{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:45:49Z","timestamp":1761630349981},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1038\/nm0997-944","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T02:14:32Z","timestamp":1092881672000},"page":"944-948","source":"Crossref","is-referenced-by-count":96,"title":["Modification of vascular responses in xenotransplantation: Inflammation and apoptosis"],"prefix":"10.1038","volume":"3","author":[{"given":"Fritz H.","family":"Bach","sequence":"first","affiliation":[]},{"given":"Christiane","family":"Ferran","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Christopher J.","family":"Wrighton","sequence":"additional","affiliation":[]},{"given":"Josef","family":"Anrather","sequence":"additional","affiliation":[]},{"given":"Hans","family":"Winkler","sequence":"additional","affiliation":[]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[]},{"given":"Wayne W.","family":"Hancock","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnm0997944_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1097\/00007890-199411270-00001","volume":"58","author":"ML Blakely","year":"1994","unstructured":"Blakely, M.L., van der Werf, W.J., Dalmasso, A.P., Bach, F. H. & Hancock, W.W. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58, 1059\u20131066 (1994).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0167-5699(96)10024-4","volume":"17","author":"FH Bach","year":"1996","unstructured":"Bach, F.H., Winkler, H., Ferran, C., Hancock, W.W. & Robson, S.C. Delayed xenograft rejection. Immunol. Today 17, 379\u2013384 (1996).","journal-title":"Immunol. Today"},{"key":"BFnm0997944_CR3","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1097\/00007890-199612270-00042","volume":"62","author":"D Candinas","year":"1996","unstructured":"Candinas, D., Koyamada, N., Miyatake, T., Bach, F.H. & Hancock, W.W. T cell-independence of macrophage and NK cell infiltration, cytokine production and endothelial activation during delayed xenograft rejection. Transplantation 62, 1920\u20131926 (1996).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR4","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/00007890-199109000-00029","volume":"52","author":"AP Dalmasso","year":"1991","unstructured":"Dalmasso, A.P., Varcellotti, C.M., Platt, J.L. & Bach, F.H. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection. Transplantation. 52, 530\u2013534 (1991).","journal-title":"Transplantation."},{"key":"BFnm0997944_CR5","first-page":"205","volume":"23","author":"FH Bach","year":"1991","unstructured":"Bach, F.H., Turman, M.A., Varcellotti, C. M., Platt, J.L. & Dalmasso, A.P. Accommodation: a working paradigm for progressing toward clinical discordant xenografting. Transplant. Proc. 23, 205\u2013207 (1991).","journal-title":"Transplant. Proc."},{"key":"BFnm0997944_CR6","first-page":"55","volume":"4","author":"AP Dalamsso","year":"1996","unstructured":"Dalamsso, A.P. & Bach, F.H. Expression of human regulators of complement on pig endothelial cells. Xenotransplantation 4, 55\u201357 (1996).","journal-title":"Xenotransplantation"},{"key":"BFnm0997944_CR7","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/00007890-199703270-00017","volume":"63","author":"SK Pruit","year":"1997","unstructured":"Pruit, S.K. et al. Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts. Transplantation 63, 900\u2013905 (1997).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/nm0297-196","volume":"3","author":"FH Bach","year":"1997","unstructured":"Bach, F.H. et al. Accomodation of vascularized xenografts: expression of \u201cprotective genes\u201d by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3, 196\u2013204 (1997).","journal-title":"Nature Med."},{"key":"BFnm0997944_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1399-3089.1996.tb00149.x","volume":"3","author":"P Hechenleitner","year":"1996","unstructured":"Hechenleitner, P. et al. Protective genes expressed in endothelial cells of second hamster heart transplants to rats carrying an accommodated first graft. Xenotransplantation 3, 279\u2013286 (1996).","journal-title":"Xenotransplantation"},{"key":"BFnm0997944_CR10","unstructured":"Mark, W. et al. Xenograft accommodation is accomplished by intragraft Th2 cytokines and expression of protective genes. Xenotransplantation (in the press)."},{"key":"BFnm0997944_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/00007890-199607270-00002","volume":"62","author":"PJ Cowan","year":"1996","unstructured":"Cowan, P.J. et al. Targeting gene expression of endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter. Transplantation 62, 155\u2013160 (1996).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR12","unstructured":"Tran, T.H. Anrather, J., Hancock, W. W., Bach, F.H. & Winkler, H. Tetracycline regulated endothelial cell specific expression of a transdominant inhibitor of NF-kB in trans-genie mice. Transplant. Proc. (in the press)."},{"key":"BFnm0997944_CR13","doi-asserted-by":"crossref","first-page":"17971","DOI":"10.1016\/S0021-9258(19)37138-8","volume":"267","author":"A Krikos","year":"1992","unstructured":"Krikos, A., Laherty, C.D. & Dixit, V.M. Transcriptional activation of theTNFa-inducible zinc finger protein, A20, is mediated by kB elements. J. Biol. Chem. 267, 17971\u201317976 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFnm0997944_CR14","doi-asserted-by":"publisher","first-page":"18068","DOI":"10.1074\/jbc.271.30.18068","volume":"271","author":"JT Cooper","year":"1996","unstructured":"Cooper, J.T. et al. A20 blocks endothelial cell activation through a NF-kB-dependent mechanism. J. Biol. Chem. 271, 18068\u201318073 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFnm0997944_CR15","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/S0041-1345(96)00184-4","volume":"29","author":"C Ferran","year":"1997","unstructured":"Ferran, C. & Stroka, D. Adenovirus-mediated gene transfer of A20 renders endothelial cells resistant to activation: a means of evaluating the role of EC activation in xenograft rejection. Transplant. Proc. 29, 879\u2013880 (1997).","journal-title":"Transplant. Proc."},{"key":"BFnm0997944_CR16","doi-asserted-by":"crossref","unstructured":"Bach, F.H., Hancock, W.W. & Ferran, C. Protective genes expressed in endothelial cells: A regulatory response to injury. Immunol. Today (in the press)","DOI":"10.1016\/S0167-5699(97)01129-8"},{"key":"BFnm0997944_CR17","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/nm1295-1261","volume":"1","author":"Sandrin","year":"1995","unstructured":"Sandrin et al. Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduces human antibody binding and complement-mediated lysis. Nature Med. 1, 1261\u20131267 (1995).","journal-title":"Nature Med."},{"key":"BFnm0997944_CR18","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1097\/00007890-199603270-00003","volume":"61","author":"SC Robson","year":"1996","unstructured":"Robson, S.C. et al. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation 61, 862\u2013868 (1996).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR19","unstructured":"Lesnikoski, B.A., Candinas, D., Siegel, J.B., Bach, F.H. & Robson, S.C. Antithrombin agents in xenograft rejection. Xenotransplantation (in the press)."},{"key":"BFnm0997944_CR20","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/00007890-199603150-00016","volume":"61","author":"DJ Goodman","year":"1996","unstructured":"Goodman, D.J., von Albertini, M., Willson, A., Millan, M.T. & Bach, F.H. Direct activation of porcine endothelial cells by human natural killer cells. Transplantation 61, 763\u2013771 (1996).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/00007890-199702150-00016","volume":"63","author":"MT Millan","year":"1997","unstructured":"Millan, M.T. et al. Human monocytes activate porcine endothelial cells, resulting in increased E-selectin, interleukin-8, monocyte chemotactic protein-1, and plasmino-gen activator inhibitor type-1 expression. Transplantation 63, 421\u2013429 (1997).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR22","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1097\/00007890-199705150-00021","volume":"63","author":"L Inverardi","year":"1997","unstructured":"Inverardi, L. et al. Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues. Transplantation 63, 1318\u20131330 (1997).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR23","doi-asserted-by":"crossref","unstructured":"Hancock, W.W. et al. Effects of leflunomide and deoxyspergualin in the guinea pig->rat cardiac model of delayed xenograft rejection: Suppression of B cell and C-C chemokine responses but not induction of macrophage lectin. Transplantation (in the press).","DOI":"10.1097\/00007890-199709150-00006"},{"key":"BFnm0997944_CR24","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1097\/00007890-199703150-00023","volume":"63","author":"CW Kopp","year":"1997","unstructured":"Kopp, C.W. et al. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation 63, 749\u2013758 (1997).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR25","unstructured":"Siegel, J. et al. Activation of human prothrombin by porcine endothelium. Transplantation (in the press)."},{"key":"BFnm0997944_CR26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/00007890-199608150-00001","volume":"62","author":"JH Lawson","year":"1996","unstructured":"Lawson, J.H. & Platt, J.L. Molecular barriers to xenotransplantation. Transplantation 62, 303\u2013310 (1996).","journal-title":"Transplantation"},{"key":"BFnm0997944_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/scel.1995.0035","volume":"6","author":"CT Esmon","year":"1995","unstructured":"Esmon, C.T. & Fukudome, K. Cellular regulation of the protein C pathway. Semin. Cell Biol. 6, 259\u201368 (1995).","journal-title":"Semin. Cell Biol."},{"key":"BFnm0997944_CR28","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.4049\/jimmunol.156.6.2256","volume":"156","author":"ST Grey","year":"1996","unstructured":"Grey, S.T. & Hancock, W.W. A physiologic anti-inflammatory pathway based upon thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J. Immunol. 156, 2256\u20132263 (1996).","journal-title":"J. Immunol."},{"key":"BFnm0997944_CR29","unstructured":"Hancock, W. & Bach, F. H. Immunobiology and therapeutic applications of protein C\/protein S\/ thrombomodulin in human and experimental allo-and xenotransplantation. Trends Cardiovasc. Med. (in the press)."},{"key":"BFnm0997944_CR30","first-page":"288","volume":"27","author":"C Wrighton","year":"1995","unstructured":"Wrighton, C., Kopp, C.W., McShea, A., Vetr, H. & Bach, F.H. High level of functional human thrombomodulin in cultured porcine aortic endothelial cells. Transplant. Proc. 27, 288\u2013289 (1995).","journal-title":"Transplant. Proc."},{"key":"BFnm0997944_CR31","first-page":"2930","volume":"25","author":"AF Coughlan","year":"1993","unstructured":"Coughlan, A.F., Berndt, M.C., Dunlop, L.C. & Hancock, W.W. In vivo studies of P-selectin and platelet-activating factor during endotoxemia, accelerated allograft rejection, and discordant xenograft rejection. Transplant. Proc. 25, 2930\u20132931 (1993).","journal-title":"Transplant. Proc."},{"key":"BFnm0997944_CR32","doi-asserted-by":"crossref","unstructured":"Kaczmarek, E. et al. Identification and characterization of CD39 as the vascular ATPDase. In: Ecto-ATPases. Proc. First Int. Workshop on Ecto-ATPases. Editors: L. Plesner, Kirley TL and Knowles AF. Plenum. New York. 1997. pp. 171\u2013185.","DOI":"10.1007\/978-1-4615-5955-9_22"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0997-944","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0997-944.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0997-944.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T06:15:38Z","timestamp":1705212938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0997-944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["BFnm0997944"],"URL":"https:\/\/doi.org\/10.1038\/nm0997-944","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}