{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:31:27Z","timestamp":1777109487512,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7331","license":[{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,1,27]]},"DOI":"10.1038\/nature09687","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T14:28:40Z","timestamp":1295965720000},"page":"529-533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":511,"title":["Comparative and demographic analysis of orang-utan genomes"],"prefix":"10.1038","volume":"469","author":[{"given":"Devin P.","family":"Locke","sequence":"first","affiliation":[]},{"given":"LaDeana W.","family":"Hillier","sequence":"additional","affiliation":[]},{"given":"Wesley C.","family":"Warren","sequence":"additional","affiliation":[]},{"given":"Kim C.","family":"Worley","sequence":"additional","affiliation":[]},{"given":"Lynne V.","family":"Nazareth","sequence":"additional","affiliation":[]},{"given":"Donna M.","family":"Muzny","sequence":"additional","affiliation":[]},{"given":"Shiaw-Pyng","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Zhengyuan","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Asif T.","family":"Chinwalla","sequence":"additional","affiliation":[]},{"given":"Pat","family":"Minx","sequence":"additional","affiliation":[]},{"given":"Makedonka","family":"Mitreva","sequence":"additional","affiliation":[]},{"given":"Lisa","family":"Cook","sequence":"additional","affiliation":[]},{"given":"Kim D.","family":"Delehaunty","sequence":"additional","affiliation":[]},{"given":"Catrina","family":"Fronick","sequence":"additional","affiliation":[]},{"given":"Heather","family":"Schmidt","sequence":"additional","affiliation":[]},{"given":"Lucinda A.","family":"Fulton","sequence":"additional","affiliation":[]},{"given":"Robert S.","family":"Fulton","sequence":"additional","affiliation":[]},{"given":"Joanne O.","family":"Nelson","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Magrini","sequence":"additional","affiliation":[]},{"given":"Craig","family":"Pohl","sequence":"additional","affiliation":[]},{"given":"Tina A.","family":"Graves","sequence":"additional","affiliation":[]},{"given":"Chris","family":"Markovic","sequence":"additional","affiliation":[]},{"given":"Andy","family":"Cree","sequence":"additional","affiliation":[]},{"given":"Huyen H.","family":"Dinh","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Hume","sequence":"additional","affiliation":[]},{"given":"Christie L.","family":"Kovar","sequence":"additional","affiliation":[]},{"given":"Gerald R.","family":"Fowler","sequence":"additional","affiliation":[]},{"given":"Gerton","family":"Lunter","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"Meader","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Heger","sequence":"additional","affiliation":[]},{"given":"Chris P.","family":"Ponting","sequence":"additional","affiliation":[]},{"given":"Tomas","family":"Marques-Bonet","sequence":"additional","affiliation":[]},{"given":"Can","family":"Alkan","sequence":"additional","affiliation":[]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Ze","family":"Cheng","sequence":"additional","affiliation":[]},{"given":"Jeffrey M.","family":"Kidd","sequence":"additional","affiliation":[]},{"given":"Evan E.","family":"Eichler","sequence":"additional","affiliation":[]},{"given":"Simon","family":"White","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"Searle","sequence":"additional","affiliation":[]},{"given":"Albert J.","family":"Vilella","sequence":"additional","affiliation":[]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Flicek","sequence":"additional","affiliation":[]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Brian","family":"Raney","sequence":"additional","affiliation":[]},{"given":"Bernard","family":"Suh","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Burhans","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Herrero","sequence":"additional","affiliation":[]},{"given":"David","family":"Haussler","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Faria","sequence":"additional","affiliation":[]},{"given":"Olga","family":"Fernando","sequence":"additional","affiliation":[]},{"given":"Fleur","family":"Darr\u00e9","sequence":"additional","affiliation":[]},{"given":"Dom\u00e8nec","family":"Farr\u00e9","sequence":"additional","affiliation":[]},{"given":"Elodie","family":"Gazave","sequence":"additional","affiliation":[]},{"given":"Meritxell","family":"Oliva","sequence":"additional","affiliation":[]},{"given":"Arcadi","family":"Navarro","sequence":"additional","affiliation":[]},{"given":"Roberta","family":"Roberto","sequence":"additional","affiliation":[]},{"given":"Oronzo","family":"Capozzi","sequence":"additional","affiliation":[]},{"given":"Nicoletta","family":"Archidiacono","sequence":"additional","affiliation":[]},{"given":"Giuliano Della","family":"Valle","sequence":"additional","affiliation":[]},{"given":"Stefania","family":"Purgato","sequence":"additional","affiliation":[]},{"given":"Mariano","family":"Rocchi","sequence":"additional","affiliation":[]},{"given":"Miriam K.","family":"Konkel","sequence":"additional","affiliation":[]},{"given":"Jerilyn A.","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Brygg","family":"Ullmer","sequence":"additional","affiliation":[]},{"given":"Mark A.","family":"Batzer","sequence":"additional","affiliation":[]},{"given":"Arian F. A.","family":"Smit","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Hubley","sequence":"additional","affiliation":[]},{"given":"Claudio","family":"Casola","sequence":"additional","affiliation":[]},{"given":"Daniel R.","family":"Schrider","sequence":"additional","affiliation":[]},{"given":"Matthew W.","family":"Hahn","sequence":"additional","affiliation":[]},{"given":"Victor","family":"Quesada","sequence":"additional","affiliation":[]},{"given":"Xose S.","family":"Puente","sequence":"additional","affiliation":[]},{"given":"Gonzalo R.","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"L\u00f3pez-Ot\u00edn","sequence":"additional","affiliation":[]},{"given":"Tomas","family":"Vinar","sequence":"additional","affiliation":[]},{"given":"Brona","family":"Brejova","sequence":"additional","affiliation":[]},{"given":"Aakrosh","family":"Ratan","sequence":"additional","affiliation":[]},{"given":"Robert S.","family":"Harris","sequence":"additional","affiliation":[]},{"given":"Webb","family":"Miller","sequence":"additional","affiliation":[]},{"given":"Carolin","family":"Kosiol","sequence":"additional","affiliation":[]},{"given":"Heather A.","family":"Lawson","sequence":"additional","affiliation":[]},{"given":"Vikas","family":"Taliwal","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 L.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Adam","family":"Siepel","sequence":"additional","affiliation":[]},{"given":"Arindam","family":"RoyChoudhury","sequence":"additional","affiliation":[]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Jeremiah","family":"Degenhardt","sequence":"additional","affiliation":[]},{"given":"Carlos D.","family":"Bustamante","sequence":"additional","affiliation":[]},{"given":"Ryan N.","family":"Gutenkunst","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Mailund","sequence":"additional","affiliation":[]},{"given":"Julien Y.","family":"Dutheil","sequence":"additional","affiliation":[]},{"given":"Asger","family":"Hobolth","sequence":"additional","affiliation":[]},{"given":"Mikkel H.","family":"Schierup","sequence":"additional","affiliation":[]},{"given":"Oliver A.","family":"Ryder","sequence":"additional","affiliation":[]},{"given":"Yuko","family":"Yoshinaga","sequence":"additional","affiliation":[]},{"given":"Pieter J.","family":"de Jong","sequence":"additional","affiliation":[]},{"given":"George M.","family":"Weinstock","sequence":"additional","affiliation":[]},{"given":"Jeffrey","family":"Rogers","sequence":"additional","affiliation":[]},{"given":"Elaine R.","family":"Mardis","sequence":"additional","affiliation":[]},{"given":"Richard A.","family":"Gibbs","sequence":"additional","affiliation":[]},{"given":"Richard K.","family":"Wilson","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,1,26]]},"reference":[{"key":"BFnature09687_CR1","doi-asserted-by":"publisher","first-page":"14048","DOI":"10.1073\/pnas.1001031107","volume":"107","author":"H Pontzer","year":"2010","unstructured":"Pontzer, H., Raichlen, D. A., Shumaker, R. W., Ocobock, C. & Wich, S. A. Metabolic adaptation for low energy throughput in orangutans. Proc. Natl Acad. Sci. USA 107, 14048\u201314052 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09687_CR2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/ajpa.10426","volume":"127","author":"MA van Noordwijk","year":"2005","unstructured":"van Noordwijk, M. A. & van Schaik, C. P. Development of ecological competence in Sumatran orangutans. Am. J. Phys. Anthropol. 127, 79\u201394 (2005)","journal-title":"Am. J. Phys. Anthropol."},{"key":"BFnature09687_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1078004","volume":"299","author":"CP van Schaik","year":"2003","unstructured":"van Schaik, C. P. et al. Orangutan cultures and the evolution of material culture. Science 299, 102\u2013105 (2003)","journal-title":"Science"},{"key":"BFnature09687_CR4","unstructured":"Singleton, I. et al. Orangutan Population and Habitat Viability Assessment: Final Report (IUCN\/SSC Conservation Breeding Specialist Group, Apple Valley, 2004)"},{"key":"BFnature09687_CR5","doi-asserted-by":"publisher","first-page":"R540","DOI":"10.1016\/j.cub.2007.05.016","volume":"17","author":"E Meijaard","year":"2007","unstructured":"Meijaard, E. & Wich, S. Putting orang-utan population trends into perspective. Curr. Biol. 17, R540 (2007)","journal-title":"Curr. Biol."},{"key":"BFnature09687_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10577-007-1209-z","volume":"16","author":"R Stanyon","year":"2008","unstructured":"Stanyon, R. et al. Primate chromosome evolution: ancestral karyotypes, marker order and neocentromeres. Chromosome Res. 16, 17\u201339 (2008)","journal-title":"Chromosome Res."},{"key":"BFnature09687_CR7","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1093\/oxfordjournals.molbev.a004043","volume":"19","author":"S Yi","year":"2002","unstructured":"Yi, S., Ellsworth, D. L. & Li, W. H. Slow molecular clocks in Old World monkeys, apes, and humans. Mol. Biol. Evol. 19, 2191\u20132198 (2002)","journal-title":"Mol. Biol. Evol."},{"key":"BFnature09687_CR8","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1534\/genetics.107.080077","volume":"177","author":"MW Hahn","year":"2007","unstructured":"Hahn, M. W., Demuth, J. P. & Han, S. G. Accelerated rate of gene gain and loss in primates. Genetics 177, 1941\u20131949 (2007)","journal-title":"Genetics"},{"key":"BFnature09687_CR9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nature07744","volume":"457","author":"T Marques-Bonet","year":"2009","unstructured":"Marques-Bonet, T. et al. A burst of segmental duplications in the genome of the African great ape ancestor. Nature 457, 877\u2013881 (2009)","journal-title":"Nature"},{"key":"BFnature09687_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000130684","volume":"17","author":"H Seuanez","year":"1976","unstructured":"Seuanez, H., Fletcher, J., Evans, H. J. & Martin, D. E. A chromosome rearrangement in orangutan studied with Q-, C-, and G-banding techniques. Cytogenet. Cell Genet. 17, 26\u201334 (1976)","journal-title":"Cytogenet. Cell Genet."},{"key":"BFnature09687_CR11","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1126\/science.1178158","volume":"326","author":"CM Wade","year":"2009","unstructured":"Wade, C. M. et al. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 326, 865\u2013867 (2009)","journal-title":"Science"},{"key":"BFnature09687_CR12","doi-asserted-by":"crossref","unstructured":"The Chimpanzee Sequencing and Analysis Consortium. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437, 69\u201387 (2005)","DOI":"10.1038\/nature04072"},{"key":"BFnature09687_CR13","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"International Human Genome Sequenci","year":"2001","unstructured":"International Human Genome Sequencing Consortium Initial sequencing and analysis of the human genome. Nature 409, 860\u2013921 (2001)","journal-title":"Nature"},{"key":"BFnature09687_CR14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1126\/science.1139247","volume":"316","author":"RA Gibbs","year":"2007","unstructured":"Gibbs, R. A. et al. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316, 222\u2013234 (2007)","journal-title":"Science"},{"key":"BFnature09687_CR15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/74184","volume":"24","author":"C Esnault","year":"2000","unstructured":"Esnault, C., Maestre, J. & Heidmann, T. Human LINE retrotransposons generate processed pseudogenes. Nature Genet. 24, 363\u2013367 (2000)","journal-title":"Nature Genet."},{"key":"BFnature09687_CR16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1101\/gr.923303","volume":"13","author":"G Liu","year":"2003","unstructured":"Liu, G. et al. Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome. Genome Res. 13, 358\u2013368 (2003)","journal-title":"Genome Res."},{"key":"BFnature09687_CR17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.gene.2006.08.029","volume":"390","author":"J Lee","year":"2007","unstructured":"Lee, J. et al. Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Gene 390, 18\u201327 (2007)","journal-title":"Gene"},{"key":"BFnature09687_CR18","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nsmb1107","volume":"13","author":"DA Kulpa","year":"2006","unstructured":"Kulpa, D. A. & Moran, J. V. Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nature Struct. Mol. Biol. 13, 655\u2013660 (2006)","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFnature09687_CR19","doi-asserted-by":"publisher","first-page":"8780","DOI":"10.1073\/pnas.0603313103","volume":"103","author":"HP Bogerd","year":"2006","unstructured":"Bogerd, H. P. et al. Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc. Natl Acad. Sci. USA 103, 8780\u20138785 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09687_CR20","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrg2640","volume":"10","author":"R Cordaux","year":"2009","unstructured":"Cordaux, R. & Batzer, M. A. The impact of retrotransposons on human genome evolution. Nature Rev. Genet. 10, 691\u2013703 (2009)","journal-title":"Nature Rev. Genet."},{"key":"BFnature09687_CR21","doi-asserted-by":"publisher","first-page":"e1000144","DOI":"10.1371\/journal.pgen.1000144","volume":"4","author":"C Kosiol","year":"2008","unstructured":"Kosiol, C. et al. Patterns of positive selection in six Mammalian genomes. PLoS Genet. 4, e1000144 (2008)","journal-title":"PLoS Genet."},{"key":"BFnature09687_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. Nature Genet. 25, 25\u201329 (2000)","journal-title":"Nature Genet."},{"key":"BFnature09687_CR23","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1085\/jgp.200308994","volume":"123","author":"CL Makino","year":"2004","unstructured":"Makino, C. L. et al. Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J. Gen. Physiol. 123, 729\u2013741 (2004)","journal-title":"J. Gen. Physiol."},{"key":"BFnature09687_CR24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/0040-5809(75)90020-9","volume":"7","author":"GA Watterson","year":"1975","unstructured":"Watterson, G. A. On the number of segregating sites in genetical models without recombination. Theor. Popul. Biol. 7, 256\u2013276 (1975)","journal-title":"Theor. Popul. Biol."},{"key":"BFnature09687_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/genetics\/129.2.513","volume":"129","author":"WH Li","year":"1991","unstructured":"Li, W. H. & Sadler, L. A. Low nucleotide diversity in man. Genetics 129, 513\u2013523 (1991)","journal-title":"Genetics"},{"key":"BFnature09687_CR26","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1371\/journal.pgen.0030007","volume":"3","author":"A Hobolth","year":"2007","unstructured":"Hobolth, A., Christensen, O. F., Mailund, T. & Schierup, M. H. Genomic relationships and speciation times of human, chimpanzee, and gorilla inferred from a coalescent hidden Markov model. PLoS Genet. 3, e7 (2007)","journal-title":"PLoS Genet."},{"key":"BFnature09687_CR27","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/nature04789","volume":"441","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Richter, D. J., Gnerre, S., Lander, E. S. & Reich, D. Genetic evidence for complex speciation of humans and chimpanzees. Nature 441, 1103\u20131108 (2006)","journal-title":"Nature"},{"key":"BFnature09687_CR28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/hdy.2008.107","volume":"102","author":"M Alcaide","year":"2009","unstructured":"Alcaide, M. et al. Population fragmentation leads to isolation by distance but not genetic impoverishment in the philopatric Lesser Kestrel: a comparison with the widespread and sympatric Eurasian Kestrel. Heredity 102, 190\u2013198 (2009)","journal-title":"Heredity"},{"key":"BFnature09687_CR29","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/genetics\/164.4.1511","volume":"164","author":"N Yu","year":"2003","unstructured":"Yu, N. et al. Low nucleotide diversity in chimpanzees and bonobos. Genetics 164, 1511\u20131518 (2003)","journal-title":"Genetics"},{"key":"BFnature09687_CR30","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1086\/318206","volume":"68","author":"FC Chen","year":"2001","unstructured":"Chen, F. C. & Li, W. H. Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees. Am. J. Hum. Genet. 68, 444\u2013456 (2001)","journal-title":"Am. J. Hum. Genet."}],"updated-by":[{"DOI":"10.1038\/s41586-022-04799-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nature09687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature09687","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature09687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T14:30:54Z","timestamp":1660141854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,26]]},"references-count":30,"journal-issue":{"issue":"7331","published-print":{"date-parts":[[2011,1,27]]}},"alternative-id":["BFnature09687"],"URL":"https:\/\/doi.org\/10.1038\/nature09687","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,26]]},"assertion":[{"value":"11 March 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41586-022-04799-7","URL":"https:\/\/doi.org\/10.1038\/s41586-022-04799-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}