{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:28:10Z","timestamp":1775100490407,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,11,30]],"date-time":"2003-11-30T00:00:00Z","timestamp":1070150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1038\/ni1015","type":"journal-article","created":{"date-parts":[[2003,11,30]],"date-time":"2003-11-30T13:33:03Z","timestamp":1070199183000},"page":"31-37","source":"Crossref","is-referenced-by-count":83,"title":["High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division"],"prefix":"10.1038","volume":"5","author":[{"given":"Henrique","family":"Veiga-Fernandes","sequence":"first","affiliation":[]},{"given":"Benedita","family":"Rocha","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,11,30]]},"reference":[{"key":"BFni1015_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev.immunol.18.1.83","volume":"18","author":"AA Freitas","year":"2000","unstructured":"Freitas, A.A. & Rocha, B. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 18, 83\u2013111 (2000).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1015_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.1996.tb00694.x","volume":"150","author":"PC Doherty","year":"1996","unstructured":"Doherty, P.C., Topham, D.J. & Tripp, R.A. Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory. Immunol. Rev. 150, 23\u201344 (1996).","journal-title":"Immunol. Rev."},{"key":"BFni1015_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","volume":"272","author":"R Ahmed","year":"1996","unstructured":"Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54\u201360 (1996).","journal-title":"Science"},{"key":"BFni1015_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-065X.1997.tb00960.x","volume":"156","author":"J Sprent","year":"1997","unstructured":"Sprent, J., Tough, D.F. & Sun, S. Factors controlling the turnover of T memory cells. Immunol. Rev. 156, 79\u201385 (1997).","journal-title":"Immunol. Rev."},{"key":"BFni1015_CR5","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.4049\/jimmunol.155.8.3719","volume":"155","author":"RA Tripp","year":"1995","unstructured":"Tripp, R.A., Lahti, J.M. & Doherty, P.C. Laser light suicide of proliferating virus-specific CD8+ T cells in an in vivo response. J. Immunol. 155, 3719\u20133721 (1995).","journal-title":"J. Immunol."},{"key":"BFni1015_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/76907","volume":"1","author":"H Veiga-Fernandes","year":"2000","unstructured":"Veiga-Fernandes, H., Walter, U., Bourgeois, C., McLean, A. & Rocha, B. Response of naive and memory CD8+ T cells to antigen stimulation in vivo. Nat. Immunol. 1, 47\u201353 (2000).","journal-title":"Nat. Immunol."},{"key":"BFni1015_CR7","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/0092-8674(93)90636-5","volume":"73","author":"CJ Sherr","year":"1993","unstructured":"Sherr, C.J. Mammalian G1 cyclins. Cell 73, 1059\u20131065 (1993).","journal-title":"Cell"},{"key":"BFni1015_CR8","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","volume":"13","author":"CJ Sherr","year":"1999","unstructured":"Sherr, C.J. & Roberts, J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501\u20131512 (1999).","journal-title":"Genes Dev."},{"key":"BFni1015_CR9","first-page":"3689","volume":"60","author":"CJ Sherr","year":"2000","unstructured":"Sherr, C.J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 60, 3689\u20133695 (2000).","journal-title":"Cancer Res."},{"key":"BFni1015_CR10","doi-asserted-by":"publisher","first-page":"25863","DOI":"10.1074\/jbc.272.41.25863","volume":"272","author":"SW Blain","year":"1997","unstructured":"Blain, S.W., Montalvo, E. & Massague, J. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272, 25863\u201325872 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFni1015_CR11","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/emboj\/18.6.1571","volume":"18","author":"M Cheng","year":"1999","unstructured":"Cheng, M. et al. The p21Cip1 and p27Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. Embo J. 18, 1571\u20131583 (1999).","journal-title":"Embo J."},{"key":"BFni1015_CR12","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1101\/gad.11.7.847","volume":"11","author":"J LaBaer","year":"1997","unstructured":"LaBaer, J. et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11, 847\u2013862 (1997).","journal-title":"Genes Dev."},{"key":"BFni1015_CR13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1128\/MCB.19.3.1775","volume":"19","author":"D Parry","year":"1999","unstructured":"Parry, D., Mahony, D., Wills, K. & Lees, E. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol. 19, 1775\u20131783 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BFni1015_CR14","first-page":"135","volume":"7","author":"TJ Soos","year":"1996","unstructured":"Soos, T.J. et al. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ. 7, 135\u2013146 (1996).","journal-title":"Cell Growth Differ."},{"key":"BFni1015_CR15","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1126\/science.276.5321.2057","volume":"276","author":"C Tanchot","year":"1997","unstructured":"Tanchot, C., Lemonnier, F.A., Perarnau, B., Freitas, A.A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057\u20132062 (1997).","journal-title":"Science"},{"key":"BFni1015_CR16","doi-asserted-by":"crossref","first-page":"Re7","DOI":"10.1126\/stke.2002.134.re7","volume":"2002","author":"N Olashaw","year":"2002","unstructured":"Olashaw, N. & Pledger, W.J. Paradigms of growth control: relation to cdk activation. Sci. STKE 2002, Re7 (2002).","journal-title":"Sci. STKE"},{"key":"BFni1015_CR17","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/73144","volume":"6","author":"VA Boussiotis","year":"2000","unstructured":"Boussiotis, V.A. et al. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat. Med. 6, 290\u2013297 (2000).","journal-title":"Nat. Med."},{"key":"BFni1015_CR18","doi-asserted-by":"publisher","first-page":"21976","DOI":"10.1074\/jbc.M009788200","volume":"276","author":"S Mohapatra","year":"2001","unstructured":"Mohapatra, S., Agrawal, D. & Pledger, W.J. p27Kip1 regulates T cell proliferation. J. Biol. Chem. 276, 21976\u201321983 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni1015_CR19","doi-asserted-by":"publisher","first-page":"7060","DOI":"10.1002\/j.1460-2075.1996.tb01097.x","volume":"15","author":"M Kitagawa","year":"1996","unstructured":"Kitagawa, M. et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A\/E-Cdk2. Embo J. 15, 7060\u20137069 (1996).","journal-title":"Embo J."},{"key":"BFni1015_CR20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1074-7613(02)00364-3","volume":"17","author":"MR Tourigny","year":"2002","unstructured":"Tourigny, M.R. et al. CDK inhibitor p18INK4c is required for the generation of functional plasma cells. Immunity 17, 179\u2013189 (2002).","journal-title":"Immunity"},{"key":"BFni1015_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1074-7613(00)80241-1","volume":"6","author":"L Morse","year":"1997","unstructured":"Morse, L., Chen, D., Franklin, D., Xiong, Y. & Chen-Kiang, S. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18INK4c and IL-6. Immunity 6, 47\u201356 (1997).","journal-title":"Immunity"},{"key":"BFni1015_CR22","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1101\/gad.9.6.650","volume":"9","author":"S Matsuoka","year":"1995","unstructured":"Matsuoka, S. et al. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9, 650\u2013662 (1995).","journal-title":"Genes Dev."},{"key":"BFni1015_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/72272","volume":"6","author":"D Balomenos","year":"2000","unstructured":"Balomenos, D. et al. The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development. Nat. Med. 6, 171\u2013176 (2000).","journal-title":"Nat. Med."},{"key":"BFni1015_CR24","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1126\/science.7863329","volume":"267","author":"SB Parker","year":"1995","unstructured":"Parker, S.B. et al. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267, 1024\u20131027 (1995).","journal-title":"Science"},{"key":"BFni1015_CR25","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.1002\/j.1460-2075.1994.tb06688.x","volume":"13","author":"J Pines","year":"1994","unstructured":"Pines, J. & Hunter, T. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. Embo J. 13, 3772\u20133781 (1994).","journal-title":"Embo J."},{"key":"BFni1015_CR26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1126\/science.277.5326.693","volume":"277","author":"M Dickens","year":"1997","unstructured":"Dickens, M. et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693\u2013696 (1997).","journal-title":"Science"},{"key":"BFni1015_CR27","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S0092-8674(00)81238-6","volume":"85","author":"H Kiyokawa","year":"1996","unstructured":"Kiyokawa, H. et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85, 721\u2013732 (1996).","journal-title":"Cell"},{"key":"BFni1015_CR28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0092-8674(00)81237-4","volume":"85","author":"K Nakayama","year":"1996","unstructured":"Nakayama, K. et al. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707\u2013720 (1996).","journal-title":"Cell"},{"key":"BFni1015_CR29","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0092-8674(00)81239-8","volume":"85","author":"ML Fero","year":"1996","unstructured":"Fero, M.L. et al. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. Cell 85, 733\u2013744 (1996).","journal-title":"Cell"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni1015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni1015","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni1015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:36:32Z","timestamp":1684434992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni1015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,30]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["BFni1015"],"URL":"https:\/\/doi.org\/10.1038\/ni1015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1017452.203232","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,30]]}}}