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An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole\/cilia positioning, a function that has not been associated with PCP in <jats:italic>Drosophila<\/jats:italic>. Here we report instructive input of Frizzled-PCP (Fz\/PCP) signalling into polarized centriole positioning in <jats:italic>Drosophila<\/jats:italic> wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz\/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz\/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole\/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.<\/jats:p>","DOI":"10.1038\/ncomms11135","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T13:58:57Z","timestamp":1459259937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling"],"prefix":"10.1038","volume":"7","author":[{"given":"Jose Maria","family":"Carvajal-Gonzalez","sequence":"first","affiliation":[]},{"given":"Angel-Carlos","family":"Roman","sequence":"additional","affiliation":[]},{"given":"Marek","family":"Mlodzik","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"BFncomms11135_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00401-009-0624-y","volume":"119","author":"MR Del Bigio","year":"2010","unstructured":"Del Bigio, M. 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