{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:17:19Z","timestamp":1768015039472,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms8539","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:15:07Z","timestamp":1437567307000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients"],"prefix":"10.1038","volume":"6","author":[{"given":"Elad","family":"Ziv","sequence":"first","affiliation":[]},{"given":"Eric","family":"Dean","sequence":"additional","affiliation":[]},{"given":"Donglei","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Martino","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Serie","sequence":"additional","affiliation":[]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[]},{"given":"Daniele","family":"Campa","sequence":"additional","affiliation":[]},{"given":"Blake","family":"Aftab","sequence":"additional","affiliation":[]},{"given":"Paige","family":"Bracci","sequence":"additional","affiliation":[]},{"given":"Gabriele","family":"Buda","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Caswell-Jin","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Diasio","sequence":"additional","affiliation":[]},{"given":"Charles","family":"Dumontet","sequence":"additional","affiliation":[]},{"given":"Marek","family":"Dudzi\u0144ski","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Fejerman","sequence":"additional","affiliation":[]},{"given":"Alexandra","family":"Greenberg","sequence":"additional","affiliation":[]},{"given":"Scott","family":"Huntsman","sequence":"additional","affiliation":[]},{"given":"Krzysztof","family":"Jamroziak","sequence":"additional","affiliation":[]},{"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-9284","authenticated-orcid":false,"given":"Shaji","family":"Kumar","sequence":"additional","affiliation":[]},{"given":"Djordje","family":"Atanackovic","sequence":"additional","affiliation":[]},{"given":"Martha","family":"Glenn","sequence":"additional","affiliation":[]},{"given":"Lisa A.","family":"Cannon-Albright","sequence":"additional","affiliation":[]},{"given":"Brandt","family":"Jones","sequence":"additional","affiliation":[]},{"given":"Adam","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Herlander","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Martin","sequence":"additional","affiliation":[]},{"given":"Joaquin","family":"Martinez-Lopez","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Rajkumar","sequence":"additional","affiliation":[]},{"given":"Juan","family":"Sainz","sequence":"additional","affiliation":[]},{"given":"Annette Juul","family":"Vangsted","sequence":"additional","affiliation":[]},{"given":"Marzena","family":"W\u0105tek","sequence":"additional","affiliation":[]},{"given":"Jeffrey","family":"Wolf","sequence":"additional","affiliation":[]},{"given":"Susan","family":"Slager","sequence":"additional","affiliation":[]},{"given":"Nicola J.","family":"Camp","sequence":"additional","affiliation":[]},{"given":"Federico","family":"Canzian","sequence":"additional","affiliation":[]},{"given":"Celine","family":"Vachon","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"BFncomms8539_CR1","unstructured":"Howlader, N. et al. SEER Cancer Statistics Review, 1975-2010 National Cancer Institute (2010)."},{"key":"BFncomms8539_CR2","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1182\/blood-2011-11-387324","volume":"119","author":"AJ Greenberg","year":"2012","unstructured":"Greenberg, A. J., Rajkumar, S. V. & Vachon, C. M. Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics. Blood 119, 5359\u20135366 (2012).","journal-title":"Blood"},{"key":"BFncomms8539_CR3","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/ng.2733","volume":"45","author":"D Chubb","year":"2013","unstructured":"Chubb, D. et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat. Genet. 45, 1221\u20131225 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms8539_CR4","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/ng.2583","volume":"45","author":"N Weinhold","year":"2013","unstructured":"Weinhold, N. et al. The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nat. Genet. 45, 522\u2013525 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms8539_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ng.993","volume":"44","author":"P Broderick","year":"2012","unstructured":"Broderick, P. et al. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat. Genet. 44, 58\u201361 (2012).","journal-title":"Nat. Genet."},{"key":"BFncomms8539_CR6","first-page":"1295","volume":"13","author":"SV Rajkumar","year":"1999","unstructured":"Rajkumar, S. V. & Greipp, P. R. Prognostic factors in multiple myeloma. Hematology 13, 1295\u20131314 (1999).","journal-title":"Hematology"},{"key":"BFncomms8539_CR7","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1182\/blood-2011-11-390658","volume":"119","author":"S Kumar","year":"2012","unstructured":"Kumar, S. et al. Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics. Blood 119, 2100\u20132105 (2012).","journal-title":"Blood"},{"key":"BFncomms8539_CR8","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1038\/sj.leu.2404403","volume":"20","author":"R Fonseca","year":"2006","unstructured":"Fonseca, R. et al. Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma. Leukemia 20, 2034\u20132040 (2006).","journal-title":"Leukemia"},{"key":"BFncomms8539_CR9","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1182\/blood-2002-10-3017","volume":"101","author":"R Fonseca","year":"2003","unstructured":"Fonseca, R. et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 101, 4569\u20134575 (2003).","journal-title":"Blood"},{"key":"BFncomms8539_CR10","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1182\/blood-2006-07-037077","volume":"109","author":"F Zhan","year":"2007","unstructured":"Zhan, F. et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis. Blood 109, 1692\u20131700 (2007).","journal-title":"Blood"},{"key":"BFncomms8539_CR11","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1182\/blood-2007-10-119321","volume":"111","author":"F Zhan","year":"2008","unstructured":"Zhan, F., Barlogie, B., Mulligan, G., Shaughnessy, J. D. Jr. & Bryant, B. High-risk myeloma: a gene expression based risk-stratification model for newly diagnosed multiple myeloma treated with high-dose therapy is predictive of outcome in relapsed disease treated with single-agent bortezomib or high-dose dexamethasone. Blood 111, 968\u2013969 (2008).","journal-title":"Blood"},{"key":"BFncomms8539_CR12","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1182\/blood.V99.5.1745","volume":"99","author":"F Zhan","year":"2002","unstructured":"Zhan, F. et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood 99, 1745\u20131757 (2002).","journal-title":"Blood"},{"key":"BFncomms8539_CR13","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1182\/blood-2005-11-013458","volume":"108","author":"F Zhan","year":"2006","unstructured":"Zhan, F. et al. The molecular classification of multiple myeloma. Blood 108, 2020\u20132028 (2006).","journal-title":"Blood"},{"key":"BFncomms8539_CR14","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1182\/blood-2002-06-1737","volume":"101","author":"F Zhan","year":"2003","unstructured":"Zhan, F. et al. Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development. Blood 101, 1128\u20131140 (2003).","journal-title":"Blood"},{"key":"BFncomms8539_CR15","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/ng.2638","volume":"45","author":"C Wu","year":"2013","unstructured":"Wu, C. et al. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma. Nat. Genet. 45, 632\u2013638 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms8539_CR16","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1093\/hmg\/ddr597","volume":"21","author":"K Kiyotani","year":"2012","unstructured":"Kiyotani, K. et al. A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese. Hum. Mol. Genet. 21, 1665\u20131672 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms8539_CR17","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1158\/0008-5472.CAN-11-2561","volume":"72","author":"XO Shu","year":"2012","unstructured":"Shu, X. O. et al. Novel genetic markers of breast cancer survival identified by a genome-wide association study. Cancer Res. 72, 1182\u20131189 (2012).","journal-title":"Cancer Res."},{"key":"BFncomms8539_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1158\/1078-0432.CCR-11-1387","volume":"18","author":"F Innocenti","year":"2012","unstructured":"Innocenti, F. et al. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin. Cancer Res. 18, 577\u2013584 (2012).","journal-title":"Clin. Cancer Res."},{"key":"BFncomms8539_CR19","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1136\/gutjnl-2012-303477","volume":"63","author":"C Wu","year":"2012","unstructured":"Wu, C. et al. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut. 63, 152\u2013160 (2012).","journal-title":"Gut."},{"key":"BFncomms8539_CR20","doi-asserted-by":"publisher","first-page":"9721","DOI":"10.1158\/0008-5472.CAN-10-1493","volume":"70","author":"C Wu","year":"2010","unstructured":"Wu, C. et al. Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. Cancer Res. 70, 9721\u20139729 (2010).","journal-title":"Cancer Res."},{"key":"BFncomms8539_CR21","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1093\/bioinformatics\/btq452","volume":"26","author":"TP Yang","year":"2010","unstructured":"Yang, T. P. et al. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 26, 2474\u20132476 (2010).","journal-title":"Bioinformatics"},{"key":"BFncomms8539_CR22","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ng.2394","volume":"44","author":"E Grundberg","year":"2012","unstructured":"Grundberg, E. et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat. Genet. 44, 1084\u20131089 (2012).","journal-title":"Nat. Genet."},{"key":"BFncomms8539_CR23","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1242\/jcs.108639","volume":"125","author":"A Aubusson-Fleury","year":"2012","unstructured":"Aubusson-Fleury, A. et al. The conserved centrosomal protein FOR20 is required for assembly of the transition zone and basal body docking at the cell surface. J. Cell Sci. 125, 4395\u20134404 (2012).","journal-title":"J. Cell Sci."},{"key":"BFncomms8539_CR24","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1242\/jcs.065045","volume":"123","author":"F Sedjai","year":"2010","unstructured":"Sedjai, F. et al. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. J. Cell Sci. 123, 2391\u20132401 (2010).","journal-title":"J. Cell Sci."},{"key":"BFncomms8539_CR25","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1182\/blood-2007-06-097774","volume":"111","author":"WJ Chng","year":"2008","unstructured":"Chng, W. J. et al. The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition. Blood 111, 1603\u20131609 (2008).","journal-title":"Blood"},{"key":"BFncomms8539_CR26","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1182\/blood-2005-09-3810","volume":"107","author":"WJ Chng","year":"2006","unstructured":"Chng, W. J. et al. Clinical implication of centrosome amplification in plasma cell neoplasm. Blood 107, 3669\u20133675 (2006).","journal-title":"Blood"},{"key":"BFncomms8539_CR27","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.1158\/0008-5472.CAN-12-2026","volume":"72","author":"MS Raab","year":"2012","unstructured":"Raab, M. S. et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 72, 5374\u20135385 (2012).","journal-title":"Cancer Res."},{"key":"BFncomms8539_CR28","doi-asserted-by":"publisher","first-page":"e38878","DOI":"10.1371\/journal.pone.0038878","volume":"7","author":"H Shiheido","year":"2012","unstructured":"Shiheido, H. et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS ONE 7, e38878 (2012).","journal-title":"PLoS ONE"},{"key":"BFncomms8539_CR29","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1086\/512821","volume":"80","author":"S Zollner","year":"2007","unstructured":"Zollner, S. & Pritchard, J. K. Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am. J. Hum. Genet. 80, 605\u2013615 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"BFncomms8539_CR30","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1038\/sj.bmt.1701800","volume":"23","author":"DA Stewart","year":"1999","unstructured":"Stewart, D. A. et al. Factors predicting engraftment of autologous blood stem cells: CD34+ subsets inferior to the total CD34+ cell dose. Bone Marrow Transplant. 23, 1237\u20131243 (1999).","journal-title":"Bone Marrow Transplant."},{"key":"BFncomms8539_CR31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/sj.bmt.1702171","volume":"25","author":"DA Stewart","year":"2000","unstructured":"Stewart, D. A. et al. The CD34+90+ cell dose does not predict early engraftment of autologous blood stem cells as well as the total CD34+ cell dose. Bone Marrow Transplant. 25, 435\u2013440 (2000).","journal-title":"Bone Marrow Transplant."},{"key":"BFncomms8539_CR32","first-page":"625","volume":"40","author":"A Martino","year":"2012","unstructured":"Martino, A. et al. Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review). Int. J. Oncol. 40, 625\u2013638 (2012).","journal-title":"Int. J. Oncol."},{"key":"BFncomms8539_CR33","doi-asserted-by":"crossref","unstructured":"International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br. J. Haematol. 121, 749\u2013757 (2003).","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"BFncomms8539_CR34","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).","journal-title":"PLoS Genet."},{"key":"BFncomms8539_CR35","doi-asserted-by":"crossref","unstructured":"Genomes Project C. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56\u201365 (2012).","DOI":"10.1038\/nature11632"},{"key":"BFncomms8539_CR36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ajhg.2009.01.005","volume":"84","author":"BL Browning","year":"2009","unstructured":"Browning, B. L. & Browning, S. R. A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet. 84, 210\u2013223 (2009).","journal-title":"Am. J. Hum. Genet."},{"key":"BFncomms8539_CR37","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).","journal-title":"PLoS Genet."},{"key":"BFncomms8539_CR38","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","volume":"81","author":"PA Grambsch","year":"1994","unstructured":"Grambsch, P. A. & Therneau, T. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81, 515\u2013526 (1994).","journal-title":"Biometrika"},{"key":"BFncomms8539_CR39","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","volume":"26","author":"RJ Pruim","year":"2010","unstructured":"Pruim, R. J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336\u20132337 (2010).","journal-title":"Bioinformatics"},{"key":"BFncomms8539_CR40","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"BFncomms8539_CR41","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1182\/blood-2009-12-261032","volume":"116","author":"A Broyl","year":"2010","unstructured":"Broyl, A. et al. Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood 116, 2543\u20132553 (2010).","journal-title":"Blood"},{"key":"BFncomms8539_CR42","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature09837","volume":"471","author":"MA Chapman","year":"2011","unstructured":"Chapman, M. A. et al. Initial genome sequencing and analysis of multiple myeloma. Nature 471, 467\u2013472 (2011).","journal-title":"Nature"},{"key":"BFncomms8539_CR43","doi-asserted-by":"publisher","first-page":"W452","DOI":"10.1093\/nar\/gks539","volume":"40","author":"NL Sim","year":"2012","unstructured":"Sim, N. L. et al. SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res. 40, W452\u2013W457 (2012).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms8539_CR44","first-page":"7","volume":"Chapter 7","author":"I Adzhubei","year":"2013","unstructured":"Adzhubei, I., Jordan, D. M. & Sunyaev, S. R. Predicting functional effect of human missense mutations using PolyPhen-2. Curr. Protoc. Hum. Genet. Chapter 7, Unit 7\u201320 (2013).","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"BFncomms8539_CR45","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1093\/nar\/gks542","volume":"40","author":"SG Coetzee","year":"2012","unstructured":"Coetzee, S. G., Rhie, S. K., Berman, B. P., Coetzee, G. A. & Noushmehr, H. FunciSNP: an R\/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic Acids Res. 40, e139 (2012).","journal-title":"Nucleic Acids Res."}],"updated-by":[{"DOI":"10.1038\/ncomms10203","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000}}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms8539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms8539","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms8539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:22:47Z","timestamp":1672917767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms8539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,24]]}},"alternative-id":["BFncomms8539"],"URL":"https:\/\/doi.org\/10.1038\/ncomms8539","relation":{"correction":[{"id-type":"doi","id":"10.1038\/ncomms10203","asserted-by":"object"}]},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,22]]},"assertion":[{"value":"18 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2015","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7539"}}