","journal-title":"Nature"},{"key":"BFnature06483_CR19","first-page":"885","volume":"50","author":"BR Conklin","year":"1996","unstructured":"Conklin, B. R. et al. Carboxyl-terminal mutations of Gq\u03b1 and Gs\u03b1 that alter the fidelity of receptor activation. Mol. Pharmacol. 50, 885\u2013890 (1996)","journal-title":"Mol. Pharmacol."},{"key":"BFnature06483_CR20","doi-asserted-by":"publisher","first-page":"15363","DOI":"10.1073\/pnas.252339599","volume":"99","author":"T Meeusen","year":"2002","unstructured":"Meeusen, T. et al. Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor. Proc. Natl Acad. Sci. USA 99, 15363\u201315368 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR21","doi-asserted-by":"publisher","first-page":"12073","DOI":"10.1073\/pnas.192442799","volume":"99","author":"G Cazzamali","year":"2002","unstructured":"Cazzamali, G. & Grimmelikhuijzen, C. J. Molecular cloning and functional expression of the first insect FMRFamide receptor. Proc. Natl Acad. Sci. USA 99, 12073\u201312078 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR22","doi-asserted-by":"publisher","first-page":"11423","DOI":"10.1073\/pnas.162276199","volume":"99","author":"Y Park","year":"2002","unstructured":"Park, Y., Kim, Y.-J. & Adams, M. E. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand\u2013receptor coevolution. Proc. Natl Acad. Sci. USA 99, 11423\u201311428 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR23","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.bbrc.2003.08.022","volume":"309","author":"C Rosenkilde","year":"2003","unstructured":"Rosenkilde, C. et al. Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem. Biophys. Res. Commun. 309, 485\u2013494 (2003)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnature06483_CR24","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1046\/j.0014-2956.2001.02733.x","volume":"269","author":"P Saudan","year":"2002","unstructured":"Saudan, P. et al. Ductus ejaculatorius peptide 99B (DUP99B), a novel Drosophila melanogaster sex-peptide pheromone. Eur. J. Biochem. 269, 989\u2013997 (2002)","journal-title":"Eur. J. Biochem."},{"key":"BFnature06483_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0012-1606(02)00125-2","volume":"256","author":"MC Bloch Qazi","year":"2003","unstructured":"Bloch Qazi, M. C., Heifetz, Y. & Wolfner, M. F. The developments between gametogenesis and fertilization: ovulation and female sperm storage in Drosophila melanogaster . Dev. Biol. 256, 195\u2013211 (2003)","journal-title":"Dev. Biol."},{"key":"BFnature06483_CR26","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s00018-003-3052","volume":"60","author":"E Kubli","year":"2003","unstructured":"Kubli, E. Sex-peptides: seminal peptides of the Drosophila male. Cell. Mol. Life Sci. 60, 1689\u20131704 (2003)","journal-title":"Cell. Mol. Life Sci."},{"key":"BFnature06483_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cub.2005.01.034","volume":"15","author":"J Peng","year":"2005","unstructured":"Peng, J. et al. Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila . Curr. Biol. 15, 207\u2013213 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature06483_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/1097-4695(200007)44:1<57::AID-NEU6>3.0.CO;2-Q","volume":"44","author":"M Ottiger","year":"2000","unstructured":"Ottiger, M., Soller, M., Stocker, R. F. & Kubli, E. Binding sites of Drosophila melanogaster sex peptide pheromones. J. Neurobiol. 44, 57\u201371 (2000)","journal-title":"J. Neurobiol."},{"key":"BFnature06483_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2005.04.026","volume":"121","author":"P Stockinger","year":"2005","unstructured":"Stockinger, P., Kvitsiani, D., Rotkopf, S., Tirian, L. & Dickson, B. J. Neural circuitry that governs Drosophila male courtship behavior. Cell 121, 795\u2013807 (2005)","journal-title":"Cell"},{"key":"BFnature06483_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0022-1910(98)00106-1","volume":"45","author":"Y Fan","year":"1999","unstructured":"Fan, Y., Rafaeli, A., Gileadi, C., Kubli, E. & Applebaum, S. W. Drosophila melanogaster sex peptide stimulates juvenile hormone synthesis and depresses sex pheromone production in Helicoverpa armigera . J. Insect Physiol. 45, 127\u2013133 (1999)","journal-title":"J. Insect Physiol."},{"key":"BFnature06483_CR31","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0965-1748(00)00052-7","volume":"30","author":"Y Fan","year":"2000","unstructured":"Fan, Y. et al. Common functional elements of Drosophila melanogaster seminal peptides involved in reproduction of Drosophila melanogaster and Helicoverpa armigera females. Insect Biochem. Mol. Biol. 30, 805\u2013812 (2000)","journal-title":"Insect Biochem. Mol. Biol."},{"key":"BFnature06483_CR32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401\u2013415 (1993)","journal-title":"Development"},{"key":"BFnature06483_CR33","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1534\/genetics.166.4.1775","volume":"166","author":"AC Groth","year":"2004","unstructured":"Groth, A. C., Fish, M., Nusse, R. & Calos, M. P. Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics 166, 1775\u20131782 (2004)","journal-title":"Genetics"},{"key":"BFnature06483_CR34","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1101\/gad.8.15.1787","volume":"8","author":"L Luo","year":"1994","unstructured":"Luo, L., Liao, Y. J., Jan, L. Y. & Jan, Y. N. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787\u20131802 (1994)","journal-title":"Genes Dev."},{"key":"BFnature06483_CR35","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1073\/pnas.0305291101","volume":"101","author":"Y-J Kim","year":"2004","unstructured":"Kim, Y.-J. et al. Corazonin receptor signaling in ecdysis initiation. Proc. Natl Acad. Sci. USA 101, 6704\u20136709 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06483_CR36","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1242\/dev.127.19.4293","volume":"127","author":"P Aza-Blanc","year":"2000","unstructured":"Aza-Blanc, P., Lin, H. Y., Ruiz i Altaba, A. & Kornberg, T. B. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127, 4293\u20134301 (2000)","journal-title":"Development"},{"key":"BFnature06483_CR37","first-page":"210","volume":"60","author":"B Backhaus","year":"1984","unstructured":"Backhaus, B., Sulkowski, E. & Schlote, F. W. A semi-synthetic, general-purpose medium for Drosophila melanogaster . Dros. Inf. Serv. 60, 210\u2013212 (1984)","journal-title":"Dros. Inf. Serv."},{"key":"BFnature06483_CR38","doi-asserted-by":"publisher","first-page":"52172","DOI":"10.1074\/jbc.M306756200","volume":"278","author":"EC Johnson","year":"2003","unstructured":"Johnson, E. C. et al. Identification of Drosophila neuropeptide receptors by G protein-coupled receptors\u2013\u03b2-arrestin2 interactions. J. Biol. Chem. 278, 52172\u201352178 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature06483_CR39","doi-asserted-by":"publisher","first-page":"730","DOI":"10.2144\/02334bm02","volume":"33","author":"WI Vernon","year":"2002","unstructured":"Vernon, W. I. & Printen, J. A. Assay for intracellular calcium using a codon-optimized aequorin. Biotechniques 33, 730\u2013734 (2002)","journal-title":"Biotechniques"},{"key":"BFnature06483_CR40","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0092-8674(94)90580-0","volume":"78","author":"EM O\u2019Neill","year":"1994","unstructured":"O\u2019Neill, E. M., Rebay, I., Tjian, R. & Rubin, G. M. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras\/MAPK pathway. Cell 78, 137\u2013147 (1994)","journal-title":"Cell"},{"key":"BFnature06483_CR41","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403\u2013410 (1990)","journal-title":"J. Mol. Biol."},{"key":"BFnature06483_CR42","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/bioinformatics\/14.9.755","volume":"14","author":"SR Eddy","year":"1998","unstructured":"Eddy, S. R. Profile hidden Markov models. Bioinformatics 14, 755\u2013763 (1998)","journal-title":"Bioinformatics"},{"key":"BFnature06483_CR43","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1471-2105-5-113","volume":"5","author":"RC Edgar","year":"2004","unstructured":"Edgar, R. C. MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 5, 113 (2004)","journal-title":"BMC Bioinformatics"},{"key":"BFnature06483_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0968-0004(98)01285-7","volume":"23","author":"F Jeanmougin","year":"1998","unstructured":"Jeanmougin, F., Thompson, J. D., Gouy, M., Higgins, D. G. & Gibson, T. J. Multiple sequence alignment with Clustal X. Trends Biochem. Sci. 23, 403\u2013405 (1998)","journal-title":"Trends Biochem. Sci."},{"key":"BFnature06483_CR45","unstructured":"Felsenstein, J. PHYLIP (Phylogeny Inference Package) version 3.6. Distributed by the author. Department of Genome Sciences, University of Washington, Seattle. (2005)"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature06483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06483","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:12:36Z","timestamp":1684419156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature06483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,9]]},"references-count":45,"journal-issue":{"issue":"7174","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["BFnature06483"],"URL":"https:\/\/doi.org\/10.1038\/nature06483","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1098827.554971","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,9]]}}}