{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:27:33Z","timestamp":1778203653464,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7296","license":[{"start":{"date-parts":[[2010,4,21]],"date-time":"2010-04-21T00:00:00Z","timestamp":1271808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1038\/nature08977","type":"journal-article","created":{"date-parts":[[2010,4,21]],"date-time":"2010-04-21T04:41:39Z","timestamp":1271824899000},"page":"316-321","source":"Crossref","is-referenced-by-count":744,"title":["Cell signalling by microRNA165\/6 directs gene dose-dependent root cell fate"],"prefix":"10.1038","volume":"465","author":[{"given":"Annelie","family":"Carlsbecker","sequence":"first","affiliation":[]},{"given":"Ji-Young","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Christina J.","family":"Roberts","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Dettmer","sequence":"additional","affiliation":[]},{"given":"Satu","family":"Lehesranta","sequence":"additional","affiliation":[]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Ove","family":"Lindgren","sequence":"additional","affiliation":[]},{"given":"Miguel A.","family":"Moreno-Risueno","sequence":"additional","affiliation":[]},{"given":"Anne","family":"Vat\u00e9n","sequence":"additional","affiliation":[]},{"given":"Siripong","family":"Thitamadee","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Campilho","sequence":"additional","affiliation":[]},{"given":"Jose","family":"Sebastian","sequence":"additional","affiliation":[]},{"given":"John L.","family":"Bowman","sequence":"additional","affiliation":[]},{"given":"Yk\u00e4","family":"Helariutta","sequence":"additional","affiliation":[]},{"given":"Philip N.","family":"Benfey","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,4,21]]},"reference":[{"key":"BFnature08977_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.semcdb.2007.01.010","volume":"18","author":"T-G Du","year":"2007","unstructured":"Du, T.-G., Schmid, M. & Jansen, R.-P. Why cells move messages: The biological functions of mRNA localization. Semin. Cell Dev. Biol. 18, 171\u2013177 (2007)","journal-title":"Semin. Cell Dev. Biol."},{"key":"BFnature08977_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1104\/pp.108.117119","volume":"147","author":"EM Tretter","year":"2008","unstructured":"Tretter, E. M., Alvarez, J. P., Eshed, Y. & Bowman, J. L. Activity range of Arabidopsis small RNAs derived from different biogenesis pathways. Plant Physiol. 147, 58\u201362 (2008)","journal-title":"Plant Physiol."},{"key":"BFnature08977_CR3","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/ng2081","volume":"39","author":"P Dunoyer","year":"2007","unstructured":"Dunoyer, P., Himber, C., Ruiz-Ferrer, V., Alioua, A. & Voinnet, O. Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways. Nature Genet. 39, 848\u2013856 (2007)","journal-title":"Nature Genet."},{"key":"BFnature08977_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1101\/gad.1770009","volume":"23","author":"DH Chitwood","year":"2009","unstructured":"Chitwood, D. H. et al. Pattern formation via small RNA mobility. Genes Dev. 23, 549\u2013554 (2009)","journal-title":"Genes Dev."},{"key":"BFnature08977_CR5","doi-asserted-by":"publisher","first-page":"e1000320","DOI":"10.1371\/journal.pgen.1000320","volume":"5","author":"FTS Nogueira","year":"2009","unstructured":"Nogueira, F. T. S. et al. Regulation of small RNA accumulation in the maize shoot apex. PLoS Genet. 5, e1000320 (2009)","journal-title":"PLoS Genet."},{"key":"BFnature08977_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nature02363","volume":"428","author":"MT Juarez","year":"2004","unstructured":"Juarez, M. T., Kui, J. S., Thomas, J., Heller, B. A. & Timmermans, M. C. P. microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity. Nature 428, 84\u201388 (2004)","journal-title":"Nature"},{"key":"BFnature08977_CR7","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1104\/pp.108.116269","volume":"147","author":"S-I Lin","year":"2008","unstructured":"Lin, S.-I. et al. Regulatory network of microRNA399 and PHO2 by systemic signaling. Plant Physiol. 147, 732\u2013746 (2008)","journal-title":"Plant Physiol."},{"key":"BFnature08977_CR8","volume-title":"Anatomy of Seed Plants","author":"K Esau","year":"1977","unstructured":"Esau, K. Anatomy of Seed Plants 2nd edn (Wiley, 1977)"},{"key":"BFnature08977_CR9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/oso\/9780195172348.003.0011","volume-title":"Assembling the Tree of Life","author":"KM Pryer","year":"2004","unstructured":"Pryer, K. M., Schneider, H. & Magall\u00f3n, S. in Assembling the Tree of Life (eds Cracraft, J. & Donoghue, M. J.) Ch. 10, 138\u2013153 (Oxford Univ. Press, 2004)"},{"key":"BFnature08977_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/B978-012088457-5\/50025-3","volume-title":"Vascular Transport in Plants","author":"C Kevin Boyce","year":"2005","unstructured":"Kevin Boyce, C., Holbrook, N. M. & Maciej, A. Z. in Vascular Transport in Plants 479\u2013499 (Academic Press, 2005)"},{"key":"BFnature08977_CR11","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.cub.2004.09.081","volume":"14","author":"KL Gallagher","year":"2004","unstructured":"Gallagher, K. L., Paquette, A. J., Nakajima, K. & Benfey, P. N. Mechanisms regulating SHORT-ROOT intercellular movement. Curr. Biol. 14, 1847\u20131851 (2004)","journal-title":"Curr. Biol."},{"key":"BFnature08977_CR12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0092-8674(00)80865-X","volume":"101","author":"Y Helariutta","year":"2000","unstructured":"Helariutta, Y. et al. The SHORT-ROOT gene controls radial patterning of the Arabidopsis root through radial signaling. Cell 101, 555\u2013567 (2000)","journal-title":"Cell"},{"key":"BFnature08977_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35095061","volume":"413","author":"K Nakajima","year":"2001","unstructured":"Nakajima, K., Sena, G., Nawy, T. & Benfey, P. N. Intercellular movement of the putative transcription factor SHR in root patterning. Nature 413, 307\u2013311 (2001)","journal-title":"Nature"},{"key":"BFnature08977_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1139531","volume":"316","author":"H Cui","year":"2007","unstructured":"Cui, H. et al. An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. Science 316, 421\u2013425 (2007)","journal-title":"Science"},{"key":"BFnature08977_CR15","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1371\/journal.pbio.0040143","volume":"4","author":"MP Levesque","year":"2006","unstructured":"Levesque, M. P. et al. Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis . PLoS Biol. 4, e143 (2006)","journal-title":"PLoS Biol."},{"key":"BFnature08977_CR16","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0092-8674(00)80115-4","volume":"86","author":"L Di Laurenzio","year":"1996","unstructured":"Di Laurenzio, L. et al. The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. Cell 86, 423\u2013433 (1996)","journal-title":"Cell"},{"key":"BFnature08977_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1101\/gad.252503","volume":"17","author":"S Sabatini","year":"2003","unstructured":"Sabatini, S., Heidstra, R., Wildwater, M. & Scheres, B. SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. Genes Dev. 17, 354\u2013358 (2003)","journal-title":"Genes Dev."},{"key":"BFnature08977_CR18","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/j.1365-313X.2008.03735.x","volume":"57","author":"KL Gallagher","year":"2009","unstructured":"Gallagher, K. L. & Benfey, P. N. Both the conserved GRAS domain and nuclear localization are required for SHORT-ROOT movement. Plant J. 57, 785\u2013797 (2009)","journal-title":"Plant J."},{"key":"BFnature08977_CR19","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1101\/gad.189200","volume":"14","author":"AP M\u00e4h\u00f6nen","year":"2000","unstructured":"M\u00e4h\u00f6nen, A. P. et al. A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root. Genes Dev. 14, 2938\u20132943 (2000)","journal-title":"Genes Dev."},{"key":"BFnature08977_CR20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/35079635","volume":"411","author":"JR McConnell","year":"2001","unstructured":"McConnell, J. R. et al. Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots. Nature 411, 709\u2013713 (2001)","journal-title":"Nature"},{"key":"BFnature08977_CR21","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1073\/pnas.0307969100","volume":"101","author":"M-H Han","year":"2004","unstructured":"Han, M.-H., Goud, S., Song, L. & Fedoroff, N. The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation. Proc. Natl Acad. Sci. USA 101, 1093\u20131098 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08977_CR22","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cub.2004.01.035","volume":"14","author":"F Vazquez","year":"2004","unstructured":"Vazquez, F., Gasciolli, V., Cr, P. & Vaucheret, H. The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Curr. Biol. 14, 346\u2013351 (2004)","journal-title":"Curr. Biol."},{"key":"BFnature08977_CR23","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1016\/j.cub.2003.09.035","volume":"13","author":"JF Emery","year":"2003","unstructured":"Emery, J. F. et al. Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI genes. Curr. Biol. 13, 1768\u20131774 (2003)","journal-title":"Curr. Biol."},{"key":"BFnature08977_CR24","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1038\/sj.emboj.7600340","volume":"23","author":"AC Mallory","year":"2004","unstructured":"Mallory, A. C. et al. MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5\u2032 region. EMBO J. 23, 3356\u20133364 (2004)","journal-title":"EMBO J."},{"key":"BFnature08977_CR25","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/pcp\/pcm008","volume":"48","author":"G-K Zhou","year":"2007","unstructured":"Zhou, G.-K., Kubo, M., Zhong, R., Demura, T. & Ye, Z.-H. Overexpression of miR165 affects apical meristem formation, organ polarity establishment and vascular development in Arabidopsis . Plant Cell Physiol. 48, 391\u2013404 (2007)","journal-title":"Plant Cell Physiol."},{"key":"BFnature08977_CR26","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1104\/pp.104.040196","volume":"135","author":"NP Hawker","year":"2004","unstructured":"Hawker, N. P. & Bowman, J. L. Roles for class III HD-Zip and KANADI genes in Arabidopsis root development. Plant Physiol. 135, 2261\u20132270 (2004)","journal-title":"Plant Physiol."},{"key":"BFnature08977_CR27","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1073\/pnas.0510607103","volume":"103","author":"J-Y Lee","year":"2006","unstructured":"Lee, J.-Y. et al. Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. Proc. Natl Acad. Sci. USA 103, 6055\u20136060 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08977_CR28","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s00425-006-0439-1","volume":"225","author":"J-H Jung","year":"2007","unstructured":"Jung, J.-H. & Park, C.-M. MIR166\/165 genes exhibit dynamic expression patterns in regulating shoot apical meristem and floral development in Arabidopsis . Planta 225, 1327\u20131338 (2007)","journal-title":"Planta"},{"key":"BFnature08977_CR29","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1101\/gad.307804","volume":"18","author":"EA Parizotto","year":"2004","unstructured":"Parizotto, E. A., Dunoyer, P., Rahm, N., Himber, C. & Voinnet, O. In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA. Genes Dev. 18, 2237\u20132242 (2004)","journal-title":"Genes Dev."},{"key":"BFnature08977_CR30","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.cell.2005.11.023","volume":"123","author":"A Stark","year":"2005","unstructured":"Stark, A., Brennecke, J., Bushati, N., Russell, R. B. & Cohen, S. M. Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3\u2032UTR evolution. Cell 123, 1133\u20131146 (2005)","journal-title":"Cell"},{"key":"BFnature08977_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1104\/pp.126.2.643","volume":"126","author":"S Baima","year":"2001","unstructured":"Baima, S. et al. The Arabidopsis ATHB-8 HD-zip protein acts as a differentiation-promoting transcription factor of the vascular meristems. Plant Physiol. 126, 643\u2013655 (2001)","journal-title":"Plant Physiol."},{"key":"BFnature08977_CR32","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1093\/pcp\/pci180","volume":"46","author":"K Ohashi-Ito","year":"2005","unstructured":"Ohashi-Ito, K., Kubo, M., Demura, T. & Fukuda, H. Class III homeodomain leucine-zipper proteins regulate xylem cell differentiation. Plant Cell Physiol. 46, 1646\u20131656 (2005)","journal-title":"Plant Cell Physiol."},{"key":"BFnature08977_CR33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1105\/tpc.104.026161","volume":"17","author":"MJ Prigge","year":"2005","unstructured":"Prigge, M. J. et al. Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development. Plant Cell 17, 61\u201376 (2005)","journal-title":"Plant Cell"},{"key":"BFnature08977_CR34","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1242\/dev.019349","volume":"135","author":"L Mu\u00f1iz","year":"2008","unstructured":"Mu\u00f1iz, L. et al. ACAULIS5 controls Arabidopsis xylem specification through the prevention of premature cell death. Development 135, 2573\u20132582 (2008)","journal-title":"Development"},{"key":"BFnature08977_CR35","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.1118875","volume":"311","author":"AP M\u00e4h\u00f6nen","year":"2006","unstructured":"M\u00e4h\u00f6nen, A. P. et al. Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development. Science 311, 94\u201398 (2006)","journal-title":"Science"},{"key":"BFnature08977_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/509079","volume":"168","author":"SK Floyd","year":"2007","unstructured":"Floyd, S. K. & Bowman, J. The ancestral developmental tool kit of land plants. Int. J. Plant Sci. 168, 1\u201335 (2007)","journal-title":"Int. J. Plant Sci."},{"key":"BFnature08977_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/428485a","volume":"428","author":"SK Floyd","year":"2004","unstructured":"Floyd, S. K. & Bowman, J. L. Gene regulation: ancient microRNA target sequences in plants. Nature 428, 485\u2013486 (2004)","journal-title":"Nature"},{"key":"BFnature08977_CR38","doi-asserted-by":"publisher","first-page":"e233","DOI":"10.1371\/journal.pcbi.0030233","volume":"3","author":"E Levine","year":"2007","unstructured":"Levine, E., McHale, P. & Levine, H. Small regulatory RNAs may sharpen spatial expression patterns. PLoS Comp. Biol. 3, e233 (2007)","journal-title":"PLoS Comp. Biol."},{"key":"BFnature08977_CR39","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2144\/000112010","volume":"39","author":"R Shi","year":"2005","unstructured":"Shi, R. & Chiang, V. L. Facile means for quantifying microRNA expression by real-time PCR. Biotechniques 39, 519\u2013525 (2005)","journal-title":"Biotechniques"},{"key":"BFnature08977_CR40","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","volume":"16","author":"SJ Clough","year":"1998","unstructured":"Clough, S. J. & Bent, A. F. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana . Plant J. 16, 735\u2013743 (1998)","journal-title":"Plant J."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature08977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08977","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T19:14:14Z","timestamp":1711394054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature08977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,21]]},"references-count":40,"journal-issue":{"issue":"7296","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["BFnature08977"],"URL":"https:\/\/doi.org\/10.1038\/nature08977","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3133959.5672057","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3133959.2818057","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3133959.3069062","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,21]]}}}