{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:32:09Z","timestamp":1772865129116,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2003,6,15]],"date-time":"2003-06-15T00:00:00Z","timestamp":1055635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1038\/nm888","type":"journal-article","created":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T19:15:05Z","timestamp":1055531705000},"page":"964-968","source":"Crossref","is-referenced-by-count":1121,"title":["BMP-7 counteracts TGF-\u03b21\u2013induced epithelial-to-mesenchymal transition and reverses chronic renal injury"],"prefix":"10.1038","volume":"9","author":[{"given":"Michael","family":"Zeisberg","sequence":"first","affiliation":[]},{"given":"Jun-ichi","family":"Hanai","sequence":"additional","affiliation":[]},{"given":"Hikaru","family":"Sugimoto","sequence":"additional","affiliation":[]},{"given":"Tadanori","family":"Mammoto","sequence":"additional","affiliation":[]},{"given":"David","family":"Charytan","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Strutz","sequence":"additional","affiliation":[]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,6,15]]},"reference":[{"key":"BFnm888_CR1","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1002\/j.1460-2075.1990.tb07376.x","volume":"9","author":"E Ozkaynak","year":"1990","unstructured":"Ozkaynak, E. et al. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J. 9, 2085\u20132093 (1990).","journal-title":"EMBO J."},{"key":"BFnm888_CR2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/S0959-437X(96)80064-5","volume":"6","author":"BL Hogan","year":"1996","unstructured":"Hogan, B.L. Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6, 432\u2013438 (1996).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnm888_CR3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/35000025","volume":"2","author":"A Cano","year":"2000","unstructured":"Cano, A. et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2, 76\u201383 (2000).","journal-title":"Nat. Cell Biol."},{"key":"BFnm888_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"110","author":"M Iwano","year":"2002","unstructured":"Iwano, M. et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110, 341\u2013350 (2002).","journal-title":"J. Clin. Invest."},{"key":"BFnm888_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","volume":"2","author":"JP Thiery","year":"2002","unstructured":"Thiery, J.P. Epithelial-mesenchymal transitions in tumor progression. Nat. Rev. Cancer 2, 442\u2013454 (2002).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnm888_CR6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/0272-6386(95)90610-X","volume":"26","author":"ED Hay","year":"1995","unstructured":"Hay, E.D. & Zuk, A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am. J. Kidney Dis. 26, 678\u2013690 (1995).","journal-title":"Am. J. Kidney Dis."},{"key":"BFnm888_CR7","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1046\/j.1523-1755.2002.00333.x","volume":"61","author":"F Strutz","year":"2002","unstructured":"Strutz, F. et al. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int. 61, 1714\u20131728 (2002).","journal-title":"Kidney Int."},{"key":"BFnm888_CR8","doi-asserted-by":"publisher","first-page":"11495","DOI":"10.1073\/pnas.88.24.11495","volume":"88","author":"J Behrens","year":"1991","unstructured":"Behrens, J., Lowrick, O., Klein-Hitpass, L. & Birchmeier, W. The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc. Natl. Acad. Sci. USA 88, 11495\u201311499 (1991).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm888_CR9","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"CH Heldin","year":"1997","unstructured":"Heldin, C.H., Miyazono, K. & ten Dijke, P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465\u2013471 (1997).","journal-title":"Nature"},{"key":"BFnm888_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0092-8674(00)81556-1","volume":"100","author":"JL Wrana","year":"2000","unstructured":"Wrana, J.L. Regulation of Smad activity. Cell 100, 189\u2013192 (2000).","journal-title":"Cell"},{"key":"BFnm888_CR11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","volume":"95","author":"R Derynck","year":"1998","unstructured":"Derynck, R., Zhang, Y. & Feng, X.H. Smads: transcriptional activators of TGF-beta responses. Cell 95, 737\u2013740 (1998).","journal-title":"Cell"},{"key":"BFnm888_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/35043051","volume":"1","author":"J Massague","year":"2000","unstructured":"Massague, J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell. Biol. 1, 169\u2013178 (2000).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"BFnm888_CR13","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1126\/science.1071809","volume":"296","author":"L Attisano","year":"2002","unstructured":"Attisano, L. & Wrana, J.L. Signal transduction by the TGF-beta superfamily. Science 296, 1646\u20131647 (2002).","journal-title":"Science"},{"key":"BFnm888_CR14","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1101\/gad.12.14.2144","volume":"12","author":"YG Chen","year":"1998","unstructured":"Chen, Y.G. et al. Determinants of specificity in TGF-beta signal transduction. Genes Dev. 12, 2144\u20132152 (1998).","journal-title":"Genes Dev."},{"key":"BFnm888_CR15","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.1074\/jbc.275.9.6075","volume":"275","author":"W Ishida","year":"2000","unstructured":"Ishida, W. et al. Smad6 is a Smad1\/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275, 6075\u20136079 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnm888_CR16","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1242\/dev.124.22.4467","volume":"124","author":"AF Candia","year":"1997","unstructured":"Candia, A.F. et al. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin\/BVg1 and BMP-2\/4 signaling mediated by Smads. Development 124, 4467\u20134480 (1997).","journal-title":"Development"},{"key":"BFnm888_CR17","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S1097-2765(01)00260-X","volume":"7","author":"J Comijn","year":"2001","unstructured":"Comijn, J. et al. The two-handed E box binding zinc finger protein SIP1 downregulates E- cadherin and induces invasion. Mol. Cell 7, 1267\u20131278 (2001).","journal-title":"Mol. Cell"},{"key":"BFnm888_CR18","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1084\/jem.185.7.1371","volume":"185","author":"CM Lloyd","year":"1997","unstructured":"Lloyd, C.M. et al. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med. 185, 1371\u20131380 (1997).","journal-title":"J. Exp. Med."},{"key":"BFnm888_CR19","doi-asserted-by":"publisher","first-page":"F130","DOI":"10.1152\/ajprenal.2000.279.1.F130","volume":"279","author":"KA Hruska","year":"2000","unstructured":"Hruska, K.A. et al. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am. J. Physiol. Renal Physiol. 279, F130\u2013F143 (2000).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnm888_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/360361a0","volume":"360","author":"WA Border","year":"1992","unstructured":"Border, W.A. et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 360, 361\u2013364 (1992).","journal-title":"Nature"},{"key":"BFnm888_CR21","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1056\/NEJM199811123392007","volume":"339","author":"G Remuzzi","year":"1998","unstructured":"Remuzzi, G. & Bertani, T. Pathophysiology of progressive nephropathies. N. Engl. J. Med. 339, 1448\u20131456 (1998).","journal-title":"N. Engl. J. Med."},{"key":"BFnm888_CR22","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1074\/jbc.271.1.595","volume":"271","author":"G Hennig","year":"1996","unstructured":"Hennig, G., Lowrick, O., Birchmeier, W. & Behrens, J. Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem. 271, 595\u2013602 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFnm888_CR23","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1093\/emboj\/17.14.4056","volume":"17","author":"M Kawabata","year":"1998","unstructured":"Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. & Miyazono, K. Smad proteins exist as monomers in vivo and undergo homo- and hetero- oligomerization upon activation by serine\/threonine kinase receptors. EMBO J. 17, 4056\u20134065 (1998).","journal-title":"EMBO J."},{"key":"BFnm888_CR24","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/39355","volume":"389","author":"T Imamura","year":"1997","unstructured":"Imamura, T. et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 389, 622\u2013626 (1997).","journal-title":"Nature"},{"key":"BFnm888_CR25","doi-asserted-by":"publisher","first-page":"F563","DOI":"10.1152\/ajpcell.1997.273.3.C755","volume":"273","author":"H Okada","year":"1997","unstructured":"Okada, H., Danoff, T.M., Kalluri, R. & Neilson, E.G. Early role of Fsp1 in epithelial-mesenchymal transformation. Am. J. Physiol. 273, F563\u2013F574 (1997).","journal-title":"Am. J. Physiol."},{"key":"BFnm888_CR26","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/S0002-9440(10)62518-7","volume":"159","author":"M Zeisberg","year":"2001","unstructured":"Zeisberg, M. et al. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am. J. Pathol. 159, 1313\u20131321 (2001).","journal-title":"Am. J. Pathol."},{"key":"BFnm888_CR27","doi-asserted-by":"publisher","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","volume":"274","author":"J Hanai","year":"1999","unstructured":"Hanai, J. et al. Interaction and functional cooperation of PEBP2\/CBF with Smads. Synergistic induction of the immunoglobulin germline C alpha promoter. J. Biol. Chem. 274, 31577\u201331582 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFnm888_CR28","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/S0002-9440(10)61150-9","volume":"160","author":"M Zeisberg","year":"2002","unstructured":"Zeisberg, M., Maeshima, Y., Mosterman, B. & Kalluri, R. Renal fibrosis: extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am. J. Pathol. 160, 2001\u20132008 (2002).","journal-title":"Am. J. Pathol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm888","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:34:39Z","timestamp":1684449279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,15]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["BFnm888"],"URL":"https:\/\/doi.org\/10.1038\/nm888","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,15]]}}}